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JoVE Journal
Immunology and Infection

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Dissecting Host-virus Interaction in Lytic Replication of a Model Herpesvirus
 

Dissecting Host-virus Interaction in Lytic Replication of a Model Herpesvirus

Article doi: 10.3791/3140
October 7th, 2011 Usage Statistics

Summary October 7th, 2011

We describe a protocol to identify key roles of host signaling molecules in lytic replication of a model herpesvirus, gamma herpesvirus 68 (γHV68). Utilizing genetically modified mouse strains and embryonic fibroblasts for γHV68 lytic replication, the protocol permits both phenotypic characterization and molecular interrogation of virus-host interactions in viral lytic replication.

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