George Coukos

Department of Oncology UNIL CHUV, University of Lausanne

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 4	2019

Other Publications

Article	Year
TIE-2 and VEGFR kinase activities drive immunosuppressive function of TIE-2-expressing monocytes in human breast tumors. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 23649001	2013
A dendritic cell vaccine pulsed with autologous hypochlorous acid-oxidized ovarian cancer lysate primes effective broad antitumor immunity: from bench to bedside. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 23838316	2013
Shikonin-loaded antibody-armed nanoparticles for targeted therapy of ovarian cancer. International journal of nanomedicine\| PubMed ID: 24790428	2014
Overexpression of SMARCE1 is associated with CD8+ T-cell infiltration in early stage ovarian cancer. The international journal of biochemistry & cell biology\| PubMed ID: 24880093	2014
Development, optimization, and validation of novel anti-TEM1/CD248 affinity agent for optical imaging in cancer. Oncotarget\| PubMed ID: 25051365	2014
T cells bearing a chimeric antigen receptor against prostate-specific membrane antigen mediate vascular disruption and result in tumor regression. Cancer immunology research\| PubMed ID: 25358763	2015
Phage antibody display libraries: a powerful antibody discovery platform for immunotherapy. Critical reviews in biotechnology\| PubMed ID: 25394539	2016
Targeting the tumor vasculature to enhance T cell activity. Current opinion in immunology\| PubMed ID: 25665467	2015
The Ovarian Cancer Chemokine Landscape Is Conducive to Homing of Vaccine-Primed and CD3/CD28-Costimulated T Cells Prepared for Adoptive Therapy. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 25712684	2015
Tumor-infiltrating lymphocytes in triple-negative breast cancer: a biomarker for use beyond prognosis? Journal of clinical oncology : official journal of the American Society of Clinical Oncology\| PubMed ID: 25753438	2015
Angiogenic activity of breast cancer patients' monocytes reverted by combined use of systems modeling and experimental approaches. PLoS computational biology\| PubMed ID: 25768678	2015
Multifunctional mitoxantrone-conjugated magnetic nanosystem for targeted therapy of folate receptor-overexpressing malignant cells. Journal of nanobiotechnology\| PubMed ID: 25880772	2015
Personalized approaches to active immunotherapy in cancer. Biochimica et biophysica acta\| PubMed ID: 26241169	2016
Whole Tumor Antigen Vaccines: Where Are We? Vaccines\| PubMed ID: 26343191	2015
Erratum to: Multifunctional mitoxantrone-conjugated magnetic nanosystem for targeted therapy of folate receptor-overexpressing malignant cells. Journal of nanobiotechnology\| PubMed ID: 26407625	2015
Overexpression of GPC6 and TMEM132D in Early Stage Ovarian Cancer Correlates with CD8+ T-Lymphocyte Infiltration and Increased Patient Survival. BioMed research international\| PubMed ID: 26448945	2015
Comprehensive Genomic Characterization of Long Non-coding RNAs across Human Cancers. Cancer cell\| PubMed ID: 26461095	2015
Targeting Programmed Cell Death 1 in Ovarian Cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology\| PubMed ID: 26503205	2015
TCR-engineered T cells to treat tumors: Seeing but not touching? Seminars in immunology\| PubMed ID: 26997556	2016
TIE-2-expressing monocytes are lymphangiogenic and associate specifically with lymphatics of human breast cancer. Oncoimmunology\| PubMed ID: 27057438	2016
The Human Vaccines Project: A roadmap for cancer vaccine development. Science translational medicine\| PubMed ID: 27075624	2016
Mass spectrometry-based antigen discovery for cancer immunotherapy. Current opinion in immunology\| PubMed ID: 27155075	2016
Ovarian cancer chemokines may not be a significant barrier during whole tumor antigen dendritic-cell vaccine and adoptive T-cell immunotherapy. Oncoimmunology\| PubMed ID: 27467909	2016
1,2,3-Triazoles as inhibitors of indoleamine 2,3-dioxygenase 2 (IDO2). Bioorganic & medicinal chemistry letters\| PubMed ID: 27469130	2016
Neoantigen-based cancer immunotherapy. Annals of translational medicine\| PubMed ID: 27563649	2016
Radiotherapy combination opportunities leveraging immunity for the next oncology practice. CA: a cancer journal for clinicians\| PubMed ID: 27570942	2017
Combine and Conquer: Double CTLA-4 and PD-1 Blockade Combined with Whole Tumor Antigen Vaccine Cooperate to Eradicate Tumors. Cancer research\| PubMed ID: 27909064	2016
Human melanomas and ovarian cancers overexpressing mechanical barrier molecule genes lack immune signatures and have increased patient mortality risk. Oncoimmunology\| PubMed ID: 28123876	2016
Engineering Chimeric Antigen Receptor T-Cells for Racing in Solid Tumors: Don't Forget the Fuel. Frontiers in immunology\| PubMed ID: 28421069	2017
TIE-2 expressing monocytes in human cancers. Oncoimmunology\| PubMed ID: 28507810	2017
and cell-based analyses reveal strong divergence between prediction and observation of T-cell-recognized tumor antigen T-cell epitopes. The Journal of biological chemistry\| PubMed ID: 28536262	2017
The T-Cell Receptor Can Bind to the Peptide-Bound Major Histocompatibility Complex and Uncomplexed β-Microglobulin through Distinct Binding Sites. Biochemistry\| PubMed ID: 28671821	2017
Identifying biological mechanisms for favorable cancer prognosis using non-hypothesis-driven iterative survival analysis. NPJ systems biology and applications\| PubMed ID: 28725481	2016
Deciphering HLA-I motifs across HLA peptidomes improves neo-antigen predictions and identifies allostery regulating HLA specificity. PLoS computational biology\| PubMed ID: 28832583	2017
Tumour-derived PGD2 and NKp30-B7H6 engagement drives an immunosuppressive ILC2-MDSC axis. Nature communications\| PubMed ID: 28928446	2017
Local endothelial complement activation reverses endothelial quiescence, enabling t-cell homing, and tumor control during t-cell immunotherapy. Oncoimmunology\| PubMed ID: 28932632	2017
'Hotspots' of Antigen Presentation Revealed by Human Leukocyte Antigen Ligandomics for Neoantigen Prioritization. Frontiers in immunology\| PubMed ID: 29104575	2017
High-throughput and Sensitive Immunopeptidomics Platform Reveals Profound Interferonγ-Mediated Remodeling of the Human Leukocyte Antigen (HLA) Ligandome. Molecular & cellular proteomics : MCP\| PubMed ID: 29242379	2018
Tumour endothelial marker 1/endosialin-mediated targeting of human sarcoma. European journal of cancer (Oxford, England : 1990)\| PubMed ID: 29304474	2018
Correction to: Characterization of the first fully human anti-TEM1 scFv in models of solid tumor imaging and immunotoxin-based therapy. Cancer immunology, immunotherapy : CII\| PubMed ID: 29313073	2018
Sensitive and frequent identification of high avidity neo-epitope specific CD8 T cells in immunotherapy-naive ovarian cancer. Nature communications\| PubMed ID: 29545564	2018
T cell-induced CSF1 promotes melanoma resistance to PD1 blockade. Science translational medicine\| PubMed ID: 29643229	2018
Personalized cancer vaccine effectively mobilizes antitumor T cell immunity in ovarian cancer. Science translational medicine\| PubMed ID: 29643231	2018
The C-terminal extension landscape of naturally presented HLA-I ligands. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 29712860	2018
Consensus guidelines for the use and interpretation of angiogenesis assays. Angiogenesis\| PubMed ID: 29766399	2018
Label-Free Optofluidic Nanobiosensor Enables Real-Time Analysis of Single-Cell Cytokine Secretion. Small (Weinheim an der Bergstrasse, Germany)\| PubMed ID: 29806234	2018
CART cells are prone to Fas- and DR5-mediated cell death. Journal for immunotherapy of cancer\| PubMed ID: 30005714	2018
Estimating the Contribution of Proteasomal Spliced Peptides to the HLA-I Ligandome. Molecular & cellular proteomics : MCP\| PubMed ID: 30171158	2018
Correction to: CART cells are prone to Fas- and DR5-mediated cell death. Journal for immunotherapy of cancer\| PubMed ID: 30253808	2018
Two-Dimensional Label-Free Affinity Analysis of Tumor-Specific CD8 T Cells with a Biomimetic Plasmonic Sensor. ACS sensors\| PubMed ID: 30339020	2018
The Length Distribution and Multiple Specificity of Naturally Presented HLA-I Ligands. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 30429286	2018
Addressing current challenges and future directions in immuno-oncology: expert perspectives from the 2017 NIBIT Foundation Think Tank, Siena, Italy. Cancer immunology, immunotherapy : CII\| PubMed ID: 30564889	2019
A severe case of refractory esophageal stenosis induced by nivolumab and responding to tocilizumab therapy. Journal for immunotherapy of cancer\| PubMed ID: 30587227	2018
Safety and Tolerability of Adoptive Cell Therapy in Cancer. Drug safety\| PubMed ID: 30649750	2019
Tumour-reactive T cell subsets in the microenvironment of ovarian cancer. British journal of cancer\| PubMed ID: 30718808	2019
Tumor Landscapes: β-Catenin Drives Immune Desertification. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 30837277	2019
The NAD-Booster Nicotinamide Riboside Potently Stimulates Hematopoiesis through Increased Mitochondrial Clearance. Cell stem cell\| PubMed ID: 30849366	2019
Computational KIR copy number discovery reveals interaction between inhibitory receptor burden and survival. Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing\| PubMed ID: 30864318	2019
Correction: Tumour-reactive T cell subsets in the microenvironment of ovarian cancer. British journal of cancer\| PubMed ID: 30890776	2019
Going Beyond the Sequences: TCR Binding Patterns at the Service of Cancer Detection. Cancer research\| PubMed ID: 30936076	2019
High-throughput Screening of Human Tumor Antigen-specific CD4 T Cells, Including Neoantigen-reactive T Cells. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 31015344	2019
Cooperation between Constitutive and Inducible Chemokines Enables T Cell Engraftment and Immune Attack in Solid Tumors. Cancer cell\| PubMed ID: 31185212	2019
Mass spectrometry driven exploration reveals nuances of neoepitope-driven tumor rejection. JCI insight\| PubMed ID: 31219806	2019
Targeting Adenosine in Cancer Immunotherapy to Enhance T-Cell Function. Frontiers in immunology\| PubMed ID: 31244820	2019
Rational combinations of immunotherapy with radiotherapy in ovarian cancer. The Lancet. Oncology\| PubMed ID: 31364594	2019
A Phase Ib Study of the Combination of Personalized Autologous Dendritic Cell Vaccine, Aspirin, and Standard of Care Adjuvant Chemotherapy Followed by Nivolumab for Resected Pancreatic Adeno... Frontiers in immunology\| PubMed ID: 31440238	2019
Integrating SpyCatcher/SpyTag covalent fusion technology into phage display workflows for rapid antibody discovery. Scientific reports\| PubMed ID: 31492910	2019
Adenosine mediates functional and metabolic suppression of peripheral and tumor-infiltrating CD8 T cells. Journal for immunotherapy of cancer\| PubMed ID: 31601268	2019
Robust prediction of HLA class II epitopes by deep motif deconvolution of immunopeptidomes. Nature biotechnology\| PubMed ID: 31611696	2019
CD8 Binding of MHC-Peptide Complexes in cis or trans Regulates CD8 T-cell Responses. Journal of molecular biology\| PubMed ID: 31704286	2019
Immunopeptidomics of colorectal cancer organoids reveals a sparse HLA class I neoantigen landscape and no increase in neoantigens with interferon or MEK-inhibitor treatment. Journal for immunotherapy of cancer\| PubMed ID: 31735170	2019
A Phase I/II trial comparing autologous dendritic cell vaccine pulsed either with personalized peptides (PEP-DC) or with tumor lysate (OC-DC) in patients with advanced high-grade ovarian ser... Journal of translational medicine\| PubMed ID: 31771601	2019
Neutrophils suppress tumor-infiltrating T cells in colon cancer via matrix metalloproteinase-mediated activation of TGFβ. EMBO molecular medicine\| PubMed ID: 31793740	2019
Analysis of Secondary Structure Biases in Naturally Presented HLA-I Ligands. Frontiers in immunology\| PubMed ID: 31824508	2019
Mass spectrometry based immunopeptidomics leads to robust predictions of phosphorylated HLA class I ligands. Molecular & cellular proteomics : MCP\| PubMed ID: 31848261	2019