Ferry Ossendorp

Department of Immunohematology and Blood Transfusion, Leiden University Medical Center

Affiliated withLeiden University Medical Center Leiden University Medical Center

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 5	2019

Other Publications

Article	Year
Combined Inhibition of TGF-β Signaling and the PD-L1 Immune Checkpoint Is Differentially Effective in Tumor Models. Cells\| PubMed ID: 30959852	2019
Specific T helper cell requirement for optimal induction of cytotoxic T lymphocytes against major histocompatibility complex class II negative tumors. The Journal of experimental medicine\| PubMed ID: 9480979	1998
CD4 T cells and their role in antitumor immune responses. The Journal of experimental medicine\| PubMed ID: 10049938	1999
Immature dendritic cells acquire CD8(+) cytotoxic T lymphocyte priming capacity upon activation by T helper cell-independent or -dependent stimuli. The Journal of experimental medicine\| PubMed ID: 10880536	2000
Differential influence on cytotoxic T lymphocyte epitope presentation by controlled expression of either proteasome immunosubunits or PA28. The Journal of experimental medicine\| PubMed ID: 10952718	2000
Efficient identification of novel HLA-A(*)0201-presented cytotoxic T lymphocyte epitopes in the widely expressed tumor antigen PRAME by proteasome-mediated digestion analysis. The Journal of experimental medicine\| PubMed ID: 11136822	2001
Expression of the serpin serine protease inhibitor 6 protects dendritic cells from cytotoxic T lymphocyte-induced apoptosis: differential modulation by T helper type 1 and type 2 cells. The Journal of experimental medicine\| PubMed ID: 11535633	2001
Reorganization of multivesicular bodies regulates MHC class II antigen presentation by dendritic cells. The Journal of cell biology\| PubMed ID: 11581285	2001
Antigen-antibody immune complexes empower dendritic cells to efficiently prime specific CD8+ CTL responses in vivo. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 11859111	2002
Identification of a novel HLA-B60-restricted T cell epitope of the minor histocompatibility antigen HA-1 locus. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 12218130	2002
Antitumor efficacy of wild-type p53-specific CD4(+) T-helper cells. Cancer research\| PubMed ID: 12414646	2002
Effective therapeutic anticancer vaccines based on precision guiding of cytolytic T lymphocytes. Immunological reviews\| PubMed ID: 12445291	2002
The minor histocompatibility antigen HA-3 arises from differential proteasome-mediated cleavage of the lymphoid blast crisis (Lbc) oncoprotein. Blood\| PubMed ID: 12663445	2003
Prolongation of skin graft survival by modulation of the alloimmune response with alternatively activated dendritic cells. Transplantation\| PubMed ID: 14702533	2003
New chelation strategy allows for quick and clean 99mTc-labeling of synthetic peptides. Nuclear medicine and biology\| PubMed ID: 15246374	2004
Gamma irradiation or CD4+-T-cell depletion causes reactivation of latent Salmonella enterica serovar Typhimurium infection in C3H/HeN mice. Infection and immunity\| PubMed ID: 15845491	2005
Differential expression regulation of the alpha and beta subunits of the PA28 proteasome activator in mature dendritic cells. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 15944286	2005
Autoreactive CD8 T cells associated with beta cell destruction in type 1 diabetes. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16339897	2005
Murine Fc receptors for IgG are redundant in facilitating presentation of immune complex derived antigen to CD8+ T cells in vivo. Molecular immunology\| PubMed ID: 16513171	2006
Selective cytotoxic T-lymphocyte targeting of tumor immune escape variants. Nature medicine\| PubMed ID: 16550190	2006
Immune complex-loaded dendritic cells are superior to soluble immune complexes as antitumor vaccine. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 16585547	2006
Dendritic cells, but not macrophages or B cells, activate major histocompatibility complex class II-restricted CD4+ T cells upon immune-complex uptake in vivo. Immunology\| PubMed ID: 16995881	2006
A novel role of complement factor C1q in augmenting the presentation of antigen captured in immune complexes to CD8+ T lymphocytes. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 17548593	2007
Steric hindrance and fast dissociation explain the lack of immunogenicity of the minor histocompatibility HA-1Arg Null allele. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 19342659	2009
Antigen storage compartments in mature dendritic cells facilitate prolonged cytotoxic T lymphocyte cross-priming capacity. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19346487	2009
DC-induced CD8(+) T-cell response is inhibited by MHC class II-dependent DX5(+)CD4(+) Treg. European journal of immunology\| PubMed ID: 19544486	2009
Effective CD8(+) T cell priming and tumor protection by enterotoxin B subunit-conjugated peptides targeted to dendritic cells. Vaccine\| PubMed ID: 19576942	2009
Activity-based profiling reveals reactivity of the murine thymoproteasome-specific subunit beta5t. Chemistry & biology\| PubMed ID: 20797608	2010
Antigen processing by nardilysin and thimet oligopeptidase generates cytotoxic T cell epitopes. Nature immunology\| PubMed ID: 21151101	2011
Improved innate and adaptive immunostimulation by genetically modified HIV-1 protein expressing NYVAC vectors. PloS one\| PubMed ID: 21347234	2011
Discovery of low-affinity preproinsulin epitopes and detection of autoreactive CD8 T-cells using combinatorial MHC multimers. Journal of autoimmunity\| PubMed ID: 21636247	2011
The inhibiting Fc receptor for IgG, FcγRIIB, is a modifier of autoimmune susceptibility. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 21724994	2011
Circulating specific antibodies enhance systemic cross-priming by delivery of complexed antigen to dendritic cells in vivo. European journal of immunology\| PubMed ID: 22488363	2012
Fcγ receptor IIb strongly regulates Fcγ receptor-facilitated T cell activation by dendritic cells. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 22649202	2012
Vaccine-induced effector-memory CD8+ T cell responses predict therapeutic efficacy against tumors. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 22914049	2012
Efficient ex vivo induction of T cells with potent anti-tumor activity by protein antigen encapsulated in nanoparticles. Cancer immunology, immunotherapy : CII\| PubMed ID: 23613147	2013
Prospects of combinatorial synthetic peptide vaccine-based immunotherapy against cancer. Seminars in immunology\| PubMed ID: 23706598	2013
Controlled local delivery of CTLA-4 blocking antibody induces CD8+ T-cell-dependent tumor eradication and decreases risk of toxic side effects. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 23788581	2013
Dendritic cells process synthetic long peptides better than whole protein, improving antigen presentation and T-cell activation. European journal of immunology\| PubMed ID: 23836147	2013
New role of signal peptide peptidase to liberate C-terminal peptides for MHC class I presentation. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 24048903	2013
Local immunomodulation for cancer therapy: Providing treatment where needed. Oncoimmunology\| PubMed ID: 24490127	2013
Effectiveness of slow-release systems in CD40 agonistic antibody immunotherapy of cancer. Vaccine\| PubMed ID: 24508038	2014
IgG-mediated anaphylaxis to a synthetic long peptide vaccine containing a B cell epitope can be avoided by slow-release formulation. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 24813207	2014
Ovalbumin-coated pH-sensitive microneedle arrays effectively induce ovalbumin-specific antibody and T-cell responses in mice. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V\| PubMed ID: 24820032	2014
Dominant contribution of the proteasome and metalloproteinases to TAP-independent MHC-I peptide repertoire. Molecular immunology\| PubMed ID: 24983205	2014
Targeting nanoparticles to CD40, DEC-205 or CD11c molecules on dendritic cells for efficient CD8(+) T cell response: a comparative study. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 25068703	2014
Enhanced cross-presentation and improved CD8+ T cell responses after mannosylation of synthetic long peptides in mice. PloS one\| PubMed ID: 25137039	2014
FcRγ-chain ITAM signaling is critically required for cross-presentation of soluble antibody-antigen complexes by dendritic cells. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 25355925	2014
Near-infrared labeled, ovalbumin loaded polymeric nanoparticles based on a hydrophilic polyester as model vaccine: In vivo tracking and evaluation of antigen-specific CD8(+) T cell immune re... Biomaterials\| PubMed ID: 25453974	2015
CD40-targeted dendritic cell delivery of PLGA-nanoparticle vaccines induce potent anti-tumor responses. Biomaterials\| PubMed ID: 25465442	2015
Vaccine-induced tumor necrosis factor-producing T cells synergize with cisplatin to promote tumor cell death. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 25501579	2015
Two in one: improving synthetic long peptide vaccines by combining antigen and adjuvant in one molecule. Oncoimmunology\| PubMed ID: 25610736	2014
Polymeric nanoparticles for co-delivery of synthetic long peptide antigen and poly IC as therapeutic cancer vaccine formulation. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 25660830	2015
The translocon protein Sec61 mediates antigen transport from endosomes in the cytosol for cross-presentation to CD8(+) T cells. Immunity\| PubMed ID: 25979419	2015
Polymeric microparticles for sustained and local delivery of antiCD40 and antiCTLA-4 in immunotherapy of cancer. Biomaterials\| PubMed ID: 25993015	2015
Therapeutic cancer vaccines. The Journal of clinical investigation\| PubMed ID: 26214521	2015
The viral context instructs the redundancy of costimulatory pathways in driving CD8(+) T cell expansion. eLife\| PubMed ID: 26263500	2015
Combination of Photodynamic Therapy and Specific Immunotherapy Efficiently Eradicates Established Tumors. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 26546617	2016
TAP-independent self-peptides enhance T cell recognition of immune-escaped tumors. The Journal of clinical investigation\| PubMed ID: 26784543	2016
Vaccines for established cancer: overcoming the challenges posed by immune evasion. Nature reviews. Cancer\| PubMed ID: 26965076	2016
Glycan modification of antigen alters its intracellular routing in dendritic cells, promoting priming of T cells. eLife\| PubMed ID: 26999763	2016
TLR2 ligand-synthetic long peptide conjugates effectively stimulate tumor-draining lymph node T cells of cervical cancer patients. Oncotarget\| PubMed ID: 27564262	2016
The Optimization of Bioorthogonal Epitope Ligation within MHC-I Complexes. ACS chemical biology\| PubMed ID: 27704768	2016
Strong in vivo antitumor responses induced by an antigen immobilized in nanogels via reducible bonds. Nanoscale\| PubMed ID: 27748778	2016
Self-Assembling Peptide Epitopes as Novel Platform for Anticancer Vaccination. Molecular pharmaceutics\| PubMed ID: 28088862	2017
C1q-Dependent Dendritic Cell Cross-Presentation of In Vivo-Formed Antigen-Antibody Complexes. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 28432146	2017
PD-L1 expression on malignant cells is no prerequisite for checkpoint therapy. Oncoimmunology\| PubMed ID: 28507803	2017
CD4 T Cell and NK Cell Interplay Key to Regression of MHC Class I Tumors upon TLR7/8 Agonist Therapy. Cancer immunology research\| PubMed ID: 28637878	2017
PD-L1 immune suppression in cancer: Tumor cells or host cells? Oncoimmunology\| PubMed ID: 28811961	2017
Photodynamic-Immune Checkpoint Therapy Eradicates Local and Distant Tumors by CD8 T Cells. Cancer immunology research\| PubMed ID: 28851692	2017
Linking T cell epitopes to a common linear B cell epitope: A targeting and adjuvant strategy to improve T cell responses. Molecular immunology\| PubMed ID: 29175591	2018
A Restricted Role for FcγR in the Regulation of Adaptive Immunity. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 29523656	2018
Sustained cross-presentation capacity of murine splenic dendritic cell subsets in vivo. European journal of immunology\| PubMed ID: 29676785	2018
Chemical Control over T-Cell Activation in Vivo Using Deprotection of trans-Cyclooctene-Modified Epitopes. ACS chemical biology\| PubMed ID: 29733186	2018
Formation of Immune Complexes with a Tetanus-Derived B Cell Epitope Boosts Human T Cell Responses to Covalently Linked Peptides in an Ex Vivo Blood Loop System. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 29752315	2018
Approaches to Improve Chemically Defined Synthetic Peptide Vaccines. Frontiers in immunology\| PubMed ID: 29755468	2018
Combinatory therapy adopting nanoparticle-based cancer vaccination with immune checkpoint blockade for treatment of post-surgical tumor recurrences. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 30008371	2018
FcγRI expression on macrophages is required for antibody-mediated tumor protection by cytomegalovirus-based vaccines. Oncotarget\| PubMed ID: 30034625	2018
FcγR interaction is not required for effective anti-PD-L1 immunotherapy but can add additional benefit depending on the tumor model. International journal of cancer\| PubMed ID: 30259976	2019
High FcγR Expression on Intratumoral Macrophages Enhances Tumor-Targeting Antibody Therapy. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 30397036	2018
: A workflow for visual and quantitative analysis of flow and mass cytometry data to discover immune signatures and correlations. Computational and structural biotechnology journal\| PubMed ID: 30450167	2018
Tumor-draining lymph nodes are pivotal in PD-1/PD-L1 checkpoint therapy. JCI insight\| PubMed ID: 30518694	2018
Novel TLR2-binding adjuvant induces enhanced T cell responses and tumor eradication. Journal for immunotherapy of cancer\| PubMed ID: 30541631	2018
A Dual-Color Bioluminescence Reporter Mouse for Simultaneous Imaging of T Cell Localization and Function. Frontiers in immunology\| PubMed ID: 30671062	2018
Dual Synthetic Peptide Conjugate Vaccine Simultaneously Triggers TLR2 and NOD2 and Activates Human Dendritic Cells. Bioconjugate chemistry\| PubMed ID: 30865430	2019
Peptides conjugated to 2-alkoxy-8-oxo-adenine as potential synthetic vaccines triggering TLR7. Bioorganic & medicinal chemistry letters\| PubMed ID: 30952595	2019
PD-L1 blockade engages tumor-infiltrating lymphocytes to co-express targetable activating and inhibitory receptors. Journal for immunotherapy of cancer\| PubMed ID: 31412943	2019
Effective chemoimmunotherapy by co-delivery of doxorubicin and immune adjuvants in biodegradable nanoparticles. Theranostics\| PubMed ID: 31588231	2019
A poly-neoantigen DNA vaccine synergizes with PD-1 blockade to induce T cell-mediated tumor control. Oncoimmunology\| PubMed ID: 31646082	2019
Cationic synthetic long peptides-loaded nanogels: An efficient therapeutic vaccine formulation for induction of T-cell responses. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 31672626	2019