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JoVE Journal Cancer Research
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In Vivo Targeting of Xenografted Human Cancer Cells with Functionalized Fluorescent Silica Nanoparticles in Zebrafish

Article DOI: 10.3791/61187-v • 10:26 min • May 8th, 2020
May 8th, 2020 •
*1, *1, 2, 1, 2,3,4, 1
1Departments of Pharmacology and Medicine, Section of Hematology and Medical Oncology, The Cancer Research Center, Boston University School of Medicine, 2Department of Biomedical Engineering, Tufts University, 3Department of Mechanical Engineering, Tufts University, 4Department of Physics, Tufts University
* These authors contributed equally

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Described here is a method for utilizing zebrafish embryos to study the ability of functionalized nanoparticles to target human cancer cells in vivo. This method allows for the evaluation and selection of optimal nanoparticles for future testing in large animals and in clinical trials.

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In Vivo Targeting Xenografted Human Cancer Cells Functionalized Fluorescent Silica Nanoparticles Zebrafish Nanoparticles Clinical Trials Research Procedure Optimal Nanoparticles Targeting Efficiency Dr. Xiodan Qin Andrew Lam Chamber Mating Tanks Fish Water Dividers Breeding Zebrafish Egg Collection Petri Dish Incubator Pronase Solution
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