Stefan G. Sarafianos

Laboratory of Biochemical Pharmacology, Emory University School of Medicine

Affiliated withEmory University School of Medicine

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 6	2020

Other Publications

Article	Year
Multiplex single-cell visualization of nucleic acids and protein during HIV infection. Nature communications\| PubMed ID: 29192235	2017
4'-Ethynyl-2-fluoro-2'-deoxyadenosine, MK-8591: a novel HIV-1 reverse transcriptase translocation inhibitor. Current opinion in HIV and AIDS\| PubMed ID: 29697468	2018
Effect of tRNA on the Maturation of HIV-1 Reverse Transcriptase. Journal of molecular biology\| PubMed ID: 29751015	2018
6-Arylthio-3-hydroxypyrimidine-2,4-diones potently inhibited HIV reverse transcriptase-associated RNase H with antiviral activity. European journal of medicinal chemistry\| PubMed ID: 30031976	2018
6-Biphenylmethyl-3-hydroxypyrimidine-2,4-diones potently and selectively inhibited HIV reverse transcriptase-associated RNase H. European journal of medicinal chemistry\| PubMed ID: 30031978	2018
Antiretroviral potency of 4'-ethnyl-2'-fluoro-2'-deoxyadenosine, tenofovir alafenamide and second-generation NNRTIs across diverse HIV-1 subtypes. The Journal of antimicrobial chemotherapy\| PubMed ID: 30053052	2018
Structural Implications of Genotypic Variations in HIV-1 Integrase From Diverse Subtypes. Frontiers in microbiology\| PubMed ID: 30116231	2018
The High Genetic Barrier of EFdA/MK-8591 Stems from Strong Interactions with the Active Site of Drug-Resistant HIV-1 Reverse Transcriptase. Cell chemical biology\| PubMed ID: 30174310	2018
Identification of a Structural Element in HIV-1 Gag Required for Virus Particle Assembly and Maturation. mBio\| PubMed ID: 30327442	2018
Small Molecule Inhibitor that Stabilizes the Autoinhibited Conformation of the Oncogenic Tyrosine Phosphatase SHP2. Journal of medicinal chemistry\| PubMed ID: 30457860	2019
Strain-specific effect on biphasic DNA binding by HIV-1 integrase. AIDS (London, England)\| PubMed ID: 30475264	2019
Novel Hepatitis B Virus Capsid-Targeting Antiviral That Aggregates Core Particles and Inhibits Nuclear Entry of Viral Cores. ACS infectious diseases\| PubMed ID: 30582687	2019
CMCdG, a Novel Nucleoside Analog with Favorable Safety Features, Exerts Potent Activity against Wild-Type and Entecavir-Resistant Hepatitis B Virus. Antimicrobial agents and chemotherapy\| PubMed ID: 30670420	2019
Pharmacophore-based design of novel 3-hydroxypyrimidine-2,4-dione subtypes as inhibitors of HIV reverse transcriptase-associated RNase H: Tolerance of a nonflexible linker. European journal of medicinal chemistry\| PubMed ID: 30739822	2019
Novel Intersubunit Interaction Critical for HIV-1 Core Assembly Defines a Potentially Targetable Inhibitor Binding Pocket. mBio\| PubMed ID: 30862755	2019
Long-Acting Anti-HIV Drugs Targeting HIV-1 Reverse Transcriptase and Integrase. Pharmaceuticals (Basel, Switzerland)\| PubMed ID: 31010004	2019
Effects of Moloney Leukemia Virus 10 Protein on Hepatitis B Virus Infection and Viral Replication. Viruses\| PubMed ID: 31319455	2019
Conformational Changes in HIV-1 Reverse Transcriptase that Facilitate Its Maturation. Structure (London, England : 1993)\| PubMed ID: 31471129	2019
Determinants of Active-Site Inhibitor Interaction with HIV-1 RNase H. ACS infectious diseases\| PubMed ID: 31577424	2019
Visualization of Positive and Negative Sense Viral RNA for Probing the Mechanism of Direct-Acting Antivirals against Hepatitis C Virus. Viruses\| PubMed ID: 31717338	2019
Cutting into the Substrate Dominance: Pharmacophore and Structure-Based Approaches toward Inhibiting Human Immunodeficiency Virus Reverse Transcriptase-Associated Ribonuclease H. Accounts of chemical research\| PubMed ID: 31880912	2020
7-Deaza-7-fluoro modification confers on 4'-cyano-nucleosides potent activity against entecavir/adefovir-resistant HBV variants and favorable safety. Antiviral research\| PubMed ID: 32084506	2020
Toward Structurally Novel and Metabolically Stable HIV-1 Capsid-Targeting Small Molecules. Viruses\| PubMed ID: 32316297	2020
Feasibility of Known RNA Polymerase Inhibitors as Anti-SARS-CoV-2 Drugs. Pathogens (Basel, Switzerland)\| PubMed ID: 32357471	2020
Chemical profiling of HIV-1 capsid-targeting antiviral PF74. European journal of medicinal chemistry\| PubMed ID: 32438252	2020
Effect of P-body component Mov10 on HCV virus production and infectivity. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 32496609	2020
HIV-1 replication complexes accumulate in nuclear speckles and integrate into speckle-associated genomic domains. Nature communications\| PubMed ID: 32665593	2020
Novel HIV-1 capsid-targeting small molecules of the PF74 binding site. European journal of medicinal chemistry\| PubMed ID: 32814250	2020