Michael Simons

Yale Cardiovascular Research Center, Yale University School of Medicine

Affiliated withYale University School of Medicine

Research Area

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 7	2022
Publication title Cited by 1	2022

Other Publications

Article	Year
The FGF system has a key role in regulating vascular integrity. The Journal of clinical investigation\| PubMed ID: 18776942	2008
Endothelium as master regulator of organ development and growth. Vascular pharmacology\| PubMed ID: 18804188	2009
Syndecan-4 regulates subcellular localization of mTOR Complex2 and Akt activation in a PKCalpha-dependent manner in endothelial cells. Molecular cell\| PubMed ID: 18851840	2008
Syndecan-4 mediates macrophage uptake of group V secretory phospholipase A2-modified LDL. Journal of lipid research\| PubMed ID: 19056705	2009
The antiangiogenic activity of rPAI-1(23) inhibits vasa vasorum and growth of atherosclerotic plaque. Circulation research\| PubMed ID: 19122176	2009
Synectin-dependent regulation of arterial maturation. Developmental dynamics : an official publication of the American Association of Anatomists\| PubMed ID: 19235722	2009
VEGF and restenosis: the rest of the story. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 19299328	2009
Regulation of vascular integrity. Journal of molecular medicine (Berlin, Germany)\| PubMed ID: 19337719	2009
FRS2 via fibroblast growth factor receptor 1 is required for platelet-derived growth factor receptor beta-mediated regulation of vascular smooth muscle marker gene expression. The Journal of biological chemistry\| PubMed ID: 19339244	2009
Endothelium-driven myocardial growth or nitric oxide at the crossroads. Trends in cardiovascular medicine\| PubMed ID: 19345317	2008
Diabetic monocyte and vascular endothelial growth factor signaling impairment. Circulation\| PubMed ID: 19564554	2009
Suppression of RhoG activity is mediated by a syndecan 4-synectin-RhoGDI1 complex and is reversed by PKCalpha in a Rac1 activation pathway. The Journal of cell biology\| PubMed ID: 19581409	2009
ERK1/2-Akt1 crosstalk regulates arteriogenesis in mice and zebrafish. The Journal of clinical investigation\| PubMed ID: 20237411	2010
Micro computed tomography for vascular exploration. Journal of angiogenesis research\| PubMed ID: 20298533	2010
VEGF receptor 2 endocytic trafficking regulates arterial morphogenesis. Developmental cell\| PubMed ID: 20434959	2010
Role of synectin in lymphatic development in zebrafish and frogs. Blood\| PubMed ID: 20631376	2010
Cell communications in the heart. Circulation\| PubMed ID: 20805439	2010
Auxiliary and autonomous proteoglycan signaling networks. Methods in enzymology\| PubMed ID: 20816202	2010
Phosphorylation of VE-cadherin controls endothelial phenotypes via p120-catenin coupling and Rac1 activation. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 21037229	2011
Antiangiogenic activity of rPAI-1(23) promotes vasa vasorum regression in hypercholesterolemic mice through a plasmin-dependent mechanism. Circulation research\| PubMed ID: 21546607	2011
FGF-dependent regulation of VEGF receptor 2 expression in mice. The Journal of clinical investigation\| PubMed ID: 21633168	2011
Development and application of a multimodal contrast agent for SPECT/CT hybrid imaging. Bioconjugate chemistry\| PubMed ID: 21851119	2011
Macrophage skewing by Phd2 haplodeficiency prevents ischaemia by inducing arteriogenesis. Nature\| PubMed ID: 21983962	2011
Endothelial-derived angiocrine signals induce and sustain regenerative lung alveolarization. Cell\| PubMed ID: 22036563	2011
VEGF signaling inside vascular endothelial cells and beyond. Current opinion in cell biology\| PubMed ID: 22366328	2012
ALK1 signaling inhibits angiogenesis by cooperating with the Notch pathway. Developmental cell\| PubMed ID: 22421041	2012
Syndecan 4 regulates FGFR1 signaling in endothelial cells by directing macropinocytosis. Science signaling\| PubMed ID: 22569333	2012
Fibroblast growth factor signaling potentiates VE-cadherin stability at adherens junctions by regulating SHP2. PloS one\| PubMed ID: 22629427	2012
"On-target" cardiac effects of anticancer drugs: lessons from new biology. Journal of the American College of Cardiology\| PubMed ID: 22703925	2012
Syndecan 4 regulation of PDK1-dependent Akt activation. Cellular signalling\| PubMed ID: 22975683	2013
Fibroblast growth factor-2 is required for vasa vasorum plexus stability in hypercholesterolemic mice. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 22982464	2012
Profilin phosphorylation as a VEGFR effector in angiogenesis. Nature cell biology\| PubMed ID: 23033049	2012
Endothelial nuclear factor-κB-dependent regulation of arteriogenesis and branching. Circulation\| PubMed ID: 23091063	2012
Endothelial deletion of murine Jag1 leads to valve calcification and congenital heart defects associated with Alagille syndrome. Development (Cambridge, England)\| PubMed ID: 23095891	2012
FGF regulates TGF-Î² signaling and endothelial-to-mesenchymal transition via control of let-7 miRNA expression. Cell reports\| PubMed ID: 23200853	2012
Endothelial ERK signaling controls lymphatic fate specification. The Journal of clinical investigation\| PubMed ID: 23391722	2013
The syndecan-4/protein kinase Cα pathway mediates prostaglandin E2-induced extracellular regulated kinase (ERK) activation in endothelial cells and angiogenesis in vivo. The Journal of biological chemistry\| PubMed ID: 23525101	2013
Endothelial RAF1/ERK activation regulates arterial morphogenesis. Blood\| PubMed ID: 23529931	2013
Dll4-Notch signaling determines the formation of native arterial collateral networks and arterial function in mouse ischemia models. Development (Cambridge, England)\| PubMed ID: 23533173	2013
Lymphatic fate determination: playing RAF with ERK. Cell cycle (Georgetown, Tex.)\| PubMed ID: 23549166	2013
The neuropilin 1 cytoplasmic domain is required for VEGF-A-dependent arteriogenesis. Developmental cell\| PubMed ID: 23639442	2013
Effects of cell grafting on coronary remodeling after myocardial infarction. Journal of the American Heart Association\| PubMed ID: 23723253	2013
VEGFR2 trafficking: speed doesn't kill. Cell cycle (Georgetown, Tex.)\| PubMed ID: 23803732	2013
Endothelial cell-dependent regulation of arteriogenesis. Circulation research\| PubMed ID: 23897694	2013
Physiology. Lymphatics are in my veins. Science (New York, N.Y.)\| PubMed ID: 23929973	2013
Need glucose to sprout: local metabolic control of angiogenesis. EMBO molecular medicine\| PubMed ID: 23982994	2013
Endothelial signaling and the molecular basis of arteriovenous malformation. Cellular and molecular life sciences : CMLS\| PubMed ID: 24077895	2013
Transmembrane protein ESDN promotes endothelial VEGF signaling and regulates angiogenesis. The Journal of clinical investigation\| PubMed ID: 24177422	2013
Angiopoietin-2 secretion by endothelial cell exosomes: regulation by the phosphatidylinositol 3-kinase (PI3K)/Akt/endothelial nitric oxide synthase (eNOS) and syndecan-4/syntenin pathways. The Journal of biological chemistry\| PubMed ID: 24235146	2014
Divergent angiocrine signals from vascular niche balance liver regeneration and fibrosis. Nature\| PubMed ID: 24256728	2014
Inter-cellular exchange of cellular components via VE-cadherin-dependent trans-endocytosis. PloS one\| PubMed ID: 24603875	2014
Angiocrine factors deployed by tumor vascular niche induce B cell lymphoma invasiveness and chemoresistance. Cancer cell\| PubMed ID: 24651014	2014
The docking protein FRS2α is a critical regulator of VEGF receptors signaling. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 24706887	2014
Receptor tyrosine kinases endocytosis in endothelium: biology and signaling. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 24925972	2014
Vasa vasorum in normal and diseased arteries. Circulation\| PubMed ID: 24934463	2014
Netrin-1 controls sympathetic arterial innervation. The Journal of clinical investigation\| PubMed ID: 24937433	2014
PTP1b is a physiologic regulator of vascular endothelial growth factor signaling in endothelial cells. Circulation\| PubMed ID: 24982127	2014
Flow-regulated lymphatic vasculature development and signaling. Vascular cell\| PubMed ID: 25053993	2014
Lymphatic fate specification: an ERK-controlled transcriptional program. Microvascular research\| PubMed ID: 25132472	2014
Endothelial Akt1 mediates angiogenesis by phosphorylating multiple angiogenic substrates. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 25136137	2014
Chemokine-coupled β2 integrin-induced macrophage Rac2-Myosin IIA interaction regulates VEGF-A mRNA stability and arteriogenesis. The Journal of experimental medicine\| PubMed ID: 25180062	2014
Fibroblast growth factor receptor 1 is a key inhibitor of TGFβ signaling in the endothelium. Science signaling\| PubMed ID: 25249657	2014
Fox(y) regulators of VEGF receptors. Circulation research\| PubMed ID: 25258399	2014
Up-regulation of thrombospondin-2 in Akt1-null mice contributes to compromised tissue repair due to abnormalities in fibroblast function. The Journal of biological chemistry\| PubMed ID: 25389299	2015
ELAVL1 regulates alternative splicing of eIF4E transporter to promote postnatal angiogenesis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 25422430	2014
Molecular controls of lymphatic VEGFR3 signaling. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 25524775	2015
Endothelial cell metabolism in normal and diseased vasculature. Circulation research\| PubMed ID: 25814684	2015
Cardiomyopathy and Worsened Ischemic Heart Failure in SM22-α Cre-Mediated Neuropilin-1 Null Mice: Dysregulation of PGC1α and Mitochondrial Homeostasis. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 25882068	2015
Angiogenesis versus arteriogenesis: neuropilin 1 modulation of VEGF signaling. F1000prime reports\| PubMed ID: 25926977	2015
Molecular controls of arterial morphogenesis. Circulation research\| PubMed ID: 25953926	2015
When it is better to regress: dynamics of vascular pruning. PLoS biology\| PubMed ID: 25978860	2015
Endothelial miR-17∼92 cluster negatively regulates arteriogenesis via miRNA-19 repression of WNT signaling. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 26417068	2015
Endothelial-to-mesenchymal transition drives atherosclerosis progression. The Journal of clinical investigation\| PubMed ID: 26517696	2015
When endothelial cells go rogue. EMBO molecular medicine\| PubMed ID: 26613939	2016
The expanding role of neuropilin: regulation of transforming growth factor-β and platelet-derived growth factor signaling in the vasculature. Current opinion in hematology\| PubMed ID: 26849476	2016
Smooth muscle FGF/TGFβ cross talk regulates atherosclerosis progression. EMBO molecular medicine\| PubMed ID: 27189169	2016
Sympathetic Innervation Promotes Arterial Fate by Enhancing Endothelial ERK Activity. Circulation research\| PubMed ID: 27354211	2016
Fibroblast growth factor (FGF) signaling regulates transforming growth factor beta (TGFβ)-dependent smooth muscle cell phenotype modulation. Scientific reports\| PubMed ID: 27634335	2016
Syndecan 4 controls lymphatic vasculature remodeling during mouse embryonic development. Development (Cambridge, England)\| PubMed ID: 27789626	2016
Modulation of VEGF receptor 2 signaling by protein phosphatases. Pharmacological research\| PubMed ID: 27888154	2017
The molecular basis of endothelial cell plasticity. Nature communications\| PubMed ID: 28181491	2017
Post-endocytic sorting of Plexin-D1 controls signal transduction and development of axonal and vascular circuits. Nature communications\| PubMed ID: 28224988	2017
FGF-dependent metabolic control of vascular development. Nature\| PubMed ID: 28467822	2017
SUMOylation Negatively Regulates Angiogenesis by Targeting Endothelial NOTCH Signaling. Circulation research\| PubMed ID: 28760777	2017
The Rab-effector protein RABEP2 regulates endosomal trafficking to mediate vascular endothelial growth factor receptor-2 (VEGFR2)-dependent signaling. The Journal of biological chemistry\| PubMed ID: 29425100	2018
Endothelial Cell Autonomous Role of Akt1: Regulation of Vascular Tone and Ischemia-Induced Arteriogenesis. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 29449333	2018
Reprogramming the Endocardium: Trials and Tribulations. Circulation research\| PubMed ID: 29599272	2018
Endothelial Metabolic Control of Lymphangiogenesis. BioEssays : news and reviews in molecular, cellular and developmental biology\| PubMed ID: 29750374	2018
Recent advances in understanding lymphangiogenesis and metabolism. F1000Research\| PubMed ID: 30079231	2018
Fibroblast growth factor-transforming growth factor beta dialogues, endothelial cell to mesenchymal transition, and atherosclerosis. Current opinion in lipidology\| PubMed ID: 30080704	2018
Lacteal junction zippering protects against diet-induced obesity. Science (New York, N.Y.)\| PubMed ID: 30093598	2018
SUMOylation of VEGFR2 regulates its intracellular trafficking and pathological angiogenesis. Nature communications\| PubMed ID: 30120232	2018
Metabolic Analysis of Lymphatic Endothelial Cells. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 30242770	2018
N-terminal syndecan-2 domain selectively enhances 6-O heparan sulfate chains sulfation and promotes VEGFA-dependent neovascularization. Nature communications\| PubMed ID: 30952866	2019
Publisher Correction: N-terminal syndecan-2 domain selectively enhances 6-O heparan sulfate chains sulfation and promotes VEGFA-dependent neovascularization. Nature communications\| PubMed ID: 31064993	2019
Endothelial ERK1/2 signaling maintains integrity of the quiescent endothelium. The Journal of experimental medicine\| PubMed ID: 31196980	2019
Author Correction: SUMOylation of VEGFR2 regulates its intracellular trafficking and pathological angiogenesis. Nature communications\| PubMed ID: 31417083	2019
Endothelial TGF-β signalling drives vascular inflammation and atherosclerosis. Nature metabolism\| PubMed ID: 31572976	2019
FRS2α-dependent cell fate transition during endocardial cushion morphogenesis. Developmental biology\| PubMed ID: 31669335	2020
Isoform-Specific Roles of ERK1 and ERK2 in Arteriogenesis. Cells\| PubMed ID: 31877781	2019
Resilience, disease and the age of single cell science. Aging\| PubMed ID: 32039835	2020
Smooth Muscle Cell Reprogramming in Aortic Aneurysms. Cell stem cell\| PubMed ID: 32243809	2020
Endothelial-to-Mesenchymal Transition, Vascular Inflammation, and Atherosclerosis. Frontiers in cardiovascular medicine\| PubMed ID: 32478094	2020
phenotype projection of endothelial ERK1/2 signaling. Aging\| PubMed ID: 32530820	2020
The quiescent endothelium: signalling pathways regulating organ-specific endothelial normalcy. Nature reviews. Cardiology\| PubMed ID: 33627876	2021
Developmental Perspectives on Arterial Fate Specification. Frontiers in cell and developmental biology\| PubMed ID: 34249941	2021
Emerging roles of PLCγ1 in endothelial biology. Science signaling\| PubMed ID: 34344833	2021
Role of Venous Endothelial Cells in Developmental and Pathologic Angiogenesis. Circulation\| PubMed ID: 34474596	2021
Fibroblast growth factors: the keepers of endothelial normalcy. The Journal of clinical investigation\| PubMed ID: 34623324	2021
Identification of driver genes for critical forms of COVID-19 in a deeply phenotyped young patient cohort. Science translational medicine\| PubMed ID: 34698500	2022
MEKK3-TGFβ crosstalk regulates inward arterial remodeling. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 34911761	2021
Endothelium-derived lactate is required for pericyte function and blood-brain barrier maintenance. The EMBO journal\| PubMed ID: 35243676	2022
Flow goes forward and cells step backward: endothelial migration. Experimental & molecular medicine\| PubMed ID: 35701563	2022
FGFR1 SUMOylation coordinates endothelial angiogenic signaling in angiogenesis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 35733256	2022
BMPR1A Promotes ID2-ZEB1 Interaction to Suppress Excessive Endothelial to Mesenchymal Transition. Cardiovascular research\| PubMed ID: 36166408	2022