Michael X. Zhu

Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston

Affiliated withThe University of Texas Health Science Center at Houston

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 32	2011

Other Publications

Article	Year
Rapid activation of protein tyrosine kinase and phospholipase C-gamma2 and increase in cytosolic free calcium are required by Ehrlichia chaffeensis for internalization and growth in THP-1 ce... Infection and immunity\| PubMed ID: 11796624	2002
A unified nomenclature for the superfamily of TRP cation channels. Molecular cell\| PubMed ID: 11864597	2002
Calmodulin regulates Ca(2+)-dependent feedback inhibition of store-operated Ca(2+) influx by interaction with a site in the C terminus of TrpC1. Molecular cell\| PubMed ID: 11983166	2002
Expression and role of TRPC proteins in human platelets: evidence that TRPC6 forms the store-independent calcium entry channel. Blood\| PubMed ID: 12351388	2002
Epidermal growth factor-induced depletion of the intracellular Ca2+ store fails to activate capacitative Ca2+ entry in a human salivary cell line. The Journal of biological chemistry\| PubMed ID: 12368284	2002
Characterization of a human peptide deformylase: implications for antibacterial drug design. Biochemistry\| PubMed ID: 12924944	2003
Ca(2+) signaling by TRPC3 involves Na(+) entry and local coupling to the Na(+)/Ca(2+) exchanger. The Journal of biological chemistry\| PubMed ID: 14736881	2004
TRPC channel interactions with calmodulin and IP3 receptors. Novartis Foundation symposium\| PubMed ID: 15104175	2004
2-aminoethoxydiphenyl borate is a common activator of TRPV1, TRPV2, and TRPV3. The Journal of biological chemistry\| PubMed ID: 15194687	2004
An alternative splicing product of the murine trpv1 gene dominant negatively modulates the activity of TRPV1 channels. The Journal of biological chemistry\| PubMed ID: 15234965	2004
Junctate is a key element in calcium entry induced by activation of InsP3 receptors and/or calcium store depletion. The Journal of cell biology\| PubMed ID: 15302852	2004
Regulation of the Ca2+ sensitivity of the nonselective cation channel TRPM4. The Journal of biological chemistry\| PubMed ID: 15590641	2005
2-aminoethoxydiphenyl borate stimulates pulmonary C neurons via the activation of TRPV channels. American journal of physiology. Lung cellular and molecular physiology\| PubMed ID: 15653710	2005
The selectivity filter of the cation channel TRPM4. The Journal of biological chemistry\| PubMed ID: 15845551	2005
Inhibition of TRPC5 channels by Ca2+-binding protein 1 in Xenopus oocytes. PflÃ¼gers Archiv : European journal of physiology\| PubMed ID: 15895247	2005
Calmodulin and calcium interplay in the modulation of TRPC5 channel activity. Identification of a novel C-terminal domain for calcium/calmodulin-mediated facilitation. The Journal of biological chemistry\| PubMed ID: 15987684	2005
Activation of the endothelial store-operated ISOC Ca2+ channel requires interaction of protein 4.1 with TRPC4. Circulation research\| PubMed ID: 16254212	2005
Cellular cholesterol controls TRPC3 function: evidence from a novel dominant-negative knockdown strategy. The Biochemical journal\| PubMed ID: 16448384	2006
Thermal sensitivity of isolated vagal pulmonary sensory neurons: role of transient receptor potential vanilloid receptors. American journal of physiology. Regulatory, integrative and comparative physiology\| PubMed ID: 16513770	2006
TRPC3 and TRPC4 associate to form a redox-sensitive cation channel. Evidence for expression of native TRPC3-TRPC4 heteromeric channels in endothelial cells. The Journal of biological chemistry\| PubMed ID: 16537542	2006
Potentiation of TRPV3 channel function by unsaturated fatty acids. Journal of cellular physiology\| PubMed ID: 16557504	2006
Analogs of methyllycaconitine as novel noncompetitive inhibitors of nicotinic receptors: pharmacological characterization, computational modeling, and pharmacophore development. Molecular pharmacology\| PubMed ID: 17308033	2007
The TRPV3 mutation associated with the hairless phenotype in rodents is constitutively active. Cell calcium\| PubMed ID: 17706768	2008
Beta-nicotinamide adenine dinucleotide is an inhibitory neurotransmitter in visceral smooth muscle. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17913880	2007
Understanding the role of voltage gating of polymodal TRP channels. The Journal of physiology\| PubMed ID: 18056113	2007
The axon-dendrite targeting of Kv3 (Shaw) channels is determined by a targeting motif that associates with the T1 domain and ankyrin G. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 18094255	2007
Calcium plays a central role in the sensitization of TRPV3 channel to repetitive stimulations. The Journal of biological chemistry\| PubMed ID: 18178557	2008
Isoform-specific inhibition of TRPC4 channel by phosphatidylinositol 4,5-bisphosphate. The Journal of biological chemistry\| PubMed ID: 18230622	2008
Sensorimotor enhancement in mouse mutants lacking the Purkinje cell-specific Gi/o modulator, Pcp2(L7). Molecular and cellular neurosciences\| PubMed ID: 18930827	2009
Effect of novel negative allosteric modulators of neuronal nicotinic receptors on cells expressing native and recombinant nicotinic receptors: implications for drug discovery. The Journal of pharmacology and experimental therapeutics\| PubMed ID: 18984653	2009
Dopamine modulates an mGluR5-mediated depolarization underlying prefrontal persistent activity. Nature neuroscience\| PubMed ID: 19169252	2009
Zinc activates damage-sensing TRPA1 ion channels. Nature chemical biology\| PubMed ID: 19202543	2009
NAADP mobilizes calcium from acidic organelles through two-pore channels. Nature\| PubMed ID: 19387438	2009
The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels. PflÃ¼gers Archiv : European journal of physiology\| PubMed ID: 19475418	2009
Deletion of TRPC4 and TRPC6 in mice impairs smooth muscle contraction and intestinal motility in vivo. Gastroenterology\| PubMed ID: 19549525	2009
Potencies of cocaine methiodide on major cocaine targets in mice. PloS one\| PubMed ID: 19855831	2009
Activation of TRPA1 channels by fenamate nonsteroidal anti-inflammatory drugs. PflÃ¼gers Archiv : European journal of physiology\| PubMed ID: 19888597	2010
Calcium signaling via two-pore channels: local or global, that is the question. American journal of physiology. Cell physiology\| PubMed ID: 20018950	2010
TPCs: Endolysosomal channels for Ca2+ mobilization from acidic organelles triggered by NAADP. FEBS letters\| PubMed ID: 20159015	2010
Purified TPC isoforms form NAADP receptors with distinct roles for Ca(2+) signaling and endolysosomal trafficking. Current biology : CB\| PubMed ID: 20346675	2010
Identification of translational activators of glial glutamate transporter EAAT2 through cell-based high-throughput screening: an approach to prevent excitotoxicity. Journal of biomolecular screening\| PubMed ID: 20508255	2010
The roles of ATF3, an adaptive-response gene, in high-fat-diet-induced diabetes and pancreatic beta-cell dysfunction. Molecular endocrinology (Baltimore, Md.)\| PubMed ID: 20519332	2010
Two-pore channels for integrative Ca signaling. Communicative & integrative biology\| PubMed ID: 20539775	2010
Negative allosteric modulators that target human alpha4beta2 neuronal nicotinic receptors. The Journal of pharmacology and experimental therapeutics\| PubMed ID: 20551292	2010
TPC2 is a novel NAADP-sensitive Ca2+ release channel, operating as a dual sensor of luminal pH and Ca2+. The Journal of biological chemistry\| PubMed ID: 20720007	2010
Agonist-activated Ca2+ influx occurs at stable plasma membrane and endoplasmic reticulum junctions. Journal of cell science\| PubMed ID: 21062895	2010
An emerging role for NAADP-mediated Ca2+ signaling in the pancreatic Î²-cell. Islets\| PubMed ID: 21099331	2010
Cyclic adenosine diphosphate ribose activates ryanodine receptors, whereas NAADP activates two-pore domain channels. The Journal of biological chemistry\| PubMed ID: 21216967	2011
Extracellular spermine exacerbates ischemic neuronal injury through sensitization of ASIC1a channels to extracellular acidosis. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 21307247	2011
Rapid and efficient generation of functional motor neurons from human pluripotent stem cells using gene delivered transcription factor codes. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 21772256	2011
Ca2+: a versatile master key for intracellular signaling cascades. Science China. Life sciences\| PubMed ID: 21786190	2011
Identification of ML204, a novel potent antagonist that selectively modulates native TRPC4/C5 ion channels. The Journal of biological chemistry\| PubMed ID: 21795696	2011
TRPM8 acute desensitization is mediated by calmodulin and requires PIP(2): distinction from tachyphylaxis. Journal of neurophysiology\| PubMed ID: 21900509	2011
Hysteresis of gating underlines sensitization of TRPV3 channels. The Journal of general physiology\| PubMed ID: 22006988	2011
Heteromeric heat-sensitive TRP channels exhibit distinct temperature and chemical response. The Journal of biological chemistry\| PubMed ID: 22184123	2011