Klaus Elenius

Medicity Research Laboratories and Institute of Biomedicine, University of Turku

Affiliated withUniversity of Turku University of Turku and Åbo Akademi University University of Turku and Turku University Hospital

Research Area

Biochemistry

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 7	2020

Other Publications

Article	Year
N-arginine dibasic convertase is a specific receptor for heparin-binding EGF-like growth factor that mediates cell migration. The EMBO journal\| PubMed ID: 11432822	2001
Endothelial cell-matrix interactions. Microscopy research and technique\| PubMed ID: 12500256	2003
Angiopoietin-regulated recruitment of vascular smooth muscle cells by endothelial-derived heparin binding EGF-like growth factor. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 12958167	2003
Identification of patients with transitional cell carcinoma of the bladder overexpressing ErbB2, ErbB3, or specific ErbB4 isoforms: real-time reverse transcription-PCR analysis in estimation... Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 14614020	2003
Cleavable ErbB4 isoform in estrogen receptor-regulated growth of breast cancer cells. Cancer research\| PubMed ID: 15735025	2005
DNA topoisomerase I is a cofactor for c-Jun in the regulation of epidermal growth factor receptor expression and cancer cell proliferation. Molecular and cellular biology\| PubMed ID: 15923621	2005
Proteolytic cleavage and phosphorylation of a tumor-associated ErbB4 isoform promote ligand-independent survival and cancer cell growth. Molecular biology of the cell\| PubMed ID: 16251361	2006
The intracellular domain of ErbB4 induces differentiation of mammary epithelial cells. Molecular biology of the cell\| PubMed ID: 16837552	2006
Intra- and extracellular signaling by endothelial neuregulin-1. Experimental cell research\| PubMed ID: 17499242	2007
Proteome analysis of cultivated vascular smooth muscle cells from a CADASIL patient. Molecular medicine (Cambridge, Mass.)\| PubMed ID: 17622327	2007
O-sulfated bacterial polysaccharides with low anticoagulant activity inhibit metastasis. Seminars in thrombosis and hemostasis\| PubMed ID: 17629853	2007
Isoform-specific monoubiquitination, endocytosis, and degradation of alternatively spliced ErbB4 isoforms. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18334649	2008
Role of ErbB4 in breast cancer. Journal of mammary gland biology and neoplasia\| PubMed ID: 18454307	2008
ErbB4 and its isoforms: patentable drug targets? Recent patents on DNA & gene sequences\| PubMed ID: 19075942	2008
Somatic mutations of ErbB4: selective loss-of-function phenotype affecting signal transduction pathways in cancer. The Journal of biological chemistry\| PubMed ID: 19098003	2009
Removal of cell surface heparan sulfate increases TACE activity and cleavage of ErbB4 receptor. BMC cell biology\| PubMed ID: 19171023	2009
Pim-1 kinase expression predicts radiation response in squamocellular carcinoma of head and neck and is under the control of epidermal growth factor receptor. Neoplasia (New York, N.Y.)\| PubMed ID: 19568408	2009
The EGFR inhibitor gefitinib suppresses recruitment of pericytes and bone marrow-derived perivascular cells into tumor vessels. Microvascular research\| PubMed ID: 19596357	2009
ErbB4 splice variants Cyt1 and Cyt2 differ by 16 amino acids and exert opposing effects on the mammary epithelium in vivo. Molecular and cellular biology\| PubMed ID: 19596786	2009
Potential of ErbB4 antibodies for cancer therapy. Future oncology (London, England)\| PubMed ID: 20021208	2010
Retention of prolyl hydroxylase PHD2 in the cytoplasm prevents PHD2-induced anchorage-independent carcinoma cell growth. Experimental cell research\| PubMed ID: 20156434	2010
EGFR targeting drugs in the treatment of head and neck squamous cell carcinoma. Expert opinion on emerging drugs\| PubMed ID: 20415599	2010
Cell death or survival promoted by alternative isoforms of ErbB4. Molecular biology of the cell\| PubMed ID: 20943952	2010
Function of ERBB4 is determined by alternative splicing. Cell cycle (Georgetown, Tex.)\| PubMed ID: 21811097	2011
ErbB4 modulates tubular cell polarity and lumen diameter during kidney development. Journal of the American Society of Nephrology : JASN\| PubMed ID: 22076439	2012
Interaction with ErbB4 promotes hypoxia-inducible factor-1α signaling. The Journal of biological chemistry\| PubMed ID: 22308027	2012
Protein inhibitor of activated STAT3 (PIAS3) protein promotes SUMOylation and nuclear sequestration of the intracellular domain of ErbB4 protein. The Journal of biological chemistry\| PubMed ID: 22584572	2012
Proteolytic processing of ErbB4 in breast cancer. PloS one\| PubMed ID: 22761786	2012
Translation of a research-based genetic test on a rare syndrome into clinical service testing, with sotos syndrome as an example. Genetic testing and molecular biomarkers\| PubMed ID: 22924495	2012
Systemic analysis of gene expression profiles identifies ErbB3 as a potential drug target in pediatric alveolar rhabdomyosarcoma. PloS one\| PubMed ID: 23227212	2012
CYT-1 isoform of ErbB4 is an independent prognostic factor in serous ovarian cancer and selectively promotes ovarian cancer cell growth in vitro. Gynecologic oncology\| PubMed ID: 23313737	2013
ERBB4 mutations that disrupt the neuregulin-ErbB4 pathway cause amyotrophic lateral sclerosis type 19. American journal of human genetics\| PubMed ID: 24119685	2013
High frequency of BRAF V600E mutations in ameloblastoma. The Journal of pathology\| PubMed ID: 24374844	2014
Hypoxia-inducible factor-1α induces ErbB4 signaling in the differentiating mammary gland. The Journal of biological chemistry\| PubMed ID: 24966332	2014
ERBB4 promoter polymorphism is associated with poor distant disease-free survival in high-risk early breast cancer. PloS one\| PubMed ID: 25036186	2014
ErbB4, a receptor tyrosine kinase, coordinates organization of the seminiferous tubules in the developing testis. Molecular endocrinology (Baltimore, Md.)\| PubMed ID: 25058600	2014
Overexpression of ERBB4 JM-a CYT-1 and CYT-2 isoforms in transgenic mice reveals isoform-specific roles in mammary gland development and carcinogenesis. Breast cancer research : BCR\| PubMed ID: 25516216	2014
Human Metaplastic Breast Carcinoma and Decorin. Cancer microenvironment : official journal of the International Cancer Microenvironment Society\| PubMed ID: 28653173	2017
Genome-wide screen of gamma-secretase-mediated intramembrane cleavage of receptor tyrosine kinases. Molecular biology of the cell\| PubMed ID: 28904208	2017
SUMOylation regulates nuclear accumulation and signaling activity of the soluble intracellular domain of the ErbB4 receptor tyrosine kinase. The Journal of biological chemistry\| PubMed ID: 28974580	2017
Gamma-secretase-dependent signaling of receptor tyrosine kinases. Oncogene\| PubMed ID: 30166589	2019
Receptor tyrosine kinase profiling of ischemic heart identifies ROR1 as a potential therapeutic target. BMC cardiovascular disorders\| PubMed ID: 30342492	2018
Different responses of colorectal cancer cells to alternative sequences of cetuximab and oxaliplatin. Scientific reports\| PubMed ID: 30410004	2018
ErbB4 tyrosine kinase inhibition impairs neuromuscular development in zebrafish embryos. Molecular biology of the cell\| PubMed ID: 30462579	2019
Endothelial Cells Regulate Physiological Cardiomyocyte Growth via VEGFR2-Mediated Paracrine Signaling. Circulation\| PubMed ID: 30922063	2019
An unbiased screen for activating epidermal growth factor receptor mutations. The Journal of biological chemistry\| PubMed ID: 30952700	2019
Decorin Expression in Human Vulva Carcinoma: Oncosuppressive Effect of Decorin cDNA Transduction on Carcinoma Cells. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society\| PubMed ID: 31009269	2019
Structural characterization of EGFR exon 19 deletion mutation using molecular dynamics simulation. PloS one\| PubMed ID: 31536605	2019
Genetic and functional implications of an exonic TRIM55 variant in heart failure. Journal of molecular and cellular cardiology\| PubMed ID: 31866377	2020