Jennifer Herrmann

Helmholtz Institute for Pharmaceutical Research Saarland, Saarland University

Affiliated withSaarland University German Centre for Infection Research (DZIF)

Research Area

Biography

Jennifer studied chemistry at the Technical University Kaiserslautern and received her diploma in 2007. She worked as visiting scholar at Drug Discovery Ltd. in Glasgow before she moved to Saarland University, where she received her PhD in Pharmaceutical Biotechnology. Jennifer continued with post-doctoral research at the Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) and in parallel, worked as visiting scientist at the Luxembourg Centre for Systems Biomedicine on zebrafish assays for drug screening. She currently holds a position as senior scientist at HIPS. Jennifer’s main research interests are the characterization of newly isolated anti-infective natural products and their further development, including mode-of-action and mode-of-resistance studies with novel antibiotics and their pharmacological characterization.

JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 4	2020

Other Publications

Article	Year
Mining the cinnabaramide biosynthetic pathway to generate novel proteasome inhibitors. Chembiochem : a European journal of chemical biology\| PubMed ID: 21387511	2011
Pretubulysin: from hypothetical biosynthetic intermediate to potential lead in tumor therapy. PloS one\| PubMed ID: 22616003	2012
The interplay of lung surfactant proteins and lipids assimilates the macrophage clearance of nanoparticles. PloS one\| PubMed ID: 22802970	2012
Activity-guided screening of bioactive natural compounds implementing a new glucocorticoid-receptor-translocation assay and detection of new anti-inflammatory steroids from bacteria. Biotechnology letters\| PubMed ID: 22983717	2013
In vivo evidence for a prodrug activation mechanism during colibactin maturation. Chembiochem : a European journal of chemical biology\| PubMed ID: 23744512	2013
Synthesis and biological activities of the respiratory chain inhibitor aurachin D and new ring versus chain analogues. Beilstein journal of organic chemistry\| PubMed ID: 23946854	2013
Discovery and biological activity of new chondramides from Chondromyces sp. Chembiochem : a European journal of chemical biology\| PubMed ID: 23959765	2013
Heterologous expression of an orphan NRPS gene cluster from Paenibacillus larvae in Escherichia coli revealed production of sevadicin. Journal of biotechnology\| PubMed ID: 25529345	2015
Total syntheses and biological evaluation of miuraenamides. Angewandte Chemie (International ed. in English)\| PubMed ID: 25688545	2015
Biosynthetic Studies of Telomycin Reveal New Lipopeptides with Enhanced Activity. Journal of the American Chemical Society\| PubMed ID: 26043159	2015
Antibiotics. Targeting DnaN for tuberculosis therapy using novel griselimycins. Science (New York, N.Y.)\| PubMed ID: 26045430	2015
Squalenoylation of Chitosan: A Platform for Drug Delivery? Biomacromolecules\| PubMed ID: 26221873	2015
Rickenyls A-E, antioxidative terphenyls from the fungus Hypoxylon rickii (Xylariaceae, Ascomycota). Phytochemistry\| PubMed ID: 26296745	2015
Effects of Halide Ions on the Carbamidocyclophane Biosynthesis in Nostoc sp. CAVN2. Marine drugs\| PubMed ID: 26805858	2016
Genetic engineering and heterologous expression of the disorazol biosynthetic gene cluster via Red/ET recombineering. Scientific reports\| PubMed ID: 26875499	2016
Room temperature electrocompetent bacterial cells improve DNA transformation and recombineering efficiency. Scientific reports\| PubMed ID: 27095488	2016
Discovery of the first small-molecule CsrA-RNA interaction inhibitors using biophysical screening technologies. Future medicinal chemistry\| PubMed ID: 27253623	2016
Isolation, Structure Elucidation, and (Bio)Synthesis of Haprolid, a Cell-Type-Specific Myxobacterial Cytotoxin. Angewandte Chemie (International ed. in English)\| PubMed ID: 27404448	2016
Strategies for the Discovery and Development of New Antibiotics from Natural Products: Three Case Studies. Current topics in microbiology and immunology\| PubMed ID: 27738913	2016
Long-Chain Alkyl Cyanides: Unprecedented Volatile Compounds Released by Pseudomonas and Micromonospora Bacteria. Angewandte Chemie (International ed. in English)\| PubMed ID: 28276609	2017
First Bispecific Inhibitors of the Epidermal Growth Factor Receptor Kinase and the NF-κB Activity As Novel Anticancer Agents. Journal of medicinal chemistry\| PubMed ID: 28291344	2017
Novel and revisited approaches in antituberculosis drug discovery. Current opinion in biotechnology\| PubMed ID: 28427007	2017
Structure and Biosynthesis of Crocagins: Polycyclic Posttranslationally Modified Ribosomal Peptides from Chondromyces crocatus. Angewandte Chemie (International ed. in English)\| PubMed ID: 28544148	2017
Pyxipyrrolones: Structure Elucidation and Biosynthesis of Cytotoxic Myxobacterial Metabolites. Angewandte Chemie (International ed. in English)\| PubMed ID: 28590072	2017
The natural product carolacton inhibits folate-dependent C1 metabolism by targeting FolD/MTHFD. Nature communications\| PubMed ID: 29142318	2017
Oxygenated N-Acyl Alanine Methyl Esters (NAMEs) from the Marine Bacterium Roseovarius tolerans EL-164. Journal of natural products\| PubMed ID: 29261310	2018
A "Motif-Oriented" Total Synthesis of Nannocystin Ax. Preparation and Biological Assessment of Analogues. The Journal of organic chemistry\| PubMed ID: 29265814	2018
Biosynthesis of the Klebsiella oxytoca Pathogenicity Factor Tilivalline: Heterologous Expression, in Vitro Biosynthesis, and Inhibitor Development. ACS chemical biology\| PubMed ID: 29389112	2018
Octapeptins: Lipopeptide Antibiotics against Multidrug-Resistant Superbugs. Cell chemical biology\| PubMed ID: 29677485	2018
Activation of the NLRP3 Inflammasome by Hyaboron, a New Asymmetric Boron-Containing Macrodiolide from the Myxobacterium Hyalangium minutum. ACS chemical biology\| PubMed ID: 30183250	2018
Expressing cytotoxic compounds in Escherichia coli Nissle 1917 for tumor-targeting therapy. Research in microbiology\| PubMed ID: 30447257	2019
BAX/BAK-Induced Apoptosis Results in Caspase-8-Dependent IL-1β Maturation in Macrophages. Cell reports\| PubMed ID: 30485805	2018
-Acylated amino acid methyl esters from marine group bacteria. Beilstein journal of organic chemistry\| PubMed ID: 30591820	2018
An endothelial cell line infected by Kaposi's sarcoma-associated herpes virus (KSHV) allows the investigation of Kaposi's sarcoma and the validation of novel viral inhibitors in vitro and in... Journal of molecular medicine (Berlin, Germany)\| PubMed ID: 30610257	2019
Aurantimycin resistance genes contribute to survival of Listeria monocytogenes during life in the environment. Molecular microbiology\| PubMed ID: 30648305	2019
Tools for studying the metabolism of new psychoactive substances for toxicological screening purposes - A comparative study using pooled human liver S9, HepaRG cells, and zebrafish larvae. Toxicology letters\| PubMed ID: 30682400	2019
Engineering Atypical Tetracycline Formation in Amycolatopsis sulphurea for the Production of Modified Chelocardin Antibiotics. ACS chemical biology\| PubMed ID: 30747520	2019
Starch-Chitosan Polyplexes: A Versatile Carrier System for Anti-Infectives and Gene Delivery. Polymers\| PubMed ID: 30966288	2018
PLGA nanocapsules improve the delivery of clarithromycin to kill intracellular Staphylococcus aureus and Mycobacterium abscessus. Nanomedicine : nanotechnology, biology, and medicine\| PubMed ID: 31751769	2020
Search for hits and early leads from soil bacteria to combat infectious diseases. Journal of infection in developing countries\| PubMed ID: 31804999	2018
Setting Our Sights on Infectious Diseases. ACS infectious diseases\| PubMed ID: 31808676	2020
Semisynthesis and biological evaluation of amidochelocardin derivatives as broad-spectrum antibiotics. European journal of medicinal chemistry\| PubMed ID: 31911294	2020
Cystobactamid 507: Concise Synthesis, Mode of Action, and Optimization toward More Potent Antibiotics. Chemistry (Weinheim an der Bergstrasse, Germany)\| PubMed ID: 31984562	2020
The glucocorticoid-induced leucine zipper mediates statin-induced muscle damage. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 32030813	2020
Squalenyl Hydrogen Sulfate Nanoparticles for Simultaneous Delivery of Tobramycin and an Alkylquinolone Quorum Sensing Inhibitor Enable the Eradication of P. aeruginosa Biofilm Infections. Angewandte Chemie (International ed. in English)\| PubMed ID: 32243047	2020
Toxicokinetics and toxicodynamics of the fentanyl homologs cyclopropanoyl-1-benzyl-4´-fluoro-4-anilinopiperidine and furanoyl-1-benzyl-4-anilinopiperidine. Archives of toxicology\| PubMed ID: 32249346	2020
Protein-Templated Hit Identification through an Ugi Four-Component Reaction. Chemistry (Weinheim an der Bergstrasse, Germany)\| PubMed ID: 32428268	2020
How to Study the Metabolism of New Psychoactive Substances for the Purpose of Toxicological Screenings-A Follow-Up Study Comparing Pooled Human Liver S9, HepaRG Cells, and Zebrafish Larvae. Frontiers in chemistry\| PubMed ID: 32766204	2020
Amidochelocardin Overcomes Resistance Mechanisms Exerted on Tetracyclines and Natural Chelocardin. Antibiotics (Basel, Switzerland)\| PubMed ID: 32962088	2020
Drug Administration Routes Impact the Metabolism of a Synthetic Cannabinoid in the Zebrafish Larvae Model. Molecules (Basel, Switzerland)\| PubMed ID: 33003405	2020