Pinghui Feng

Department of Microbiology, UT Southwestern Medical Center

Affiliated withUT Southwestern Medical Center Keck School of Medicine, University of Southern California University of Southern California

Research Area

Immunology and Infection

Biography

Pinghui Feng has not added Biography.
If you are Pinghui Feng and would like to personalize this page please email our Author Liaison for assistance.

JoVE Journal Publications

ArticleTotal : 3	Year
Publication title Cited by 2	2011
Publication title Cited by 2	2014
Publication title	2025

Other Publications

Article	Year
mRNA degradation by the virion host shutoff (Vhs) protein of herpes simplex virus: genetic and biochemical evidence that Vhs is a nuclease. Journal of virology\| PubMed ID: 12163576	2002
Kaposi's sarcoma-associated herpesvirus mitochondrial K7 protein targets a cellular calcium-modulating cyclophilin ligand to modulate intracellular calcium concentration and inhibit apoptosi... Journal of virology\| PubMed ID: 12388711	2002
Distinct roles of cellular Lck and p80 proteins in herpesvirus saimiri Tip function on lipid rafts. Journal of virology\| PubMed ID: 12885920	2003
Kaposi's sarcoma-associated herpesvirus K7 protein targets a ubiquitin-like/ubiquitin-associated domain-containing protein to promote protein degradation. Molecular and cellular biology\| PubMed ID: 15082787	2004
Activation of Stat3 transcription factor by Herpesvirus saimiri STP-A oncoprotein. Journal of virology\| PubMed ID: 15163742	2004
Modulation of T-cell receptor signal transduction by herpesvirus signaling adaptor protein. Molecular and cellular biology\| PubMed ID: 15169900	2004
Inhibition of T cell receptor signal transduction by tyrosine kinase-interacting protein of Herpesvirus saimiri. The Journal of experimental medicine\| PubMed ID: 15337788	2004
mRNA decay during herpes simplex virus (HSV) infections: protein-protein interactions involving the HSV virion host shutoff protein and translation factors eIF4H and eIF4A. Journal of virology\| PubMed ID: 16014927	2005
Characterization of the Kaposi's sarcoma-associated herpesvirus K1 signalosome. Journal of virology\| PubMed ID: 16160144	2005
Inhibition of the ATM/p53 signal transduction pathway by Kaposi's sarcoma-associated herpesvirus interferon regulatory factor 1. Journal of virology\| PubMed ID: 16474133	2006
Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG. Nature cell biology\| PubMed ID: 16799551	2006
UVRAG: a new player in autophagy and tumor cell growth. Autophagy\| PubMed ID: 17106237	2007
A novel inhibitory mechanism of mitochondrion-dependent apoptosis by a herpesviral protein. PLoS pathogens\| PubMed ID: 18069888	2007
Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking. Nature cell biology\| PubMed ID: 18552835	2008
Kaposi's sarcoma-associated herpesvirus K7 induces viral G protein-coupled receptor degradation and reduces its tumorigenicity. PLoS pathogens\| PubMed ID: 18802460	2008
Sulfotyrosines of the Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor promote tumorigenesis through autocrine activation. Journal of virology\| PubMed ID: 20106924	2010
Murine gamma-herpesvirus 68 hijacks MAVS and IKKbeta to initiate lytic replication. PLoS pathogens\| PubMed ID: 20686657	2010
Murine gamma herpesvirus 68 hijacks MAVS and IKKÎ² to abrogate NFÎºB activation and antiviral cytokine production. PLoS pathogens\| PubMed ID: 22110409	2011
Murine Gammaherpesvirus 68 Evades Host Cytokine Production via Replication Transactivator-Induced RelA Degradation. Journal of virology\| PubMed ID: 22130545	2012
Evasion of adaptive and innate immune response mechanisms by γ-herpesviruses. Current opinion in virology\| PubMed ID: 23735334	2013
IKK epsilon kinase is crucial for viral G protein-coupled receptor tumorigenesis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 23771900	2013
Kaposi's sarcoma-associated herpesvirus K7 modulates Rubicon-mediated inhibition of autophagosome maturation. Journal of virology\| PubMed ID: 24027317	2013
PtdIns(3)P-bound UVRAG coordinates Golgi-ER retrograde and Atg9 transport by differential interactions with the ER tether and the beclin 1 complex. Nature cell biology\| PubMed ID: 24056303	2013
NF-κB activation coordinated by IKKβ and IKKε enables latent infection of Kaposi's sarcoma-associated herpesvirus. Journal of virology\| PubMed ID: 24155403	2014
Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor 4 (vIRF4) targets expression of cellular IRF4 and the Myc gene to facilitate lytic replication. Journal of virology\| PubMed ID: 24335298	2014
Kaposi's sarcoma-associated herpesvirus K3 and K5 ubiquitin E3 ligases have stage-specific immune evasion roles during lytic replication. Journal of virology\| PubMed ID: 24899205	2014
Identification of the Essential Role of Viral Bcl-2 for Kaposi's Sarcoma-Associated Herpesvirus Lytic Replication. Journal of virology\| PubMed ID: 25740994	2015
Viral pseudo-enzymes activate RIG-I via deamidation to evade cytokine production. Molecular cell\| PubMed ID: 25752576	2015
Association of Kaposi's Sarcoma-Associated Herpesvirus ORF31 with ORF34 and ORF24 Is Critical for Late Gene Expression. Journal of virology\| PubMed ID: 25810551	2015
Herpesviral G protein-coupled receptors activate NFAT to induce tumor formation via inhibiting the SERCA calcium ATPase. PLoS pathogens\| PubMed ID: 25811856	2015
CBP-dependent Wnt/β-catenin signaling is crucial in regulation of MDR1 transcription. Current cancer drug targets\| PubMed ID: 25968898	2015
Recombinant Murine Gamma Herpesvirus 68 Carrying KSHV G Protein-Coupled Receptor Induces Angiogenic Lesions in Mice. PLoS pathogens\| PubMed ID: 26107716	2015
An Internally Translated MAVS Variant Exposes Its Amino-terminal TRAF-Binding Motifs to Deregulate Interferon Induction. PLoS pathogens\| PubMed ID: 26221961	2015
Recent advances on viral manipulation of NF-κB signaling pathway. Current opinion in virology\| PubMed ID: 26385424	2015
Akt Kinase-Mediated Checkpoint of cGAS DNA Sensing Pathway. Cell reports\| PubMed ID: 26440888	2015
A Gammaherpesvirus Noncoding RNA Is Essential for Hematogenous Dissemination and Establishment of Peripheral Latency. mSphere\| PubMed ID: 27110595	2016
An Oncogenic Virus Promotes Cell Survival and Cellular Transformation by Suppressing Glycolysis. PLoS pathogens\| PubMed ID: 27187079	2016
PRKAA/AMPK restricts HBV replication through promotion of autophagic degradation. Autophagy\| PubMed ID: 27305174	2016
IκB Kinase ε Is an NFATc1 Kinase that Inhibits T Cell Immune Response. Cell reports\| PubMed ID: 27346349	2016
A Viral Deamidase Targets the Helicase Domain of RIG-I to Block RNA-Induced Activation. Cell host & microbe\| PubMed ID: 27866900	2016
Roles of IκB kinase ε in the innate immune defense and beyond. Virologica Sinica\| PubMed ID: 28063014	2016
Novel Role of vBcl2 in the Virion Assembly of Kaposi's Sarcoma-Associated Herpesvirus. Journal of virology\| PubMed ID: 29167347	2018
Deregulation of HDAC5 by Viral Interferon Regulatory Factor 3 Plays an Essential Role in Kaposi's Sarcoma-Associated Herpesvirus-Induced Lymphangiogenesis. mBio\| PubMed ID: 29339432	2018
Species-Specific Deamidation of cGAS by Herpes Simplex Virus UL37 Protein Facilitates Viral Replication. Cell host & microbe\| PubMed ID: 30092200	2018
Interplay between Cellular Metabolism and Cytokine Responses during Viral Infection. Viruses\| PubMed ID: 30249998	2018
FoxO1 Suppresses Kaposi's Sarcoma-Associated Herpesvirus Lytic Replication and Controls Viral Latency. Journal of virology\| PubMed ID: 30404794	2019
Modulation of Innate Immune Signaling Pathways by Herpesviruses. Viruses\| PubMed ID: 31234396	2019
Viperin catalyzes methionine oxidation to promote protein expression and function of helicases. Science advances\| PubMed ID: 31489375	2019
Antiviral activity of a purine synthesis enzyme reveals a key role of deamidation in regulating protein nuclear import. Science advances\| PubMed ID: 31633017	2019
Post-translational Control of Innate Immune Signaling Pathways by Herpesviruses. Frontiers in microbiology\| PubMed ID: 31798565	2019
Herpesvirus-bacteria synergistic interaction in periodontitis. Periodontology 2000\| PubMed ID: 31850623	2020
Oncogenic human herpesvirus hijacks proline metabolism for tumorigenesis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 32213586	2020
Deamidation Shunts RelA from Mediating Inflammation to Aerobic Glycolysis. Cell metabolism\| PubMed ID: 32325032	2020
Crystal Structures of Ternary Complexes of MEF2 and NKX2-5 Bound to DNA Reveal a Disease Related Protein-Protein Interaction Interface. Journal of molecular biology\| PubMed ID: 32681840	2020
Viral pseudoenzymes in infection and immunity. The FEBS journal\| PubMed ID: 32889786	2020
DNA-PK deficiency potentiates cGAS-mediated antiviral innate immunity. Nature communications\| PubMed ID: 33273464	2020
Targeting CTP Synthetase 1 to Restore Interferon Induction and Impede Nucleotide Synthesis in SARS-CoV-2 Infection. bioRxiv : the preprint server for biology\| PubMed ID: 33564769	2021
Herpes Simplex Virus and Pattern Recognition Receptors: An Arms Race. Frontiers in immunology\| PubMed ID: 33584700	2020
Species-Specific Deamidation of RIG-I Reveals Collaborative Action between Viral and Cellular Deamidases in HSV-1 Lytic Replication. mBio\| PubMed ID: 33785613	2021
SARS-CoV-2 Nsp5 Demonstrates Two Distinct Mechanisms Targeting RIG-I and MAVS To Evade the Innate Immune Response. mBio\| PubMed ID: 34544279	2021
The Roles of APOBEC-mediated RNA Editing in SARS-CoV-2 Mutations, Replication and Fitness. bioRxiv : the preprint server for biology\| PubMed ID: 34981048	2022
Simultaneous Detection of Herpes Simplex Virus Type 1 Latent and Lytic Transcripts in Brain Tissue. ASN neuro\| PubMed ID: 35164537	2022
SARS-CoV-2: Mechanism of infection and emerging technologies for future prospects. Reviews in medical virology\| PubMed ID: 35349206	2021
The Roles of APOBEC-mediated RNA Editing in SARS-CoV-2 Mutations, Replication and Fitness. Research square\| PubMed ID: 35441170	2022
SARS-CoV-2 couples evasion of inflammatory response to activated nucleotide synthesis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 35700355	2022
The roles of APOBEC-mediated RNA editing in SARS-CoV-2 mutations, replication and fitness. Scientific reports\| PubMed ID: 36100631	2022
STeerING PI4P for innate immune activation. Immunity\| PubMed ID: 36921569	2023
Potent NKT cell ligands overcome SARS-CoV-2 immune evasion to mitigate viral pathogenesis in mouse models. PLoS pathogens\| PubMed ID: 36961850	2023
Genome-Wide CRISPR-Cas9 Screen Identifies SMCHD1 as a Restriction Factor for Herpesviruses. mBio\| PubMed ID: 37010434	2023
Factor Xa cleaves SARS-CoV-2 spike protein to block viral entry and infection. Nature communications\| PubMed ID: 37024459	2023
STING is a cell-intrinsic metabolic checkpoint restricting aerobic glycolysis by targeting HK2. Nature cell biology\| PubMed ID: 37443289	2023
Alkyne as a Latent Warhead to Covalently Target SARS-CoV-2 Main Protease. Journal of medicinal chemistry\| PubMed ID: 37595260	2023
METTL16 controls Kaposi's sarcoma-associated herpesvirus replication by regulating S-adenosylmethionine cycle. Cell death & disease\| PubMed ID: 37673880	2023
Mechanistic insights into the role of herpes simplex virus 1 in Alzheimer's disease. Frontiers in aging neuroscience\| PubMed ID: 37744399	2023
The Apolipoprotein E neutralizing antibody inhibits SARS-CoV-2 infection by blocking cellular entry of lipoviral particles. MedComm\| PubMed ID: 37822714	2023
The Interferon-inducible NAMPT acts as a protein phosphoribosylase to restrict viral infection. bioRxiv : the preprint server for biology\| PubMed ID: 37905103	2023
Non-canonical regulation of the reactivation of an oncogenic herpesvirus by the OTUD4-USP7 deubiquitinases. PLoS pathogens\| PubMed ID: 38215174	2024
Metabolic Enzymes in Viral Infection and Host Innate Immunity. Viruses\| PubMed ID: 38257735	2023
The emerging roles of glutamine amidotransferases in metabolism and immune defense. Nucleosides, nucleotides & nucleic acids\| PubMed ID: 38743960	2024
Cryptic phosphoribosylase activity of NAMPT restricts the virion incorporation of viral proteins. Nature metabolism\| PubMed ID: 39572750	2024
Pyrimidine synthesis enzyme CTP synthetase 1 suppresses antiviral interferon induction by deamidating IRF3. Immunity\| PubMed ID: 39719712	2025
Oral Neisseria gonorrhoeae Promotes KSHV Lytic Replication. Journal of medical virology\| PubMed ID: 40171956	2025
Disrupting the OTUD4-USP7 deubiquitinase complex to suppress herpesvirus replication: a novel antiviral strategy. PLoS pathogens\| PubMed ID: 40208866	2025
Targeting CTP synthetase 1 to restore interferon induction and impede nucleotide synthesis in SARS-CoV-2 infection. mBio\| PubMed ID: 40298378	2025
Kaposi's sarcoma-associated herpesvirus induces mitochondrial fission to evade host immune responses and promote viral production. Nature microbiology\| PubMed ID: 40404827	2025