Charles O. Rock

Department of Infectious Diseases, St. Jude Children's Research Hospital

Affiliated withSt. Jude Children's Research Hospital

Research Area

Biography

Charles O. Rock has not added Biography.
If you are Charles O. Rock and would like to personalize this page please email our Author Liaison for assistance.

JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 11	2019

Other Publications

Article	Year
Roles of the FabA and FabZ beta-hydroxyacyl-acyl carrier protein dehydratases in Escherichia coli fatty acid biosynthesis. The Journal of biological chemistry\| PubMed ID: 8910376	1996
A conserved histidine is essential for glycerolipid acyltransferase catalysis. Journal of bacteriology\| PubMed ID: 9515909	1998
A missense mutation accounts for the defect in the glycerol-3-phosphate acyltransferase expressed in the plsB26 mutant. Journal of bacteriology\| PubMed ID: 10074094	1999
beta-ketoacyl-acyl carrier protein synthase III (FabH) is a determining factor in branched-chain fatty acid biosynthesis. Journal of bacteriology\| PubMed ID: 10629181	2000
Response of Bacillus subtilis to cerulenin and acquisition of resistance. Journal of bacteriology\| PubMed ID: 11325930	2001
The licC gene of Streptococcus pneumoniae encodes a CTP:phosphocholine cytidylyltransferase. Journal of bacteriology\| PubMed ID: 11466299	2001
Structure and mechanism of CTP:phosphocholine cytidylyltransferase (LicC) from Streptococcus pneumoniae. The Journal of biological chemistry\| PubMed ID: 11706035	2002
Disabled-2 is transcriptionally regulated by ICSBP and augments macrophage spreading and adhesion. The EMBO journal\| PubMed ID: 11823414	2002
The solution structure of acyl carrier protein from Mycobacterium tuberculosis. The Journal of biological chemistry\| PubMed ID: 11825906	2002
The FabR (YijC) transcription factor regulates unsaturated fatty acid biosynthesis in Escherichia coli. The Journal of biological chemistry\| PubMed ID: 11859088	2002
Dual roles for the Dab2 adaptor protein in embryonic development and kidney transport. The EMBO journal\| PubMed ID: 11927540	2002
A missense mutation in the fabB (beta-ketoacyl-acyl carrier protein synthase I) gene confers tiolactomycin resistance to Escherichia coli. Antimicrobial agents and chemotherapy\| PubMed ID: 11959552	2002
Forty years of bacterial fatty acid synthesis. Biochemical and biophysical research communications\| PubMed ID: 11969206	2002
The murine pantothenate kinase (Pank1) gene encodes two differentially regulated pantothenate kinase isozymes. Gene\| PubMed ID: 12095677	2002
A new mechanism for anaerobic unsaturated fatty acid formation in Streptococcus pneumoniae. The Journal of biological chemistry\| PubMed ID: 12237320	2002
The Claisen condensation in biology. Natural product reports\| PubMed ID: 12430724	2002
Characterization of Streptococcus pneumoniae enoyl-(acyl-carrier protein) reductase (FabK). The Biochemical journal\| PubMed ID: 12487627	2003
The application of computational methods to explore the diversity and structure of bacterial fatty acid synthase. Journal of lipid research\| PubMed ID: 12518017	2003
Role of feedback regulation of pantothenate kinase (CoaA) in control of coenzyme A levels in Escherichia coli. Journal of bacteriology\| PubMed ID: 12754240	2003
Crystal structures of the Dab homology domains of mouse disabled 1 and 2. The Journal of biological chemistry\| PubMed ID: 12826668	2003
The 1.3-Angstrom-resolution crystal structure of beta-ketoacyl-acyl carrier protein synthase II from Streptococcus pneumoniae. Journal of bacteriology\| PubMed ID: 12837788	2003
Key residues responsible for acyl carrier protein and beta-ketoacyl-acyl carrier protein reductase (FabG) interaction. The Journal of biological chemistry\| PubMed ID: 14527946	2003
Cofactor-induced conformational rearrangements establish a catalytically competent active site and a proton relay conduit in FabG. Structure (London, England : 1993)\| PubMed ID: 15016358	2004
Fatty acid biosynthesis as a target for novel antibacterials. Current opinion in investigational drugs (London, England : 2000)\| PubMed ID: 15043388	2004
Product diversity and regulation of type II fatty acid synthases. Biochemistry and cell biology = Biochimie et biologie cellulaire\| PubMed ID: 15052334	2004
Evaluation of epigallocatechin gallate and related plant polyphenols as inhibitors of the FabG and FabI reductases of bacterial type II fatty-acid synthase. The Journal of biological chemistry\| PubMed ID: 15133034	2004
The structure of the pantothenate kinase.ADP.pantothenate ternary complex reveals the relationship between the binding sites for substrate, allosteric regulator, and antimetabolites. The Journal of biological chemistry\| PubMed ID: 15136582	2004
Prediction of mechanisms of action of antibacterial compounds by gene expression profiling. Antimicrobial agents and chemotherapy\| PubMed ID: 15273089	2004
Acyl carrier protein is a cellular target for the antibacterial action of the pantothenamide class of pantothenate antimetabolites. The Journal of biological chemistry\| PubMed ID: 15459190	2004
A pantothenate kinase from Staphylococcus aureus refractory to feedback regulation by coenzyme A. The Journal of biological chemistry\| PubMed ID: 15548531	2005
The reductase steps of the type II fatty acid synthase as antimicrobial targets. Lipids\| PubMed ID: 15726819	2004
Coenzyme A: back in action. Progress in lipid research\| PubMed ID: 15893380	2005
Feedback regulation of murine pantothenate kinase 3 by coenzyme A and coenzyme A thioesters. The Journal of biological chemistry\| PubMed ID: 16040613	2005
Biochemical properties of human pantothenate kinase 2 isoforms and mutations linked to pantothenate kinase-associated neurodegeneration. The Journal of biological chemistry\| PubMed ID: 16272150	2006
Structure-activity relationships at the 5-position of thiolactomycin: an intact (5R)-isoprene unit is required for activity against the condensing enzymes from Mycobacterium tuberculosis and... Journal of medicinal chemistry\| PubMed ID: 16392800	2006
Two aerobic pathways for the formation of unsaturated fatty acids in Pseudomonas aeruginosa. Molecular microbiology\| PubMed ID: 16573679	2006
Roles of the active site water, histidine 303, and phenylalanine 396 in the catalytic mechanism of the elongation condensing enzyme of Streptococcus pneumoniae. The Journal of biological chemistry\| PubMed ID: 16618705	2006
Structure of RhlG, an essential beta-ketoacyl reductase in the rhamnolipid biosynthetic pathway of Pseudomonas aeruginosa. The Journal of biological chemistry\| PubMed ID: 16624803	2006
Inhibiting bacterial fatty acid synthesis. The Journal of biological chemistry\| PubMed ID: 16648134	2006
Placental thrombosis and spontaneous fetal death in mice deficient in ethanolamine kinase 2. The Journal of biological chemistry\| PubMed ID: 16861741	2006
Acyl-phosphates initiate membrane phospholipid synthesis in Gram-positive pathogens. Molecular cell\| PubMed ID: 16949372	2006
Activation of human mitochondrial pantothenate kinase 2 by palmitoylcarnitine. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17242360	2007
Topology and active site of PlsY: the bacterial acylphosphate:glycerol-3-phosphate acyltransferase. The Journal of biological chemistry\| PubMed ID: 17308305	2007
Chemical knockout of pantothenate kinase reveals the metabolic and genetic program responsible for hepatic coenzyme A homeostasis. Chemistry & biology\| PubMed ID: 17379144	2007
Crystal structure and allosteric regulation of the cytoplasmic Escherichia coli L-asparaginase I. Journal of molecular biology\| PubMed ID: 17451745	2007
Identification of a soluble diacylglycerol kinase required for lipoteichoic acid production in Bacillus subtilis. The Journal of biological chemistry\| PubMed ID: 17535816	2007
Coupling of fatty acid and phospholipid synthesis in Bacillus subtilis. Journal of bacteriology\| PubMed ID: 17557823	2007
Localization and regulation of mouse pantothenate kinase 2. FEBS letters\| PubMed ID: 17825826	2007
A Pseudomonas aeruginosa transcription factor that senses fatty acid structure. Molecular microbiology\| PubMed ID: 17877713	2007
Membrane lipid homeostasis in bacteria. Nature reviews. Microbiology\| PubMed ID: 18264115	2008
RhlA converts beta-hydroxyacyl-acyl carrier protein intermediates in fatty acid synthesis to the beta-hydroxydecanoyl-beta-hydroxydecanoate component of rhamnolipids in Pseudomonas aeruginos... Journal of bacteriology\| PubMed ID: 18326581	2008
Thematic review series: Glycerolipids. Acyltransferases in bacterial glycerophospholipid synthesis. Journal of lipid research\| PubMed ID: 18369234	2008
Analysis of the Staphylococcus aureus DgkB structure reveals a common catalytic mechanism for the soluble diacylglycerol kinases. Structure (London, England : 1993)\| PubMed ID: 18611377	2008
PqsD is responsible for the synthesis of 2,4-dihydroxyquinoline, an extracellular metabolite produced by Pseudomonas aeruginosa. The Journal of biological chemistry\| PubMed ID: 18728009	2008
Transcriptional regulation in bacterial membrane lipid synthesis. Journal of lipid research\| PubMed ID: 18941141	2009
Novel acyl phosphate mimics that target PlsY, an essential acyltransferase in gram-positive bacteria. ChemMedChem\| PubMed ID: 19016283	2008
Molecular determinants for interfacial binding and conformational change in a soluble diacylglycerol kinase. The Journal of biological chemistry\| PubMed ID: 19112175	2009
Structural modification of acyl carrier protein by butyryl group. Protein science : a publication of the Protein Society\| PubMed ID: 19177367	2009
Acyl-Acyl carrier protein regulates transcription of fatty acid biosynthetic genes via the FabT repressor in Streptococcus pneumoniae. The Journal of biological chemistry\| PubMed ID: 19376778	2009
Elimination of the CDP-ethanolamine pathway disrupts hepatic lipid homeostasis. The Journal of biological chemistry\| PubMed ID: 19666474	2009
Opening a new path to lipoic acid. Journal of bacteriology\| PubMed ID: 19734307	2009
Transcriptional regulation of membrane lipid homeostasis in Escherichia coli. The Journal of biological chemistry\| PubMed ID: 19854834	2009
FabH selectivity for anteiso branched-chain fatty acid precursors in low-temperature adaptation in Listeria monocytogenes. FEMS microbiology letters\| PubMed ID: 19863661	2009
DesT coordinates the expression of anaerobic and aerobic pathways for unsaturated fatty acid biosynthesis in Pseudomonas aeruginosa. Journal of bacteriology\| PubMed ID: 19880602	2010
Pantothenate kinase 1 is required to support the metabolic transition from the fed to the fasted state. PloS one\| PubMed ID: 20559429	2010
Structural basis for the transcriptional regulation of membrane lipid homeostasis. Nature structural & molecular biology\| PubMed ID: 20639888	2010
Modulation of pantothenate kinase 3 activity by small molecules that interact with the substrate/allosteric regulatory domain. Chemistry & biology\| PubMed ID: 20797618	2010
A rainbow coalition of lipid transcriptional regulators. Molecular microbiology\| PubMed ID: 20941840	2010
A σW-dependent stress response in Bacillus subtilis that reduces membrane fluidity. Molecular microbiology\| PubMed ID: 21542858	2011
Is bacterial fatty acid synthesis a valid target for antibacterial drug discovery? Current opinion in microbiology\| PubMed ID: 21862391	2011
Metabolic basis for the differential susceptibility of Gram-positive pathogens to fatty acid synthesis inhibitors. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21876172	2011
Atg8 transfer from Atg7 to Atg3: a distinctive E1-E2 architecture and mechanism in the autophagy pathway. Molecular cell\| PubMed ID: 22055190	2011
Cancer-associated isocitrate dehydrogenase mutations inactivate NADPH-dependent reductive carboxylation. The Journal of biological chemistry\| PubMed ID: 22442146	2012
Acyl-sulfamates target the essential glycerol-phosphate acyltransferase (PlsY) in Gram-positive bacteria. Bioorganic & medicinal chemistry\| PubMed ID: 22795901	2012
Will the initiator of fatty acid synthesis in Pseudomonas aeruginosa please stand up? Journal of bacteriology\| PubMed ID: 22821980	2012
Membrane disruption by antimicrobial fatty acids releases low-molecular-weight proteins from Staphylococcus aureus. Journal of bacteriology\| PubMed ID: 22843840	2012
Sustained generation of nitric oxide and control of mycobacterial infection requires argininosuccinate synthase 1. Cell host & microbe\| PubMed ID: 22980328	2012
Phosphatidic acid synthesis in bacteria. Biochimica et biophysica acta\| PubMed ID: 22981714	2013
Preface: phospholipids and phospholipid metabolism. Biochimica et biophysica acta\| PubMed ID: 23369660	2013
Perturbation of Staphylococcus aureus gene expression by the enoyl-acyl carrier protein reductase inhibitor AFN-1252. Antimicrobial agents and chemotherapy\| PubMed ID: 23459481	2013
Bacterial lipids: metabolism and membrane homeostasis. Progress in lipid research\| PubMed ID: 23500459	2013
Staphylococcus aureus fatty acid auxotrophs do not proliferate in mice. Antimicrobial agents and chemotherapy\| PubMed ID: 23979734	2013
Resistance to AFN-1252 arises from missense mutations in Staphylococcus aureus enoyl-acyl carrier protein reductase (FabI). The Journal of biological chemistry\| PubMed ID: 24189061	2013
Phosphatidylglycerol homeostasis in glycerol-phosphate auxotrophs of Staphylococcus aureus. BMC microbiology\| PubMed ID: 24238430	2013
The identification, analysis and structure-based development of novel inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase. Bioorganic & medicinal chemistry\| PubMed ID: 24613625	2014
Incorporation of extracellular fatty acids by a fatty acid kinase-dependent pathway in Staphylococcus aureus. Molecular microbiology\| PubMed ID: 24673884	2014
Discovery of novel bacterial elongation condensing enzyme inhibitors by virtual screening. Bioorganic & medicinal chemistry letters\| PubMed ID: 24755430	2014
Pank1 deletion in leptin-deficient mice reduces hyperglycaemia and hyperinsulinaemia and modifies global metabolism without affecting insulin resistance. Diabetologia\| PubMed ID: 24781151	2014
Type II fatty acid synthesis is essential for the replication of Chlamydia trachomatis. The Journal of biological chemistry\| PubMed ID: 24958721	2014
Identification of a two-component fatty acid kinase responsible for host fatty acid incorporation by Staphylococcus aureus. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 25002480	2014
FabH mutations confer resistance to FabF-directed antibiotics in Staphylococcus aureus. Antimicrobial agents and chemotherapy\| PubMed ID: 25403676	2015
A thioesterase bypasses the requirement for exogenous fatty acids in the plsX deletion of Streptococcus pneumoniae. Molecular microbiology\| PubMed ID: 25534847	2015
A high-throughput screen reveals new small-molecule activators and inhibitors of pantothenate kinases. Journal of medicinal chemistry\| PubMed ID: 25569308	2015
How bacterial pathogens eat host lipids: implications for the development of fatty acid synthesis therapeutics. The Journal of biological chemistry\| PubMed ID: 25648887	2015
Chlamydia trachomatis Relies on Autonomous Phospholipid Synthesis for Membrane Biogenesis. The Journal of biological chemistry\| PubMed ID: 25995447	2015
Discovery of bacterial fatty acid synthase type II inhibitors using a novel cellular bioluminescent reporter assay. Antimicrobial agents and chemotherapy\| PubMed ID: 26169404	2015
Chlamydia trachomatis Scavenges Host Fatty Acids for Phospholipid Synthesis via an Acyl-Acyl Carrier Protein Synthetase. The Journal of biological chemistry\| PubMed ID: 26195634	2015
Maternal bile acid transporter deficiency promotes neonatal demise. Nature communications\| PubMed ID: 26416771	2015
Correction of a genetic deficiency in pantothenate kinase 1 using phosphopantothenate replacement therapy. Molecular genetics and metabolism\| PubMed ID: 26549575	2015
Activation of Exogenous Fatty Acids to Acyl-Acyl Carrier Protein Cannot Bypass FabI Inhibition in Neisseria. The Journal of biological chemistry\| PubMed ID: 26567338	2016
Biochemical Roles for Conserved Residues in the Bacterial Fatty Acid-binding Protein Family. The Journal of biological chemistry\| PubMed ID: 26774272	2016
Resistance Mechanisms and the Future of Bacterial Enoyl-Acyl Carrier Protein Reductase (FabI) Antibiotics. Cold Spring Harbor perspectives in medicine\| PubMed ID: 26931811	2016
A Pathogen-Selective Antibiotic Minimizes Disturbance to the Microbiome. Antimicrobial agents and chemotherapy\| PubMed ID: 27161626	2016
Allosteric Regulation of Mammalian Pantothenate Kinase. The Journal of biological chemistry\| PubMed ID: 27555321	2016
Bacterial fatty acid metabolism in modern antibiotic discovery. Biochimica et biophysica acta. Molecular and cell biology of lipids\| PubMed ID: 27668701	2017
Enoyl-Acyl Carrier Protein Reductase I (FabI) Is Essential for the Intracellular Growth of Listeria monocytogenes. Infection and immunity\| PubMed ID: 27736774	2016
Pyruvate Oxidase as a Critical Link between Metabolism and Capsule Biosynthesis in Streptococcus pneumoniae. PLoS pathogens\| PubMed ID: 27760231	2016
T Cells Encountering Myeloid Cells Programmed for Amino Acid-dependent Immunosuppression Use Rictor/mTORC2 Protein for Proliferative Checkpoint Decisions. The Journal of biological chemistry\| PubMed ID: 27903651	2017
Excess coenzyme A reduces skeletal muscle performance and strength in mice overexpressing human PANK2. Molecular genetics and metabolism\| PubMed ID: 28189602	2017
Sonic Hedgehog Activates Phospholipase A2 to Enhance Smoothened Ciliary Translocation. Cell reports\| PubMed ID: 28591579	2017
Exogenous fatty acid metabolism in bacteria. Biochimie\| PubMed ID: 28668270	2017
A two-helix motif positions the lysophosphatidic acid acyltransferase active site for catalysis within the membrane bilayer. Nature structural & molecular biology\| PubMed ID: 28714993	2017
Role of Fatty Acid Kinase in Cellular Lipid Homeostasis and SaeRS-Dependent Virulence Factor Expression in . mBio\| PubMed ID: 28765222	2017
The Structural and Functional Basis for Recurring Sulfa Drug Resistance Mutations in Dihydropteroate Synthase. Frontiers in microbiology\| PubMed ID: 30065703	2018
Therapeutic Targets in Chlamydial Fatty Acid and Phospholipid Synthesis. Frontiers in microbiology\| PubMed ID: 30319589	2018
A therapeutic approach to pantothenate kinase associated neurodegeneration. Nature communications\| PubMed ID: 30352999	2018
Acyl-chain selectivity and physiological roles of fatty acid-binding proteins. The Journal of biological chemistry\| PubMed ID: 30429218	2019
Human pantothenate kinase 4 is a pseudo-pantothenate kinase. Protein science : a publication of the Protein Society\| PubMed ID: 30927326	2019
Oleate hydratase from protects against palmitoleic acid, the major antimicrobial fatty acid produced by mammalian skin. The Journal of biological chemistry\| PubMed ID: 31018965	2019
Disruption of Glycolysis by Nutritional Immunity Activates a Two-Component System That Coordinates a Metabolic and Antihost Response by Staphylococcus aureus. mBio\| PubMed ID: 31387906	2019
A fatty acid binding protein of facilitates the acquisition of host polyunsaturated fatty acids. The Journal of biological chemistry\| PubMed ID: 31530637	2019