Lei Chen

Spinal Cord and Brain Injury Research Center, University of Kentucky

Affiliated withUniversity of Kentucky University of Massachusetts Lowell Tongji University

Research Area

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JoVE Journal Publications

ArticleTotal : 4	Year
Publication title Cited by 12	2020
Publication title Cited by 4	2022
Publication title Cited by 10	2021
Publication title	2026

Other Publications

Article	Year
Manufactured aluminum oxide nanoparticles decrease expression of tight junction proteins in brain vasculature. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology\| PubMed ID: 18830698	2008
Nicotine attenuates iNOS expression and contributes to neuroprotection in a compressive model of spinal cord injury. Journal of neuroscience research\| PubMed ID: 18855939	2009
An integrative multi-platform analysis for discovering biomarkers of osteosarcoma. BMC cancer\| PubMed ID: 19445706	2009
Polychlorinated biphenyls disrupt blood-brain barrier integrity and promote brain metastasis formation. Environmental health perspectives\| PubMed ID: 20064788	2010
Polychlorinated biphenyls disrupt intestinal integrity via NADPH oxidase-induced alterations of tight junction protein expression. Environmental health perspectives\| PubMed ID: 20299304	2010
Deficiency of telomerase activity aggravates the blood-brain barrier disruption and neuroinflammatory responses in a model of experimental stroke. Journal of neuroscience research\| PubMed ID: 20564349	2010
HIV-1 Tat-induced cerebrovascular toxicity is enhanced in mice with amyloid deposits. Neurobiology of aging\| PubMed ID: 21764480	2012
Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomise... The Lancet. Oncology\| PubMed ID: 21783417	2011
Diffuse optical monitoring of repeated cerebral ischemia in mice. Optics express\| PubMed ID: 21997041	2011
Proinflammatory adhesion molecules facilitate polychlorinated biphenyl-mediated enhancement of brain metastasis formation. Toxicological sciences : an official journal of the Society of Toxicology\| PubMed ID: 22240979	2012
Interleukin 2 gene polymorphisms are associated with non-Hodgkin lymphoma. DNA and cell biology\| PubMed ID: 22472080	2012
Autophagy is involved in nanoalumina-induced cerebrovascular toxicity. Nanomedicine : nanotechnology, biology, and medicine\| PubMed ID: 22687898	2013
Cerebrovascular toxicity of PCB153 is enhanced by binding to silica nanoparticles. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology\| PubMed ID: 23081707	2012
T-cell immunoglobulin- and mucin-domain-containing molecule 3 genetic variants and HIV+ non-Hodgkin lymphomas. Inflammation\| PubMed ID: 23385979	2013
MiR-15a is underexpressed and inhibits the cell cycle by targeting CCNE1 in breast cancer. International journal of oncology\| PubMed ID: 23900351	2013
MiRNA-497 regulates cell growth and invasion by targeting cyclin E1 in breast cancer. Cancer cell international\| PubMed ID: 24112607	2013
Genetic modification of mesenchymal stem cells in spinal cord injury repair strategies. Bioscience trends\| PubMed ID: 24241170	2013
miR-96 promotes tumor proliferation and invasion by targeting RECK in breast cancer. Oncology reports\| PubMed ID: 24366472	2014
MicroRNA-195-5p is a potential diagnostic and therapeutic target for breast cancer. Oncology reports\| PubMed ID: 24402230	2014
PPAR agonist-mediated protection against HIV Tat-induced cerebrovascular toxicity is enhanced in MMP-9-deficient mice. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 24424383	2014
Luminescent hybrid materials based on zeolite L crystals and lanthanide complexes: host-guest assembly and ultraviolet-visible excitation. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy\| PubMed ID: 24815195	2014
Transplantation of bone marrow mesenchymal stem cells pretreated with valproic acid in rats with an acute spinal cord injury. Bioscience trends\| PubMed ID: 24815388	2014
Extraction of diffuse correlation spectroscopy flow index by integration of Nth-order linear model with Monte Carlo simulation. Applied physics letters\| PubMed ID: 24926099	2014
Screening of surface markers on rat intestinal mucosa microfold cells by using laser capture microdissection combined with protein chip technology. International journal of clinical and experimental medicine\| PubMed ID: 24955164	2014
Alterations of microRNAs are associated with impaired growth of MCF-7 breast cancer cells induced by inhibition of casein kinase 2. International journal of clinical and experimental pathology\| PubMed ID: 25120778	2014
Multi-component assembly and luminescence tuning of lanthanide hybrids based with both zeolite L/A and SBA-15 through two organically grafted linkers. Dalton transactions (Cambridge, England : 2003)\| PubMed ID: 25135303	2014
Interleukin-1β/Iinterleukin-1 receptor-associated kinase 1 inflammatory signaling contributes to persistent Gankyrin activation during hepatocarcinogenesis. Hepatology (Baltimore, Md.)\| PubMed ID: 25294684	2015
Multi-component lanthanide hybrids based on zeolite A/L and zeolite A/L-polymers for tunable luminescence. Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology\| PubMed ID: 25411917	2015
Human umbilical cord and dental pulp-derived mesenchymal stem cells: biological characteristics and potential roles in vitro and in vivo. Molecular medicine reports\| PubMed ID: 25591506	2015
The ubiquitination of rag A GTPase by RNF152 negatively regulates mTORC1 activation. Molecular cell\| PubMed ID: 25936802	2015
Regulation of MET-mediated proliferation of thyroid carcinoma cells by miR-449b. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine\| PubMed ID: 26044563	2015
Novel multi-component hybrids through double luminescent lanthanide unit functionalized zeolite L and titania. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy\| PubMed ID: 26125989	2015
Ultradispersed Palladium Nanoparticles in Three-Dimensional Dendritic Mesoporous Silica Nanospheres: Toward Active and Stable Heterogeneous Catalysts. ACS applied materials & interfaces\| PubMed ID: 26192924	2015
Type I Interferons Triggered through the Toll-Like Receptor 3-TRIF Pathway Control Coxsackievirus A16 Infection in Young Mice. Journal of virology\| PubMed ID: 26292317	2015
Silencing of DUSP6 gene by RNAi-mediation inhibits proliferation and growth in MDA-MB-231 breast cancer cells: an in vitro study. International journal of clinical and experimental medicine\| PubMed ID: 26379838	2015
The clinical effect of percutaneous kyphoplasty for the treatment of multiple osteoporotic vertebral compression fractures and the prevention of new vertebral fractures. International journal of clinical and experimental medicine\| PubMed ID: 26550284	2015
Effectiveness of Intravitreal Injection of Ranibizumab for Neovascular Age-Related Macular Degeneration with Serous Pigment Epithelial Detachment. Medical science monitor : international medical journal of experimental and clinical research\| PubMed ID: 26972376	2016
Transcriptional regulator PrqR plays a negative role in glucose metabolism and oxidative stress acclimation in Synechocystis sp. PCC 6803. Scientific reports\| PubMed ID: 27582046	2016
An Alternative Approach for Registration of High-Resolution Satellite Optical Imagery and ICESat Laser Altimetry Data. Sensors (Basel, Switzerland)\| PubMed ID: 27898048	2016
Near-Infrared-Activated Upconversion Nanoprobes for Sensitive Endogenous Zn Detection and Selective On-Demand Photodynamic Therapy. Analytical chemistry\| PubMed ID: 28220697	2017
miR-29b contributes to multiple types of muscle atrophy. Nature communications\| PubMed ID: 28541289	2017
Preliminary Experience of Nontransecting Urethroplasty for Pelvic Fracture-related Urethral Injury. Urology\| PubMed ID: 28735015	2017
Targeted gene panel sequencing prenatally detects two novel mutations of DYNC2H1 in a fetus with increased biparietal diameter and polyhydramnios. Birth defects research\| PubMed ID: 29359448	2018
Alterations of oral microbiota distinguish children with autism spectrum disorders from healthy controls. Scientific reports\| PubMed ID: 29371629	2018
OTUB1 protein suppresses mTOR complex 1 (mTORC1) activity by deubiquitinating the mTORC1 inhibitor DEPTOR. The Journal of biological chemistry\| PubMed ID: 29382726	2018
Associations of IL-1, 6, and 10 Gene Polymorphisms with Susceptibility to Recurrent Aphthous Stomatitis: Insights from a Meta-Analysis. Genetic testing and molecular biomarkers\| PubMed ID: 29641282	2018
Identification of aberrant circulating miRNAs in Parkinson's disease plasma samples. Brain and behavior\| PubMed ID: 29670823	2018
[Therapeutic effect of Jinghuosu on oligospermia and asthenospermia.]. Zhonghua nan ke xue = National journal of andrology\| PubMed ID: 29706043	2017
miR-519a enhances chemosensitivity and promotes autophagy in glioblastoma by targeting STAT3/Bcl2 signaling pathway. Journal of hematology & oncology\| PubMed ID: 29843746	2018
Unbiased transcriptomic analyses reveal distinct effects of immune deficiency in CNS function with and without injury. Protein & cell\| PubMed ID: 29956125	2019
SET1A-Mediated Mono-Methylation at K342 Regulates YAP Activation by Blocking Its Nuclear Export and Promotes Tumorigenesis. Cancer cell\| PubMed ID: 30008322	2018
Integrated analysis of key mRNAs and lncRNAs in osteoarthritis. Experimental and therapeutic medicine\| PubMed ID: 30186409	2018
Ubiquitination of Rheb governs growth factor-induced mTORC1 activation. Cell research\| PubMed ID: 30514904	2019
Erlotinib versus gemcitabine/cisplatin in Chinese patients with EGFR mutation-positive advanced non-small-cell lung cancer: Crossover extension and post-hoc analysis of the ENSURE study. Lung cancer (Amsterdam, Netherlands)\| PubMed ID: 30885342	2019
Immune contexture defined by single cell technology for prognosis prediction and immunotherapy guidance in cancer. Cancer communications (London, England)\| PubMed ID: 30999966	2019
Anti-tumor activity and mechanism of oligoclonal hepatocellular carcinoma tumor-infiltrating lymphocytes and . Cancer biology & therapy\| PubMed ID: 31018748	2019
Noninvasive noncontact speckle contrast diffuse correlation tomography of cerebral blood flow in rats. NeuroImage\| PubMed ID: 31112789	2019
Genome-wide mapping of 5-hydroxymethylcytosines in circulating cell-free DNA as a non-invasive approach for early detection of hepatocellular carcinoma. Gut\| PubMed ID: 31358576	2019
Therapeutic potential of natural compounds from Chinese medicine in acute and subacute phases of ischemic stroke. Neural regeneration research\| PubMed ID: 31571650	2020
A Wearable Fiberless Optical Sensor for Continuous Monitoring of Cerebral Blood Flow in Mice. IEEE journal of selected topics in quantum electronics : a publication of the IEEE Lasers and Electro-optics Society\| PubMed ID: 31666792	2019
Heat shock cognate protein 70 promotes the differentiation of C2C12 myoblast and targets Yin Yang 1. Annals of translational medicine\| PubMed ID: 31807532	2019
Is the result of modified Allen's test still accurate after endoscopic thoracic sympathectomy? Journal of thoracic disease\| PubMed ID: 32274135	2020
The role of ubiquitination in tumorigenesis and targeted drug discovery. Signal transduction and targeted therapy\| PubMed ID: 32296023	2020
Exercise and Osteoarthritis. Advances in experimental medicine and biology\| PubMed ID: 32342461	2020
PS1 FAD mutants decrease ephrinB2-regulated angiogenic functions, ischemia-induced brain neovascularization and neuronal survival. Molecular psychiatry\| PubMed ID: 32541930	2020
Trajectory and Functional Analysis of PD-1 CD4CD8 T Cells in Hepatocellular Carcinoma by Single-Cell Cytometry and Transcriptome Sequencing. Advanced science (Weinheim, Baden-Wurttemberg, Germany)\| PubMed ID: 32670760	2020
Ulinastatin Promotes Regeneration of Peripheral Nerves After Sciatic Nerve Injury by Targeting let-7 microRNAs and Enhancing NGF Expression. Drug design, development and therapy\| PubMed ID: 32753848	2020
The diabetes medication canagliflozin promotes mitochondrial remodelling of adipocyte via the AMPK-Sirt1-Pgc-1α signalling pathway. Adipocyte\| PubMed ID: 32835596	2020
MiR-506-3p suppresses papillary thyroid cancer cells tumorigenesis by targeting YAP1. Pathology, research and practice\| PubMed ID: 33059240	2020
Comparison of Ivor Lewis and Sweet esophagectomy for middle and lower esophageal squamous cell carcinoma: A systematic review and pooled analysis. EClinicalMedicine\| PubMed ID: 33089129	2020
The identification and functional analysis of CD8+PD-1+CD161+ T cells in hepatocellular carcinoma. NPJ precision oncology\| PubMed ID: 33145436	2020
Inhibition of lncRNA MAAT Controls Multiple Types of Muscle Atrophy by cis- and trans-Regulatory Actions. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 33279721	2021
Inhibition of the sodium-glucose co-transporter SGLT2 by canagliflozin ameliorates diet-induced obesity by increasing intra-adipose sympathetic innervation. British journal of pharmacology\| PubMed ID: 33480065	2021
Adverse Outcomes Associated With Corticosteroid Use in Critical COVID-19: A Retrospective Multicenter Cohort Study. Frontiers in medicine\| PubMed ID: 33634148	2021
Facile Synthesis of Hollow MnO Nanoparticles for Reactive Oxygen Species Scavenging in Osteoarthritis. ACS biomaterials science & engineering\| PubMed ID: 33787210	2021
Eradication of specific donor-dependent variations of mesenchymal stem cells in immunomodulation to enhance therapeutic values. Cell death & disease\| PubMed ID: 33824286	2021
Myelocytomatosis-Protein Arginine N-Methyltransferase 5 Axis Defines the Tumorigenesis and Immune Response in Hepatocellular Carcinoma. Hepatology (Baltimore, Md.)\| PubMed ID: 33896016	2021
The kynurenine derivative 3-HAA sensitizes hepatocellular carcinoma to sorafenib by upregulating phosphatases. Theranostics\| PubMed ID: 33897895	2021
Simultaneous Vascular Reconstruction and Cervical Anastomosis in McKeown Esophagectomy. Frontiers in surgery\| PubMed ID: 33898507	2021
Mitochondrial Fusion Protein Mfn2 and Its Role in Heart Failure. Frontiers in molecular biosciences\| PubMed ID: 34026850	2021
Calibration and measurement of mitochondrial pH in intact adult rat cardiomyocytes. STAR protocols\| PubMed ID: 34036286	2021
Single-Cell Transcriptome Analysis Uncovers Intratumoral Heterogeneity and Underlying Mechanisms for Drug Resistance in Hepatobiliary Tumor Organoids. Advanced science (Weinheim, Baden-Wurttemberg, Germany)\| PubMed ID: 34105295	2021
MA Demethylase ALKBH5 Regulates PD-L1 Expression and Tumor Immunoenvironment in Intrahepatic Cholangiocarcinoma. Cancer research\| PubMed ID: 34301762	2021
Discovery of a Carbamoyl Phosphate Synthetase 1-Deficient HCC Subtype With Therapeutic Potential Through Integrative Genomic and Experimental Analysis. Hepatology (Baltimore, Md.)\| PubMed ID: 34343359	2021
Comparison of k-wire insertion using oscillatory and unidirectional drilling modes under constant thrust force. Journal of orthopaedic research : official publication of the Orthopaedic Research Society\| PubMed ID: 34387900	2021
The effect of biliary obstruction, biliary drainage and bile reinfusion on bile acid metabolism and gut microbiota in mice. Liver international : official journal of the International Association for the Study of the Liver\| PubMed ID: 34459095	2022
Shape optimization of egg-shaped sewer pipes based on the nondominated sorting genetic algorithm (NSGA-II). Environmental research\| PubMed ID: 34506787	2022
Tubeless video-assisted thoracic surgery for pulmonary ground-glass nodules: expert consensus and protocol (Guangzhou). Translational lung cancer research\| PubMed ID: 34584853	2021
Depletion of m A reader protein YTHDC1 induces dilated cardiomyopathy by abnormal splicing of Titin. Journal of cellular and molecular medicine\| PubMed ID: 34716659	2021
Single cell atlas for 11 non-model mammals, reptiles and birds. Nature communications\| PubMed ID: 34873160	2021
Comprehensive analysis of spatial architecture in primary liver cancer. Science advances\| PubMed ID: 34919432	2021
BMPR1B Polymorphisms (rs1434536 and rs1970801) are Associated With Breast Cancer Susceptibility in Northwest Chinese Han Females: A Case-Control Study. Clinical breast cancer\| PubMed ID: 35501253	2022
Hepatocyte-derived VEGFA accelerates the progression of non-alcoholic fatty liver disease to hepatocellular carcinoma via activating hepatic stellate cells. Acta pharmacologica Sinica\| PubMed ID: 35508720	2022
Mitochondrial autophagy: molecular mechanisms and implications for cardiovascular disease. Cell death & disease\| PubMed ID: 35534453	2022
AKAP12 ameliorates liver injury via targeting PI3K/AKT/PCSK6 pathway. Redox biology\| PubMed ID: 35576690	2022
PGC-1-Mediated Mitochondrial Quality Control: Molecular Mechanisms and Implications for Heart Failure. Frontiers in cell and developmental biology\| PubMed ID: 35721484	2022
Effects of Total Flavonoids of Epimedium on Bone Marrow Adipose Tissue in Ovariectomized Rats. Frontiers in endocrinology\| PubMed ID: 35733771	2022
Levalbuterol albuterol for hospitalized patients with COPD in China: cost-utility and budget impact analysis. Journal of medical economics\| PubMed ID: 35786135	2022
Operation analysis of freeway mixed traffic flow based on catch-up coordination platoon. Accident; analysis and prevention\| PubMed ID: 35933931	2022
Inhibition of mitochondrial superoxide promotes the development of hiPS-CMs during differentiation. Free radical biology & medicine\| PubMed ID: 35952922	2022
The immuno-therapeutic potential of miR-2392 in patients with hepatocellular carcinoma. Liver international : official journal of the International Association for the Study of the Liver\| PubMed ID: 35962762	2022
The Association Between Circulating Sex Hormones and Central Serous Chorioretinopathy: A Case-Control Study. Therapeutics and clinical risk management\| PubMed ID: 36046103	2022
Cystine Induced-mTORC2 Activation through Promoting Sin1 Phosphorylation to Suppress Cancer Cell Ferroptosis. Molecular nutrition & food research\| PubMed ID: 36189894	2022
Thymosin β4, a potential marker of malignancy and prognosis in hepatocellular carcinoma. Scandinavian journal of gastroenterology\| PubMed ID: 36269095	2022
Secreted phosphoprotein 1 promotes angiogenesis of glioblastoma through upregulating PSMA expression via transcription factor HIF-1α. Acta biochimica et biophysica Sinica\| PubMed ID: 36305723	2022
Denosumab biosimilar (LY06006) in Chinese postmenopausal osteoporotic women: A randomized, double-blind, placebo-controlled, multicenter phase III study. Journal of orthopaedic translation\| PubMed ID: 36381249	2023
Accuracy and feasibility with AI-assisted OCT in retinal disorder community screening. Frontiers in cell and developmental biology\| PubMed ID: 36407116	2022
Vessel microport technique for applications in cerebrovascular research. Journal of neuroscience research\| PubMed ID: 19115415	2009
Inhibition of telomerase activity alters tight junction protein expression and induces transendothelial migration of HIV-1-infected cells. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 20139322	2010
Noncontact optical imaging of brain hemodynamics in preterm infants: a preliminary study. Physics in medicine and biology\| PubMed ID: 33113516	2020
Speckle contrast diffuse correlation tomography of cerebral blood flow in perinatal disease model of neonatal piglets. Journal of biophotonics\| PubMed ID: 33295142	2021
Simultaneous measurements of tissue blood flow and oxygenation using a wearable fiber-free optical sensor. Journal of biomedical optics\| PubMed ID: 33515216	2021
Depth-sensitive diffuse speckle contrast topography for high-density mapping of cerebral blood flow in rodents. Neurophotonics\| PubMed ID: 38076725	2023
Wearable fiber-free optical sensor for continuous monitoring of neonatal cerebral blood flow and oxygenation. Pediatric research\| PubMed ID: 38503982	2024
Programmable scanning diffuse speckle contrast imaging of cerebral blood flow. ArXiv\| PubMed ID: 39253639	2024
Programmable scanning diffuse speckle contrast imaging of cerebral blood flow. Neurophotonics\| PubMed ID: 39872020	2025
Detection of low-frequency oscillations in neonatal piglets with speckle contrast diffuse correlation tomography. Journal of biomedical optics\| PubMed ID: 40060305	2023
Using the latent diffusion model to enhance time-resolved laser speckle contrast imaging (TR-LSCI) of cerebral blood flow. Biomedical optics express\| PubMed ID: 41112794	2025
Affordable miniaturized speckle contrast diffuse correlation tomography device for depth-sensitive mapping of cerebral blood flow in rodents. Journal of biomedical optics\| PubMed ID: 41140550	2025
Noncontact diffuse optical imaging of blood flow and oxygenation distributions in reconstructive rat skin flaps. Biomedical optics express\| PubMed ID: 41368087	2025