Shelton Earp

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill

Affiliated withUniversity of North Carolina at Chapel Hill

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title	2019

Other Publications

Article	Year
Inactivation of the antiapoptotic phosphatidylinositol 3-kinase-Akt pathway by the combined treatment of taxol and mitogen-activated protein kinase kinase inhibition. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 12114408	2002
Human epidermal receptor-2 expression in prostate cancer. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 12631612	2003
The EGF receptor family--multiple roles in proliferation, differentiation, and neoplasia with an emphasis on HER4. Transactions of the American Clinical and Climatological Association\| PubMed ID: 12813928	2003
Dependence of peroxisome proliferator-activated receptor ligand-induced mitogen-activated protein kinase signaling on epidermal growth factor receptor transactivation. The Journal of biological chemistry\| PubMed ID: 12966092	2003
Transactivation of the EGF receptor: is the PDGF receptor an unexpected accomplice? Molecular interventions\| PubMed ID: 14993390	2002
Dendritic cells can be rapidly expanded ex vivo and safely administered in patients with metastatic breast cancer. Cancer immunology, immunotherapy : CII\| PubMed ID: 15185007	2004
The C-mer gene is induced by Epstein-Barr virus immediate-early protein BRLF1. Journal of virology\| PubMed ID: 15479819	2004
Role of Gas6 receptors in platelet signaling during thrombus stabilization and implications for antithrombotic therapy. The Journal of clinical investigation\| PubMed ID: 15650770	2005
Activated tyrosine kinase Ack1 promotes prostate tumorigenesis: role of Ack1 in polyubiquitination of tumor suppressor Wwox. Cancer research\| PubMed ID: 16288044	2005
The intracellular domain of ErbB4 induces differentiation of mammary epithelial cells. Molecular biology of the cell\| PubMed ID: 16837552	2006
Apoptotic cells induce Mer tyrosine kinase-dependent blockade of NF-kappaB activation in dendritic cells. Blood\| PubMed ID: 17008547	2007
Activated Cdc42-associated kinase Ack1 promotes prostate cancer progression via androgen receptor tyrosine phosphorylation. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17494760	2007
The HER4 cytoplasmic domain, but not its C terminus, inhibits mammary cell proliferation. Molecular endocrinology (Baltimore, Md.)\| PubMed ID: 17505063	2007
Capacitative calcium entry contributes to the differential transactivation of the epidermal growth factor receptor in response to thiazolidinediones. Molecular pharmacology\| PubMed ID: 17686966	2007
Research for North Carolina: The University Cancer Research Fund. North Carolina medical journal\| PubMed ID: 18828322	2008
The E3 ubiquitin ligase WWP1 selectively targets HER4 and its proteolytically derived signaling isoforms for degradation. Molecular and cellular biology\| PubMed ID: 19047365	2009
ErbB4 splice variants Cyt1 and Cyt2 differ by 16 amino acids and exert opposing effects on the mammary epithelium in vivo. Molecular and cellular biology\| PubMed ID: 19596786	2009
TAM receptors are dispensable in the phagocytosis and killing of bacteria. Cellular immunology\| PubMed ID: 19625016	2009
A novel role for c-Src and STAT3 in apoptotic cell-mediated MerTK-dependent immunoregulation of dendritic cells. Blood\| PubMed ID: 19667404	2009
Dasatinib inhibits site-specific tyrosine phosphorylation of androgen receptor by Ack1 and Src kinases. Oncogene\| PubMed ID: 20383201	2010
Increased hematopoietic cells in the mertk-/- mouse peritoneal cavity: a result of augmented migration. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 20483720	2010
Discovery of Novel Small Molecule Mer Kinase Inhibitors for the Treatment of Pediatric Acute Lymphoblastic Leukemia. ACS medicinal chemistry letters\| PubMed ID: 22662287	2012
MERTK receptor tyrosine kinase is a therapeutic target in melanoma. The Journal of clinical investigation\| PubMed ID: 23585477	2013
UNC1062, a new and potent Mer inhibitor. European journal of medicinal chemistry\| PubMed ID: 23693152	2013
Molecular Pathways: MERTK Signaling in Cancer. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 23833304	2013
UNC569, a novel small molecule Mer inhibitor with efficacy against acute lymphoblastic leukemia in vitro and in vivo. Molecular cancer therapeutics\| PubMed ID: 23997116	2013
Pseudo-cyclization through intramolecular hydrogen bond enables discovery of pyridine substituted pyrimidines as new Mer kinase inhibitors. Journal of medicinal chemistry\| PubMed ID: 24195762	2013
Discovery of Mer specific tyrosine kinase inhibitors for the treatment and prevention of thrombosis. Journal of medicinal chemistry\| PubMed ID: 24219778	2013
UNC2025, a potent and orally bioavailable MER/FLT3 dual inhibitor. Journal of medicinal chemistry\| PubMed ID: 25068800	2014
Mer590, a novel monoclonal antibody targeting MER receptor tyrosine kinase, decreases colony formation and increases chemosensitivity in non-small cell lung cancer. Oncotarget\| PubMed ID: 25372020	2014
Mutation of androgen receptor N-terminal phosphorylation site Tyr-267 leads to inhibition of nuclear translocation and DNA binding. PloS one\| PubMed ID: 25950519	2015
Combined Targeted DNA Sequencing in Non-Small Cell Lung Cancer (NSCLC) Using UNCseq and NGScopy, and RNA Sequencing Using UNCqeR for the Detection of Genetic Aberrations in NSCLC. PloS one\| PubMed ID: 26076459	2015
Small Molecule Inhibition of MERTK Is Efficacious in Non-Small Cell Lung Cancer Models Independent of Driver Oncogene Status. Molecular cancer therapeutics\| PubMed ID: 26162689	2015
Germline Analysis from Tumor-Germline Sequencing Dyads to Identify Clinically Actionable Secondary Findings. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 27083775	2016
The MERTK/FLT3 inhibitor MRX-2843 overcomes resistance-conferring FLT3 mutations in acute myeloid leukemia. JCI insight\| PubMed ID: 27158668	2016
MERTK Inhibition Induces Polyploidy and Promotes Cell Death and Cellular Senescence in Glioblastoma Multiforme. PloS one\| PubMed ID: 27783662	2016
Design and Synthesis of Novel Macrocyclic Mer Tyrosine Kinase Inhibitors. ACS medicinal chemistry letters\| PubMed ID: 27994735	2016
Discovery of Macrocyclic Pyrimidines as MerTK-Specific Inhibitors. ChemMedChem\| PubMed ID: 28032464	2017
Racial Differences in PAM50 Subtypes in the Carolina Breast Cancer Study. Journal of the National Cancer Institute\| PubMed ID: 28859290	2018
The small-molecule MERTK inhibitor UNC2025 decreases platelet activation and prevents thrombosis. Journal of thrombosis and haemostasis : JTH\| PubMed ID: 29045015	2018
Enhancing Next-Generation Sequencing-Guided Cancer Care Through Cognitive Computing. The oncologist\| PubMed ID: 29158372	2018
Tumor-secreted Pros1 inhibits macrophage M1 polarization to reduce antitumor immune response. The Journal of clinical investigation\| PubMed ID: 29708510	2018
Factor XIIIA-expressing inflammatory monocytes promote lung squamous cancer through fibrin cross-linking. Nature communications\| PubMed ID: 29777108	2018
Identification of Clonal Hematopoiesis Mutations in Solid Tumor Patients Undergoing Unpaired Next-Generation Sequencing Assays. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 29866652	2018
MERTK Mediates Intrinsic and Adaptive Resistance to AXL-targeting Agents. Molecular cancer therapeutics\| PubMed ID: 30093568	2018
MERTK Promotes Resistance to Irreversible EGFR Tyrosine Kinase Inhibitors in Non-small Cell Lung Cancers Expressing Wild-type Family Members. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 30194074	2018
ZFX Mediates Non-canonical Oncogenic Functions of the Androgen Receptor Splice Variant 7 in Castrate-Resistant Prostate Cancer. Molecular cell\| PubMed ID: 30270106	2018
Inhibition of MERTK Promotes Suppression of Tumor Growth in BRAF Mutant and BRAF Wild-Type Melanoma. Molecular cancer therapeutics\| PubMed ID: 30482852	2019
The Prognostic Significance of Low-Frequency Somatic Mutations in Metastatic Cutaneous Melanoma. Frontiers in oncology\| PubMed ID: 30662871	2018
SGC-GAK-1: A Chemical Probe for Cyclin G Associated Kinase (GAK). Journal of medicinal chemistry\| PubMed ID: 30768268	2019
MERTK mediated novel site Akt phosphorylation alleviates SAV1 suppression. Nature communications\| PubMed ID: 30944303	2019
Beyond growth signaling: apoptotic sensor MERTK activates AKT by a novel mechanism. Molecular & cellular oncology\| PubMed ID: 31211243	2019
Kinome profiling of non-Hodgkin lymphoma identifies Tyro3 as a therapeutic target in primary effusion lymphoma. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 31346082	2019
TAM Family Receptor Kinase Inhibition Reverses MDSC-Mediated Suppression and Augments Anti-PD-1 Therapy in Melanoma. Cancer immunology research\| PubMed ID: 31451482	2019
Data-Driven Construction of Antitumor Agents with Controlled Polypharmacology. Journal of the American Chemical Society\| PubMed ID: 31497954	2019
Bimodal age distribution at diagnosis in breast cancer persists across molecular and genomic classifications. Breast cancer research and treatment\| PubMed ID: 31535320	2019