Michelle Sargent

Division of Molecular Cardiovascular Biology, Cincinnati Children's Hospital Medical Center

Affiliated withCincinnati Children's Hospital Medical Center

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 4	2021

Other Publications

Article	Year
Age-dependent effect of myostatin blockade on disease severity in a murine model of limb-girdle muscular dystrophy. The American journal of pathology\| PubMed ID: 16723712	2006
Cardiac myosin binding protein C phosphorylation is cardioprotective. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17075052	2006
Genetic disruption of calcineurin improves skeletal muscle pathology and cardiac disease in a mouse model of limb-girdle muscular dystrophy. The Journal of biological chemistry\| PubMed ID: 17289669	2007
Inducible and myocyte-specific inhibition of PKCalpha enhances cardiac contractility and protects against infarction-induced heart failure. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 17921332	2007
Cardiomyocyte GATA4 functions as a stress-responsive regulator of angiogenesis in the murine heart. The Journal of clinical investigation\| PubMed ID: 17975667	2007
Genetic and pharmacologic inhibition of mitochondrial-dependent necrosis attenuates muscular dystrophy. Nature medicine\| PubMed ID: 18345011	2008
DUSP6 (MKP3) null mice show enhanced ERK1/2 phosphorylation at baseline and increased myocyte proliferation in the heart affecting disease susceptibility. The Journal of biological chemistry\| PubMed ID: 18753132	2008
Genetic manipulation of periostin expression in the heart does not affect myocyte content, cell cycle activity, or cardiac repair. Circulation research\| PubMed ID: 19038863	2009
Cardiac myosin binding protein-C phosphorylation in a {beta}-myosin heavy chain background. Circulation\| PubMed ID: 19237661	2009
Plasma membrane Ca2+-ATPase isoform 4 antagonizes cardiac hypertrophy in association with calcineurin inhibition in rodents. The Journal of clinical investigation\| PubMed ID: 19287093	2009
ASK1 regulates cardiomyocyte death but not hypertrophy in transgenic mice. Circulation research\| PubMed ID: 19815822	2009
Genetic manipulation of dysferlin expression in skeletal muscle: novel insights into muscular dystrophy. The American journal of pathology\| PubMed ID: 19834057	2009
Calcineurin protects the heart in a murine model of dilated cardiomyopathy. Journal of molecular and cellular cardiology\| PubMed ID: 19854199	2010
Calcium influx is sufficient to induce muscular dystrophy through a TRPC-dependent mechanism. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19864620	2009
Genetic deletion of myostatin from the heart prevents skeletal muscle atrophy in heart failure. Circulation\| PubMed ID: 20065166	2010
Mitigation of muscular dystrophy in mice by SERCA overexpression in skeletal muscle. The Journal of clinical investigation\| PubMed ID: 21285509	2011
Decreased cardiac L-type CaÂ²âº channel activity induces hypertrophy and heart failure in mice. The Journal of clinical investigation\| PubMed ID: 22133878	2012
A thrombospondin-dependent pathway for a protective ER stress response. Cell\| PubMed ID: 22682248	2012
Bax and Bak function as the outer membrane component of the mitochondrial permeability pore in regulating necrotic cell death in mice. eLife\| PubMed ID: 23991283	2013
Enhanced Ca²⁺ influx from STIM1-Orai1 induces muscle pathology in mouse models of muscular dystrophy. Human molecular genetics\| PubMed ID: 24556214	2014
P38α MAPK underlies muscular dystrophy and myofiber death through a Bax-dependent mechanism. Human molecular genetics\| PubMed ID: 24876160	2014
Genetic Analysis of Connective Tissue Growth Factor as an Effector of Transforming Growth Factor β Signaling and Cardiac Remodeling. Molecular and cellular biology\| PubMed ID: 25870108	2015
Necroptosis Interfaces with MOMP and the MPTP in Mediating Cell Death. PloS one\| PubMed ID: 26061004	2015
The Mitochondrial Calcium Uniporter Selectively Matches Metabolic Output to Acute Contractile Stress in the Heart. Cell reports\| PubMed ID: 26119742	2015
STIM1 elevation in the heart results in aberrant Ca²⁺ handling and cardiomyopathy. Journal of molecular and cellular cardiology\| PubMed ID: 26241845	2015
Cardiac-specific deletion of protein phosphatase 1β promotes increased myofilament protein phosphorylation and contractile alterations. Journal of molecular and cellular cardiology\| PubMed ID: 26334248	2015
Dissection of Thrombospondin-4 Domains Involved in Intracellular Adaptive Endoplasmic Reticulum Stress-Responsive Signaling. Molecular and cellular biology\| PubMed ID: 26459760	2016
Genetic overexpression of Serpina3n attenuates muscular dystrophy in mice. Human molecular genetics\| PubMed ID: 26744329	2016
Cathepsin S Contributes to the Pathogenesis of Muscular Dystrophy in Mice. The Journal of biological chemistry\| PubMed ID: 26966179	2016
Thrombospondin expression in myofibers stabilizes muscle membranes. eLife\| PubMed ID: 27669143	2016
Nemo-Like Kinase (NLK) Is a Pathological Signaling Effector in the Mouse Heart. PloS one\| PubMed ID: 27764156	2016
Fibroblast-Specific Genetic Manipulation of p38 Mitogen-Activated Protein Kinase In Vivo Reveals Its Central Regulatory Role in Fibrosis. Circulation\| PubMed ID: 28356446	2017
Caveolae-localized L-type Ca2+ channels do not contribute to function or hypertrophic signalling in the mouse heart. Cardiovascular research\| PubMed ID: 28402392	2017
Mitsugumin 29 regulates t-tubule architecture in the failing heart. Scientific reports\| PubMed ID: 28706255	2017
TGFBI functions similar to periostin but is uniquely dispensable during cardiac injury. PloS one\| PubMed ID: 28750100	2017
Pharmacological and Activated Fibroblast Targeting of Gβγ-GRK2 After Myocardial Ischemia Attenuates Heart Failure Progression. Journal of the American College of Cardiology\| PubMed ID: 28818206	2017
Autophagic cell death is dependent on lysosomal membrane permeability through Bax and Bak. eLife\| PubMed ID: 29148970	2017
Inhibiting Fibronectin Attenuates Fibrosis and Improves Cardiac Function in a Model of Heart Failure. Circulation\| PubMed ID: 29653926	2018
Specialized fibroblast differentiated states underlie scar formation in the infarcted mouse heart. The Journal of clinical investigation\| PubMed ID: 29664017	2018
Defective Flux of Thrombospondin-4 through the Secretory Pathway Impairs Cardiomyocyte Membrane Stability and Causes Cardiomyopathy. Molecular and cellular biology\| PubMed ID: 29712757	2018
Genetic Lineage Tracing of Sca-1 Cells Reveals Endothelial but Not Myogenic Contribution to the Murine Heart. Circulation\| PubMed ID: 29991486	2018
Thrombospondin-3 augments injury-induced cardiomyopathy by intracellular integrin inhibition and sarcolemmal instability. Nature communications\| PubMed ID: 30622267	2019
ERK1/2 signaling induces skeletal muscle slow fiber-type switching and reduces muscular dystrophy disease severity. JCI insight\| PubMed ID: 30964448	2019
Disruption of valosin-containing protein activity causes cardiomyopathy and reveals pleiotropic functions in cardiac homeostasis. The Journal of biological chemistry\| PubMed ID: 31006653	2019
An acute immune response underlies the benefit of cardiac stem cell therapy. Nature\| PubMed ID: 31775156	2020
Cardiac Cell Therapy Rejuvenates the Infarcted Rodent Heart via Direct Injection but Not by Vascular Infusion. Circulation\| PubMed ID: 32202933	2020
MCUb Induction Protects the Heart From Postischemic Remodeling. Circulation research\| PubMed ID: 32299299	2020