Xin Hu

National Center for Advancing Translational Sciences, National Institutes of Health

Affiliated withNational Institutes of Health German Center for Neurodegenerative Diseases (DZNE)

Research Area

Biography

Xinyan Huang is work at Dr. Antony Rodriguez lab as a postdoc from 2019.6 to 2021.5.

JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 5	2019
Publication title Cited by 8	2024

Other Publications

Article	Year
LSD1-mediated epigenetic modification is required for TAL1 function and hematopoiesis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19497860	2009
H4R3 methylation facilitates beta-globin transcription by regulating histone acetyltransferase binding and H3 acetylation. Blood\| PubMed ID: 20068219	2010
Novel patient cell-based HTS assay for identification of small molecules for a lysosomal storage disease. PloS one\| PubMed ID: 22216298	2011
Probing the Donor and Acceptor Substrate Specificity of the Î³-Glutamyl Transpeptidase. Biochemistry\| PubMed ID: 22257032	2012
Discovery of a novel noniminosugar acid α glucosidase chaperone series. Journal of medicinal chemistry\| PubMed ID: 22834902	2012
A high-throughput screening assay using Krabbe disease patient cells. Analytical biochemistry\| PubMed ID: 23138179	2013
Identification of small-molecule agonists of human relaxin family receptor 1 (RXFP1) by using a homogenous cell-based cAMP assay. Journal of biomolecular screening\| PubMed ID: 23212924	2013
Synthesis and biological evaluation of analogues of the kinase inhibitor nilotinib as Abl and Kit inhibitors. Bioorganic & medicinal chemistry letters\| PubMed ID: 23273517	2013
Inhibitors of the Yersinia protein tyrosine phosphatase through high throughput and virtual screening approaches. Bioorganic & medicinal chemistry letters\| PubMed ID: 23294700	2013
Identification and optimization of small-molecule agonists of the human relaxin hormone receptor RXFP1. Nature communications\| PubMed ID: 23764525	2013
Disrupting malaria parasite AMA1-RON2 interaction with a small molecule prevents erythrocyte invasion. Nature communications\| PubMed ID: 23907321	2013
Novel cell-based hepatitis C virus infection assay for quantitative high-throughput screening of anti-hepatitis C virus compounds. Antimicrobial agents and chemotherapy\| PubMed ID: 24277038	2014
Structure-activity relationship studies and biological characterization of human NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase inhibitors. Bioorganic & medicinal chemistry letters\| PubMed ID: 24360556	2014
Discovery, optimization, and characterization of novel D2 dopamine receptor selective antagonists. Journal of medicinal chemistry\| PubMed ID: 24666157	2014
A high throughput screening assay system for the identification of small molecule inhibitors of gsp. PloS one\| PubMed ID: 24667240	2014
Allosteric inhibitors of the Eya2 phosphatase are selective and inhibit Eya2-mediated cell migration. The Journal of biological chemistry\| PubMed ID: 24755226	2014
Discovery and characterization of a G protein-biased agonist that inhibits β-arrestin recruitment to the D2 dopamine receptor. Molecular pharmacology\| PubMed ID: 24755247	2014
Structural insight into exosite binding and discovery of novel exosite inhibitors of botulinum neurotoxin serotype A through in silico screening. Journal of computer-aided molecular design\| PubMed ID: 24958623	2014
Small Molecule, NSC95397, Inhibits the CtBP1-Protein Partner Interaction and CtBP1-Mediated Transcriptional Repression. Journal of biomolecular screening\| PubMed ID: 25477201	2015
Repurposing of the antihistamine chlorcyclizine and related compounds for treatment of hepatitis C virus infection. Science translational medicine\| PubMed ID: 25855495	2015
Discovery of NCT-501, a Potent and Selective Theophylline-Based Inhibitor of Aldehyde Dehydrogenase 1A1 (ALDH1A1). Journal of medicinal chemistry\| PubMed ID: 26207746	2015
High-Throughput Screening, Discovery, and Optimization To Develop a Benzofuran Class of Hepatitis C Virus Inhibitors. ACS combinatorial science\| PubMed ID: 26332742	2015
Activation of Relaxin Family Receptor 1 from Different Mammalian Species by Relaxin Peptide and Small-Molecule Agonist ML290. Frontiers in endocrinology\| PubMed ID: 26347712	2015
Identification of novel anti-hepatitis C virus agents by a quantitative high throughput screen in a cell-based infection assay. Antiviral research\| PubMed ID: 26515788	2015
Discovery, Optimization, and Characterization of Novel Chlorcyclizine Derivatives for the Treatment of Hepatitis C Virus Infection. Journal of medicinal chemistry\| PubMed ID: 26599718	2016
Structural Insights into the Activation of Human Relaxin Family Peptide Receptor 1 by Small-Molecule Agonists. Biochemistry\| PubMed ID: 26866459	2016
CERAPP: Collaborative Estrogen Receptor Activity Prediction Project. Environmental health perspectives\| PubMed ID: 26908244	2016
Targeting Estrogen Receptor Signaling with Fulvestrant Enhances Immune and Chemotherapy-Mediated Cytotoxicity of Human Lung Cancer. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 27267852	2016
Efficacy and Mechanism of Action of Low Dose Emetine against Human Cytomegalovirus. PLoS pathogens\| PubMed ID: 27336364	2016
Cell-based high-throughput screening identifies galactocerebrosidase enhancers as potential small-molecule therapies for Krabbe's disease. Journal of neuroscience research\| PubMed ID: 27638606	2016
High throughput cell-based assay for identification of glycolate oxidase inhibitors as a potential treatment for Primary Hyperoxaluria Type 1. Scientific reports\| PubMed ID: 27670739	2016
Synthetic non-peptide low molecular weight agonists of the relaxin receptor 1. British journal of pharmacology\| PubMed ID: 27771940	2017
Development of an Aryloxazole Class of Hepatitis C Virus Inhibitors Targeting the Entry Stage of the Viral Replication Cycle. Journal of medicinal chemistry\| PubMed ID: 28636348	2017
Mutation of Asn-475 in the Venezuelan Equine Encephalitis Virus nsP2 Cysteine Protease Leads to a Self-Inhibited State. Biochemistry\| PubMed ID: 29064679	2017
Discovery of a Positive Allosteric Modulator of the Thyrotropin Receptor: Potentiation of Thyrotropin-Mediated Preosteoblast Differentiation In Vitro. The Journal of pharmacology and experimental therapeutics\| PubMed ID: 29089368	2018
Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH). Journal of medicinal chemistry\| PubMed ID: 29120638	2017
Insights into the Action of Inhibitor Enantiomers against Histone Lysine Demethylase 5A. Journal of medicinal chemistry\| PubMed ID: 29537847	2018
In vivo CRISPR screening unveils histone demethylase UTX as an important epigenetic regulator in lung tumorigenesis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 29632194	2018
High-throughput screening identified selective inhibitors of exosome biogenesis and secretion: A drug repurposing strategy for advanced cancer. Scientific reports\| PubMed ID: 29802284	2018
Emetine inhibits Zika and Ebola virus infections through two molecular mechanisms: inhibiting viral replication and decreasing viral entry. Cell discovery\| PubMed ID: 29872540	2018
Optimization of the first small-molecule relaxin/insulin-like family peptide receptor (RXFP1) agonists: Activation results in an antifibrotic gene expression profile. European journal of medicinal chemistry\| PubMed ID: 30006176	2018
KDM5 histone demethylases repress immune response via suppression of STING. PLoS biology\| PubMed ID: 30080846	2018
Discovery and lead identification of quinazoline-based BRD4 inhibitors. Bioorganic & medicinal chemistry letters\| PubMed ID: 30268702	2018
Structure-Based Engineering of Irreversible Inhibitors against Histone Lysine Demethylase KDM5A. Journal of medicinal chemistry\| PubMed ID: 30392349	2018
Identification of Chemotype Agonists for Human Resolvin D1 Receptor DRV1 with Pro-Resolving Functions. Cell chemical biology\| PubMed ID: 30554914	2019
A large scale high-throughput screen identifies chemical inhibitors of phosphatidylinositol 4-kinase type II alpha. Journal of lipid research\| PubMed ID: 30626625	2019
Discovery of novel inhibitors of human galactokinase by virtual screening. Journal of computer-aided molecular design\| PubMed ID: 30806949	2019
Lead optimization and efficacy evaluation of quinazoline-based BET family inhibitors for potential treatment of cancer and inflammatory diseases. Bioorganic & medicinal chemistry letters\| PubMed ID: 30905542	2019
Therapeutic effects of a small molecule agonist of the relaxin receptor ML290 in liver fibrosis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 31419161	2019
Implementation of biohybrid olfactory bulb on a high-density CMOS-chip to reveal large-scale spatiotemporal circuit information. Biosensors & bioelectronics\| PubMed ID: 34852985	2022
High-resolution CMOS-based biosensor for assessing hippocampal circuit dynamics in experience-dependent plasticity. Biosensors & bioelectronics\| PubMed ID: 37379793	2023