Wan L. Lam

Wan L. Lam

Department of Cancer Genetics, BC Cancer Research Centre

Affiliated withBC Cancer Research CentreUniversity of British Columbia - UBC

Research Area

Biology

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JoVE Journal Publications

ArticleTotal : 3
Year
Technical Demonstration of Whole Genome Array Comparative Genomic Hybridization
Publication title

Cited by 5

2008
Methylated DNA Immunoprecipitation
Publication title

Cited by 43

2009
DNA Extraction from Paraffin Embedded Material for Genetic and Epigenetic Analyses
Publication title

Cited by 131

2011

Other Publications

Article
Year
Two-dimensional display and whole genome comparison of bacterial pathogen genomes of high G+C DNA content.

Gene| PubMed ID: 12137959

2002
An efficient method for the assessment of DNA quality of archival microdissected specimens.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc| PubMed ID: 12181275

2002
Two-dimensional bacterial genome display: a method for the genomic analysis of mycobacteria.

Microbiology (Reading, England)| PubMed ID: 12368444

2002
3p14 and 9p21 loss is a simple tool for predicting second oral malignancy at previously treated oral cancer sites.

Cancer research| PubMed ID: 12438233

2002
Characterization of the recurrent translocation t(1;1)(p36.3;q21.1-2) in non-Hodgkin lymphoma by multicolor banding and fluorescence in situ hybridization analysis.

Genes, chromosomes & cancer| PubMed ID: 12619161

2003
Novel regions of amplification on 8q distinct from the MYC locus and frequently altered in oral dysplasia and cancer.

Genes, chromosomes & cancer| PubMed ID: 14603447

2004
Overexpression of LRP12, a gene contained within an 8q22 amplicon identified by high-resolution array CGH analysis of oral squamous cell carcinomas.

Oncogene| PubMed ID: 14676824

2004
Use of complete coverage array comparative genomic hybridization to define copy number alterations on chromosome 3p in oral squamous cell carcinomas.

Cancer research| PubMed ID: 14695166

2003
Methods for high throughput validation of amplified fragment pools of BAC DNA for constructing high resolution CGH arrays.

BMC genomics| PubMed ID: 14723794

2004
A tiling resolution DNA microarray with complete coverage of the human genome.

Nature genetics| PubMed ID: 14981516

2004
OCGR array: an oral cancer genomic regional array for comparative genomic hybridization analysis.

Oral oncology| PubMed ID: 15006624

2004
Delineation of a minimal region of deletion at 6q16.3 in follicular lymphoma and construction of a bacterial artificial chromosome contig spanning a 6-megabase region of 6q16-q21.

Genes, chromosomes & cancer| PubMed ID: 15034870

2004
Genetic alteration and gene expression modulation during cancer progression.

Molecular cancer| PubMed ID: 15035667

2004
SeeGH--a software tool for visualization of whole genome array comparative genomic hybridization data.

BMC bioinformatics| PubMed ID: 15040819

2004
Serial analysis of gene expression profiles of developmental stages in non-small cell lung carcinoma.

Chest| PubMed ID: 15136435

2004
Comprehensive whole genome array CGH profiling of mantle cell lymphoma model genomes.

Human molecular genetics| PubMed ID: 15229187

2004
High-resolution chromosome arm 5p array CGH analysis of small cell lung carcinoma cell lines.

Genes, chromosomes & cancer| PubMed ID: 15611929

2005
Involvement of multiple developmental genes on chromosome 1p in lung tumorigenesis.

Human molecular genetics| PubMed ID: 15615770

2005
An integrated mBAND and submegabase resolution tiling set (SMRT) CGH array analysis of focal amplification, microdeletions, and ladder structures consistent with breakage-fusion-bridge cycle...

Genes, chromosomes & cancer| PubMed ID: 15660435

2005
Alteration of AKAP220, an upstream component of the Rb pathway, in oral carcinogenesis.

International journal of cancer. Journal international du cancer| PubMed ID: 15849745

2005
Array CGH technologies and their applications to cancer genomes.

Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology| PubMed ID: 15868418

2005
Chromosome 5p aberrations are early events in lung cancer: implication of glial cell line-derived neurotrophic factor in disease progression.

Oncogene| PubMed ID: 15870700

2005
High-resolution array CGH increases heterogeneity tolerance in the analysis of clinical samples.

Genomics| PubMed ID: 15885505

2005
Chromosome-wide and promoter-specific analyses identify sites of differential DNA methylation in normal and transformed human cells.

Nature genetics| PubMed ID: 16007088

2005
Gain of a region on 7p22.3, containing MAD1L1, is the most frequent event in small-cell lung cancer cell lines.

Genes, chromosomes & cancer| PubMed ID: 16130125

2006
Multiple microalterations detected at high frequency in oral cancer.

Cancer research| PubMed ID: 16140918

2005
Toluidine blue staining identifies high-risk primary oral premalignant lesions with poor outcome.

Cancer research| PubMed ID: 16140975

2005
High resolution analysis of non-small cell lung cancer cell lines by whole genome tiling path array CGH.

International journal of cancer. Journal international du cancer| PubMed ID: 16187286

2006
Microarray-based CGH of sporadic and syndrome-related pheochromocytomas using a 0.1-0.2 Mb bacterial artificial chromosome array spanning chromosome arm 1p.

Genes, chromosomes & cancer| PubMed ID: 16215979

2006
Recent advances in array comparative genomic hybridization technologies and their applications in human genetics.

European journal of human genetics : EJHG| PubMed ID: 16288307

2006
A stepwise framework for the normalization of array CGH data.

BMC bioinformatics| PubMed ID: 16297240

2005
Epigenomics: mapping the methylome.

Cell cycle (Georgetown, Tex.)| PubMed ID: 16397413

2006
Comprehensive copy number profiles of breast cancer cell model genomes.

Breast cancer research : BCR| PubMed ID: 16417655

2006
Identification of novel lung genes in bronchial epithelium by serial analysis of gene expression.

American journal of respiratory cell and molecular biology| PubMed ID: 16809635

2006
Integrating copy number polymorphisms into array CGH analysis using a robust HMM.

Bioinformatics (Oxford, England)| PubMed ID: 16873504

2006
Genomic alterations in lobular neoplasia: a microarray comparative genomic hybridization signature for early neoplastic proliferationin the breast.

Genes, chromosomes & cancer| PubMed ID: 16897748

2006
Cytogenetically balanced translocations are associated with focal copy number alterations.

Human genetics| PubMed ID: 17051368

2007
Whole genome tiling path array CGH analysis of segmental copy number alterations in cervical cancer cell lines.

International journal of cancer. Journal international du cancer| PubMed ID: 17096350

2007
Large fragment Bst DNA polymerase for whole genome amplification of DNA from formalin-fixed paraffin-embedded tissues.

BMC genomics| PubMed ID: 17156491

2006
A comprehensive analysis of common copy-number variations in the human genome.

American journal of human genetics| PubMed ID: 17160897

2007
SIGMA: a system for integrative genomic microarray analysis of cancer genomes.

BMC genomics| PubMed ID: 17192189

2006
Resolving the resolution of array CGH.

Genomics| PubMed ID: 17276656

2007
Heritable skewed X-chromosome inactivation leads to haemophilia A expression in heterozygous females.

European journal of human genetics : EJHG| PubMed ID: 17342157

2007
Skewed X-chromosome inactivation is associated with primary but not secondary ovarian failure.

American journal of medical genetics. Part A| PubMed ID: 17431892

2007
Whole-genome analysis and HLA genotyping of enteropathy-type T-cell lymphoma reveals 2 distinct lymphoma subtypes.

Gastroenterology| PubMed ID: 17484883

2007
Comprehensive serial analysis of gene expression of the cervical transcriptome.

BMC genomics| PubMed ID: 17543121

2007
Modeling recurrent DNA copy number alterations in array CGH data.

Bioinformatics (Oxford, England)| PubMed ID: 17646330

2007
Genetic changes in the evolution of multidrug resistance for cultured human ovarian cancer cells.

Genes, chromosomes & cancer| PubMed ID: 17726699

2007
Effect of active smoking on the human bronchial epithelium transcriptome.

BMC genomics| PubMed ID: 17727719

2007
Frequent occurrence of deletions in primary mediastinal B-cell lymphoma.

Genes, chromosomes & cancer| PubMed ID: 17823928

2007
Computational methods for the analysis of array comparative genomic hybridization.

Cancer informatics| PubMed ID: 17992253

2006
Genomics and premalignant breast lesions: clues to the development and progression of lobular breast cancer.

Breast cancer research : BCR| PubMed ID: 18036272

2007
Sub-megabase resolution tiling (SMRT) array-based comparative genomic hybridization profiling reveals novel gains and losses of chromosomal regions in Hodgkin Lymphoma and Anaplastic Large C...

Molecular cancer| PubMed ID: 18179710

2008
Up regulation in gene expression of chromatin remodelling factors in cervical intraepithelial neoplasia.

BMC genomics| PubMed ID: 18248679

2008
Inverted duplication with terminal deletion of 5p and no cat-like cry.

American journal of medical genetics. Part A| PubMed ID: 18266247

2008
Epigenetics of cancer progression.

Pharmacogenomics| PubMed ID: 18370850

2008
Comment re: a comparison of DNA copy number profiling platforms.

Cancer research| PubMed ID: 18483289

2008
MD-SeeGH: a platform for integrative analysis of multi-dimensional genomic data.

BMC bioinformatics| PubMed ID: 18492270

2008
Genomic markers for malignant progression in pulmonary adenocarcinoma with bronchioloalveolar features.

Proceedings of the National Academy of Sciences of the United States of America| PubMed ID: 18632575

2008
High-resolution whole genome tiling path array CGH analysis of CD34+ cells from patients with low-risk myelodysplastic syndromes reveals cryptic copy number alterations and predicts overall ...

Blood| PubMed ID: 18663149

2008
Characterization of genes differentially expressed within macrophages by virulent and attenuated Mycobacterium tuberculosis identifies candidate genes involved in intracellular growth.

Microbiology (Reading, England)| PubMed ID: 18667562

2008
Evolving strategies for global gene expression analysis of cancer.

Journal of cellular physiology| PubMed ID: 18680120

2008
Bacterial artificial chromosome fingerprint arrays for the differentiation of transcriptomic differences in mycobacteria.

Journal of microbiological methods| PubMed ID: 18706942

2008
PIK3CA mutations and copy number gains in human lung cancers.

Cancer research| PubMed ID: 18757405

2008
SIGMA2: a system for the integrative genomic multi-dimensional analysis of cancer genomes, epigenomes, and transcriptomes.

BMC bioinformatics| PubMed ID: 18840289

2008
Integrative genomic and gene expression analysis of chromosome 7 identified novel oncogene loci in non-small cell lung cancer.

Genome / National Research Council Canada = Génome / Conseil national de recherches Canada| PubMed ID: 19088816

2008
MET gene amplification or EGFR mutation activate MET in lung cancers untreated with EGFR tyrosine kinase inhibitors.

International journal of cancer. Journal international du cancer| PubMed ID: 19117057

2009
Multiple aberrations of chromosome 3p detected in oral premalignant lesions.

Cancer prevention research (Philadelphia, Pa.)| PubMed ID: 19138989

2008
Array-comparative genomic hybridization in sporadic benign pheochromocytomas.

Endocrine-related cancer| PubMed ID: 19153209

2009
Defining genomic alteration boundaries for a combined small cell and non-small cell lung carcinoma.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer| PubMed ID: 19179901

2009
Alterations in genes of the EGFR signaling pathway and their relationship to EGFR tyrosine kinase inhibitor sensitivity in lung cancer cell lines.

PloS one| PubMed ID: 19238210

2009
Minimum altered regions in early prostate cancer progression identified by high resolution whole genome tiling path BAC array comparative hybridization.

The Prostate| PubMed ID: 19267368

2009
High-resolution array CGH identifies novel regions of genomic alteration in intermediate-risk prostate cancer.

The Prostate| PubMed ID: 19350549

2009
Public databases and software for the pathway analysis of cancer genomes.

Cancer informatics| PubMed ID: 19455256

2007
Comparative genomic hybridization on BAC arrays.

Methods in molecular biology (Clifton, N.J.)| PubMed ID: 19488868

2009
Methylation analysis by DNA immunoprecipitation (MeDIP).

Methods in molecular biology (Clifton, N.J.)| PubMed ID: 19488876

2009
Multiple pathways in the FGF signaling network are frequently deregulated by gene amplification in oral dysplasias.

International journal of cancer. Journal international du cancer| PubMed ID: 19623652

2009
Genomic imbalances in precancerous tissues signal oral cancer risk.

Molecular cancer| PubMed ID: 19627613

2009
Using LongSAGE to Detect Biomarkers of Cervical Cancer Potentially Amenable to Optical Contrast Agent Labelling.

Biomarker insights| PubMed ID: 19662225

2007
Oncogene mutations, copy number gains and mutant allele specific imbalance (MASI) frequently occur together in tumor cells.

PloS one| PubMed ID: 19826477

2009
Methylation analysis by DNA immunoprecipitation.

Journal of cellular physiology| PubMed ID: 20020444

2010
Integrating the multiple dimensions of genomic and epigenomic landscapes of cancer.

Cancer metastasis reviews| PubMed ID: 20108112

2010
Transcriptome profiles of carcinoma-in-situ and invasive non-small cell lung cancer as revealed by SAGE.

PloS one| PubMed ID: 20161782

2010
Patient-derived first generation xenografts of non-small cell lung cancers: promising tools for predicting drug responses for personalized chemotherapy.

Clinical cancer research : an official journal of the American Association for Cancer Research| PubMed ID: 20179238

2010
Copy number variations in the human genome and strategies for analysis.

Methods in molecular biology (Clifton, N.J.)| PubMed ID: 20238078

2010
Disruption of the non-canonical WNT pathway in lung squamous cell carcinoma.

Clinical medicine. Oncology| PubMed ID: 20401333

2008
An integrative multi-dimensional genetic and epigenetic strategy to identify aberrant genes and pathways in cancer.

BMC systems biology| PubMed ID: 20478067

2010
Contrasting transcriptional responses of a virulent and an attenuated strain of Mycobacterium tuberculosis infecting macrophages.

PloS one| PubMed ID: 20548782

2010
FACADE: a fast and sensitive algorithm for the segmentation and calling of high resolution array CGH data.

Nucleic acids research| PubMed ID: 20551132

2010
Array comparative genomic hybridization of peripheral blood granulocytes of patients with myelodysplastic syndrome detects karyotypic abnormalities.

American journal of clinical pathology| PubMed ID: 20551276

2010
Integrative genomic analyses identify BRF2 as a novel lineage-specific oncogene in lung squamous cell carcinoma.

PLoS medicine| PubMed ID: 20668658

2010
Lung cancer cell lines as tools for biomedical discovery and research.

Journal of the National Cancer Institute| PubMed ID: 20679594

2010
A sequence-based approach to identify reference genes for gene expression analysis.

BMC medical genomics| PubMed ID: 20682026

2010
Copy number alterations at polymorphic loci may be acquired somatically in patients with myelodysplastic syndromes.

Leukemia research| PubMed ID: 20801506

2011
Genome-wide identification of human microRNAs located in leukemia-associated genomic alterations.

Blood| PubMed ID: 20962326

2011
Deciphering squamous cell carcinoma using multidimensional genomic approaches.

Journal of skin cancer| PubMed ID: 21234096

2011
Comparison of genome-wide array genomic hybridization platforms for the detection of copy number variants in idiopathic mental retardation.

BMC medical genomics| PubMed ID: 21439053

2011
Cyclin E1 is amplified and overexpressed in osteosarcoma.

The Journal of molecular diagnostics : JMD| PubMed ID: 21458381

2011
The functional role of long non-coding RNA in human carcinomas.

Molecular cancer| PubMed ID: 21489289

2011
MicroRNA gene dosage alterations and drug response in lung cancer.

Journal of biomedicine & biotechnology| PubMed ID: 21541180

2011
Chromosome-wide DNA methylation analysis predicts human tissue-specific X inactivation.

Human genetics| PubMed ID: 21597963

2011
Genetic disruption of KEAP1/CUL3 E3 ubiquitin ligase complex components is a key mechanism of NF-kappaB pathway activation in lung cancer.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer| PubMed ID: 21795997

2011
Long non-coding RNAs are expressed in oral mucosa and altered in oral premalignant lesions.

Oral oncology| PubMed ID: 21835683

2011
miR-101 DNA copy loss is a prominent subtype specific event in lung cancer.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer| PubMed ID: 21849855

2011
TRAF6 is an amplified oncogene bridging the RAS and NF-κB pathways in human lung cancer.

The Journal of clinical investigation| PubMed ID: 21911935

2011
Human cancer long non-coding RNA transcriptomes.

PloS one| PubMed ID: 21991387

2011
NKX3.1 haploinsufficiency is prognostic for prostate cancer relapse following surgery or image-guided radiotherapy.

Clinical cancer research : an official journal of the American Association for Cancer Research| PubMed ID: 22048240

2012
Arsenic biotransformation as a cancer promoting factor by inducing DNA damage and disruption of repair mechanisms.

Molecular biology international| PubMed ID: 22091411

2011
Arsenic exposure and the induction of human cancers.

Journal of toxicology| PubMed ID: 22174709

2011
Induction of human squamous cell-type carcinomas by arsenic.

Journal of skin cancer| PubMed ID: 22175027

2011
Allelic loss of the loci containing the androgen synthesis gene, StAR, is prognostic for relapse in intermediate-risk prostate cancer.

The Prostate| PubMed ID: 22213075

2011
Copy number alterations of c-MYC and PTEN are prognostic factors for relapse after prostate cancer radiotherapy.

Cancer| PubMed ID: 22281794

2012
Translating cancer 'omics' to improved outcomes.

Genome research| PubMed ID: 22301133

2012
Integrative Genomics Identified RFC3 as an Amplified Candidate Oncogene in Esophageal Adenocarcinoma.

Clinical cancer research : an official journal of the American Association for Cancer Research| PubMed ID: 22328562

2012