Juan Iovanna

Aix-Marseille Univ, Institut Paoli-Calmettes, CRCM

Affiliated withInstitut Paoli-Calmettes, CRCM

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 1	2019

Other Publications

Article	Year
Nuclear protein 1 promotes pancreatic cancer development and protects cells from stress by inhibiting apoptosis. The Journal of clinical investigation\| PubMed ID: 22565310	2012
PAP/HIP protein is an obesogenic factor. Journal of cellular physiology\| PubMed ID: 23881718	2014
Genetic inactivation of Nupr1 acts as a dominant suppressor event in a two-hit model of pancreatic carcinogenesis. Gut\| PubMed ID: 24026351	2014
Pancreatitis-associated protein does not predict disease relapse in inflammatory bowel disease patients. PloS one\| PubMed ID: 24416322	2014
Oligomerization and phosphorylation dependent regulation of ArgBP2 adaptive capabilities and associated functions. PloS one\| PubMed ID: 24475245	2014
Development of an ELISA detecting Tumor Protein 53-Induced Nuclear Protein 1 in serum of prostate cancer patients. Results in immunology\| PubMed ID: 24600558	2013
Pancreatic cancer-induced cachexia is Jak2-dependent in mice. Journal of cellular physiology\| PubMed ID: 24648112	2014
Further characterization of HDAC and SIRT gene expression patterns in pancreatic cancer and their relation to disease outcome. PloS one\| PubMed ID: 25275504	2014
P8 deficiency increases cellular ROS and induces HO-1. Archives of biochemistry and biophysics\| PubMed ID: 25475530	2015
A subgroup of pancreatic adenocarcinoma is sensitive to the 5-aza-dC DNA methyltransferase inhibitor. Oncotarget\| PubMed ID: 25481873	2015
The thymus-specific serine protease TSSP/PRSS16 is crucial for the antitumoral role of CD4(+) T cells. Cell reports\| PubMed ID: 25543139	2015
Methodological aspects of the molecular and histological study of prostate cancer: focus on PTEN. Methods (San Diego, Calif.)\| PubMed ID: 25697760	2015
Transcriptomic analysis predicts survival and sensitivity to anticancer drugs of patients with a pancreatic adenocarcinoma. The American journal of pathology\| PubMed ID: 25765988	2015
Deciphering the cellular source of tumor relapse identifies CD44 as a major therapeutic target in pancreatic adenocarcinoma. Oncotarget\| PubMed ID: 25797268	2015
Defects in mitophagy promote redox-driven metabolic syndrome in the absence of TP53INP1. EMBO molecular medicine\| PubMed ID: 25828351	2015
Functional Characterization of Nupr1L, A Novel p53-Regulated Isoform of the High-Mobility Group (HMG)-Related Protumoral Protein Nupr1. Journal of cellular physiology\| PubMed ID: 25899918	2015
The Aurora A-HP1γ pathway regulates gene expression and mitosis in cells from the sperm lineage. BMC developmental biology\| PubMed ID: 26021315	2015
IER3 in pancreatic carcinogenesis. Oncotarget\| PubMed ID: 26158545	2015
Targeting CD44 as a novel therapeutic approach for treating pancreatic cancer recurrence. Oncoscience\| PubMed ID: 26244163	2015
Response to "Is the Reg3α (HIP/PAP) Protein Really an Obesogenic Factor?". Journal of cellular physiology\| PubMed ID: 26280560	2016
IL17 Functions through the Novel REG3β-JAK2-STAT3 Inflammatory Pathway to Promote the Transition from Chronic Pancreatitis to Pancreatic Cancer. Cancer research\| PubMed ID: 26404002	2015
A Mycobacterium tuberculosis Dormancy Antigen Differentiates Latently Infected Bacillus Calmette-Guérin-vaccinated Individuals. EBioMedicine\| PubMed ID: 26425695	2015
α-Lipoic Acid Protects Against Ischemia-Reperfusion Injury in Simultaneous Kidney-Pancreas Transplantation. Transplantation\| PubMed ID: 26502371	2016
Pivotal Role of the Chromatin Protein Nupr1 in Kras-Induced Senescence and Transformation. Scientific reports\| PubMed ID: 26617245	2015
REG3β Plays a Key Role in IL17RA Protumoral Effect-Response. Cancer research\| PubMed ID: 26992425	2016
Determinants of the pKa values of ionizable residues in an intrinsically disordered protein. Archives of biochemistry and biophysics\| PubMed ID: 27046343	2016
Pancreatitis promotes oncogenic Kras(G12D)-induced pancreatic transformation through activation of Nupr1. Molecular & cellular oncology\| PubMed ID: 27308320	2014
Redox-sensitive TP53INP1 SUMOylation as an oxidative stress sensor to activate TP53. Molecular & cellular oncology\| PubMed ID: 27308354	2014
GATA6 regulates EMT and tumour dissemination, and is a marker of response to adjuvant chemotherapy in pancreatic cancer. Gut\| PubMed ID: 27325420	2017
The promise of epigenomic therapeutics in pancreatic cancer. Epigenomics\| PubMed ID: 27337224	2016
A pancreatic ductal adenocarcinoma subpopulation is sensitive to FK866, an inhibitor of NAMPT. Oncotarget\| PubMed ID: 27462772	2016
Stratification and therapeutic potential of PML in metastatic breast cancer. Nature communications\| PubMed ID: 27553708	2016
Autophagy Induced during Pancreatitis Promotes -Dependent Transformation in the Pancreas. Frontiers in oncology\| PubMed ID: 27833900	2016
Identification of a Drug Targeting an Intrinsically Disordered Protein Involved in Pancreatic Adenocarcinoma. Scientific reports\| PubMed ID: 28054562	2017
Gene expression profiling of patient-derived pancreatic cancer xenografts predicts sensitivity to the BET bromodomain inhibitor JQ1: implications for individualized medicine efforts. EMBO molecular medicine\| PubMed ID: 28275007	2017
[Autophagy contributes to the initiation of pancreatic cancer]. Medecine sciences : M/S\| PubMed ID: 28367822	2017
Combined AURKA and H3K9 Methyltransferase Targeting Inhibits Cell Growth By Inducing Mitotic Catastrophe. Molecular cancer research : MCR\| PubMed ID: 28442587	2017
REG3β modifies cell tumor function by impairing extracellular vesicle uptake. Scientific reports\| PubMed ID: 28600520	2017
Collagen-derived proline promotes pancreatic ductal adenocarcinoma cell survival under nutrient limited conditions. Nature communications\| PubMed ID: 28685754	2017
Speeding towards individualized treatment for pancreatic cancer by taking an alternative road. Cancer letters\| PubMed ID: 28947138	2017
Factors released by the tumor far microenvironment are decisive for pancreatic adenocarcinoma development and progression. Oncoimmunology\| PubMed ID: 29147622	2017
Prevalence of Microsatellite Instability in Intraductal Papillary Mucinous Neoplasms of the Pancreas. Gastroenterology\| PubMed ID: 29158190	2018
Cadherin-1 and cadherin-3 cooperation determines the aggressiveness of pancreatic ductal adenocarcinoma. British journal of cancer\| PubMed ID: 29161242	2018
Pancreatic Adenocarcinoma Therapeutic Targets Revealed by Tumor-Stroma Cross-Talk Analyses in Patient-Derived Xenografts. Cell reports\| PubMed ID: 29186684	2017
BTN3A is a prognosis marker and a promising target for Vγ9Vδ2 T cells based-immunotherapy in pancreatic ductal adenocarcinoma (PDAC). Oncoimmunology\| PubMed ID: 29296524	2017
Amphipathic helical peptides hamper protein-protein interactions of the intrinsically disordered chromatin nuclear protein 1 (NUPR1). Biochimica et biophysica acta. General subjects\| PubMed ID: 29530795	2018
Optimization of a Bioluminescence Resonance Energy Transfer-Based Assay for Screening of Trypanosoma cruzi Protein/Protein Interaction Inhibitors. Molecular biotechnology\| PubMed ID: 29600316	2018
Distinct epigenetic landscapes underlie the pathobiology of pancreatic cancer subtypes. Nature communications\| PubMed ID: 29773832	2018
E2F signature is predictive for the pancreatic adenocarcinoma clinical outcome and sensitivity to E2F inhibitors, but not for the response to cytotoxic-based treatments. Scientific reports\| PubMed ID: 29844366	2018
Pancreatic Ductal Adenocarcinoma: A Strong Imbalance of Good and Bad Immunological Cops in the Tumor Microenvironment. Frontiers in immunology\| PubMed ID: 29868007	2018
[Multi-omic approaches reveal new therapeutic targets for the treatment of pancreatic cancer]. Medecine sciences : M/S\| PubMed ID: 29900832	2018
The chromatin nuclear protein NUPR1L is intrinsically disordered and binds to the same proteins as its paralogue. The Biochemical journal\| PubMed ID: 29925531	2018
α-lipoic acid reduces postreperfusion syndrome in human liver transplantation - a pilot study. Transplant international : official journal of the European Society for Organ Transplantation\| PubMed ID: 29974521	2018
Epigenetics of gastrointestinal diseases: notes from a workshop. Epigenetics\| PubMed ID: 30056798	2018
Chloroquine plays a cell-dependent role in the response to treatment of pancreatic adenocarcinoma. Oncotarget\| PubMed ID: 30112111	2018
Mechanisms Underlying the Regulation of HP1γ by the NGF-PKA Signaling Pathway. Scientific reports\| PubMed ID: 30305677	2018
Self-assembling supramolecular dendrimer nanosystem for PET imaging of tumors. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 30348798	2018
Inactivation of NUPR1 promotes cell death by coupling ER-stress responses with necrosis. Scientific reports\| PubMed ID: 30451898	2018
Ribonuclease MCPiP1 contributes to the loss of micro-RNA-200 family members in pancreatic cancer cells. Oncotarget\| PubMed ID: 30542509	2018
Pancreatic cancer chemo-resistance is driven by tumor phenotype rather than tumor genotype. Heliyon\| PubMed ID: 30582059	2018
Prognostic significance of circulating PD-1, PD-L1, pan-BTN3As, BTN3A1 and BTLA in patients with pancreatic adenocarcinoma. Oncoimmunology\| PubMed ID: 30906655	2019
Ligand-based design identifies a potent NUPR1 inhibitor exerting anticancer activity via necroptosis. The Journal of clinical investigation\| PubMed ID: 30920390	2019
Complete Regression of Advanced Pancreatic Ductal Adenocarcinomas upon Combined Inhibition of EGFR and C-RAF. Cancer cell\| PubMed ID: 30975481	2019
Pancreatic Cancer Heterogeneity Can Be Explained Beyond the Genome. Frontiers in oncology\| PubMed ID: 31024848	2019
Aurora kinase B-phosphorylated HP1α functions in chromosomal instability. Cell cycle (Georgetown, Tex.)\| PubMed ID: 31130069	2019
Dendrimers as Competitors of Protein-Protein Interactions of the Intrinsically Disordered Nuclear Chromatin Protein NUPR1. Biomacromolecules\| PubMed ID: 31181156	2019
Can the plasma PD-1 levels predict the presence and efficiency of tumor-infiltrating lymphocytes in patients with metastatic melanoma? Therapeutic advances in medical oncology\| PubMed ID: 31205506	2019
Pancreatic Cancer Organoids for Determining Sensitivity to Bromodomain and Extra-Terminal Inhibitors (BETi). Frontiers in oncology\| PubMed ID: 31231611	2019
Flavonoid-alkylphospholipid conjugates elicit dual inhibition of cancer cell growth and lipid accumulation. Chemical communications (Cambridge, England)\| PubMed ID: 31270526	2019
Dynamics of the intrinsically disordered protein NUPR1 in isolation and in its fuzzy complexes with DNA and prothymosin α. Biochimica et biophysica acta. Proteins and proteomics\| PubMed ID: 31325636	2019
Emerging epigenomic landscapes of pancreatic cancer in the era of precision medicine. Nature communications\| PubMed ID: 31462645	2019
Designing and repurposing drugs to target intrinsically disordered proteins for cancer treatment: using NUPR1 as a paradigm. Molecular & cellular oncology\| PubMed ID: 31528692	2019
PML hyposumoylation is responsible for the resistance of pancreatic cancer. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 31557059	2019