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Immunology and Infection

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JoVE Journal Immunology and Infection
Chronic Salmonella Infection Induced Intestinal Fibrosis
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Chronic Salmonella Infection Induced Intestinal Fibrosis

Article DOI: 10.3791/60068-v • 08:40 min • September 22nd, 2019
September 22nd, 2019 •
1, 1, 1, 1
1The Biomedical Research Centre, University of British Columbia

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Summary
Automatic Translation

This protocol describes a mouse model of Salmonella driven intestinal fibrosis that resembles key pathological hallmarks of Crohn’s disease including transmural inflammation and fibrosis. This method can be used to evaluate host factors that alter fibrotic outcomes using mutant mice maintained on a C57Bl/6 genetic background.

Tags

Chronic Salmonella Infection Intestinal Fibrosis Organ Failure Chronic Inflammation Aging Mouse Model Crohn's Disease Gut Fibrosis Surgical Removal Robust Model Handling Mice Oral Gavage Safety Precautions Sterile Technique Salmonella Handling
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