a-murine-model-ischemic-retinal-injury-induced-transient-bilateral

A Murine Model of Ischemic Retinal Injury Induced by Transient Bilateral Common Carotid Artery Occlusion

Diverse vascular diseases such as diabetic retinopathy, occlusion of retinal veins or arteries and ocular ischemic syndrome can lead to retinal ischemia. ...

Keio University School of Medicine

To evaluate visual function in patients with early presbyopia using the functional visual acuity (FVA) test.

Functional Visual Acuity of Early Presbyopia.

To investigate whether suppression of blue light can improve visual function in patients with short tear break up time (BUT) dry eye (DE).

Reducing Short-Wavelength Blue Light in Dry Eye Patients with Unstable Tear Film Improves Performance on Tests of Visual Acuity.

Prevalence of myopia is increasing worldwide. Outdoor activity is one of the most important environmental factors for myopia control. Here we show that violet light (VL, 360-400nm wavelength) suppresses myopia progression. First, we confirmed that VL suppressed the axial length (AL) elongation in the chick myopia model. Expression microarray analyses revealed that myopia suppressive gene EGR1 was upregulated by VL exposure. VL exposure induced significantly higher upregulation of EGR1 in chick chorioretinal tissues than blue light under the same conditions. Next, we conducted clinical research retrospectively to compare the AL elongation among myopic children who wore eyeglasses (VL blocked) and two types of contact lenses (partially VL blocked and VL transmitting). The data showed the VL transmitting contact lenses suppressed myopia progression most. These results suggest that VL is one of the important outdoor environmental factors for myopia control. Since VL is apt to be excluded from our modern society due to the excessive UV protection, VL exposure can be a preventive strategy against myopia progression.

Article	Year
Functional Visual Acuity of Early Presbyopia. PloS one\| PubMed ID: 26959362	2016
Reducing Short-Wavelength Blue Light in Dry Eye Patients with Unstable Tear Film Improves Performance on Tests of Visual Acuity. PloS one\| PubMed ID: 27045760	2016
Violet Light Exposure Can Be a Preventive Strategy Against Myopia Progression. EBioMedicine\| PubMed ID: 28063778	2017

Yusaku Katada

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