Changwon Kho

Changwon Kho

Cardiovascular Research Center, Icahn School of Medicine at Mount Sinai

Affiliated withIcahn School of Medicine at Mount SinaiIcahn School of Medicine at Mount Sinai

Research Area

Biography

Chang Won is an Assistant Professor of Department of Medicine and Division of Cardiology at the Icahn School of Medicine at Mount Sinai, New York since 2015. In the last decade, his research has been focused on identifying and characterizing novel molecular pathways in heart failure. One area of particular interest to him is the role of post-translational modification of key proteins involved in cardiac dysfunction. He designed a multi-faceted approach to profile proteins in cardiomyocytes that interact with sarcoplasmic reticulum calcium ATPase (SERCA2a) pump. His efforts have led to the identification of Small Ubiquitin-like Modifier type 1 (SUMO1) as a potentially important target for heart failure therapy.

JoVE Journal Publications

ArticleTotal : 1
Year
Generation of Ventricular-Like HiPSC-Derived Cardiomyocytes and High-Quality Cell Preparations for Calcium Handling Characterization
Publication title

Cited by 3

2020

Other Publications

Article
Year
Atrial stretch and arrhythmia after myocardial infarction.

Aging| PubMed ID: 30594913

2018
Experimental models of cardiac physiology and pathology.

Heart failure reviews| PubMed ID: 30666533

2019
2013
2014
The role of SUMO-1 in cardiac oxidative stress and hypertrophy.

Antioxidants & redox signaling| PubMed ID: 24893265

2014
2015
2015
2016
2016
2016
Matricellular Protein CCN5 Reverses Established Cardiac Fibrosis.

Journal of the American College of Cardiology| PubMed ID: 27150688

2016
2017
Protein Phosphatase Inhibitor-1 Gene Therapy in a Swine Model of Nonischemic Heart Failure.

Journal of the American College of Cardiology| PubMed ID: 28958332

2017
miR-25 Tough Decoy Enhances Cardiac Function in Heart Failure.

Molecular therapy : the journal of the American Society of Gene Therapy| PubMed ID: 29273502

2018
Measuring Cardiomyocyte Contractility and Calcium Handling In Vitro.

Methods in molecular biology (Clifton, N.J.)| PubMed ID: 29987813

2018
Acute Left Ventricular Unloading Reduces Atrial Stretch and Inhibits Atrial Arrhythmias.

Journal of the American College of Cardiology| PubMed ID: 30092950

2018
2018
Role of the PRC2-Six1-miR-25 signaling axis in heart failure.

Journal of molecular and cellular cardiology| PubMed ID: 30771307

2019
2019
Cross-communication between fibroblasts and cardiomyocytes.

Non-coding RNA investigation| PubMed ID: 31008445

2019
2019