Kelly M. McNagny

The Biomedical Research Centre, University of British Columbia

Affiliated withUniversity of British Columbia

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 4	2019

Other Publications

Article	Year
Anuria, omphalocele, and perinatal lethality in mice lacking the CD34-related protein podocalyxin. The Journal of experimental medicine\| PubMed ID: 11435469	2001
Avian models to study the transcriptional control of hematopoietic lineage commitment and to identify lineage-specific genes. Cells, tissues, organs\| PubMed ID: 12021491	2002
CD34 is a specific marker of mature murine mast cells. Experimental hematology\| PubMed ID: 12384153	2002
E26 leukemia virus converts primitive erythroid cells into cycling multilineage progenitors. Blood\| PubMed ID: 12393697	2003
Overexpression of the anti-adhesin podocalyxin is an independent predictor of breast cancer progression. Cancer research\| PubMed ID: 15289306	2004
CD34 and CD43 inhibit mast cell adhesion and are required for optimal mast cell reconstitution. Immunity\| PubMed ID: 15664158	2005
Podocalyxin is a CD34-related marker of murine hematopoietic stem cells and embryonic erythroid cells. Blood\| PubMed ID: 15701716	2005
Hematopoietic stem cells do not engraft with absolute efficiencies. Blood\| PubMed ID: 16204316	2006
Na+/H+ exchanger regulatory factor-1 is a hematopoietic ligand for a subset of the CD34 family of stem cell surface proteins. Stem cells (Dayton, Ohio)\| PubMed ID: 16410385	2006
The CD34-related molecule podocalyxin is a potent inducer of microvillus formation. PloS one\| PubMed ID: 17311105	2007
CD34 facilitates the development of allergic asthma. Blood\| PubMed ID: 17557898	2007
Mast cells are an essential hematopoietic component for polyp development. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18077429	2007
Podocalyxin selectively marks erythroid-committed progenitors during anemic stress but is dispensable for efficient recovery. Experimental hematology\| PubMed ID: 19004540	2009
Mast cells in tumor growth: angiogenesis, tissue remodelling and immune-modulation. Biochimica et biophysica acta\| PubMed ID: 19233249	2009
Bone marrow-derived mast cells accumulate in the central nervous system during inflammation but are dispensable for experimental autoimmune encephalomyelitis pathogenesis. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 19380799	2009
SHIP1 is a repressor of mast cell hyperplasia, cytokine production, and allergic inflammation in vivo. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 19542434	2009
Prion protein expression and release by mast cells after activation. The Journal of infectious diseases\| PubMed ID: 19642931	2009
Loss of CD34 leads to exacerbated autoimmune arthritis through increased vascular permeability. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 20038636	2010
Stem cells, inflammation and allergy. Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology\| PubMed ID: 20066174	2009
The metalloprotease-disintegrin ADAM8 is essential for the development of experimental asthma. American journal of respiratory and critical care medicine\| PubMed ID: 20194813	2010
CD34 mediates intestinal inflammation in Salmonella-infected mice. Cellular microbiology\| PubMed ID: 20497179	2010
Interleukin-11 reduces TLR4-induced colitis in TLR2-deficient mice and restores intestinal STAT3 signaling. Gastroenterology\| PubMed ID: 20600022	2010
CD34 is required for infiltration of eosinophils into the colon and pathology associated with DSS-induced ulcerative colitis. The American journal of pathology\| PubMed ID: 20696776	2010
A novel ENU-generated truncation mutation lacking the spectrin-binding and C-terminal regulatory domains of Ank1 models severe hemolytic hereditary spherocytosis. Experimental hematology\| PubMed ID: 21193012	2011
Opposing roles for CD34 in B16 melanoma tumor growth alter early stage vasculature and late stage immune cell infiltration. PloS one\| PubMed ID: 21494591	2011
CD34 is required for dendritic cell trafficking and pathology in murine hypersensitivity pneumonitis. American journal of respiratory and critical care medicine\| PubMed ID: 21642249	2011
Infiltrating monocytes trigger EAE progression, but do not contribute to the resident microglia pool. Nature neuroscience\| PubMed ID: 21804537	2011
Cytopenia induction by 5-fluorouracil identifies thrombopoietic mutants in sensitized ENU mutagenesis screens. Experimental hematology\| PubMed ID: 21924221	2012
CD34 promotes satellite cell motility and entry into proliferation to facilitate efficient skeletal muscle regeneration. Stem cells (Dayton, Ohio)\| PubMed ID: 21997891	2011
Analysis of the mobilities of band 3 populations associated with ankyrin protein and junctional complexes in intact murine erythrocytes. The Journal of biological chemistry\| PubMed ID: 22147703	2012
The anti-adhesive mucin podocalyxin may help initiate the transperitoneal metastasis of high grade serous ovarian carcinoma. Clinical & experimental metastasis\| PubMed ID: 22262060	2012
Early life antibiotic-driven changes in microbiota enhance susceptibility to allergic asthma. EMBO reports\| PubMed ID: 22422004	2012
IL-7Rα and L-selectin, but not CD103 or CD34, are required for murine peanut-induced anaphylaxis. Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology\| PubMed ID: 22935073	2012
Perinatal antibiotic treatment affects murine microbiota, immune responses and allergic asthma. Gut microbes\| PubMed ID: 23333861	2013
A familiar stranger: CD34 expression and putative functions in SVF cells of adipose tissue. World journal of stem cells\| PubMed ID: 23362435	2013
Requirement for core 2 O-glycans for optimal resistance to helminth infection. PloS one\| PubMed ID: 23555902	2013
SIGIRR, a negative regulator of TLR/IL-1R signalling promotes Microbiota dependent resistance to colonization by enteric bacterial pathogens. PLoS pathogens\| PubMed ID: 23950714	2013
Enu mutagenesis identifies a novel platelet phenotype in a loss-of-function Jak2 allele. PloS one\| PubMed ID: 24086539	2013
Group 2 innate lymphoid cells are critical for the initiation of adaptive T helper 2 cell-mediated allergic lung inflammation. Immunity\| PubMed ID: 24613091	2014
Methyltransferase G9A regulates T cell differentiation during murine intestinal inflammation. The Journal of clinical investigation\| PubMed ID: 24667637	2014
Group 2 innate lymphoid cells facilitate sensitization to local, but not systemic, TH2-inducing allergen exposures. The Journal of allergy and clinical immunology\| PubMed ID: 24679471	2014
Perinatal Immunization With Vaccine-Grade Listeria monocytogenes Provides Protection Against Murine Th2 Airway Inflammation. Allergy, asthma & immunology research\| PubMed ID: 24991458	2014
Perinatal antibiotic-induced shifts in gut microbiota have differential effects on inflammatory lung diseases. The Journal of allergy and clinical immunology\| PubMed ID: 25145536	2015
Podocalyxin regulates murine lung vascular permeability by altering endothelial cell adhesion. PloS one\| PubMed ID: 25303643	2014
Mast cells in human health and disease. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 25388247	2015
Pulmonary CD103 expression regulates airway inflammation in asthma. American journal of physiology. Lung cellular and molecular physiology\| PubMed ID: 25681437	2015
Lineage-specific regulation of allergic airway inflammation by the lipid phosphatase Src homology 2 domain-containing inositol 5-phosphatase (SHIP-1). The Journal of allergy and clinical immunology\| PubMed ID: 25746967	2015
Podocalyxin enhances breast tumor growth and metastasis and is a target for monoclonal antibody therapy. Breast cancer research : BCR\| PubMed ID: 25887862	2015
Early infancy microbial and metabolic alterations affect risk of childhood asthma. Science translational medicine\| PubMed ID: 26424567	2015
Modelling kidney disease with CRISPR-mutant kidney organoids derived from human pluripotent epiblast spheroids. Nature communications\| PubMed ID: 26493500	2015
Dendritic-cell expression of Ship1 regulates Th2 immunity to helminth infection in mice. European journal of immunology\| PubMed ID: 26518471	2016
Morphometric analysis of inflammation in bronchial biopsies following exposure to inhaled diesel exhaust and allergen challenge in atopic subjects. Particle and fibre toxicology\| PubMed ID: 26758251	2016
The cell surface mucin podocalyxin regulates collective breast tumor budding. Breast cancer research : BCR\| PubMed ID: 26796961	2016
Impact of a CXCL12/CXCR4 Antagonist in Bleomycin (BLM) Induced Pulmonary Fibrosis and Carbon Tetrachloride (CCl4) Induced Hepatic Fibrosis in Mice. PloS one\| PubMed ID: 26998906	2016
DMSO Represses Inflammatory Cytokine Production from Human Blood Cells and Reduces Autoimmune Arthritis. PloS one\| PubMed ID: 27031833	2016
SETD7 Controls Intestinal Regeneration and Tumorigenesis by Regulating Wnt/β-Catenin and Hippo/YAP Signaling. Developmental cell\| PubMed ID: 27046831	2016
G9a regulates group 2 innate lymphoid cell development by repressing the group 3 innate lymphoid cell program. The Journal of experimental medicine\| PubMed ID: 27298444	2016
CD34 Promotes Pathological Epi-Retinal Neovascularization in a Mouse Model of Oxygen-Induced Retinopathy. PloS one\| PubMed ID: 27352134	2016
Chronic Trichuris muris infection alters hematopoiesis and causes IFN-γ-expressing T-cell accumulation in the mouse bone marrow. European journal of immunology\| PubMed ID: 27594558	2016
Protein interaction screening identifies SH3RF1 as a new regulator of FAT1 protein levels. FEBS letters\| PubMed ID: 28129444	2017
induces a type IV hypersensitivity response in a mouse model of airway inflammation. Physiological reports\| PubMed ID: 28364028	2017
The orphan nuclear receptor ROR alpha and group 3 innate lymphoid cells drive fibrosis in a mouse model of Crohn's disease. Science immunology\| PubMed ID: 28670633	2016
Loss of Vascular CD34 Results in Increased Sensitivity to Lung Injury. American journal of respiratory cell and molecular biology\| PubMed ID: 28683207	2017
The orphan nuclear receptor RORα and group 3 innate lymphoid cells drive fibrosis in a mouse model of Crohn's disease. Science immunology\| PubMed ID: 28783681	2016
Gene-Edited Human Kidney Organoids Reveal Mechanisms of Disease in Podocyte Development. Stem cells (Dayton, Ohio)\| PubMed ID: 28905451	2017
The Sialidase (Kdnase) Contributes to Cell Wall Integrity and Virulence in Amphotericin B-Treated Mice. Frontiers in microbiology\| PubMed ID: 29403452	2017
Mast cells promote small bowel cancer in a tumor stage-specific and cytokine-dependent manner. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 29429965	2018
IL-22 Preserves Gut Epithelial Integrity and Promotes Disease Remission during Chronic Infection. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 30617224	2019
The first identified heterozygous nonsense mutations in podocalyxin offer new perspectives on the biology of podocytopathies. Clinical science (London, England : 1979)\| PubMed ID: 30737302	2019
Podocalyxin is required for maintaining blood-brain barrier function during acute inflammation. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 30787191	2019
HDAC2 Regulates Site-Specific Acetylation of MDM2 and Its Ubiquitination Signaling in Tumor Suppression. iScience\| PubMed ID: 30818224	2019