Andrew M. Lowy

Moores Cancer Center, University of California San Diego

Affiliated withUniversity of California San Diego University of California

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 3	2022
Publication title Cited by 5	2020

Other Publications

Article	Year
Incidence, natural history, and patterns of locoregional recurrence in gastric cancer patients treated with preoperative chemoradiotherapy. International journal of radiation oncology, biology, physics\| PubMed ID: 18164837	2008
Neoadjuvant therapy for pancreatic cancer. Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract\| PubMed ID: 18259825	2008
Beyond the ivory tower: outcomes following surgery for ampullary cancer. Annals of surgical oncology\| PubMed ID: 18425553	2008
Case report: focal nesidioblastosis ("nesidioblastoma") in an adult. Human pathology\| PubMed ID: 20004945	2010
Silencing of RON receptor signaling promotes apoptosis and gemcitabine sensitivity in pancreatic cancers. Cancer research\| PubMed ID: 20103639	2010
Pancreatic cancer: preface. Surgical oncology clinics of North America\| PubMed ID: 20159512	2010
Cystic neoplasms of the pancreas. Surgical oncology clinics of North America\| PubMed ID: 20159515	2010
The RON tyrosine kinase receptor regulates vascular endothelial growth factor production in pancreatic cancer cells. Pancreas\| PubMed ID: 20358644	2010
Development of an orthotopic model of invasive pancreatic cancer in an immunocompetent murine host. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 20534740	2010
IGF1-R signals through the RON receptor to mediate pancreatic cancer cell migration. Carcinogenesis\| PubMed ID: 21565828	2011
Disruption of p16 and activation of Kras in pancreas increase ductal adenocarcinoma formation and metastasis in vivo. Oncotarget\| PubMed ID: 22113502	2011
The RON-receptor regulates pancreatic cancer cell migration through phosphorylation-dependent breakdown of the hemidesmosome. International journal of cancer\| PubMed ID: 22275185	2012
Chemokine CXCL12 activates dual CXCR4 and CXCR7-mediated signaling pathways in pancreatic cancer cells. Journal of translational medicine\| PubMed ID: 22472349	2012
Changing the way we do business: recommendations to accelerate biomarker development in pancreatic cancer. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 23344262	2013
Borderline resectable pancreatic cancer: need for standardization and methods for optimal clinical trial design. Annals of surgical oncology\| PubMed ID: 23435609	2013
Therapeutic advances in pancreatic cancer. Gastroenterology\| PubMed ID: 23622141	2013
A dual-color genetically engineered mouse model for multispectral imaging of the pancreatic microenvironment. Pancreas\| PubMed ID: 23648841	2013
PI3Kα activates integrin α4β1 to establish a metastatic niche in lymph nodes. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 23671068	2013
Improved perioperative outcomes with minimally invasive distal pancreatectomy: results from a population-based analysis. JAMA surgery\| PubMed ID: 24402232	2014
Generation of orthotopic patient-derived xenografts from gastrointestinal stromal tumor. Journal of translational medicine\| PubMed ID: 24507750	2014
The RON receptor tyrosine kinase in pancreatic cancer pathogenesis and its potential implications for future targeted therapies. Pancreas\| PubMed ID: 24518495	2014
Single-incision laparoscopic surgery through an ostomy site: a natural approach by an unnatural orifice. Surgical laparoscopy, endoscopy & percutaneous techniques\| PubMed ID: 24743670	2015
An integrin β₃-KRAS-RalB complex drives tumour stemness and resistance to EGFR inhibition. Nature cell biology\| PubMed ID: 24747441	2014
Genome-wide mutational landscape of mucinous carcinomatosis peritonei of appendiceal origin. Genome medicine\| PubMed ID: 24944587	2014
Dual blockade of epidermal growth factor receptor and insulin-like growth factor receptor-1 signaling in metastatic pancreatic cancer: phase Ib and randomized phase II trial of gemcitabine, ... Cancer\| PubMed ID: 25041791	2014
Predictors of progression in high-grade appendiceal or colorectal peritoneal carcinomatosis after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. Annals of surgical oncology\| PubMed ID: 25145504	2015
Borderline resectable pancreatic cancer: definitions and management. World journal of gastroenterology\| PubMed ID: 25152577	2014
Long-term outcomes after total pancreatectomy and islet cell autotransplantation: is it a durable operation? Annals of surgery\| PubMed ID: 25203883	2014
Correction: Genome-wide mutational landscape of mucinous carcinomatosis peritonei of appendiceal origin. Genome medicine\| PubMed ID: 25228923	2014
A hypusine-eIF5A-PEAK1 switch regulates the pathogenesis of pancreatic cancer. Cancer research\| PubMed ID: 25261239	2014
A next-generation dual-recombinase system for time- and host-specific targeting of pancreatic cancer. Nature medicine\| PubMed ID: 25326799	2014
Enteral stenting for gastric outlet obstruction and afferent limb syndrome following pancreaticoduodenectomy. Annals of gastroenterology\| PubMed ID: 25332208	2014
Tumor-penetrating iRGD peptide inhibits metastasis. Molecular cancer therapeutics\| PubMed ID: 25392370	2015
Laparoscopic evacuation of mucinous ascites for palliation of pseudomyxoma peritonei. Annals of surgical oncology\| PubMed ID: 25395145	2015
Tumor radiosensitization by monomethyl auristatin E: mechanism of action and targeted delivery. Cancer research\| PubMed ID: 25681274	2015
BAP1 mutation is a frequent somatic event in peritoneal malignant mesothelioma. Journal of translational medicine\| PubMed ID: 25889843	2015
Approach to patients with pancreatic cancer without detectable metastases. Journal of clinical oncology : official journal of the American Society of Clinical Oncology\| PubMed ID: 25918279	2015
SWOG S0809: A Phase II Intergroup Trial of Adjuvant Capecitabine and Gemcitabine Followed by Radiotherapy and Concurrent Capecitabine in Extrahepatic Cholangiocarcinoma and Gallbladder Carci... Journal of clinical oncology : official journal of the American Society of Clinical Oncology\| PubMed ID: 25964250	2015
A tumor-penetrating peptide enhances circulation-independent targeting of peritoneal carcinomatosis. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 26071630	2015
A novel protein isoform of the RON tyrosine kinase receptor transforms human pancreatic duct epithelial cells. Oncogene\| PubMed ID: 26477314	2016
Laparoscopy is Safe and Accurate to Evaluate Peritoneal Surface Metastasis Prior to Cytoreductive Surgery. Annals of surgical oncology\| PubMed ID: 26542584	2016
A Novel Tool for Predicting Major Complications After Cytoreductive Surgery with Hyperthermic Intraperitoneal Chemotherapy. Annals of surgical oncology\| PubMed ID: 26678406	2016
FRAX597, a PAK1 inhibitor, synergistically reduces pancreatic cancer growth when combined with gemcitabine. BMC cancer\| PubMed ID: 26774265	2016
Urokinase-controlled tumor penetrating peptide. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 27106816	2016
Macrophage PI3Kγ Drives Pancreatic Ductal Adenocarcinoma Progression. Cancer discovery\| PubMed ID: 27179037	2016
Preoperative Modified FOLFIRINOX Treatment Followed by Capecitabine-Based Chemoradiation for Borderline Resectable Pancreatic Cancer: Alliance for Clinical Trials in Oncology Trial A021101. JAMA surgery\| PubMed ID: 27275632	2016
Image-based detection and targeting of therapy resistance in pancreatic adenocarcinoma. Nature\| PubMed ID: 27281208	2016
Characterization of RON protein isoforms in pancreatic cancer: implications for biology and therapeutics. Oncotarget\| PubMed ID: 27323855	2016
Safety and Outcome Measures of First-in-Human Intraperitoneal α Radioimmunotherapy With 212Pb-TCMC-Trastuzumab. American journal of clinical oncology\| PubMed ID: 27906723	2018
Effect of Selumetinib and MK-2206 vs Oxaliplatin and Fluorouracil in Patients With Metastatic Pancreatic Cancer After Prior Therapy: SWOG S1115 Study Randomized Clinical Trial. JAMA oncology\| PubMed ID: 27978579	2017
Hyaluronan-binding peptide for targeting peritoneal carcinomatosis. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine\| PubMed ID: 28468593	2017
Overinterpretation is common in pathological diagnosis of appendix cancer during patient referral for oncologic care. PloS one\| PubMed ID: 28591173	2017
Molecular Pathways: Targeting the Microenvironment of Liver Metastases. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 28615370	2017
An Intergroup Randomized Phase II Study of Bevacizumab or Cetuximab in Combination with Gemcitabine and in Combination with Chemoradiation in Patients with Resected Pancreatic Carcinoma: A T... Oncology\| PubMed ID: 29040974	2018
Factors Associated with 60-Day Readmission Following Cytoreduction and Hyperthermic Intraperitoneal Chemotherapy. Annals of surgical oncology\| PubMed ID: 29090402	2018
GPR68, a proton-sensing GPCR, mediates interaction of cancer-associated fibroblasts and cancer cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 29092903	2018
Reprogramming pancreatic stellate cells via p53 activation: A putative target for pancreatic cancer therapy. PloS one\| PubMed ID: 29211796	2017
Histologic Predictors of Recurrence in Mucinous Appendiceal Tumors with Peritoneal Dissemination after HIPEC. Annals of surgical oncology\| PubMed ID: 29282599	2018
Cirrhosis is not a contraindication to cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in highly selected patients. World journal of surgical oncology\| PubMed ID: 29699564	2018
GPCRomics: GPCR Expression in Cancer Cells and Tumors Identifies New, Potential Biomarkers and Therapeutic Targets. Frontiers in pharmacology\| PubMed ID: 29872392	2018
Preoperative Circulating Tumor DNA in Patients with Peritoneal Carcinomatosis is an Independent Predictor of Progression-Free Survival. Annals of surgical oncology\| PubMed ID: 29948422	2018
E47 Governs the MYC-CDKN1B/p27-RB Network to Growth Arrest PDA Cells Independent of CDKN2A/p16 and Wild-Type p53. Cellular and molecular gastroenterology and hepatology\| PubMed ID: 30003124	2018
Does Primary Tumor Side Matter in Patients with Metastatic Colon Cancer Treated with Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy? Annals of surgical oncology\| PubMed ID: 30815802	2019
Exosomes from Pancreatic Juice: A Step Closer to the Holy Grail? Annals of surgical oncology\| PubMed ID: 30820788	2019
Inhibition of invasive pancreatic cancer: restoring cell apoptosis by activating mitochondrial p53. American journal of cancer research\| PubMed ID: 30906636	2019
A Multiscale Map of the Stem Cell State in Pancreatic Adenocarcinoma. Cell\| PubMed ID: 30955884	2019
MST1R kinase accelerates pancreatic cancer progression via effects on both epithelial cells and macrophages. Oncogene\| PubMed ID: 30967626	2019
Targeting LIF-mediated paracrine interaction for pancreatic cancer therapy and monitoring. Nature\| PubMed ID: 30996350	2019
Primary Tumor Sidedness is Predictive of Survival in Colon Cancer Patients Treated with Cytoreductive Surgery With or Without Hyperthermic Intraperitoneal Chemotherapy: A US HIPEC Collaborat... Annals of surgical oncology\| PubMed ID: 31016486	2019
Incidence, Risk Factors, and Prevention Strategies for Venous Thromboembolism after Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy. Annals of surgical oncology\| PubMed ID: 31065960	2019
Obstruction-Free Survival Following Operative Intervention for Malignant Bowel Obstruction in Appendiceal Cancer. Annals of surgical oncology\| PubMed ID: 31190209	2019
Optimal Surveillance Frequency After CRS/HIPEC for Appendiceal and Colorectal Neoplasms: A Multi-institutional Analysis of the US HIPEC Collaborative. Annals of surgical oncology\| PubMed ID: 31243668	2020
Association of an acute pain service with postoperative outcomes following pancreaticoduodenectomy. Journal of perioperative practice\| PubMed ID: 31524066	2019
Precision Chemoradiotherapy for HER2 Tumors Using Antibody Conjugates of an Auristatin Derivative with Reduced Cell Permeability. Molecular cancer therapeutics\| PubMed ID: 31597712	2020
Detection and Quantification of GPCR mRNA: An Assessment and Implications of Data from High-Content Methods. ACS omega\| PubMed ID: 31646252	2019
Adherence with operative standards in the treatment of gastric cancer in the United States. Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association\| PubMed ID: 31745679	2020
Institutional variation in recovery after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy: An opportunity for enhanced recovery pathways. Journal of surgical oncology\| PubMed ID: 32627199	2020
Surgical Outcome Results From SWOG S1505: A Randomized Clinical Trial of mFOLFIRINOX Versus Gemcitabine/Nab-paclitaxel for Perioperative Treatment of Resectable Pancreatic Ductal Adenocarcin... Annals of surgery\| PubMed ID: 32740235	2020
Prognostic Utility of Pre- and Postoperative Circulating Tumor DNA Liquid Biopsies in Patients with Peritoneal Metastases. Annals of surgical oncology\| PubMed ID: 32767050	2020
Preoperative bevacizumab does not increase complications following cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. PloS one\| PubMed ID: 33270763	2020
A Multi-institutional Study of Peritoneal Recurrence Following Resection of Low-grade Appendiceal Mucinous Neoplasms. Annals of surgical oncology\| PubMed ID: 33415564	2021
A MET Targeting Antibody-Drug Conjugate Overcomes Gemcitabine Resistance in Pancreatic Cancer. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 33451980	2021
Efficacy of Perioperative Chemotherapy for Resectable Pancreatic Adenocarcinoma: A Phase 2 Randomized Clinical Trial. JAMA oncology\| PubMed ID: 33475684	2021
Phase I Trial of Stereotactic Body Radiation Therapy Dose Escalation in Pancreatic Cancer. International journal of radiation oncology, biology, physics\| PubMed ID: 33571625	2021
Macropinocytosis in Cancer-Associated Fibroblasts Is Dependent on CaMKK2/ARHGEF2 Signaling and Functions to Support Tumor and Stromal Cell Fitness. Cancer discovery\| PubMed ID: 33653692	2021
Predictors and significance of histologic response to neoadjuvant therapy for gastric cancer. Journal of surgical oncology\| PubMed ID: 33735448	2021
Clinical Data Prediction Model to Identify Patients With Early-Stage Pancreatic Cancer. JCO clinical cancer informatics\| PubMed ID: 33739856	2021
Cancer cells escape autophagy inhibition via NRF2-induced macropinocytosis. Cancer cell\| PubMed ID: 33740421	2021
Tumor-penetrating therapy for β5 integrin-rich pancreas cancer. Nature communications\| PubMed ID: 33750829	2021
Ki67 does not predict recurrence for low-grade appendiceal mucinous neoplasms with peritoneal dissemination after cytoreductive surgery and HIPEC. Human pathology\| PubMed ID: 33905776	2021
Tri-modal management of primary small cell carcinoma of the pancreas (SCCP): a rare neuroendocrine carcinoma (NEC). BMC gastroenterology\| PubMed ID: 34479480	2021
Randomized Phase II Study of PARP Inhibitor ABT-888 (Veliparib) with Modified FOLFIRI versus FOLFIRI as Second-line Treatment of Metastatic Pancreatic Cancer: SWOG S1513. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 34580114	2021
Using Organotypic Tissue Slices to Investigate the Microenvironment of Pancreatic Cancer: Pharmacotyping and Beyond. Cancers\| PubMed ID: 34638476	2021
Author Correction: Targeting LIF-mediated paracrine interaction for pancreatic cancer therapy and monitoring. Nature\| PubMed ID: 34848876	2021
Establishment of Patient-Derived Pancreatic Cancer Organoids from Endoscopic Ultrasound-Guided Fine-Needle Aspiration Biopsies. Gut and liver\| PubMed ID: 34916338	2022
Fluorescent Anti-MUC5AC Brightly Targets Pancreatic Cancer in a Patient-derived Orthotopic Xenograft. In vivo (Athens, Greece)\| PubMed ID: 34972700	2022
The MST1R/RON Tyrosine Kinase in Cancer: Oncogenic Functions and Therapeutic Strategies. Cancers\| PubMed ID: 35454943	2022
Early-stage multi-cancer detection using an extracellular vesicle protein-based blood test. Communications medicine\| PubMed ID: 35603292	2022
An Ex Vivo Organotypic Culture Platform for Functional Interrogation of Human Appendiceal Cancer Reveals a Prominent and Heterogenous Immunological Landscape. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 36067351	2022
Alvimopan for Enhanced Gastrointestinal Recovery after Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy: A Randomized Controlled Trial. Journal of the American College of Surgeons\| PubMed ID: 36102565	2022
Collagenolysis-dependent DDR1 signalling dictates pancreatic cancer outcome. Nature\| PubMed ID: 36198801	2022
Is Routine Omentectomy a Necessary Component of Cytoreductive Surgery and HIPEC? Annals of surgical oncology\| PubMed ID: 36305990	2022
ASO Visual Abstract: Is Routine Omentectomy a Necessary Component of Cytoreductive Surgery and HIPEC? Annals of surgical oncology\| PubMed ID: 36369408	2022
Laparoscopic cytoreductive surgery and hyperthermic intraperitoneal chemotherapy: a prospective clinical trial and comparative analysis. Surgical endoscopy\| PubMed ID: 36477643	2022