Hui Feng

Departments of Pharmacology and Medicine, Boston University School of Medicine

Affiliated withBoston University School of Medicine Xinyu University

Research Area

Biography

Trained as a physician and cancer biologist, Dr. Feng has applied the zebrafish as a model to study MYC-driven cancers over seventeen years. Her laboratory at Boston University (www.bu.edu/zgct) utilizes multiple zebrafish models of cancer to gain mechanistic insights into MYC-mediated oncogenic pathways and identify novel therapeutic targets for MYC-driven cancers.

JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 5	2020
Publication title	2025

Other Publications

Article	Year
BCL2-specific inhibitor ABT-199 synergizes strongly with cytarabine against the early immature LOUCY cell line but not more-differentiated T-ALL cell lines. Leukemia\| PubMed ID: 24342948	2014
Loss of function tp53 mutations do not accelerate the onset of myc-induced T-cell acute lymphoblastic leukaemia in the zebrafish. British journal of haematology\| PubMed ID: 24690081	2014
The c-Cbl ubiquitin ligase regulates nuclear β-catenin and angiogenesis by its tyrosine phosphorylation mediated through the Wnt signaling pathway. The Journal of biological chemistry\| PubMed ID: 25784557	2015
Hypoxia-induced expression of phosducin-like 3 regulates expression of VEGFR-2 and promotes angiogenesis. Angiogenesis\| PubMed ID: 26059764	2015
Efficient transgenesis mediated by pigmentation rescue in zebrafish. BioTechniques\| PubMed ID: 26757807	2016
Zebrafish Models of Human Leukemia: Technological Advances and Mechanistic Insights. Advances in experimental medicine and biology\| PubMed ID: 27165361	2016
CK2 inhibitor CX-4945 destabilizes NOTCH1 and synergizes with JQ1 against human T-acute lymphoblastic leukemic cells. Haematologica\| PubMed ID: 27758824	2017
Aberrant activation of the GIMAP enhancer by oncogenic transcription factors in T-cell acute lymphoblastic leukemia. Leukemia\| PubMed ID: 28028313	2017
Zebrafish B Cell Development without a Pre-B Cell Stage, Revealed by CD79 Fluorescence Reporter Transgenes. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 28739882	2017
The emerging role and targetability of the TCA cycle in cancer metabolism. Protein & cell\| PubMed ID: 28748451	2018
Towards Resolving the Pro- and Anti-Tumor Effects of the Aryl Hydrocarbon Receptor. International journal of molecular sciences\| PubMed ID: 29735912	2018
UFD1 contributes to MYC-mediated leukemia aggressiveness through suppression of the proapoptotic unfolded protein response. Leukemia\| PubMed ID: 29743725	2018
Functional and genomic analyses reveal therapeutic potential of targeting β-catenin/CBP activity in head and neck cancer. Genome medicine\| PubMed ID: 30029671	2018
SHQ1 regulation of RNA splicing is required for T-lymphoblastic leukemia cell survival. Nature communications\| PubMed ID: 30323192	2018
Data on ultrabright fluorescent cellulose acetate nanoparticles for imaging tumors through systemic and topical applications. Data in brief\| PubMed ID: 30596135	2019
Ultrabright fluorescent cellulose acetate nanoparticles for imaging tumors through systemic and topical applications. Materials today (Kidlington, England)\| PubMed ID: 31057328	2019
Promoter demethylation of the asparagine synthetase gene is required for ATF4-dependent adaptation to asparagine depletion. The Journal of biological chemistry\| PubMed ID: 31659118	2019
Glutamine Anabolism Plays a Critical Role in Pancreatic Cancer by Coupling Carbon and Nitrogen Metabolism. Cell reports\| PubMed ID: 31665640	2019
Targeting RICTOR Sensitizes SMAD4-Negative Colon Cancer to Irinotecan. Molecular cancer research : MCR\| PubMed ID: 31932471	2020
Direct Phosphorylation and Stabilization of MYC by Aurora B Kinase Promote T-cell Leukemogenesis. Cancer cell\| PubMed ID: 32049046	2020
Cross organelle stress response disruption promotes gentamicin-induced proteotoxicity. Cell death & disease\| PubMed ID: 32245975	2020
Integrated transcriptome and metabolome analysis reveals the regulation of phlorizin synthesis in Lithocarpus polystachyus under nitrogen fertilization. BMC plant biology\| PubMed ID: 38711037	2024