Frederick J. Ehlert

Department of Pharmacology, University of California, Irvine

Affiliated withUniversity of California, Irvine

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 10	2011

Other Publications

Article	Year
Identification and molecular characterization of two closely related G protein-coupled receptors activated by prokineticins/endocrine gland vascular endothelial growth factor. The Journal of biological chemistry\| PubMed ID: 11886876	2002
Increased relaxant action of forskolin and isoproterenol against muscarinic agonist-induced contractions in smooth muscle from M2 receptor knockout mice. The Journal of pharmacology and experimental therapeutics\| PubMed ID: 12649358	2003
Comparison of the pharmacological antagonism of M2 and M3 muscarinic receptors expressed in isolation and in combination. Biochemical pharmacology\| PubMed ID: 12694864	2003
Pharmacological analysis of the contractile role of M2 and M3 muscarinic receptors in smooth muscle. Receptors & channels\| PubMed ID: 12893538	2003
Muscarinic agonist-mediated heterologous desensitization in isolated ileum requires activation of both muscarinic M2 and M3 receptors. The Journal of pharmacology and experimental therapeutics\| PubMed ID: 14563784	2004
Contractile role of M2 and M3 muscarinic receptors in gastrointestinal, airway and urinary bladder smooth muscle. Life sciences\| PubMed ID: 14607264	2003
Comparison of the antimuscarinic action of p-fluorohexahydrosiladifenidol in ileal and tracheal smooth muscle. The Journal of pharmacology and experimental therapeutics\| PubMed ID: 15456838	2005
Functional analysis of muscarinic acetylcholine receptors using knockout mice. Life sciences\| PubMed ID: 15474550	2004
The M2 muscarinic receptor mediates contraction through indirect mechanisms in mouse urinary bladder. The Journal of pharmacology and experimental therapeutics\| PubMed ID: 15608083	2005
Analysis of allosterism in functional assays. The Journal of pharmacology and experimental therapeutics\| PubMed ID: 16046613	2005
Determination of the rate of muscarinic M1 receptor plasma membrane delivery using a regulated secretion/aggregation system. Journal of pharmacological and toxicological methods\| PubMed ID: 16213169	2006
Differential coupling of muscarinic M1, M2, and M3 receptors to phosphoinositide hydrolysis in urinary bladder and longitudinal muscle of the ileum of the mouse. The Journal of pharmacology and experimental therapeutics\| PubMed ID: 16675640	2006
Estimation of agonist activity at G protein-coupled receptors: analysis of M2 muscarinic receptor signaling through Gi/o,Gs, and G15. The Journal of pharmacology and experimental therapeutics\| PubMed ID: 17392404	2007
Neuronally released acetylcholine acts on the M2 muscarinic receptor to oppose the relaxant effect of isoproterenol on cholinergic contractions in mouse urinary bladder. The Journal of pharmacology and experimental therapeutics\| PubMed ID: 17473176	2007
Cysteine pairs in the third intracellular loop of the muscarinic m1 acetylcholine receptor play a role in agonist-induced internalization. The Journal of pharmacology and experimental therapeutics\| PubMed ID: 17540859	2008
On the analysis of ligand-directed signaling at G protein-coupled receptors. Naunyn-Schmiedeberg's archives of pharmacology\| PubMed ID: 18253722	2008
Two-state models and the analysis of the allosteric effect of gallamine at the M2 muscarinic receptor. The Journal of pharmacology and experimental therapeutics\| PubMed ID: 18305010	2008
Use of acetylcholine mustard to study allosteric interactions at the M(2) muscarinic receptor. The Journal of pharmacology and experimental therapeutics\| PubMed ID: 18682569	2008
Selectivity of agonists for the active state of M1 to M4 muscarinic receptor subtypes. The Journal of pharmacology and experimental therapeutics\| PubMed ID: 18824613	2009
Estimation of relative microscopic affinity constants of agonists for the active state of the receptor in functional studies on M2 and M3 muscarinic receptors. Molecular pharmacology\| PubMed ID: 18996972	2009
The guinea pig ileum lacks the direct, high-potency, M(2)-muscarinic, contractile mechanism characteristic of the mouse ileum. Naunyn-Schmiedeberg's archives of pharmacology\| PubMed ID: 19582435	2009
A conserved motif in the membrane proximal C-terminal tail of human muscarinic m1 acetylcholine receptors affects plasma membrane expression. The Journal of pharmacology and experimental therapeutics\| PubMed ID: 19841475	2010
Investigating the interaction of McN-A-343 with the M2 muscarinic receptor using its nitrogen mustard derivative. Biochemical pharmacology\| PubMed ID: 19913516	2010
Mutagenesis of nucleophilic residues near the orthosteric binding pocket of M1 and M2 muscarinic receptors: effect on the binding of nitrogen mustard analogs of acetylcholine and McN-A-343. Molecular pharmacology\| PubMed ID: 20643905	2010
Analysis of agonism and inverse agonism in functional assays with constitutive activity: estimation of orthosteric ligand affinity constants for active and inactive receptor states. The Journal of pharmacology and experimental therapeutics\| PubMed ID: 21576379	2011
Analysis of functional responses at G protein-coupled receptors: estimation of relative affinity constants for the inactive receptor state. The Journal of pharmacology and experimental therapeutics\| PubMed ID: 21576380	2011
Characterization of muscarinic receptors in the human bladder mucosa: direct quantification of subtypes using 4-DAMP mustard. Urology\| PubMed ID: 21777958	2011
Muscarinic agonists and antagonists: effects on gastrointestinal function. Handbook of experimental pharmacology\| PubMed ID: 22222706	2012