Koji Okamoto

Devision of Cancer Differentiation, National Cancer Center Research Institute

Affiliated withNational Cancer Center Research Institute

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 1	2020

Other Publications

Article	Year
Functional role of Mdm2 phosphorylation by ATR in attenuation of p53 nuclear export. Oncogene\| PubMed ID: 14654783	2003
DNA damage-induced phosphorylation of MdmX at serine 367 activates p53 by targeting MdmX for Mdm2-dependent degradation. Molecular and cellular biology\| PubMed ID: 16227609	2005
Differential roles of ATM- and Chk2-mediated phosphorylations of Hdmx in response to DNA damage. Molecular and cellular biology\| PubMed ID: 16943424	2006
KAP1 dictates p53 response induced by chemotherapeutic agents via Mdm2 interaction. Biochemical and biophysical research communications\| PubMed ID: 17056014	2006
Hedgehog signaling overrides p53-mediated tumor suppression by activating Mdm2. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18359851	2008
Cytoplasmic tethering is involved in synergistic inhibition of p53 by Mdmx and Mdm2. Cancer science\| PubMed ID: 19432880	2009
Mdmx enhances p53 ubiquitination by altering the substrate preference of the Mdm2 ubiquitin ligase. FEBS letters\| PubMed ID: 19619542	2009
Functional screening using a microRNA virus library and microarrays: a new high-throughput assay to identify tumor-suppressive microRNAs. Carcinogenesis\| PubMed ID: 20525881	2010
Cancer susceptibility polymorphism of p53 at codon 72 affects phosphorylation and degradation of p53 protein. The Journal of biological chemistry\| PubMed ID: 21454683	2011
Tumor suppressor miR-22 determines p53-dependent cellular fate through post-transcriptional regulation of p21. Cancer research\| PubMed ID: 21565979	2011
Systematic exploration of cancer-associated microRNA through functional screening assays. Cancer science\| PubMed ID: 21668585	2011
Differential expression of nanog1 and nanogp8 in colon cancer cells. Biochemical and biophysical research communications\| PubMed ID: 22079639	2012
miR-493 induction during carcinogenesis blocks metastatic settlement of colon cancer cells in liver. The EMBO journal\| PubMed ID: 22373578	2012
Induction of the stem-like cell regulator CD44 by Rho kinase inhibition contributes to the maintenance of colon cancer-initiating cells. Cancer research\| PubMed ID: 23002207	2012
Genome engineering of mammalian haploid embryonic stem cells using the Cas9/RNA system. PeerJ\| PubMed ID: 24432195	2013
MKK7 mediates miR-493-dependent suppression of liver metastasis of colon cancer cells. Cancer science\| PubMed ID: 24533778	2014
Senescence-inducing stress promotes proteolysis of phosphoglycerate mutase via ubiquitin ligase Mdm2. The Journal of cell biology\| PubMed ID: 24567357	2014
Short hairpin RNA library-based functional screening identified ribosomal protein L31 that modulates prostate cancer cell growth via p53 pathway. PloS one\| PubMed ID: 25285958	2014
MicroRNA Library-Based Functional Screening Identified Androgen-Sensitive miR-216a as a Player in Bicalutamide Resistance in Prostate Cancer. Journal of clinical medicine\| PubMed ID: 26506397	2015
Establishment and Characterization of an In Vitro Model of Ovarian Cancer Stem-like Cells with an Enhanced Proliferative Capacity. Cancer research\| PubMed ID: 26669863	2016
TNIK inhibition abrogates colorectal cancer stemness. Nature communications\| PubMed ID: 27562646	2016
Genomic Landscape of Experimental Bladder Cancer in Rodents and Its Application to Human Bladder Cancer: Gene Amplification and Potential Overexpression of Cyp2a5/CYP2A6 Are Associated with ... PloS one\| PubMed ID: 27902773	2016
Tumor-derived spheroids: Relevance to cancer stem cells and clinical applications. Cancer science\| PubMed ID: 28064442	2017
Investigations in the possibility of early detection of colorectal cancer by gas chromatography/triple-quadrupole mass spectrometry. Oncotarget\| PubMed ID: 28179577	2017
Sox2-dependent inhibition of p21 is associated with poor prognosis of endometrial cancer. Cancer science\| PubMed ID: 28188685	2017
The Induction of Selected Wnt Target Genes by Tcf1 Mediates Generation of Tumorigenic Colon Stem Cells. Cell reports\| PubMed ID: 28467911	2017
Heterogeneity among -positive colon stem cells. Molecular & cellular oncology\| PubMed ID: 28868346	2017
Proteasome 26S subunit PSMD1 regulates breast cancer cell growth through p53 protein degradation. Journal of biochemistry\| PubMed ID: 28992264	2018
Semaphorin signaling via MICAL3 induces symmetric cell division to expand breast cancer stem-like cells. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 30587593	2019
Hormonal Regulation of Patient-Derived Endometrial Cancer Stem-like Cells Generated by Three-Dimensional Culture. Endocrinology\| PubMed ID: 31265065	2019
NOX1-Dependent mTORC1 Activation via S100A9 Oxidation in Cancer Stem-like Cells Leads to Colon Cancer Progression. Cell reports\| PubMed ID: 31365870	2019
N822K- or V560G-mutated KIT activation preferentially occurs in lipid rafts of the Golgi apparatus in leukemia cells. Cell communication and signaling : CCS\| PubMed ID: 31484543	2019
ALDH-Dependent Glycolytic Activation Mediates Stemness and Paclitaxel Resistance in Patient-Derived Spheroid Models of Uterine Endometrial Cancer. Stem cell reports\| PubMed ID: 31564647	2019
Slow-Cycling Cancer Stem Cells Regulate Progression and Chemoresistance in Colon Cancer. Cancer research\| PubMed ID: 32816913	2020