Jong-Ik Hwang

Graduate School of Medicine, Korea University

Affiliated withKorea University Korea University

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 8	2019

Other Publications

Article	Year
Molecular cloning and characterization of a novel phospholipase C, PLC-eta. The Biochemical journal\| PubMed ID: 15702972	2005
Role of Galpha12 and Galpha13 as novel switches for the activity of Nrf2, a key antioxidative transcription factor. Molecular and cellular biology\| PubMed ID: 17591699	2007
Cloning and activation of the bullfrog apelin receptor: Gi/o coupling and high affinity for [Pro1]apelin-13. Molecular and cellular endocrinology\| PubMed ID: 17825479	2007
Extracellular loop 3 (ECL3) and ECL3-proximal transmembrane domains VI and VII of the mesotocin and vasotocin receptors confer differential ligand selectivity and signaling activity. General and comparative endocrinology\| PubMed ID: 18158152	2008
Involvement of amino acids flanking Glu7.32 of the gonadotropin-releasing hormone receptor in the selectivity of antagonists. Molecules and cells\| PubMed ID: 18319619	2008
Identification of farnesyl pyrophosphate and N-arachidonylglycine as endogenous ligands for GPR92. The Journal of biological chemistry\| PubMed ID: 18499677	2008
Molecular cloning of the bullfrog kisspeptin receptor GPR54 with high sensitivity to Xenopus kisspeptin. Peptides\| PubMed ID: 18550222	2009
GbetaL regulates TNFalpha-induced NF-kappaB signaling by directly inhibiting the activation of IkappaB kinase. Cellular signalling\| PubMed ID: 18755269	2008
Gene expression profiling of light-induced retinal degeneration in phototransduction gene knockout mice. Experimental & molecular medicine\| PubMed ID: 18985007	2008
Molecular evolution of multiple forms of kisspeptins and GPR54 receptors in vertebrates. Endocrinology\| PubMed ID: 19164475	2009
A gonadotropin-releasing hormone-II antagonist induces autophagy of prostate cancer cells. Cancer research\| PubMed ID: 19176390	2009
Phylogenetic history, pharmacological features, and signal transduction of neurotensin receptors in vertebrates. Annals of the New York Academy of Sciences\| PubMed ID: 19456337	2009
Splicing variants of the orphan G-protein-coupled receptor GPR56 regulate the activity of transcription factors associated with tumorigenesis. Journal of cancer research and clinical oncology\| PubMed ID: 19572147	2010
Suppression of NF-kappaB signaling by KEAP1 regulation of IKKbeta activity through autophagic degradation and inhibition of phosphorylation. Cellular signalling\| PubMed ID: 20600852	2010
Molecular coevolution of kisspeptins and their receptors from fish to mammals. Annals of the New York Academy of Sciences\| PubMed ID: 20633134	2010
Tyr1 and Ile7 of glucose-dependent insulinotropic polypeptide (GIP) confer differential ligand selectivity toward GIP and glucagon-like peptide-1 receptors. Molecules and cells\| PubMed ID: 20799012	2010
Revisiting the evolution of gonadotropin-releasing hormones and their receptors in vertebrates: secrets hidden in genomes. General and comparative endocrinology\| PubMed ID: 21036176	2011
Regulation of IκB kinase by GβL through recruitment of the protein phosphatases. Molecules and cells\| PubMed ID: 21110129	2010
Insulin contributes to fine-tuning of the pancreatic beta-cell response to glucagon-like peptide-1. Molecules and cells\| PubMed ID: 21904878	2011
Evolutionarily conserved residues at glucagon-like peptide-1 (GLP-1) receptor core confer ligand-induced receptor activation. The Journal of biological chemistry\| PubMed ID: 22105074	2012
Molecular Coevolution of Neuropeptides Gonadotropin-Releasing Hormone and Kisspeptin with their Cognate G Protein-Coupled Receptors. Frontiers in neuroscience\| PubMed ID: 22291614	2012
Spatiotemporal expression and functional implication of CXCL14 in the developing mice cerebellum. Molecules and cells\| PubMed ID: 22843118	2012
Anti-cancer activity of a novel small molecule compound that simultaneously activates p53 and inhibits NF-κB signaling. PloS one\| PubMed ID: 23028510	2012
Generation and characterization of human heme oxygenase-1 transgenic pigs. PloS one\| PubMed ID: 23071605	2012
CXCL14 enhances proliferation and migration of NCI-H460 human lung cancer cells overexpressing the glycoproteins containing heparan sulfate or sialic acid. Journal of cellular biochemistry\| PubMed ID: 23161284	2013
Structural and molecular conservation of glucagon-like Peptide-1 and its receptor confers selective ligand-receptor interaction. Frontiers in endocrinology\| PubMed ID: 23181056	2012
Expansion of secretin-like G protein-coupled receptors and their peptide ligands via local duplications before and after two rounds of whole-genome duplication. Molecular biology and evolution\| PubMed ID: 23427277	2013
A novel glucagon-related peptide (GCRP) and its receptor GCRPR account for coevolution of their family members in vertebrates. PloS one\| PubMed ID: 23776481	2013
Expression analysis of combinatorial genes using a bi-cistronic T2A expression system in porcine fibroblasts. PloS one\| PubMed ID: 23922997	2013
Local duplication of gonadotropin-releasing hormone (GnRH) receptor before two rounds of whole genome duplication and origin of the mammalian GnRH receptor. PloS one\| PubMed ID: 24498396	2014
Coevolution of the spexin/galanin/kisspeptin family: Spexin activates galanin receptor type II and III. Endocrinology\| PubMed ID: 24517231	2014
A splicing variant of NME1 negatively regulates NF-κB signaling and inhibits cancer metastasis by interacting with IKKβ. The Journal of biological chemistry\| PubMed ID: 24811176	2014
Apoptotic death of prostate cancer cells by a gonadotropin-releasing hormone-II antagonist. PloS one\| PubMed ID: 24926857	2014
Does Kisspeptin Belong to the Proposed RF-Amide Peptide Family? Frontiers in endocrinology\| PubMed ID: 25165463	2014
A Novel Long-Acting Glucagon-Like Peptide-1 Agonist with Improved Efficacy in Insulin Secretion and β-Cell Growth. Endocrinology and metabolism (Seoul, Korea)\| PubMed ID: 25309791	2014
Ligand binding pocket formed by evolutionarily conserved residues in the glucagon-like peptide-1 (GLP-1) receptor core domain. The Journal of biological chemistry\| PubMed ID: 25561730	2015
Human thrombomodulin regulates complement activation as well as the coagulation cascade in xeno-immune response. Xenotransplantation\| PubMed ID: 26179123	2015
Dimer of arfaptin 2 regulates NF-κB signaling by interacting with IKKβ/NEMO and inhibiting IKKβ kinase activity. Cellular signalling\| PubMed ID: 26296658	2015
Prevertebrate Local Gene Duplication Facilitated Expansion of the Neuropeptide GPCR Superfamily. Molecular biology and evolution\| PubMed ID: 26337547	2015
NME1L Negatively Regulates IGF1-Dependent Proliferation of Breast Cancer Cells. Journal of cellular biochemistry\| PubMed ID: 26565392	2016
Beneficial effects of the transgenic expression of human sTNF-αR-Fc and HO-1 on pig-to-mouse islet xenograft survival. Transplant immunology\| PubMed ID: 26777482	2016
Ninjurin1 suppresses metastatic property of lung cancer cells through inhibition of interleukin 6 signaling pathway. International journal of cancer\| PubMed ID: 26815582	2016
Development of Spexin-based Human Galanin Receptor Type II-Specific Agonists with Increased Stability in Serum and Anxiolytic Effect in Mice. Scientific reports\| PubMed ID: 26907960	2016
Characterization of Functional Domains in NME1L Regulation of NF-κB Signaling. Molecules and cells\| PubMed ID: 27094059	2016
Ninjurin1 inhibits colitis-mediated colon cancer development and growth by suppression of macrophage infiltration through repression of FAK signaling. Oncotarget\| PubMed ID: 27127177	2016
Human antibody reactivity against xenogeneic N-glycolylneuraminic acid and galactose-α-1,3-galactose antigen. Xenotransplantation\| PubMed ID: 27373998	2016
The accessory proteins REEP5 and REEP6 refine CXCR1-mediated cellular responses and lung cancer progression. Scientific reports\| PubMed ID: 27966653	2016
Generation of CMAHKO/GTKO/shTNFRI-Fc/HO-1 quadruple gene modified pigs. Transgenic research\| PubMed ID: 28553699	2017
Nafamostat mesilate negatively regulates the metastasis of triple-negative breast cancer cells. Archives of pharmacal research\| PubMed ID: 29196918	2018
Conformational signatures in β-arrestin2 reveal natural biased agonism at a G-protein-coupled receptor. Communications biology\| PubMed ID: 30272007	2018
Ninjurin1 Plays a Crucial Role in Pulmonary Fibrosis by Promoting Interaction between Macrophages and Alveolar Epithelial Cells. Scientific reports\| PubMed ID: 30510259	2018
Generation by somatic cell nuclear transfer of GGTA1 knockout pigs expressing soluble human TNFRI-Fc and human HO-1. Transgenic research\| PubMed ID: 30552552	2019
SP-8356, a (1S)-(-)-verbenone derivative, exerts in vitro and in vivo anti-breast cancer effects by inhibiting NF-κB signaling. Scientific reports\| PubMed ID: 31036845	2019
Spexin-Based Galanin Receptor Type 2 Agonist for Comorbid Mood Disorders and Abnormal Body Weight. Frontiers in neuroscience\| PubMed ID: 31057364	2019