solid-phase-11c-methylation-purification-formulation-for-production

Solid Phase <sup>11</sup>C-Methylation, Purification and Formulation for the Production of PET Tracers

Routine production of radiotracers used in positron emission tomography (PET) mostly relies on wet chemistry where the radioactive synthon reacts with a ...

McGill University

The central benzodiazepine receptor (cBZR)-gamma-aminobutyric acid (GABA(A)) receptor complex in the human brain plays an important role in many neurological and psychiatric disorders. (18)F-Labeled flumazenil ([(18)F]FZ) provides a potentially useful tracer to investigate those disorders by means of positron emission tomography (PET).

Improved work-up procedure for the production of [(18)F]flumazenil and first results of its use with a high-resolution research tomograph in human stroke.

Case series with (11)C-PK11195 and positron emission tomography (PET) in stroke patients suggest that activated microglia may be detected in remote brain regions with fiber tract connections to the lesion site as an indicator of poststroke neuroinflammation. However, the specificity of these imaging findings remains to be demonstrated.

Multimodal microglia imaging of fiber tracts in acute subcortical stroke.

Translation of carbon-11 labeled PET tracers to clinical settings is currently impeded by the technical difficulties associated with [C]CO conversion into the highly reactive methylating agents [C]CHI and [C]CHOTf using automated modules relying on stationary valves. Here we describe development of the first in its kind "[C]kit" for production of carbon-11 radiotracer using disposable manifolds. This method proved to be very reliable and allows for consecutive production of PET tracers with minimal intervals between the syntheses.

Article	Year
Improved work-up procedure for the production of [(18)F]flumazenil and first results of its use with a high-resolution research tomograph in human stroke. Nuclear medicine and biology\| PubMed ID: 19720284	2009
Multimodal microglia imaging of fiber tracts in acute subcortical stroke. Annals of neurology\| PubMed ID: 20035510	2009
Development of "[C]kits" for a fast, efficient and reliable production of carbon-11 labeled radiopharmaceuticals for Positron Emission Tomography. Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine\| PubMed ID: 28038410	2017

Dean Jolly

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