Jari Yli-Kauhaluoma

Drug Research Program, University of Helsinki

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 6	2019

Other Publications

Article	Year
On the hydrolytic behavior of tinidazole, metronidazole, and ornidazole. Journal of pharmaceutical sciences\| PubMed ID: 12661060	2003
Recent advances in 1,3-dipolar cycloaddition reactions on solid supports. Molecular diversity\| PubMed ID: 15789565	2005
Analysis of small molecules by ultra thin-layer chromatography-atmospheric pressure matrix-assisted laser desorption/ionization mass spectrometry. Journal of the American Society for Mass Spectrometry\| PubMed ID: 15907705	2005
A modification of the Hammett equation for predicting ionisation constants of p-vinyl phenols. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences\| PubMed ID: 15979536	2005
Microwave-assisted synthesis of imidazoles: reaction of p-toluenesulfonylmethyl isocyanide and polymer-bound imines. Bioorganic & medicinal chemistry letters\| PubMed ID: 15993061	2005
Methadone increases intracellular calcium in SH-SY5Y and SH-EP1-halpha7 cells by activating neuronal nicotinic acetylcholine receptors. Journal of neurochemistry\| PubMed ID: 16000156	2005
Stereochemical sensitivity of the human UDP-glucuronosyltransferases 2B7 and 2B17. Journal of medicinal chemistry\| PubMed ID: 16509597	2006
Solid-phase synthesis of pyrazolopyridines from polymer-bound alkyne and azomethine imines. Journal of combinatorial chemistry\| PubMed ID: 16677003	2006
Pharmacological properties of the ubiquitous natural product betulin. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences\| PubMed ID: 16716572	2006
Morphine, oxycodone, methadone and its enantiomers in different models of nociception in the rat. Anesthesia and analgesia\| PubMed ID: 16717324	2006
Microplate screening assay for binding of ligands to bovine or reindeer beta-lactoglobulins. Journal of biochemical and biophysical methods\| PubMed ID: 16766039	2006
Assessing the data quality in predictive toxicology using a panel of cell lines and cytotoxicity assays. Analytical biochemistry\| PubMed ID: 17266913	2007
Stereoselective aza Diels-Alder reaction on solid phase: a facile synthesis of hexahydrocinnoline derivatives. Journal of combinatorial chemistry\| PubMed ID: 17348732	2007
Isoform-selective inhibition of the human UDP-glucuronosyltransferase 2B7 by isolongifolol derivatives. Journal of medicinal chemistry\| PubMed ID: 17474732	2007
Potent inhibitors of the human UDP-glucuronosyltransferase 2B7 derived from the sesquiterpenoid alcohol longifolol. ChemMedChem\| PubMed ID: 17479992	2007
Regioselective sulfonation of dopamine by SULT1A3 in vitro provides a molecular explanation for the preponderance of dopamine-3-O-sulfate in human blood circulation. Biochemical pharmacology\| PubMed ID: 17548063	2007
Eudismic analysis of tricyclic sesquiterpenoid alcohols: lead structures for the design of potent inhibitors of the human UDP-glucuronosyltransferase 2B7. Bioorganic chemistry\| PubMed ID: 17706742	2007
A new insight into solid-state conformation of macrolide antibiotics. Bioorganic & medicinal chemistry\| PubMed ID: 17936632	2008
Stereochemical and steric control of the UDP-glucuronosyltransferase-catalyzed conjugation reaction: a rational approach for the design of inhibitors for the human UGT2B7. ChemMedChem\| PubMed ID: 17943712	2007
Acetylcholinesterase inhibitory guided fractionation of Melissa officinalis L. Bioorganic & medicinal chemistry\| PubMed ID: 19070498	2009
Synthesis and characterization of hydroxylated mesocarb metabolites for doping control. Archiv der Pharmazie\| PubMed ID: 19340833	2009
Design, synthesis, and biological activity of isophthalic acid derivatives targeted to the C1 domain of protein kinase C. Journal of medicinal chemistry\| PubMed ID: 19438240	2009
Synthesis, structure characterization, and enzyme screening of clenbuterol glucuronides. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences\| PubMed ID: 19447177	2009
Brain-derived neurotrophic factor controls activity-dependent maturation of CA1 synapses by downregulating tonic activation of presynaptic kainate receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 19741136	2009
The binding of synthetic retinoids to lipocalin beta-lactoglobulins. Journal of medicinal chemistry\| PubMed ID: 19938842	2010
Glucuronidation of psilocin and 4-hydroxyindole by the human UDP-glucuronosyltransferases. Drug metabolism and disposition: the biological fate of chemicals\| PubMed ID: 20007669	2010
Synthesis and anti-leishmanial activity of heterocyclic betulin derivatives. Bioorganic & medicinal chemistry\| PubMed ID: 20116263	2010
Anti-leishmanial activity of betulin derivatives. The Journal of antibiotics\| PubMed ID: 20139867	2010
HIV-1 Tat-peptide inhibits protein kinase C and protein kinase A through substrate competition. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences\| PubMed ID: 20433920	2010
Polyketide derivatives active against Botrytis cinerea in Gerbera hybrida. Planta\| PubMed ID: 20878179	2011
Design and synthesis of 2-arylbenzimidazoles and evaluation of their inhibitory effect against Chlamydia pneumoniae. Journal of medicinal chemistry\| PubMed ID: 20932010	2010
Synthesis and tautomerization of benzo[cd]azulen-3-ones. Organic letters\| PubMed ID: 21370863	2011
Synthesis and evaluation of library of betulin derivatives against the botulinum neurotoxin A protease. Bioorganic & medicinal chemistry letters\| PubMed ID: 21421315	2011
Current status and future prospects of C1 domain ligands as drug candidates. Current topics in medicinal chemistry\| PubMed ID: 21513495	2011
C1 Domain-targeted isophthalate derivatives induce cell elongation and cell cycle arrest in HeLa cells. PloS one\| PubMed ID: 21629792	2011
Design, synthesis, and biological activity of urea derivatives as anaplastic lymphoma kinase inhibitors. ChemMedChem\| PubMed ID: 21721129	2011
UDP-glucuronic acid binds first and the aglycone substrate binds second to form a ternary complex in UGT1A9-catalyzed reactions, in both the presence and absence of bovine serum albumin. Drug metabolism and disposition: the biological fate of chemicals\| PubMed ID: 22912433	2012
Albumin stimulates the activity of the human UDP-glucuronosyltransferases 1A7, 1A8, 1A10, 2A1 and 2B15, but the effects are enzyme and substrate dependent. PloS one\| PubMed ID: 23372764	2013
Tricyclic Benzo[cd]azulenes selectively inhibit activities of Pim kinases and restrict growth of Epstein-Barr virus-transformed cells. PloS one\| PubMed ID: 23405147	2013
Interaction between retinoid acid receptor-related orphan receptor alpha (RORA) and neuropeptide S receptor 1 (NPSR1) in asthma. PloS one\| PubMed ID: 23565190	2013
The C1 domain-targeted isophthalate derivative HMI-1b11 promotes neurite outgrowth and GAP-43 expression through PKCα activation in SH-SY5Y cells. Pharmacological research\| PubMed ID: 23643828	2013
(+)-Dehydroabietic acid, an abietane-type diterpene, inhibits Staphylococcus aureus biofilms in vitro. International journal of molecular sciences\| PubMed ID: 23739682	2013
Discovery of triterpenoids as reversible inhibitors of α/β-hydrolase domain containing 12 (ABHD12). PloS one\| PubMed ID: 24879289	2014
Screening and characterisation of antimicrobial properties of semisynthetic betulin derivatives. PloS one\| PubMed ID: 25032708	2014
Exploring marine resources for bioactive compounds. Planta medica\| PubMed ID: 25203732	2014
Betulin derivatives impair Leishmania braziliensis viability and host-parasite interaction. Bioorganic & medicinal chemistry\| PubMed ID: 25240731	2014
C1 domain-targeted isophthalates as protein kinase C modulators: structure-based design, structure-activity relationships and biological activities. Biochemical Society transactions\| PubMed ID: 25399568	2014
Synthesis and biological evaluation of 2-arylbenzimidazoles targeting Leishmania donovani. Bioorganic & medicinal chemistry letters\| PubMed ID: 25827525	2015
Mass-tag enhanced immuno-laser desorption/ionization mass spectrometry for sensitive detection of intact protein antigens. Analytical chemistry\| PubMed ID: 25867450	2015
A Developability-Focused Optimization Approach Allows Identification of in Vivo Fast-Acting Antimalarials: N-[3-[(Benzimidazol-2-yl)amino]propyl]amides. Journal of medicinal chemistry\| PubMed ID: 25906200	2015
Optimization of Invasion-Specific Effects of Betulin Derivatives on Prostate Cancer Cells through Lead Development. PloS one\| PubMed ID: 25965345	2015
Pim Kinases Promote Migration and Metastatic Growth of Prostate Cancer Xenografts. PloS one\| PubMed ID: 26075720	2015
New derivatives of dehydroabietic acid target planktonic and biofilm bacteria in Staphylococcus aureus and effectively disrupt bacterial membrane integrity. European journal of medicinal chemistry\| PubMed ID: 26241878	2015
Synthesis of 1,3,6-Trisubstituted Azulenes. The Journal of organic chemistry\| PubMed ID: 26528547	2015
Synthesis and Biological Evaluation of 2-Aminobenzothiazole and Benzimidazole Analogs Based on the Clathrodin Structure. Archiv der Pharmazie\| PubMed ID: 26709468	2016
Abietane-Type Diterpenoid Amides with Highly Potent and Selective Activity against Leishmania donovani and Trypanosoma cruzi. Journal of natural products\| PubMed ID: 26849852	2016
Betulin Derivatives Effectively Suppress Inflammation in Vitro and in Vivo. Journal of natural products\| PubMed ID: 26915998	2016
Synthesis and Anti-Proliferative Activity of Sulfanyltriazolylnaphthalenols and Sulfanyltriazolylnaphthalene-1,4-diones. Archiv der Pharmazie\| PubMed ID: 27404773	2016
Quercetin-Based Modified Porous Silicon Nanoparticles for Enhanced Inhibition of Doxorubicin-Resistant Cancer Cells. Advanced healthcare materials\| PubMed ID: 27943644	2017
In vitro evaluation of biodegradable lignin-based nanoparticles for drug delivery and enhanced antiproliferation effect in cancer cells. Biomaterials\| PubMed ID: 28081462	2017
Nucleophilic Substitution of Hydrogen Facilitated by Quinone Methide Moieties in Benzo[cd]azulen-3-ones. Organic letters\| PubMed ID: 28379712	2017
Functionalization of carboxylated lignin nanoparticles for targeted and pH-responsive delivery of anticancer drugs. Nanomedicine (London, England)\| PubMed ID: 28960138	2017
Synthesis of novel purpurealidin analogs and evaluation of their effect on the cancer-relevant potassium channel KV10.1. PloS one\| PubMed ID: 29220359	2017
Trisubstituted barbiturates and thiobarbiturates: Synthesis and biological evaluation as xanthine oxidase inhibitors, antioxidants, antibacterial and anti-proliferative agents. European journal of medicinal chemistry\| PubMed ID: 29223098	2018
Biotransformation of Cyclodextrine-Complexed Semisynthetic Betulin Derivatives by Plant Cells. Planta medica\| PubMed ID: 29518814	2018
Scaffold hopping from (5-hydroxymethyl) isophthalates to multisubstituted pyrimidines diminishes binding affinity to the C1 domain of protein kinase C. PloS one\| PubMed ID: 29641588	2018
Synthesis of 7β-hydroxy-8-ketone opioid derivatives with antagonist activity at mu- and delta-opioid receptors. European journal of medicinal chemistry\| PubMed ID: 29649744	2018
Natural Stilbenoids Have Anti-Inflammatory Properties in Vivo and Down-Regulate the Production of Inflammatory Mediators NO, IL6, and MCP1 Possibly in a PI3K/Akt-Dependent Manner. Journal of natural products\| PubMed ID: 29726680	2018
Conditioned Reward of Opioids, but not Psychostimulants, is Impaired in GABA-A Receptor δ Subunit Knockout Mice. Basic & clinical pharmacology & toxicology\| PubMed ID: 29781560	2018
Stem cells are the most sensitive screening tool to identify toxicity of GATA4-targeted novel small-molecule compounds. Archives of toxicology\| PubMed ID: 29987409	2018
Azulene-based compounds for targeting orexin receptors. European journal of medicinal chemistry\| PubMed ID: 30077889	2018
Dehydroabietic oximes halt pancreatic cancer cell growth in the G1 phase through induction of p27 and downregulation of cyclin D1. Scientific reports\| PubMed ID: 30374056	2018
Synthesis and Antiproliferative Activity of Marine Bromotyrosine Purpurealidin I and Its Derivatives. Marine drugs\| PubMed ID: 30513862	2018
Discovery of 12-Thiazole Abietanes as Selective Inhibitors of the Human Metabolic Serine Hydrolase hABHD16A. ACS medicinal chemistry letters\| PubMed ID: 30613338	2018
Tissue-specific study across the stem reveals the chemistry and transcriptome dynamics of birch bark. The New phytologist\| PubMed ID: 30724367	2019
Structure-Activity Relationships of 1-Benzoylazulenes at the OX and OX Orexin Receptors. ChemMedChem\| PubMed ID: 30892823	2019
Pyrazine-Fused Triterpenoids Block the TRPA1 Ion Channel in Vitro and Inhibit TRPA1-Mediated Acute Inflammation in Vivo. ACS chemical neuroscience\| PubMed ID: 31034197	2019
Preparation and Characterization of Dentin Phosphophoryn-Derived Peptide-Functionalized Lignin Nanoparticles for Enhanced Cellular Uptake. Small (Weinheim an der Bergstrasse, Germany)\| PubMed ID: 31062448	2019
Asymmetry in catalysis by membrane-bound pyrophosphatase demonstrated by a nonphosphorus allosteric inhibitor. Science advances\| PubMed ID: 31131322	2019
Ketamine-induced regulation of TrkB-GSK3β signaling is accompanied by slow EEG oscillations and sedation but is independent of hydroxynorketamine metabolites. Neuropharmacology\| PubMed ID: 31251996	2019
Simple 3D printed stainless steel microreactors for online mass spectrometric analysis. Heliyon\| PubMed ID: 31312730	2019
Catalytic, Tunable, One-Step Bismuth(III) Triflate Reaction with Alcohols: Dehydration Versus Dimerization. ACS omega\| PubMed ID: 31459017	2018