Clare L. Hawkins

Heart Research Institute

Affiliated withHeart Research Institute University of Sydney University of Copenhagen

Research Area

Biography

Clare L. Hawkins has not added Biography.
If you are Clare L. Hawkins and would like to personalize this page please email our Author Liaison for assistance.

JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 13	2019

Other Publications

Article	Year
Superoxide radicals can act synergistically with hypochlorite to induce damage to proteins. FEBS letters\| PubMed ID: 11755528	2002
Hypochlorite-induced damage to DNA, RNA, and polynucleotides: formation of chloramines and nitrogen-centered radicals. Chemical research in toxicology\| PubMed ID: 11800600	2002
Reaction of protein chloramines with DNA and nucleosides: evidence for the formation of radicals, protein-DNA cross-links and DNA fragmentation. The Biochemical journal\| PubMed ID: 12010123	2002
Singlet oxygen-mediated protein oxidation: evidence for the formation of reactive side chain peroxides on tyrosine residues. Photochemistry and photobiology\| PubMed ID: 12126305	2002
Photo-oxidation of cells generates long-lived intracellular protein peroxides. Free radical biology & medicine\| PubMed ID: 12633741	2003
Hypochlorous acid-mediated oxidation of lipid components and antioxidants present in low-density lipoproteins: absolute rate constants, product analysis, and computational modeling. Chemical research in toxicology\| PubMed ID: 12703960	2003
Hypochlorite-mediated fragmentation of hyaluronan, chondroitin sulfates, and related N-acetyl glycosamines: evidence for chloramide intermediates, free radical transfer reactions, and site-s... Journal of the American Chemical Society\| PubMed ID: 14599211	2003
Hypochlorite and superoxide radicals can act synergistically to induce fragmentation of hyaluronan and chondroitin sulphates. The Biochemical journal\| PubMed ID: 15078224	2004
EPR spin trapping of protein radicals. Free radical biology & medicine\| PubMed ID: 15082061	2004
The role of reactive N-bromo species and radical intermediates in hypobromous acid-induced protein oxidation. Free radical biology & medicine\| PubMed ID: 16140210	2005
The role of aromatic amino acid oxidation, protein unfolding, and aggregation in the hypobromous acid-induced inactivation of trypsin inhibitor and lysozyme. Chemical research in toxicology\| PubMed ID: 16300375	2005
Sensitizer-mediated photooxidation of histidine residues: evidence for the formation of reactive side-chain peroxides. Free radical biology & medicine\| PubMed ID: 16458201	2006
Inactivation of protease inhibitors and lysozyme by hypochlorous acid: role of side-chain oxidation and protein unfolding in loss of biological function. Chemical research in toxicology\| PubMed ID: 16533025	2005
Hypochlorous acid-mediated protein oxidation: how important are chloramine transfer reactions and protein tertiary structure? Biochemistry\| PubMed ID: 17676767	2007
Mammalian heme peroxidases: from molecular mechanisms to health implications. Antioxidants & redox signaling\| PubMed ID: 18331199	2008
Hypothiocyanous acid is a more potent inducer of apoptosis and protein thiol depletion in murine macrophage cells than hypochlorous acid or hypobromous acid. The Biochemical journal\| PubMed ID: 18459943	2008
Tryptophan residues are targets in hypothiocyanous acid-mediated protein oxidation. The Biochemical journal\| PubMed ID: 18652572	2008
Identification of plasma proteins that are susceptible to thiol oxidation by hypochlorous acid and N-chloramines. Chemical research in toxicology\| PubMed ID: 18698849	2008
Separation, detection, and quantification of hydroperoxides formed at side-chain and backbone sites on amino acids, peptides, and proteins. Free radical biology & medicine\| PubMed ID: 18762246	2008
What are the plasma targets of the oxidant hypochlorous acid? A kinetic modeling approach. Chemical research in toxicology\| PubMed ID: 19326902	2009
Singlet-oxygen-mediated amino acid and protein oxidation: formation of tryptophan peroxides and decomposition products. Free radical biology & medicine\| PubMed ID: 19375501	2009
Quantification of protein modification by oxidants. Free radical biology & medicine\| PubMed ID: 19439229	2009
The role of hypothiocyanous acid (HOSCN) in biological systems. Free radical research\| PubMed ID: 19905977	2009
Acetaminophen (paracetamol) inhibits myeloperoxidase-catalyzed oxidant production and biological damage at therapeutically achievable concentrations. Biochemical pharmacology\| PubMed ID: 19968966	2010
Cellular effects of peptide and protein hydroperoxides. Free radical biology & medicine\| PubMed ID: 20109544	2010
The myeloperoxidase-derived oxidant HOSCN inhibits protein tyrosine phosphatases and modulates cell signalling via the mitogen-activated protein kinase (MAPK) pathway in macrophages. The Biochemical journal\| PubMed ID: 20528774	2010
Ability of hypochlorous acid and N-chloramines to chlorinate DNA and its constituents. Chemical research in toxicology\| PubMed ID: 20593802	2010
Cellular effects of photogenerated oxidants and long-lived, reactive, hydroperoxide photoproducts. Free radical biology & medicine\| PubMed ID: 20708682	2010
Amino acid, peptide, and protein hydroperoxides and their decomposition products modify the activity of the 26S proteasome. Free radical biology & medicine\| PubMed ID: 21111806	2011
High plasma thiocyanate levels in smokers are a key determinant of thiol oxidation induced by myeloperoxidase. Free radical biology & medicine\| PubMed ID: 21884783	2011
Hypothiocyanous acid: benign or deadly? Chemical research in toxicology\| PubMed ID: 22053976	2012
Nitric oxide storage and transport in cells are mediated by glutathione S-transferase P1-1 and multidrug resistance protein 1 via dinitrosyl iron complexes. The Journal of biological chemistry\| PubMed ID: 22084240	2012
Inactivation of thiol-dependent enzymes by hypothiocyanous acid: role of sulfenyl thiocyanate and sulfenic acid intermediates. Free radical biology & medicine\| PubMed ID: 22248862	2012
Reactions and reactivity of myeloperoxidase-derived oxidants: differential biological effects of hypochlorous and hypothiocyanous acids. Free radical research\| PubMed ID: 22348603	2012
Reduced circulating oxidized LDL is associated with hypocholesterolemia and enhanced thiol status in Gilbert syndrome. Free radical biology & medicine\| PubMed ID: 22521902	2012
Identification of proteins susceptible to thiol oxidation in endothelial cells exposed to hypochlorous acid and N-chloramines. Biochemical and biophysical research communications\| PubMed ID: 22819842	2012
Myeloperoxidase-derived oxidants modify apolipoprotein A-I and generate dysfunctional high-density lipoproteins: comparison of hypothiocyanous acid (HOSCN) with hypochlorous acid (HOCl). The Biochemical journal\| PubMed ID: 23088652	2013
Detection and characterisation of radicals in biological materials using EPR methodology. Biochimica et biophysica acta\| PubMed ID: 23567797	2014
Comparative reactivity of the myeloperoxidase-derived oxidants hypochlorous acid and hypothiocyanous acid with human coronary artery endothelial cells. Free radical biology & medicine\| PubMed ID: 24120969	2013
Inhibition of myeloperoxidase- and neutrophil-mediated oxidant production by tetraethyl and tetramethyl nitroxides. Free radical biology & medicine\| PubMed ID: 24566469	2014
Comparative reactivity of myeloperoxidase-derived oxidants with mammalian cells. Free radical biology & medicine\| PubMed ID: 24632382	2014
Tryptophan oxidation in proteins exposed to thiocyanate-derived oxidants. Archives of biochemistry and biophysics\| PubMed ID: 25172223	2014
Role of cyanate in the induction of vascular dysfunction during uremia: more than protein carbamylation? Kidney international\| PubMed ID: 25360490	2014
Comparative reactivity of the myeloperoxidase-derived oxidants HOCl and HOSCN with low-density lipoprotein (LDL): Implications for foam cell formation in atherosclerosis. Archives of biochemistry and biophysics\| PubMed ID: 25795019	2015
Reactivity of selenium-containing compounds with myeloperoxidase-derived chlorinating oxidants: Second-order rate constants and implications for biological damage. Free radical biology & medicine\| PubMed ID: 25841785	2015
Manganese superoxide dismutase promotes interaction of actin, S100A4 and Talin, and enhances rat gastric tumor cell invasion. Journal of clinical biochemistry and nutrition\| PubMed ID: 26236095	2015
β3 Adrenergic Stimulation Restores Nitric Oxide/Redox Balance and Enhances Endothelial Function in Hyperglycemia. Journal of the American Heart Association\| PubMed ID: 26896479	2016
Cellular targets of the myeloperoxidase-derived oxidant hypothiocyanous acid (HOSCN) and its role in the inhibition of glycolysis in macrophages. Free radical biology & medicine\| PubMed ID: 26898502	2016
Chasing great paths of Helmut Sies "Oxidative Stress". Archives of biochemistry and biophysics\| PubMed ID: 27095216	2016
Cross-linking of lens crystallin proteins induced by tryptophan metabolites and metal ions: implications for cataract development. Free radical research\| PubMed ID: 27383194	2016
A Nitric Oxide Storage and Transport System That Protects Activated Macrophages from Endogenous Nitric Oxide Cytotoxicity. The Journal of biological chemistry\| PubMed ID: 27866158	2016
Changes in mitochondrial homeostasis and redox status in astronauts following long stays in space. Scientific reports\| PubMed ID: 27982062	2016
Role of Myeloperoxidase Oxidants in the Modulation of Cellular Lysosomal Enzyme Function: A Contributing Factor to Macrophage Dysfunction in Atherosclerosis? PloS one\| PubMed ID: 27997605	2016
Role of Mitochondrial Reactive Oxygen Species in the Activation of Cellular Signals, Molecules, and Function. Handbook of experimental pharmacology\| PubMed ID: 28176043	2017
Catalytic oxidant scavenging by selenium-containing compounds: Reduction of selenoxides and N-chloramines by thiols and redox enzymes. Redox biology\| PubMed ID: 28458184	2017
Low-density lipoprotein modified by myeloperoxidase oxidants induces endothelial dysfunction. Redox biology\| PubMed ID: 28818791	2017
Molecular Alterations in a Mouse Cardiac Model of Friedreich Ataxia: An Impaired Nrf2 Response Mediated via Upregulation of Keap1 and Activation of the Gsk3β Axis. The American journal of pathology\| PubMed ID: 28935570	2017
A pivotal role for NF-κB in the macrophage inflammatory response to the myeloperoxidase oxidant hypothiocyanous acid. Archives of biochemistry and biophysics\| PubMed ID: 29410057	2018
Protein carbamylation: a key driver of vascular calcification during chronic kidney disease. Kidney international\| PubMed ID: 29933841	2018
Role of hypochlorous acid (HOCl) and other inflammatory mediators in the induction of macrophage extracellular trap formation. Free radical biology & medicine\| PubMed ID: 30189264	2018
Hypochlorous acid-modified extracellular matrix contributes to the behavioral switching of human coronary artery smooth muscle cells. Free radical biology & medicine\| PubMed ID: 30716431	2019
Characterization of the cellular effects of myeloperoxidase-derived oxidants on H9c2 cardiac myoblasts. Archives of biochemistry and biophysics\| PubMed ID: 30872062	2019
Oxidation of human plasma fibronectin by inflammatory oxidants perturbs endothelial cell function. Free radical biology & medicine\| PubMed ID: 30959171	2019
A Role for Chlorinated Nucleosides in the Perturbation of Macrophage Function and Promotion of Inflammation. Chemical research in toxicology\| PubMed ID: 31066272	2019
8-Chloroadenosine induces apoptosis in human coronary artery endothelial cells through the activation of the unfolded protein response. Redox biology\| PubMed ID: 31307008	2019