Branden S. Moriarity

Department of Pediatrics, University of Minnesota

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 13	2020
Publication title	2025

Other Publications

Article	Year
Efficient non-viral integration and stable gene expression in multipotent adult progenitor cells. Stem cells international\| PubMed ID: 21977042	2011
Sex bias occurrence of hepatocellular carcinoma in Poly7 molecular subclass is associated with EGFR. Hepatology (Baltimore, Md.)\| PubMed ID: 22899566	2013
Conditional Inactivation of Pten with EGFR Overexpression in Schwann Cells Models Sporadic MPNST. Sarcoma\| PubMed ID: 23319880	2012
Modular assembly of transposon integratable multigene vectors using RecWay assembly. Nucleic acids research\| PubMed ID: 23444141	2013
Canonical Wnt/β-catenin signaling drives human schwann cell transformation, progression, and tumor maintenance. Cancer discovery\| PubMed ID: 23535903	2013
Forward genetic screen for malignant peripheral nerve sheath tumor formation identifies new genes and pathways driving tumorigenesis. Nature genetics\| PubMed ID: 23685747	2013
Simple and efficient methods for enrichment and isolation of endonuclease modified cells. PloS one\| PubMed ID: 24798371	2014
Trp53 haploinsufficiency modifies EGFR-driven peripheral nerve sheath tumorigenesis. The American journal of pathology\| PubMed ID: 24832557	2014
HomeRun Vector Assembly System: a flexible and standardized cloning system for assembly of multi-modular DNA constructs. PloS one\| PubMed ID: 24959875	2014
PVT1 dependence in cancer with MYC copy-number increase. Nature\| PubMed ID: 25043044	2014
Using RNA-seq and targeted nucleases to identify mechanisms of drug resistance in acute myeloid leukemia. Scientific reports\| PubMed ID: 25116387	2014
A Sleeping Beauty forward genetic screen identifies new genes and pathways driving osteosarcoma development and metastasis. Nature genetics\| PubMed ID: 25961939	2015
Sleeping Beauty transposon insertional mutagenesis based mouse models for cancer gene discovery. Current opinion in genetics & development\| PubMed ID: 26051241	2015
A Genome-Wide Scan Identifies Variants in NFIB Associated with Metastasis in Patients with Osteosarcoma. Cancer discovery\| PubMed ID: 26084801	2015
RNA sequencing of Sleeping Beauty transposon-induced tumors detects transposon-RNA fusions in forward genetic cancer screens. Genome research\| PubMed ID: 26553456	2016
Transposon mouse models to elucidate the genetic mechanisms of hepatitis B viral induced hepatocellular carcinoma. World journal of gastroenterology\| PubMed ID: 26576100	2015
Coping with cancer genes altered by copy number. Oncotarget\| PubMed ID: 26577648	2015
mTORC1 Coordinates Protein Synthesis and Immunoproteasome Formation via PRAS40 to Prevent Accumulation of Protein Stress. Molecular cell\| PubMed ID: 26876939	2016
RALB provides critical survival signals downstream of Ras in acute myeloid leukemia. Oncotarget\| PubMed ID: 27556501	2016
Using genome-wide CRISPR library screening with library resistant DCK to find new sources of Ara-C drug resistance in AML. Scientific reports\| PubMed ID: 27808171	2016
Slit-Robo GTPase-Activating Protein 2 as a metastasis suppressor in osteosarcoma. Scientific reports\| PubMed ID: 27966608	2016
Relative importance of β- and γ-actin in primary mouse embryonic fibroblasts. Molecular biology of the cell\| PubMed ID: 28077619	2017
Prosurvival long noncoding RNA regulates a subset of p53 targets in human colorectal cancer cells by binding to Matrin 3. eLife\| PubMed ID: 28580901	2017
Rapid generation of Col7a1 mouse model of recessive dystrophic epidermolysis bullosa and partial rescue via immunosuppressive dermal mesenchymal stem cells. Laboratory investigation; a journal of technical methods and pathology\| PubMed ID: 28892093	2017
A novel role for SALL4 during scar-free wound healing in axolotl. NPJ Regenerative medicine\| PubMed ID: 28955504	2016
Comparative Transcriptome Analysis Quantifies Immune Cell Transcript Levels, Metastatic Progression, and Survival in Osteosarcoma. Cancer research\| PubMed ID: 29066513	2018
CRISPR/Cas9 library screening for drug target discovery. Journal of human genetics\| PubMed ID: 29158600	2018
Human iPSC-Derived Natural Killer Cells Engineered with Chimeric Antigen Receptors Enhance Anti-tumor Activity. Cell stem cell\| PubMed ID: 30082067	2018
Engineering of Primary Human B cells with CRISPR/Cas9 Targeted Nuclease. Scientific reports\| PubMed ID: 30108345	2018
The Molecular Imaging of Natural Killer Cells. Molecular imaging\| PubMed ID: 30203710	2018
Highly multiplexed genome engineering using CRISPR/Cas9 gRNA arrays. PloS one\| PubMed ID: 30222773	2018
Screen Identifies and Other Genetic Drivers in Human B-cell Lymphoma. Molecular cancer research : MCR\| PubMed ID: 30355676	2019
Cancer Gene Discovery Utilizing Sleeping Beauty Transposon Mutagenesis. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 30542999	2019
Insertional Mutagenesis Reveals Important Genetic Drivers of Central Nervous System Embryonal Tumors. Cancer research\| PubMed ID: 30674530	2019
Identification of candidate neoantigens produced by fusion transcripts in human osteosarcomas. Scientific reports\| PubMed ID: 30674975	2019
HBx-K130M/V131I Promotes Liver Cancer in Transgenic Mice via AKT/FOXO1 Signaling Pathway and Arachidonic Acid Metabolism. Molecular cancer research : MCR\| PubMed ID: 30975706	2019
EditR: A Method to Quantify Base Editing from Sanger Sequencing. The CRISPR journal\| PubMed ID: 31021262	2018
Engineering Genetic Predisposition in Human Neuroepithelial Stem Cells Recapitulates Medulloblastoma Tumorigenesis. Cell stem cell\| PubMed ID: 31204176	2019
SEMA4C is a novel target to limit osteosarcoma growth, progression, and metastasis. Oncogene\| PubMed ID: 31582836	2020
A Genetically Engineered Primary Human Natural Killer Cell Platform for Cancer Immunotherapy. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 31704085	2020
Highly efficient multiplex human T cell engineering without double-strand breaks using Cas9 base editors. Nature communications\| PubMed ID: 31745080	2019
Author Correction: Highly efficient multiplex human T cell engineering without double-strand breaks using Cas9 base editors. Nature communications\| PubMed ID: 31811147	2019
CRISPR/Cas9-Mediated Genome Engineering of Primary Human B Cells. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 32006415	2020
PLX3397 treatment inhibits constitutive CSF1R-induced oncogenic ERK signaling, reduces tumor growth, and metastatic burden in osteosarcoma. Bone\| PubMed ID: 32251854	2020
Efficient targeted integration directed by short homology in zebrafish and mammalian cells. eLife\| PubMed ID: 32412410	2020
C-to-U RNA Editing: From Computational Detection to Experimental Validation. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 32729074	2021
Implication of ZNF217 in accelerating tumor development and therapeutically targeting ZNF217-induced PI3K-AKT signaling for the treatment of metastatic osteosarcoma. Molecular cancer therapeutics\| PubMed ID: 32999043	2020
The S-phase-induced lncRNA promotes cell proliferation by controlling YAP1/Hippo signaling pathway. eLife\| PubMed ID: 33108271	2020
Breast Tumor Kinase (Brk/PTK6) Mediates Advanced Cancer Phenotypes via SH2-Domain Dependent Activation of RhoA and Aryl Hydrocarbon Receptor (AhR) Signaling. Molecular cancer research : MCR\| PubMed ID: 33172975	2021
Genetic and epigenetic modification of human primary NK cells for enhanced antitumor activity. Seminars in hematology\| PubMed ID: 33256913
ZBTB20 regulates WNT/CTNNB1 signalling pathway by suppressing PPARG during hepatocellular carcinoma tumourigenesis. JHEP reports : innovation in hepatology\| PubMed ID: 33604532	2021
Transposon Mutagenesis-Guided CRISPR/Cas9 Screening Strongly Implicates Dysregulation of Hippo/YAP Signaling in Malignant Peripheral Nerve Sheath Tumor Development. Cancers\| PubMed ID: 33808166	2021
CRISPR-Cas9 cytidine and adenosine base editing of splice-sites mediates highly-efficient disruption of proteins in primary and immortalized cells. Nature communications\| PubMed ID: 33893286	2021
Engineering T cells to enhance 3D migration through structurally and mechanically complex tumor microenvironments. Nature communications\| PubMed ID: 33990566	2021
Nonviral genome engineering of natural killer cells. Stem cell research & therapy\| PubMed ID: 34134774	2021
Targeted genome editing for the correction or alleviation of primary Immunodeficiencies. Progress in molecular biology and translational science\| PubMed ID: 34175040	2021
MultiEditR: The first tool for the detection and quantification of RNA editing from Sanger sequencing demonstrates comparable fidelity to RNA-seq. Molecular therapy. Nucleic acids\| PubMed ID: 34589274	2021
A BAFF ligand-based CAR-T cell targeting three receptors and multiple B cell cancers. Nature communications\| PubMed ID: 35017485	2022
Primary B cell engineering for therapeutic research. Trends in molecular medicine\| PubMed ID: 35430120	2022
A dominant function of LynB kinase in preventing autoimmunity. Science advances\| PubMed ID: 35452291	2022
Myosin Heavy Chain Converter Domain Mutations Drive Early-Stage Changes in Extracellular Matrix Dynamics in Hypertrophic Cardiomyopathy. Frontiers in cell and developmental biology\| PubMed ID: 35784482	2022
Optimization and validation of CAR transduction into human primary NK cells using CRISPR and AAV. Cell reports methods\| PubMed ID: 35784645	2022
Correction of Fanconi Anemia Mutations Using Digital Genome Engineering. International journal of molecular sciences\| PubMed ID: 35955545	2022
Developing Bottom-Up Induced Pluripotent Stem Cell Derived Solid Tumor Models Using Precision Genome Editing Technologies. The CRISPR journal\| PubMed ID: 35972367	2022
Internal checkpoint regulates T cell neoantigen reactivity and susceptibility to PD1 blockade. Med (New York, N.Y.)\| PubMed ID: 36007524	2022
A Pan-RNase Inhibitor Enabling CRISPR-mRNA Platforms for Engineering of Primary Human Monocytes. International journal of molecular sciences\| PubMed ID: 36077152	2022
CRISPR-Cas9 base editors and their current role in human therapeutics. Cytotherapy\| PubMed ID: 36635153	2023
Germline T cell receptor exchange results in physiological T cell development and function. Nature communications\| PubMed ID: 36726009	2023
Ablation of SYK Kinase from Expanded Primary Human NK Cells via CRISPR/Cas9 Enhances Cytotoxicity and Cytokine Production. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 36881874	2023
Indirect CRISPR screening with photoconversion revealed key factors of drug resistance with cell-cell interactions. Communications biology\| PubMed ID: 37264057	2023
Transposon delivery for CRISPR-based loss-of-function screen in mice identifies NF2 as a cooperating gene involved with the canonical WNT signaling molecular class of hepatocellular carcinom... Heliyon\| PubMed ID: 37576222	2023
Cas9-induced targeted integration of large DNA payloads in primary human T cells via homology-mediated end-joining DNA repair. Nature biomedical engineering\| PubMed ID: 38092857	2024
Precision Enhancement of CAR-NK Cells through Non-Viral Engineering and Highly Multiplexed Base Editing. bioRxiv : the preprint server for biology\| PubMed ID: 38496503	2024
Evolution of the clinical-stage hyperactive TcBuster transposase as a platform for robust non-viral production of adoptive cellular therapies. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 38627969	2024
Development and testing of a versatile genome editing application reporter (V-GEAR) system. Molecular therapy. Methods & clinical development\| PubMed ID: 38764780	2024
Advancing gene targeting for primary immune deficiencies: Adenine base editing of the human IL2RG locus for correction of SCID-X1. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 38781958	2024
Engineering memory T cells as a platform for long-term enzyme replacement therapy in lysosomal storage disorders. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 39367605	2024
Efficient multiplex non-viral engineering and expansion of polyclonal γδ CAR-T cells for immunotherapy. bioRxiv : the preprint server for biology\| PubMed ID: 39464114	2024
Ablation of FAS confers allogeneic CD3 CAR T cells with resistance to rejection by T cells and natural killer cells. Nature biomedical engineering\| PubMed ID: 39558141	2024
CAR-T cell targeting three receptors on autoreactive B cells for systemic lupus erythematosus therapy. Journal of autoimmunity\| PubMed ID: 39832454	2025
A forward genetic screen identifies potassium channel essentiality in SHH medulloblastoma maintenance. Developmental cell\| PubMed ID: 39862856	2025
Osteosarcoma: A comprehensive review of model systems and experimental therapies. Medical research archives\| PubMed ID: 39916749	2024
Techniques for Validating CRISPR Changes Using RNA-Sequencing Data. Genes\| PubMed ID: 40282329	2025
Machine Learning Reveals Amine Type in Polymer Micelles Determines mRNA Binding, Performance for Lung-Selective Delivery. JACS Au\| PubMed ID: 40313817	2025
Targeting the intracellular immune checkpoint CISH with CRISPR-Cas9-edited T cells in patients with metastatic colorectal cancer: a first-in-human, single-centre, phase 1 trial. The Lancet. Oncology\| PubMed ID: 40315882	2025
Precision enhancement of CAR-NK cells through non-viral engineering and highly multiplexed base editing. Journal for immunotherapy of cancer\| PubMed ID: 40341025	2025