Jae Young Seong

Graduate School of Medicine, Korea University

Affiliated withKorea University Korea University

Research Area

Biochemistry

Biography

Jae Young Seong, Professor

Lab of GPCR

Graduate School of Meical Sciences, Korea University

Seoul

Republic of KOREA

e-mail: jyseong@korea.ac.kr

Homepage: www.gpcr.or.kr

JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 8	2019

Other Publications

Article	Year
The accessory proteins REEP5 and REEP6 refine CXCR1-mediated cellular responses and lung cancer progression. Scientific reports\| PubMed ID: 27966653	2016
Cellular and molecular biology of orphan G protein-coupled receptors. International review of cytology\| PubMed ID: 16984818	2006
Molecular evolution of neuropeptide receptors with regard to maintaining high affinity to their authentic ligands. General and comparative endocrinology\| PubMed ID: 17286976	2007
Integrin-linked kinase controls Notch1 signaling by down-regulation of protein stability through Fbw7 ubiquitin ligase. Molecular and cellular biology\| PubMed ID: 17526737	2007
Cloning and activation of the bullfrog apelin receptor: Gi/o coupling and high affinity for [Pro1]apelin-13. Molecular and cellular endocrinology\| PubMed ID: 17825479	2007
Extracellular loop 3 (ECL3) and ECL3-proximal transmembrane domains VI and VII of the mesotocin and vasotocin receptors confer differential ligand selectivity and signaling activity. General and comparative endocrinology\| PubMed ID: 18158152	2008
Involvement of amino acids flanking Glu7.32 of the gonadotropin-releasing hormone receptor in the selectivity of antagonists. Molecules and cells\| PubMed ID: 18319619	2008
Identification of farnesyl pyrophosphate and N-arachidonylglycine as endogenous ligands for GPR92. The Journal of biological chemistry\| PubMed ID: 18499677	2008
Molecular cloning of the bullfrog kisspeptin receptor GPR54 with high sensitivity to Xenopus kisspeptin. Peptides\| PubMed ID: 18550222	2009
GbetaL regulates TNFalpha-induced NF-kappaB signaling by directly inhibiting the activation of IkappaB kinase. Cellular signalling\| PubMed ID: 18755269	2008
Molecular evolution of multiple forms of kisspeptins and GPR54 receptors in vertebrates. Endocrinology\| PubMed ID: 19164475	2009
A gonadotropin-releasing hormone-II antagonist induces autophagy of prostate cancer cells. Cancer research\| PubMed ID: 19176390	2009
Nova-1 mediates glucocorticoid-induced inhibition of pre-mRNA splicing of gonadotropin-releasing hormone transcripts. The Journal of biological chemistry\| PubMed ID: 19282286	2009
Phylogenetic history, pharmacological features, and signal transduction of neurotensin receptors in vertebrates. Annals of the New York Academy of Sciences\| PubMed ID: 19456337	2009
Splicing variants of the orphan G-protein-coupled receptor GPR56 regulate the activity of transcription factors associated with tumorigenesis. Journal of cancer research and clinical oncology\| PubMed ID: 19572147	2010
Suppression of NF-kappaB signaling by KEAP1 regulation of IKKbeta activity through autophagic degradation and inhibition of phosphorylation. Cellular signalling\| PubMed ID: 20600852	2010
Molecular coevolution of kisspeptins and their receptors from fish to mammals. Annals of the New York Academy of Sciences\| PubMed ID: 20633134	2010
Tyr1 and Ile7 of glucose-dependent insulinotropic polypeptide (GIP) confer differential ligand selectivity toward GIP and glucagon-like peptide-1 receptors. Molecules and cells\| PubMed ID: 20799012	2010
Revisiting the evolution of gonadotropin-releasing hormones and their receptors in vertebrates: secrets hidden in genomes. General and comparative endocrinology\| PubMed ID: 21036176	2011
Regulation of IκB kinase by GβL through recruitment of the protein phosphatases. Molecules and cells\| PubMed ID: 21110129	2010
Secretoneurin stimulates the production and release of luteinizing hormone in mouse L{beta}T2 gonadotropin cells. American journal of physiology. Endocrinology and metabolism\| PubMed ID: 21521715	2011
Class-C SOX transcription factors control GnRH gene expression via the intronic transcriptional enhancer. Molecular endocrinology (Baltimore, Md.)\| PubMed ID: 21527504	2011
Regulatory roles of heterogeneous nuclear ribonucleoprotein M and Nova-1 protein in alternative splicing of dopamine D2 receptor pre-mRNA. The Journal of biological chemistry\| PubMed ID: 21622564	2011
Insulin contributes to fine-tuning of the pancreatic beta-cell response to glucagon-like peptide-1. Molecules and cells\| PubMed ID: 21904878	2011
Evolutionarily conserved residues at glucagon-like peptide-1 (GLP-1) receptor core confer ligand-induced receptor activation. The Journal of biological chemistry\| PubMed ID: 22105074	2012
Molecular Coevolution of Neuropeptides Gonadotropin-Releasing Hormone and Kisspeptin with their Cognate G Protein-Coupled Receptors. Frontiers in neuroscience\| PubMed ID: 22291614	2012
Regulation of neurosteroid biosynthesis by neurotransmitters and neuropeptides. Frontiers in endocrinology\| PubMed ID: 22654849	2012
Spatiotemporal expression and functional implication of CXCL14 in the developing mice cerebellum. Molecules and cells\| PubMed ID: 22843118	2012
Anti-cancer activity of a novel small molecule compound that simultaneously activates p53 and inhibits NF-κB signaling. PloS one\| PubMed ID: 23028510	2012
CXCL14 enhances proliferation and migration of NCI-H460 human lung cancer cells overexpressing the glycoproteins containing heparan sulfate or sialic acid. Journal of cellular biochemistry\| PubMed ID: 23161284	2013
Structural and molecular conservation of glucagon-like Peptide-1 and its receptor confers selective ligand-receptor interaction. Frontiers in endocrinology\| PubMed ID: 23181056	2012
Expansion of secretin-like G protein-coupled receptors and their peptide ligands via local duplications before and after two rounds of whole-genome duplication. Molecular biology and evolution\| PubMed ID: 23427277	2013
Synchronous activation of gonadotropin-releasing hormone gene transcription and secretion by pulsatile kisspeptin stimulation. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 23509283	2013
A novel glucagon-related peptide (GCRP) and its receptor GCRPR account for coevolution of their family members in vertebrates. PloS one\| PubMed ID: 23776481	2013
Natalisin, a tachykinin-like signaling system, regulates sexual activity and fecundity in insects. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 23980168	2013
Local duplication of gonadotropin-releasing hormone (GnRH) receptor before two rounds of whole genome duplication and origin of the mammalian GnRH receptor. PloS one\| PubMed ID: 24498396	2014
Coevolution of the spexin/galanin/kisspeptin family: Spexin activates galanin receptor type II and III. Endocrinology\| PubMed ID: 24517231	2014
Molecular evolution of GPCRs: GLP1/GLP1 receptors. Journal of molecular endocrinology\| PubMed ID: 24598200	2014
Neuropeptide GPCRs in Neuroendocrinology. Frontiers in endocrinology\| PubMed ID: 24772105	2014
Identification of a novel insect neuropeptide, CNMa and its receptor. FEBS letters\| PubMed ID: 24796791	2014
A splicing variant of NME1 negatively regulates NF-κB signaling and inhibits cancer metastasis by interacting with IKKβ. The Journal of biological chemistry\| PubMed ID: 24811176	2014
Apoptotic death of prostate cancer cells by a gonadotropin-releasing hormone-II antagonist. PloS one\| PubMed ID: 24926857	2014
Does Kisspeptin Belong to the Proposed RF-Amide Peptide Family? Frontiers in endocrinology\| PubMed ID: 25165463	2014
A Novel Long-Acting Glucagon-Like Peptide-1 Agonist with Improved Efficacy in Insulin Secretion and β-Cell Growth. Endocrinology and metabolism (Seoul, Korea)\| PubMed ID: 25309791	2014
Ligand binding pocket formed by evolutionarily conserved residues in the glucagon-like peptide-1 (GLP-1) receptor core domain. The Journal of biological chemistry\| PubMed ID: 25561730	2015
Histidine(7.36(305)) in the conserved peptide receptor activation domain of the gonadotropin releasing hormone receptor couples peptide binding and receptor activation. Molecular and cellular endocrinology\| PubMed ID: 25583361	2015
Dimer of arfaptin 2 regulates NF-κB signaling by interacting with IKKβ/NEMO and inhibiting IKKβ kinase activity. Cellular signalling\| PubMed ID: 26296658	2015
Prevertebrate Local Gene Duplication Facilitated Expansion of the Neuropeptide GPCR Superfamily. Molecular biology and evolution\| PubMed ID: 26337547	2015
NME1L Negatively Regulates IGF1-Dependent Proliferation of Breast Cancer Cells. Journal of cellular biochemistry\| PubMed ID: 26565392	2016
Development of Spexin-based Human Galanin Receptor Type II-Specific Agonists with Increased Stability in Serum and Anxiolytic Effect in Mice. Scientific reports\| PubMed ID: 26907960	2016
Characterization of Functional Domains in NME1L Regulation of NF-κB Signaling. Molecules and cells\| PubMed ID: 27094059	2016
Distribution of galanin receptor 2b neurons and interaction with galanin in the zebrafish central nervous system. Neuroscience letters\| PubMed ID: 27315774	2016
Evolutionary and Comparative Genomics to Drive Rational Drug Design, with Particular Focus on Neuropeptide Seven-Transmembrane Receptors. Biomolecules & therapeutics\| PubMed ID: 28035082	2017
GABBR2 mutations determine phenotype in rett syndrome and epileptic encephalopathy. Annals of neurology\| PubMed ID: 28856709	2017
FAM19A5, a brain-specific chemokine, inhibits RANKL-induced osteoclast formation through formyl peptide receptor 2. Scientific reports\| PubMed ID: 29138422	2017
Nafamostat mesilate negatively regulates the metastasis of triple-negative breast cancer cells. Archives of pharmacal research\| PubMed ID: 29196918	2018
mRNA expression and metabolic regulation of npy and agrp1/2 in the zebrafish brain. Neuroscience letters\| PubMed ID: 29329911	2018
Replacement of the C-terminal Trp-cage of exendin-4 with a fatty acid improves therapeutic utility. Biochemical pharmacology\| PubMed ID: 29522713	2018
Conformational signatures in β-arrestin2 reveal natural biased agonism at a G-protein-coupled receptor. Communications biology\| PubMed ID: 30272007	2018
Distribution and neuronal circuit of spexin 1/2 neurons in the zebrafish CNS. Scientific reports\| PubMed ID: 30903017	2019
SP-8356, a (1S)-(-)-verbenone derivative, exerts in vitro and in vivo anti-breast cancer effects by inhibiting NF-κB signaling. Scientific reports\| PubMed ID: 31036845	2019
Spexin-Based Galanin Receptor Type 2 Agonist for Comorbid Mood Disorders and Abnormal Body Weight. Frontiers in neuroscience\| PubMed ID: 31057364	2019