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Preparation of Quality Inositol Pyrophosphates

Preparation of Quality Inositol Pyrophosphates

Article DOI: 10.3791/3027-v 10:35 min September 3rd, 2011
September 3rd, 2011



Inositol pyrophosphates play an important role in human pathologies such cancer, diabetes and obesity; however, the exact mechanism of action is a matter of dispute. The lack of commercially available inositol pyrophosphates renders detailed studies problematic. Here we describe a simple protocol to produce and isolate milligrams of inositol pyrophosphates.


Inositol Pyrophosphates Myo-inositol IP5 IP6 Inositol Pentakisphosphate Phytic Acid Inositol Hexakisphosphate IP7 IP8 Phosphorylation Enzymes IP6 Kinases VIP1 Cellular Processes Insulin Secretion Telomere Length Chemotaxis Vesicular Trafficking Phosphate Homeostasis HIV-1 Gag Release
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