Karen Duff

Department of Pathology, Columbia University

Affiliated withColumbia University Columbia College

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 270	2008

Other Publications

Article	Year
Imaging brain amyloid of Alzheimer disease in vivo in transgenic mice with an Abeta peptide radiopharmaceutical. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 11823720	2002
Statin therapy for Alzheimer's disease: will it work? Journal of molecular neuroscience : MN\| PubMed ID: 12212773	2002
Cholesterol in Alzheimer's disease and tauopathy. Annals of the New York Academy of Sciences\| PubMed ID: 12480774	2002
Novel therapeutic approach for the treatment of Alzheimer's disease by peripheral administration of agents with an affinity to beta-amyloid. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 12514198	2003
Organotypic slice cultures from transgenic mice as disease model systems. Journal of molecular neuroscience : MN\| PubMed ID: 12540058	2002
Co-localization of cholesterol, apolipoprotein E and fibrillar Abeta in amyloid plaques. Brain research. Molecular brain research\| PubMed ID: 12573540	2003
Brain damage results in down-regulation of N-acetylaspartate as a neuronal osmolyte. Neuromolecular medicine\| PubMed ID: 12728192	2003
Use of in vivo models to study the role of cholesterol in the etiology of Alzheimer's disease. Neurochemical research\| PubMed ID: 12737522	2003
Cdk5 is a key factor in tau aggregation and tangle formation in vivo. Neuron\| PubMed ID: 12765608	2003
Presenilin redistribution associated with aberrant cholesterol transport enhances beta-amyloid production in vivo. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 12843267	2003
Hyperphosphorylation and aggregation of tau in mice expressing normal human tau isoforms. Journal of neurochemistry\| PubMed ID: 12859672	2003
Detection of Alzheimer's amyloid in transgenic mice using magnetic resonance microimaging. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine\| PubMed ID: 12876705	2003
Evidence for peripheral clearance of cerebral Abeta protein following chronic, active Abeta immunization in PSAPP mice. Neurobiology of disease\| PubMed ID: 13678662	2003
Changes in apolipoprotein E expression in response to dietary and pharmacological modulation of cholesterol. Journal of molecular neuroscience : MN\| PubMed ID: 14501024	2003
Rapid neurofibrillary tangle formation after localized gene transfer of mutated tau. The American journal of pathology\| PubMed ID: 14695347	2004
MRI assessment of neuropathology in a transgenic mouse model of Alzheimer's disease. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine\| PubMed ID: 15065253	2004
Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration. Neuron\| PubMed ID: 15066262	2004
Transgenic mouse models of Alzheimer's disease: how useful have they been for therapeutic development? Briefings in functional genomics & proteomics\| PubMed ID: 15163359	2004
Links between the pathology of Alzheimer's disease and vascular dementia. Neurochemical research\| PubMed ID: 15176482	2004
Development of Abeta terminal end-specific antibodies and sensitive ELISA for Abeta variant. Biochemical and biophysical research communications\| PubMed ID: 15184044	2004
Amyloid-beta deposition is associated with decreased hippocampal glucose metabolism and spatial memory impairment in APP/PS1 mice. Journal of neuropathology and experimental neurology\| PubMed ID: 15198121	2004
Rat transgenic models with a phenotype of intracellular Abeta accumulation in hippocampus and cortex. Journal of Alzheimer's disease : JAD\| PubMed ID: 15201476	2004
Mostly separate distributions of CLAC- versus Abeta40- or thioflavin S-reactivities in senile plaques reveal two distinct subpopulations of beta-amyloid deposits. The American journal of pathology\| PubMed ID: 15215182	2004
Brain on steroids resists neurodegeneration. Nature medicine\| PubMed ID: 15229510	2004
Presenilin mutations in familial Alzheimer disease and transgenic mouse models accelerate neuronal lysosomal pathology. Journal of neuropathology and experimental neurology\| PubMed ID: 15330337	2004
Visualization of beta-amyloid plaques in a transgenic mouse model of Alzheimer's disease using MR microscopy without contrast reagents. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine\| PubMed ID: 15334572	2004
Fibrillar amyloid deposition leads to local synaptic abnormalities and breakage of neuronal branches. Nature neuroscience\| PubMed ID: 15475950	2004
Inhibition of glycogen synthase kinase-3 by lithium correlates with reduced tauopathy and degeneration in vivo. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15867159	2005
Histological co-localization of iron in Abeta plaques of PS/APP transgenic mice. Neurochemical research\| PubMed ID: 15895823	2005
Cell-cycle reentry and cell death in transgenic mice expressing nonmutant human tau isoforms. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 15930395	2005
An Abeta sequestration approach using non-antibody Abeta binding agents. Current Alzheimer research\| PubMed ID: 15974928	2005
Dense-core plaques in Tg2576 and PSAPP mouse models of Alzheimer's disease are centered on vessel walls. The American journal of pathology\| PubMed ID: 16049337	2005
Untangling memory deficits. Nature medicine\| PubMed ID: 16079873	2005
Macroautophagy--a novel Beta-amyloid peptide-generating pathway activated in Alzheimer's disease. The Journal of cell biology\| PubMed ID: 16203860	2005
The amyloid pathology progresses in a neurotransmitter-specific manner. Neurobiology of aging\| PubMed ID: 16271419	2006
Using proteomics and network analysis to elucidate the consequences of synaptic protein oxidation in a PS1 + AbetaPP mouse model of Alzheimer's disease. Journal of Alzheimer's disease : JAD\| PubMed ID: 16340081	2005
The effects of ABCA1 on cholesterol efflux and Abeta levels in vitro and in vivo. Journal of neurochemistry\| PubMed ID: 16771834	2006
Cholesterol distribution, not total levels, correlate with altered amyloid precursor protein processing in statin-treated mice. Neuromolecular medicine\| PubMed ID: 16775383	2006
Normal and abnormal tau neurobiology. Alzheimer disease and associated disorders\| PubMed ID: 17132962	2006
Antibody against C-terminal Abeta selectively elevates plasma Abeta. Neuroreport\| PubMed ID: 17314674	2007
Anesthesia leads to tau hyperphosphorylation through inhibition of phosphatase activity by hypothermia. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 17376970	2007
Collapsin response mediator protein-2 hyperphosphorylation is an early event in Alzheimer's disease progression. Journal of neurochemistry\| PubMed ID: 17683481	2007
Increased dopaminergic neuron sensitivity to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in transgenic mice expressing mutant A53T alpha-synuclein. Neurochemical research\| PubMed ID: 17999181	2008
Insulin dysfunction induces in vivo tau hyperphosphorylation through distinct mechanisms. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 18077675	2007
Axonal transport rates in vivo are unaffected by tau deletion or overexpression in mice. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 18272688	2008
Interplay between cyclin-dependent kinase 5 and glycogen synthase kinase 3 beta mediated by neuregulin signaling leads to differential effects on tau phosphorylation and amyloid precursor pr... The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 18322105	2008
Transcriptional regulation of beta-secretase by p25/cdk5 leads to enhanced amyloidogenic processing. Neuron\| PubMed ID: 18341989	2008
Retromer deficiency observed in Alzheimer's disease causes hippocampal dysfunction, neurodegeneration, and Abeta accumulation. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18480253	2008
Females exhibit more extensive amyloid, but not tau, pathology in an Alzheimer transgenic model. Brain research\| PubMed ID: 18486110	2008
A transgenic rat that develops Alzheimer's disease-like amyloid pathology, deficits in synaptic plasticity and cognitive impairment. Neurobiology of disease\| PubMed ID: 18504134	2008
New directions for frontotemporal dementia drug discovery. Alzheimer's & dementia : the journal of the Alzheimer's Association\| PubMed ID: 18631953	2008
Is tau aggregation toxic or protective? Journal of Alzheimer's disease : JAD\| PubMed ID: 18688098	2008
Anesthesia-induced hyperphosphorylation detaches 3-repeat tau from microtubules without affecting their stability in vivo. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 19036972	2008
Linking Abeta and tau in late-onset Alzheimer's disease: a dual pathway hypothesis. Neuron\| PubMed ID: 19038212	2008
Noninvasive and transient blood-brain barrier opening in the hippocampus of Alzheimer's double transgenic mice using focused ultrasound. Ultrasonic imaging\| PubMed ID: 19149463	2008
Optical visualization of Alzheimer's pathology via multiphoton-excited intrinsic fluorescence and second harmonic generation. Optics express\| PubMed ID: 19259208	2009
Acceleration and persistence of neurofibrillary pathology in a mouse model of tauopathy following anesthesia. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 19279139	2009
Structure-activity relationship of cyanine tau aggregation inhibitors. Journal of medicinal chemistry\| PubMed ID: 19432420	2009
Inhibition of tau polymerization with a cyanine dye in two distinct model systems. The Journal of biological chemistry\| PubMed ID: 19478088	2009
Metabolic activity determines efficacy of macroautophagic clearance of pathological oligomeric alpha-synuclein. The American journal of pathology\| PubMed ID: 19628769	2009
Age-dependent impairment of cognitive and synaptic function in the htau mouse model of tau pathology. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 19710325	2009
Presenilins are enriched in endoplasmic reticulum membranes associated with mitochondria. The American journal of pathology\| PubMed ID: 19834068	2009
Lowering beta-amyloid levels rescues learning and memory in a Down syndrome mouse model. PloS one\| PubMed ID: 20532168	2010
Phenothiazine-mediated rescue of cognition in tau transgenic mice requires neuroprotection and reduced soluble tau burden. Molecular neurodegeneration\| PubMed ID: 21040568	2010
Phospholipase d2 ablation ameliorates Alzheimer's disease-linked synaptic dysfunction and cognitive deficits. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 21147981	2010
Modulation of ABCA1 by an LXR agonist reduces Î²-amyloid levels and improves outcome after traumatic brain injury. Journal of neurotrauma\| PubMed ID: 21175399	2011
The phospholipase D1 pathway modulates macroautophagy. Nature communications\| PubMed ID: 21266992	2010
Age and Î±-synuclein expression interact to reveal a dependence of dopaminergic axons on endogenous Akt/PKB signaling. Neurobiology of disease\| PubMed ID: 21782946	2011
Microarray analysis of CA1 pyramidal neurons in a mouse model of tauopathy reveals progressive synaptic dysfunction. Neurobiology of disease\| PubMed ID: 22079237	2012
Comparative lipidomic analysis of mouse and human brain with Alzheimer disease. The Journal of biological chemistry\| PubMed ID: 22134919	2012
Trans-synaptic spread of tau pathology in vivo. PloS one\| PubMed ID: 22312444	2012