Gerald B. Pier

Channing Laboratory, Harvard Medical School

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 8	2011

Other Publications

Article	Year
CFTR mutations and host susceptibility to Pseudomonas aeruginosa lung infection. Current opinion in microbiology\| PubMed ID: 11834374	2002
Construction and characterization of a live, attenuated aroA deletion mutant of Pseudomonas aeruginosa as a candidate intranasal vaccine. Infection and immunity\| PubMed ID: 11854239	2002
Lung infections associated with cystic fibrosis. Clinical microbiology reviews\| PubMed ID: 11932230	2002
Structural studies on the core and the O-polysaccharide repeating unit of Pseudomonas aeruginosa immunotype 1 lipopolysaccharide. European journal of biochemistry / FEBS\| PubMed ID: 11985598	2002
CFTR is a pattern recognition molecule that extracts Pseudomonas aeruginosa LPS from the outer membrane into epithelial cells and activates NF-kappa B translocation. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 11997458	2002
Immunochemical properties of the staphylococcal poly-N-acetylglucosamine surface polysaccharide. Infection and immunity\| PubMed ID: 12117954	2002
Salmonella enterica serovar typhi modulates cell surface expression of its receptor, the cystic fibrosis transmembrane conductance regulator, on the intestinal epithelium. Infection and immunity\| PubMed ID: 12379722	2002
Hypersusceptibility of cystic fibrosis mice to chronic Pseudomonas aeruginosa oropharyngeal colonization and lung infection. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12578988	2003
Protection against fatal Pseudomonas aeruginosa pneumonia in mice after nasal immunization with a live, attenuated aroA deletion mutant. Infection and immunity\| PubMed ID: 12595463	2003
Isolation, structural characterization, and immunological evaluation of a high-molecular-weight exopolysaccharide from Staphylococcus aureus. Carbohydrate research\| PubMed ID: 12681914	2003
Identification of a 5-nucleotide sequence that controls expression of the ica locus in Staphylococcus aureus and characterization of the DNA-binding properties of IcaR. Molecular microbiology\| PubMed ID: 12753184	2003
Construction and characterization of a Pseudomonas aeruginosa mucoid exopolysaccharide-alginate conjugate vaccine. Infection and immunity\| PubMed ID: 12819072	2003
Pseudomonas aeruginosa-induced apoptosis is defective in respiratory epithelial cells expressing mutant cystic fibrosis transmembrane conductance regulator. American journal of respiratory cell and molecular biology\| PubMed ID: 12878584	2003
Structure of the biological repeating unit of the O-antigen of Pseudomonas aeruginosa immunotype 4 containing both 2-acetamido-2,6-dideoxy-D-glucose and 2-acetamido-2,6-dideoxy-D-galactose. Carbohydrate research\| PubMed ID: 12892948	2003
Pseudomonas aeruginosa activates Cl- channels in host epithelial cells. PflÃ¼gers Archiv : European journal of physiology\| PubMed ID: 12920599	2003
Structure of the lipopolysaccharide of Pseudomonas aeruginosa O-12 with a randomly O-acetylated core region. Carbohydrate research\| PubMed ID: 12932374	2003
Transcription of quorum-sensing system genes in clinical and environmental isolates of Pseudomonas aeruginosa. Journal of bacteriology\| PubMed ID: 14645283	2003
Promises and pitfalls of Pseudomonas aeruginosa lipopolysaccharide as a vaccine antigen. Carbohydrate research\| PubMed ID: 14670716	2003
Localization of cystic fibrosis transmembrane conductance regulator to lipid rafts of epithelial cells is required for Pseudomonas aeruginosa-induced cellular activation. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 14688350	2004
Assessment of the role of antibiotics and enterococcal virulence factors in a mouse model of extraintestinal translocation. Critical care medicine\| PubMed ID: 14758165	2004
Meeting summary: possibilities for active and passive vaccination against opportunistic infections. Vaccine\| PubMed ID: 15040930	2004
Biologic properties and vaccine potential of the staphylococcal poly-N-acetyl glucosamine surface polysaccharide. Vaccine\| PubMed ID: 15040940	2004
The teicoplanin-associated locus regulator (TcaR) and the intercellular adhesin locus regulator (IcaR) are transcriptional inhibitors of the ica locus in Staphylococcus aureus. Journal of bacteriology\| PubMed ID: 15060048	2004
Intraspecific diversity of Yersinia pestis. Clinical microbiology reviews\| PubMed ID: 15084509	2004
The galU Gene of Pseudomonas aeruginosa is required for corneal infection and efficient systemic spread following pneumonia but not for infection confined to the lung. Infection and immunity\| PubMed ID: 15213167	2004
Human monoclonal antibodies to Pseudomonas aeruginosa alginate that protect against infection by both mucoid and nonmucoid strains. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 15494518	2004
Comparative evaluation of coagulase-negative staphylococci (CoNS) adherence to acrylic by a static method and a parallel-plate flow dynamic method. Research in microbiology\| PubMed ID: 15501653	2004
Hypoxia increases corneal cell expression of CFTR leading to increased Pseudomonas aeruginosa binding, internalization, and initiation of inflammation. Investigative ophthalmology & visual science\| PubMed ID: 15505057	2004
Temperature-dependent variations and intraspecies diversity of the structure of the lipopolysaccharide of Yersinia pestis. Biochemistry\| PubMed ID: 15683257	2005
Virulence of Pseudomonas aeruginosa in a murine model of gastrointestinal colonization and dissemination in neutropenia. Infection and immunity\| PubMed ID: 15784570	2005
Quantitative analysis of adhesion and biofilm formation on hydrophilic and hydrophobic surfaces of clinical isolates of Staphylococcus epidermidis. Research in microbiology\| PubMed ID: 15862449	2005
Cold temperature-induced modifications to the composition and structure of the lipopolysaccharide of Yersinia pestis. Carbohydrate research\| PubMed ID: 15907814	2005
Use of confocal microscopy to analyze the rate of vancomycin penetration through Staphylococcus aureus biofilms. Antimicrobial agents and chemotherapy\| PubMed ID: 15917548	2005
The relationship between inhibition of bacterial adhesion to a solid surface by sub-MICs of antibiotics and subsequent development of a biofilm. Research in microbiology\| PubMed ID: 15950124	2005
Comparative assessment of antibiotic susceptibility of coagulase-negative staphylococci in biofilm versus planktonic culture as assessed by bacterial enumeration or rapid XTT colorimetry. The Journal of antimicrobial chemotherapy\| PubMed ID: 15980094	2005
Nonmucoid Pseudomonas aeruginosa expresses alginate in the lungs of patients with cystic fibrosis and in a mouse model. The Journal of infectious diseases\| PubMed ID: 15995954	2005
Comparative opsonic and protective activities of Staphylococcus aureus conjugate vaccines containing native or deacetylated Staphylococcal Poly-N-acetyl-beta-(1-6)-glucosamine. Infection and immunity\| PubMed ID: 16177353	2005
Influence of cystic fibrosis transmembrane conductance regulator on gene expression in response to Pseudomonas aeruginosa infection of human bronchial epithelial cells. Infection and immunity\| PubMed ID: 16177360	2005
Poly-N-acetylglucosamine production in Staphylococcus aureus is essential for virulence in murine models of systemic infection. Infection and immunity\| PubMed ID: 16177366	2005
Intraspecies and temperature-dependent variations in susceptibility of Yersinia pestis to the bactericidal action of serum and to polymyxin B. Infection and immunity\| PubMed ID: 16239530	2005
The role of epitope specificity in the human opsonic antibody response to the staphylococcal surface polysaccharide poly N-acetyl glucosamine. The Journal of infectious diseases\| PubMed ID: 16267775	2005
Effects of growth in the presence of subinhibitory concentrations of dicloxacillin on Staphylococcus epidermidis and Staphylococcus haemolyticus biofilms. Applied and environmental microbiology\| PubMed ID: 16332862	2005
Structures of the core oligosaccharide and O-units in the R- and SR-type lipopolysaccharides of reference strains of Pseudomonas aeruginosa O-serogroups. FEMS immunology and medical microbiology\| PubMed ID: 16420601	2006
A live-attenuated Pseudomonas aeruginosa vaccine elicits outer membrane protein-specific active and passive protection against corneal infection. Infection and immunity\| PubMed ID: 16428743	2006
Characterization of the opsonic and protective activity against Staphylococcus aureus of fully human monoclonal antibodies specific for the bacterial surface polysaccharide poly-N-acetylgluc... Infection and immunity\| PubMed ID: 16622211	2006
Comparative antibody-mediated phagocytosis of Staphylococcus epidermidis cells grown in a biofilm or in the planktonic state. Infection and immunity\| PubMed ID: 16861673	2006
Synthesis of beta-(1-->6)-linked glucosamine oligosaccharides corresponding to fragments of the bacterial surface polysaccharide poly-N-acetylglucosamine. Carbohydrate research\| PubMed ID: 16952342	2007
Airway epithelial (nasal) cell monolayers used to study Pseudomonas aeruginosa invasion are hyperpolarized and not representative of the human airway epithelium. Infection and immunity\| PubMed ID: 17116966	2006
Inflammatory markers of lung disease in adult patients with cystic fibrosis. Pediatric pulmonology\| PubMed ID: 17245735	2007
Conserved and variable structural features in the lipopolysaccharide of Pseudomonas aeruginosa. Journal of endotoxin research\| PubMed ID: 17254386	2006
Is Pseudomonas aeruginosa exotoxin A a good carrier protein for conjugate vaccines? Human vaccines\| PubMed ID: 17268204	2007
Resistance to Pseudomonas aeruginosa chronic lung infection requires cystic fibrosis transmembrane conductance regulator-modulated interleukin-1 (IL-1) release and signaling through the IL-1... Infection and immunity\| PubMed ID: 17283089	2007
Intranasal immunization with heterologously expressed polysaccharide protects against multiple Pseudomonas aeruginosa infections. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17360574	2007
Effect of deletion of the lpxM gene on virulence and vaccine potential of Yersinia pestis in mice. Journal of medical microbiology\| PubMed ID: 17374882	2007
Protection against Escherichia coli infection by antibody to the Staphylococcus aureus poly-N-acetylglucosamine surface polysaccharide. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17446272	2007
Pseudomonas aeruginosa lipopolysaccharide: a major virulence factor, initiator of inflammation and target for effective immunity. International journal of medical microbiology : IJMM\| PubMed ID: 17466590	2007
Molecular basis for preferential protective efficacy of antibodies directed to the poorly acetylated form of staphylococcal poly-N-acetyl-beta-(1-6)-glucosamine. Infection and immunity\| PubMed ID: 17470540	2007
Host resistance to lung infection mediated by major vault protein in epithelial cells. Science (New York, N.Y.)\| PubMed ID: 17615361	2007
Relationship of the lipopolysaccharide structure of Yersinia pestis to resistance to antimicrobial factors. Advances in experimental medicine and biology\| PubMed ID: 17966406	2007
Vaccines and immunotherapy against Pseudomonas aeruginosa. Vaccine\| PubMed ID: 18242792	2008
Airway epithelial control of Pseudomonas aeruginosa infection in cystic fibrosis. Trends in molecular medicine\| PubMed ID: 18262467	2008
Mucosal damage and neutropenia are required for Candida albicans dissemination. PLoS pathogens\| PubMed ID: 18282097	2008
Wall teichoic acids are dispensable for anchoring the PNAG exopolysaccharide to the Staphylococcus aureus cell surface. Microbiology (Reading, England)\| PubMed ID: 18310032	2008
Disruption of CFTR-dependent lipid rafts reduces bacterial levels and corneal disease in a murine model of Pseudomonas aeruginosa keratitis. Investigative ophthalmology & visual science\| PubMed ID: 18326723	2008
Predictors of mucoid Pseudomonas colonization in cystic fibrosis patients. Pediatric pulmonology\| PubMed ID: 18361452	2008
Dropping acid to help cystic fibrosis. Nature medicine\| PubMed ID: 18391932	2008
ClpXP proteases positively regulate alginate overexpression and mucoid conversion in Pseudomonas aeruginosa. Microbiology (Reading, England)\| PubMed ID: 18599839	2008
Prophylactic and therapeutic efficacy of a fully human immunoglobulin G1 monoclonal antibody to Pseudomonas aeruginosa alginate in murine keratitis infection. Infection and immunity\| PubMed ID: 18644881	2008
On the greatly exaggerated reports of the death of infectious diseases. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America\| PubMed ID: 18800937	2008
IL-17 is a critical component of vaccine-induced protection against lung infection by lipopolysaccharide-heterologous strains of Pseudomonas aeruginosa. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 18802100	2008
First synthesis of pentasaccharide glycoform I of the outer core region of the Pseudomonas aeruginosa lipopolysaccharide. The Journal of organic chemistry\| PubMed ID: 18842026	2008
Cystic fibrosis transmembrane conductance regulator and caveolin-1 regulate epithelial cell internalization of Pseudomonas aeruginosa. American journal of physiology. Cell physiology\| PubMed ID: 19386787	2009
IL1B polymorphisms modulate cystic fibrosis lung disease. Pediatric pulmonology\| PubMed ID: 19431193	2009
Inactivation of the rhlA gene in Pseudomonas aeruginosa prevents rhamnolipid production, disabling the protection against polymorphonuclear leukocytes. APMIS : acta pathologica, microbiologica, et immunologica Scandinavica\| PubMed ID: 19594494	2009
The pgaABCD locus of Acinetobacter baumannii encodes the production of poly-beta-1-6-N-acetylglucosamine, which is critical for biofilm formation. Journal of bacteriology\| PubMed ID: 19633088	2009
Inescapable need for neutrophils as mediators of cellular innate immunity to acute Pseudomonas aeruginosa pneumonia. Infection and immunity\| PubMed ID: 19805527	2009
Role of neutrophils, MyD88-mediated neutrophil recruitment, and complement in antibody-mediated defense against Pseudomonas aeruginosa keratitis. Investigative ophthalmology & visual science\| PubMed ID: 19892865	2010
Analysis of acquisition of Pseudomonas aeruginosa gastrointestinal mucosal colonization and horizontal transmission in a murine model. The Journal of infectious diseases\| PubMed ID: 19938976	2010
Synthetic {beta}-(1->6)-linked N-acetylated and nonacetylated oligoglucosamines used to produce conjugate vaccines for bacterial pathogens. Infection and immunity\| PubMed ID: 19948836	2010
Caveolin-1 modifies the immunity to Pseudomonas aeruginosa. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 19949109	2010
Evaluation of flagella and flagellin of Pseudomonas aeruginosa as vaccines. Infection and immunity\| PubMed ID: 19995892	2010
Antibody-mediated enhancement of community-acquired methicillin-resistant Staphylococcus aureus infection. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20133867	2010
Antibiotic prophylaxis and recurrent urinary tract infection in children. The New England journal of medicine\| PubMed ID: 20175297	2010
Is exposure to mercury a driving force for the carriage of antibiotic resistance genes? Journal of medical microbiology\| PubMed ID: 20339018	2010
Alveolar inflammation in cystic fibrosis. Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society\| PubMed ID: 20347403	2010
Inhibition of macrophage migration inhibitory factor ameliorates ocular Pseudomonas aeruginosa-induced keratitis. PLoS pathogens\| PubMed ID: 20361053	2010
Lack of correlation between pulmonary disease and cystic fibrosis transmembrane conductance regulator dysfunction in cystic fibrosis: a case report. Journal of medical case reports\| PubMed ID: 20420703	2010
Animal and human antibodies to distinct Staphylococcus aureus antigens mutually neutralize opsonic killing and protection in mice. The Journal of clinical investigation\| PubMed ID: 20739753	2010
High levels of antibody to panton-valentine leukocidin are not associated with resistance to Staphylococcus aureus-associated skin and soft-tissue infection. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America\| PubMed ID: 20946065	2010
Mucosal vaccination with a multivalent, live-attenuated vaccine induces multifactorial immunity against Pseudomonas aeruginosa acute lung infection. Infection and immunity\| PubMed ID: 21149583	2011
Utility of in vivo transcription profiling for identifying Pseudomonas aeruginosa genes needed for gastrointestinal colonization and dissemination. PloS one\| PubMed ID: 21170272	2010
Synthesis of five nona-Î²-(1â†’6)-d-glucosamines with various patterns of N-acetylation corresponding to the fragments of exopolysaccharide of Staphylococcus aureus. Carbohydrate research\| PubMed ID: 21474120	2011
Efficacy of a conjugate vaccine containing polymannuronic acid and flagellin against experimental Pseudomonas aeruginosa lung infection in mice. Infection and immunity\| PubMed ID: 21628521	2011
Refers to: J.-P. Rasigade, N. Sicot, F. Laurent, G. Lina, F. Vandenesch, J. Etienne, A history of Panton-Valentine leukocidin (PVL)-associated infection protects against death in PVL-associa... Vaccine\| PubMed ID: 21821077	2011
NMR and conformational studies of linear and cyclic oligo-(1â†’6)-Î²-D-glucosamines. Carbohydrate research\| PubMed ID: 21945383	2011
Poly-N-Acetyl-Î²-(1-6)-Glucosamine Is a Target for Protective Immunity against Acinetobacter baumannii Infections. Infection and immunity\| PubMed ID: 22104104	2012