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JoVE Journal
Biology

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A Technique for Serial Collection of Cerebrospinal Fluid from the Cisterna Magna in Mouse
 

A Technique for Serial Collection of Cerebrospinal Fluid from the Cisterna Magna in Mouse

Article DOI: 10.3791/960
November 10th, 2008

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Summary November 10th, 2008

Transgenic (Tg) mouse models of AD provide an excellent opportunity to investigate how and why Aβ or tau levels in CSF change as the disease progresses in human patients. Here, we demonstrate a refined cisterna magna puncture technique for serial CSF sampling from the mouse.

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