Igor R. Efimov

Igor R. Efimov

Department of Biomedical Engineering, Washington University in St. Louis

Affiliated withWashington University in St. LouisThe George Washington UniversityWashington University in St. Louis

Research Area

Biography

Professor Efimov is the Director of Cardiovascular Engineering Laboratory, an NIH-funded cardiovascular research and engineering laboratory, which focusses on the physiological mechanisms of cardiovascular disease and on development of novel therapies for heart diseases with emphasis on heart rhythm disorders. Professor Efimov served as an inaugural chairman of Biomedical Engineering Department at the George Washington University from January 2015 to December 2019. In 2008, Dr. Efimov founded Cardialen to develop low energy implantable electrotherapy of atrial and ventricular arrhythmias. Cardialen has raised $28M in venture funding and is conducting clinical trials.

Dr. Efimov earned his M.Sc. and PhD from Moscow Institute of Physics and Technology in 1986 and 1992, respectively, and completed his postdoctoral training at the University of Pittsburgh (1992-1994). He served on the faculty of the Cleveland Clinic Foundation (1994-2000) and Case Western Reserve University (2000-2004) in Cleveland, OH, and Washington University in St. Louis, MO (2004-2015), prior to joining the George Washington University in 2015 as the founding chairman of its new BME Department.

Dr. Efimov is Fellow of the National Academy of Inventors, the American Institute for Medical & Biological Engineering, the Heart Rhythm Society, the American Heart Association, etc. He has received numerous awards including: RASA George Gamow Prize, Astor Visiting Fellowship at University of Oxford, Washington University Chancellor’s Hartwell Prize for Innovative Research, The Doris J.W. Escher Lectureship at Montefiore Medical Center of the Albert Einstein College of Medicine, Walter Lillehei Lectureship at University of Minnesota, Richard B. and Lynne V. Cheney Lectureship at the George Washington University, etc. Dr. Efimov held visiting or adjunct professorships at the University of Bordeaux, France; University of Nizhny Novgorod, Russia; and his alma mater Moscow Institute of Physics and Technology, Russia.

He has served as Associate Editor of the American Journal of Physiology: Heart and Circulatory Physiology and IEEE Transactions in Biomedical Engineering. He has served on editorial boards of Scientific Reports, Circulation Research, Heart Rhythm Journal, Journal of Cardiovascular Electrophysiology, Journal of Molecular and Cellular Cardiology, and other premier cardiovascular and biomedical engineering professional journals. He has served as a chartered member of National Institutes of Health Electrical Signaling, Transporters and Arrhythmia (ESTA) Study Section and NHLBI Systems Biology Collaborations review group. He served on numerous expert panels of the World Bank, Canadian Academies, British Heart Foundation, Russian Ministry of Science and Education, the Royal Society of New Zeeland, Swiss National Science Foundation, National Sciences and Engineering Research Council of Canada, and other international funds and organizations.

JoVE Journal Publications

ArticleTotal : 3
Year
Multiparametric Optical Mapping of the Langendorff-perfused Rabbit Heart
Publication title

Cited by 30

2011
2011
2020

Other Publications

Article
Year
Mechanisms of make and break excitation revisited: paradoxical break excitation during diastolic stimulation.

American journal of physiology. Heart and circulatory physiology| PubMed ID: 11788404

2002
The pinwheel experiment re-revisited.

Journal of theoretical biology| PubMed ID: 11812169

2002
Imaging of the atrioventricular node using optical coherence tomography.

Journal of cardiovascular electrophysiology| PubMed ID: 11843494

2002
2007
Phase I and phase II of short-term mechanical restitution in perfused rat left ventricles.

American journal of physiology. Heart and circulatory physiology| PubMed ID: 11893566

2002
Mechanical alternans and restitution in failing SHHF rat left ventricles.

American journal of physiology. Heart and circulatory physiology| PubMed ID: 11893567

2002
Mechanisms of shock-induced arrhythmogenesis during acute global ischemia.

American journal of physiology. Heart and circulatory physiology| PubMed ID: 12003822

2002
Virtual electrodes in virtual reality of defibrillation.

Journal of cardiovascular electrophysiology| PubMed ID: 12139291

2002
2002
2003
2003
Nonlinear effects in subthreshold virtual electrode polarization.

American journal of physiology. Heart and circulatory physiology| PubMed ID: 12742834

2003
2003
Shock-induced arrhythmogenesis is enhanced by 2,3-butanedione monoxime compared with cytochalasin D.

American journal of physiology. Heart and circulatory physiology| PubMed ID: 12958029

2004
2003
Diastolic shocking experience: do virtual electrodes exist only during systole?

Journal of cardiovascular electrophysiology| PubMed ID: 14678139

2003
Virtual electrode theory explains pacing threshold increase caused by cardiac tissue damage.

American journal of physiology. Heart and circulatory physiology| PubMed ID: 14726298

2004
Effects of lidocaine on shock-induced vulnerability.

Journal of cardiovascular electrophysiology| PubMed ID: 14760929

2003
Optical imaging of the heart.

Circulation research| PubMed ID: 15242982

2004
Structure-function relationship in the AV junction.

The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology| PubMed ID: 15368340

2004
Dynamics of virtual electrode-induced scroll-wave reentry in a 3D bidomain model.

American journal of physiology. Heart and circulatory physiology| PubMed ID: 15371264

2004
Functional imaging of the embryonic pacemaking and cardiac conduction system over the past 150 years: technologies to overcome the challenges.

The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology| PubMed ID: 15372434

2004
2005
2005
Optical coherence tomography imaging of the purkinje network.

Journal of cardiovascular electrophysiology| PubMed ID: 15877631

2005
Mechanisms of enhanced shock-induced arrhythmogenesis in the rabbit heart with healed myocardial infarction.

American journal of physiology. Heart and circulatory physiology| PubMed ID: 15879480

2005
2005
Chessboard of atrial fibrillation: reentry or focus? Single or multiple source(s)? Neurogenic or myogenic?

American journal of physiology. Heart and circulatory physiology| PubMed ID: 16100254

2005
Electroporation of the heart.

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology| PubMed ID: 16102512

2005
2005
Optical mapping of the atrioventricular junction.

Journal of electrocardiology| PubMed ID: 16226086

2005
2005
Three-dimensional anatomy of the conduction system of the early embryonic rabbit heart.

The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology| PubMed ID: 16287158

2006
2006
Precordial thump and commotio cordis: the yin and yang of mechanoelectric feedback in the heart.

Heart rhythm : the official journal of the Heart Rhythm Society| PubMed ID: 16443534

2006
Mechanisms of unpinning and termination of ventricular tachycardia.

American journal of physiology. Heart and circulatory physiology| PubMed ID: 16501014

2006
Postganglionic nerve stimulation induces temporal inhibition of excitability in rabbit sinoatrial node.

American journal of physiology. Heart and circulatory physiology| PubMed ID: 16565321

2006
2006
2006
2006
Connections, connections, connexins: towards systems biology paradigm of cardiac arrhythmia.

Journal of molecular and cellular cardiology| PubMed ID: 17030039

2006
Direct measurements of membrane time constant during defibrillation strength shocks.

Heart rhythm : the official journal of the Heart Rhythm Society| PubMed ID: 17399638

2007
2007
Application of blebbistatin as an excitation-contraction uncoupler for electrophysiologic study of rat and rabbit hearts.

Heart rhythm : the official journal of the Heart Rhythm Society| PubMed ID: 17467631

2007
Atrioventricular conduction with and without AV nodal delay: two pathways to the bundle of His in the rabbit heart.

American journal of physiology. Heart and circulatory physiology| PubMed ID: 17496219

2007
Innovation in optical imaging: looking inside the heart.

Heart rhythm : the official journal of the Heart Rhythm Society| PubMed ID: 17599679

2007
Cloning, sequence analysis and phylogeny of connexin43 isolated from American black bear heart.

DNA sequence : the journal of DNA sequencing and mapping| PubMed ID: 17654014

2007
2007
2007
Autonomic control and innervation of the atrioventricular junctional pacemaker.

Heart rhythm : the official journal of the Heart Rhythm Society| PubMed ID: 17905339

2007
Finite element modeling of electric field effects of TASER devices on nerve and muscle.

Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference| PubMed ID: 17946454

2006
2007
2008
2008
2008
2008
Effect of electroporation on cardiac electrophysiology.

Methods in molecular biology (Clifton, N.J.)| PubMed ID: 18370220

2008
2008
2008
2008
Quantitative panoramic imaging of epicardial electrical activity.

Annals of biomedical engineering| PubMed ID: 18654852

2008
2009
2008
2009
2008
Chronaxie of defibrillation: a pathway toward further optimization of defibrillation waveform?

Journal of cardiovascular electrophysiology| PubMed ID: 19175836

2009
2009
2009
2009
Multiple monophasic shocks improve electrotherapy of ventricular tachycardia in a rabbit model of chronic infarction.

Heart rhythm : the official journal of the Heart Rhythm Society| PubMed ID: 19560090

2009
2009
Differential K(ATP) channel pharmacology in intact mouse heart.

Journal of molecular and cellular cardiology| PubMed ID: 19744493

2010
Cardioversion: past, present, and future.

Circulation| PubMed ID: 19841308

2009
Virtual histology of the human heart using optical coherence tomography.

Journal of biomedical optics| PubMed ID: 19895104

2009
Enhanced susceptibility to alternans in a rabbit model of chronic myocardial infarction.

Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference| PubMed ID: 19964643

2009
2010
2010
2010
Anatomy and electrophysiology of the human AV node.

Pacing and clinical electrophysiology : PACE| PubMed ID: 20180918

2010
2010
2010
2010
Optical mapping of the isolated coronary-perfused human sinus node.

Journal of the American College of Cardiology| PubMed ID: 20946995

2010
Termination of sustained atrial flutter and fibrillation using low-voltage multiple-shock therapy.

Heart rhythm : the official journal of the Heart Rhythm Society| PubMed ID: 20969974

2011
Structured light imaging of epicardial mechanics.

Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference| PubMed ID: 21095816

2010
Multiscale imaging of the human heart: Building the foundation for human systems physiology and translational medicine.

Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference| PubMed ID: 21095821

2010
2011
2011
2011
Role of Pyk2 in cardiac arrhythmogenesis.

American journal of physiology. Heart and circulatory physiology| PubMed ID: 21666110

2011
2012
Spatiotemporal control of heart rate in a rabbit heart.

Journal of electrocardiology| PubMed ID: 21937057

2011
2011
2012
Longitudinal Study of Cardiac Remodelling in Rabbits Following Infarction.

The Canadian journal of cardiology| PubMed ID: 22265993

2012
Three Potential Mechanisms for Failure of HIFU Ablation in Cardiac Tissue.

Circulation. Arrhythmia and electrophysiology| PubMed ID: 22322367

2012
2015
Dual Vm/Ca imaging of premature ventricular contractions: bridging the gap of anatomical scales.

Circulation. Arrhythmia and electrophysiology| PubMed ID: 26082526

2015
2015
2015
A technical review of optical mapping of intracellular calcium within myocardial tissue.

American journal of physiology. Heart and circulatory physiology| PubMed ID: 27016580

2016
Mitochondrial structure and function are not different between nonfailing donor and end-stage failing human hearts.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology| PubMed ID: 27075244

2016
Technical advances in studying cardiac electrophysiology - Role of rabbit models.

Progress in biophysics and molecular biology| PubMed ID: 27210306

2016
Optical Mapping of Cardiac Electromechanics.

Biophysical journal| PubMed ID: 27463128

2016
2016
2017
2017
2017
2017
2017
Ventricular Fibrillation: Rotors or Foci? Both!

Circulation. Arrhythmia and electrophysiology| PubMed ID: 29247034

2017
2017
2018
Left Septal Slow Pathway Ablation for Atrioventricular Nodal Reentrant Tachycardia.

Circulation. Arrhythmia and electrophysiology| PubMed ID: 29540373

2018
Cardiac connexin genotyping for identification of the circuit of atrioventricular nodal re-entrant tachycardia.

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology| PubMed ID: 29860485

2019
Multiparametric slice culture platform for the investigation of human cardiac tissue physiology.

Progress in biophysics and molecular biology| PubMed ID: 29960680

2019
2018
Open-Source Multiparametric Optocardiography.

Scientific reports| PubMed ID: 30679527

2019
2019
2019
2019
Optocardiography: A Review of its Past, Present and Future.

Current opinion in biomedical engineering| PubMed ID: 31803858

2019
2019
2020