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JoVE Journal
Immunology and Infection

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Chronic Salmonella Infection Induced Intestinal Fibrosis
 

Chronic Salmonella Infection Induced Intestinal Fibrosis

Article DOI: 10.3791/60068-v
September 22nd, 2019

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Summary September 22nd, 2019

This protocol describes a mouse model of Salmonella driven intestinal fibrosis that resembles key pathological hallmarks of Crohn’s disease including transmural inflammation and fibrosis. This method can be used to evaluate host factors that alter fibrotic outcomes using mutant mice maintained on a C57Bl/6 genetic background.

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