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Solid Phase 11C-Methylation, Purification and Formulation for the Production of PET Tracers

Article DOI: 10.3791/60237-v • 09:25 min • October 24th, 2019
October 24th, 2019 •
*1, *1, 1, 1, 1, 1,2
1McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, 2Department of Neurology and Neurosurgery, McGill University
* These authors contributed equally

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Summary
Automatic Translation

We report an efficient carbon-11 radiolabeling technique to produce clinically relevant tracers for Positron Emission Tomography (PET) using solid phase extraction cartridges. 11C-methylating agent is passed through a cartridge preloaded with precursor and successive elution with aqueous ethanol provides chemically and radiochemically pure PET tracers in high radiochemical yields.

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Solid Phase 11C-Methylation Purification Formulation PET Tracers Carbon-11 Radiolabeling Solid-phase Extraction Cartridges HPLC-free Technique Radiosynthesis Time Synthesis Reliability Automation Process Good Manufacturing Practices (GMP) C11 PiB Amyloid Plaques Imaging Alzheimer's Disease C11 ABP688 Metabotropic Glutamate Receptors Type Five Imaging Carbon-11 Labeled Tracers Acetic Acid Solution Sodium Acetate Solution Acetate Buffer Preparation PH Verification Aqueous Ethanol Solution
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