detrusor-underactivity-model-in-rats-by-conus-medullaris-transection

Detrusor Underactivity Model in Rats by Conus Medullaris Transection

The goal of the presented protocol was to establish a detrusor underactivity (DU) model in the rat through conus medullaris transection. Laminectomy was ...

Capital Medical University

To evaluate the efficacy of intermittent percutaneous posterior tibial nerve stimulation twice a week in Chinese female patients with interstitial cystitis.

Posterior tibial nerve stimulation twice a week in patients with interstitial cystitis.

We estimated the diagnostic accuracy of Abrams-Griffiths number (AG), urethral resistance factor (URA) and detrusor-adjusted mean passive urethral resistance relation factor (DAMPF) for bladder outlet obstruction (BOO) in benign prostate hyperplasia (BPH) patients.

The diagnostic accuracy and lower cutoff value of three methods for quantifying urethral resistance in men.

Activating mutations of the epidermal growth factor receptor (EGFR) confers sensitivity to tyrosine kinase inhibitors (TKIs). In colorectal cancer and in lung adenocarcinomas, clinical trials have shown a lack of response to anti-EGFR therapy when KRAS gene mutations are present. In this study, the mutation status of specified exons of the EGFR and KRAS genes was profiled in patients with prostate cancer (PCa). Direct Sanger sequencing was used to screen for mutations in exons 19-21 of EGFR and in exon 2 of KRAS in 88 Chinese patients diagnosed with prostate adenocarcinomas. Mutations were detected in 11 patients. In nine cases (10 %), activating mutations in the region of EGFR encoding the tyrosine kinase (TK) domain were present. Deletions in exon 19 and the L858R substitution in exon 21 were "hotspot" mutations, together accounting for five (55 %) of nine cases. Many synonymous substitutions were also detected. KRAS mutations were found in two cases (2.3 % of 88). There were no cases with mutations in both EGFR and KRAS, suggesting that mutations in the two genes might be mutually exclusive. Although prognostic relevance of EGFR expression by immunohistochemistry (IHC) was observed in PCa patients in previous studies, we found no statistically significant association between EGFR or KRAS mutations and clinicopathological features (including age, smoking status, preoperative prostate-specific antigen, Gleason scores, and tumor stage). We contend that accurate profiling of the mutation status of EGFR and KRAS could improve prognostic stratification, and we suggest a potential anti-EGFR therapy for patients with PCa with EGFR mutations.

Mutation status of somatic EGFR and KRAS genes in Chinese patients with prostate cancer (PCa).

To identify the risk factors in interstitial cystitis/painful bladder syndrome (IC/PBS) patients with lower urinary tract symptoms (LUTS) without urinary tract infection or benign prostate hyperplasia in China.

[Risk factors for interstitial cystitis/painful bladder syndrome in patients with lower urinary tract symptoms presenting for urologic care].

Sacral spinal cord injury (SCI) could induce underactive bladder (UAB). Malfunction of connexin 43 (CX43) regulated by TGF-β1 might involve in urinary bladder dysfunction. We studied the changes of CX43 and TGF-β1/Smad3 signaling in detrusor of neurogenic bladder (NB) in sacral SCI rats.

Article	Year
Posterior tibial nerve stimulation twice a week in patients with interstitial cystitis. Urology\| PubMed ID: 18372023	2008
The diagnostic accuracy and lower cutoff value of three methods for quantifying urethral resistance in men. Urologia internationalis\| PubMed ID: 20881362	2011
Mutation status of somatic EGFR and KRAS genes in Chinese patients with prostate cancer (PCa). Virchows Archiv : an international journal of pathology\| PubMed ID: 24595526	2014
[Risk factors for interstitial cystitis/painful bladder syndrome in patients with lower urinary tract symptoms presenting for urologic care]. Zhonghua yi xue za zhi\| PubMed ID: 24754986	2014
TGF-β1 and connexin-43 expression in neurogenic bladder from rats with sacral spinal cord injury. Neurourology and urodynamics\| PubMed ID: 30070388	2018

Jimao Zhao

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