Jeffery D. Molkentin

Division of Molecular Cardiovascular Biology, Cincinnati Children's Hospital Medical Center

Affiliated withCincinnati Children's Hospital Medical Center

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 4	2021

Other Publications

Article	Year
Redefining the roles of p38 and JNK signaling in cardiac hypertrophy: dichotomy between cultured myocytes and animal models. Journal of molecular and cellular cardiology\| PubMed ID: 14654364	2003
Genetic loss of calcineurin blocks mechanical overload-induced skeletal muscle fiber type switching but not hypertrophy. The Journal of biological chemistry\| PubMed ID: 15082723	2004
Calcineurin-NFAT signaling regulates the cardiac hypertrophic response in coordination with the MAPKs. Cardiovascular research\| PubMed ID: 15276472	2004
Calcium-calcineurin signaling in the regulation of cardiac hypertrophy. Biochemical and biophysical research communications\| PubMed ID: 15336966	2004
Cardiomyocytes fuse with surrounding noncardiomyocytes and reenter the cell cycle. The Journal of cell biology\| PubMed ID: 15492039	2004
STRESS signaling pathways that modulate cardiac myocyte apoptosis. Journal of molecular and cellular cardiology\| PubMed ID: 15623421	2005
Identification of a cooperative mechanism involving interleukin-13 and eotaxin-2 in experimental allergic lung inflammation. The Journal of biological chemistry\| PubMed ID: 15647285	2005
Direct and indirect interactions between calcineurin-NFAT and MEK1-extracellular signal-regulated kinase 1/2 signaling pathways regulate cardiac gene expression and cellular growth. Molecular and cellular biology\| PubMed ID: 15657416	2005
Regulation of calcineurin through transcriptional induction of the calcineurin A beta promoter in vitro and in vivo. Molecular and cellular biology\| PubMed ID: 16024800	2005
Inhibition of p38 reduces myocardial infarction injury in the mouse but not pig after ischemia-reperfusion. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 16143643	2005
The DnaJ-related factor Mrj interacts with nuclear factor of activated T cells c3 and mediates transcriptional repression through class II histone deacetylase recruitment. Molecular and cellular biology\| PubMed ID: 16260608	2005
Myocyte enhancer factors 2A and 2C induce dilated cardiomyopathy in transgenic mice. The Journal of biological chemistry\| PubMed ID: 16469744	2006
Dichotomy of Ca2+ in the heart: contraction versus intracellular signaling. The Journal of clinical investigation\| PubMed ID: 16511595	2006
Modulatory calcineurin-interacting proteins 1 and 2 function as calcineurin facilitators in vivo. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16648267	2006
Direct interaction and reciprocal regulation between ASK1 and calcineurin-NFAT control cardiomyocyte death and growth. Molecular and cellular biology\| PubMed ID: 16648474	2006
Age-dependent effect of myostatin blockade on disease severity in a murine model of limb-girdle muscular dystrophy. The American journal of pathology\| PubMed ID: 16723712	2006
Calcineurin-dependent cardiomyopathy is activated by TRPC in the adult mouse heart. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 16873889	2006
Pharmacological- and gene therapy-based inhibition of protein kinase Calpha/beta enhances cardiac contractility and attenuates heart failure. Circulation\| PubMed ID: 16880328	2006
Genetic disruption of calcineurin improves skeletal muscle pathology and cardiac disease in a mouse model of limb-girdle muscular dystrophy. The Journal of biological chemistry\| PubMed ID: 17289669	2007
Voltage-dependent anion channels are dispensable for mitochondrial-dependent cell death. Nature cell biology\| PubMed ID: 17417626	2007
Mediating ERK 1/2 signaling rescues congenital heart defects in a mouse model of Noonan syndrome. The Journal of clinical investigation\| PubMed ID: 17641779	2007
Ca2+- and mitochondrial-dependent cardiomyocyte necrosis as a primary mediator of heart failure. The Journal of clinical investigation\| PubMed ID: 17694179	2007
Genetic inhibition of cardiac ERK1/2 promotes stress-induced apoptosis and heart failure but has no effect on hypertrophy in vivo. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17709754	2007
Inducible and myocyte-specific inhibition of PKCalpha enhances cardiac contractility and protects against infarction-induced heart failure. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 17921332	2007
Cardiomyocyte GATA4 functions as a stress-responsive regulator of angiogenesis in the murine heart. The Journal of clinical investigation\| PubMed ID: 17975667	2007
Genetic and pharmacologic inhibition of mitochondrial-dependent necrosis attenuates muscular dystrophy. Nature medicine\| PubMed ID: 18345011	2008
Does contractile Ca2+ control calcineurin-NFAT signaling and pathological hypertrophy in cardiac myocytes? Science signaling\| PubMed ID: 18577756	2008
DUSP6 (MKP3) null mice show enhanced ERK1/2 phosphorylation at baseline and increased myocyte proliferation in the heart affecting disease susceptibility. The Journal of biological chemistry\| PubMed ID: 18753132	2008
Ca2+ influx through T- and L-type Ca2+ channels have different effects on myocyte contractility and induce unique cardiac phenotypes. Circulation research\| PubMed ID: 18832749	2008
With great power comes great responsibility: using mouse genetics to study cardiac hypertrophy and failure. Journal of molecular and cellular cardiology\| PubMed ID: 18845155	2009
Role of ERK1/2 signaling in congenital valve malformations in Noonan syndrome. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19017799	2008
Genetic manipulation of periostin expression in the heart does not affect myocyte content, cell cycle activity, or cardiac repair. Circulation research\| PubMed ID: 19038863	2009
Rcan1 negatively regulates Fc epsilonRI-mediated signaling and mast cell function. The Journal of experimental medicine\| PubMed ID: 19124655	2009
Interaction between TAK1-TAB1-TAB2 and RCAN1-calcineurin defines a signalling nodal control point. Nature cell biology\| PubMed ID: 19136967	2009
PKCalpha regulates platelet granule secretion and thrombus formation in mice. The Journal of clinical investigation\| PubMed ID: 19147982	2009
Cardiac myosin binding protein-C phosphorylation in a {beta}-myosin heavy chain background. Circulation\| PubMed ID: 19237661	2009
The mitochondrial permeability transition pore in motor neurons: involvement in the pathobiology of ALS mice. Experimental neurology\| PubMed ID: 19272377	2009
Plasma membrane Ca2+-ATPase isoform 4 antagonizes cardiac hypertrophy in association with calcineurin inhibition in rodents. The Journal of clinical investigation\| PubMed ID: 19287093	2009
Adenine nucleotide translocase-1 induces cardiomyocyte death through upregulation of the pro-apoptotic protein Bax. Journal of molecular and cellular cardiology\| PubMed ID: 19452617	2009
Periostin as a heterofunctional regulator of cardiac development and disease. Current genomics\| PubMed ID: 19516962	2008
Protein kinase C{alpha}, but not PKC{beta} or PKC{gamma}, regulates contractility and heart failure susceptibility: implications for ruboxistaurin as a novel therapeutic approach. Circulation research\| PubMed ID: 19556521	2009
CaMKII negatively regulates calcineurin-NFAT signaling in cardiac myocytes. Circulation research\| PubMed ID: 19608982	2009
Lack of periostin leads to suppression of Notch1 signaling and calcific aortic valve disease. Physiological genomics\| PubMed ID: 19723774	2009
Cdc42 is an antihypertrophic molecular switch in the mouse heart. The Journal of clinical investigation\| PubMed ID: 19741299	2009
ASK1 regulates cardiomyocyte death but not hypertrophy in transgenic mice. Circulation research\| PubMed ID: 19815822	2009
Genetic manipulation of dysferlin expression in skeletal muscle: novel insights into muscular dystrophy. The American journal of pathology\| PubMed ID: 19834057	2009
Blockade of Hsp20 phosphorylation exacerbates cardiac ischemia/reperfusion injury by suppressed autophagy and increased cell death. Circulation research\| PubMed ID: 19850943	2009
Calcineurin protects the heart in a murine model of dilated cardiomyopathy. Journal of molecular and cellular cardiology\| PubMed ID: 19854199	2010
Calcium influx is sufficient to induce muscular dystrophy through a TRPC-dependent mechanism. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19864620	2009
alpha1G-dependent T-type Ca2+ current antagonizes cardiac hypertrophy through a NOS3-dependent mechanism in mice. The Journal of clinical investigation\| PubMed ID: 19920353	2009
Heart-specific deletion of CnB1 reveals multiple mechanisms whereby calcineurin regulates cardiac growth and function. The Journal of biological chemistry\| PubMed ID: 20037164	2010
Genetic deletion of myostatin from the heart prevents skeletal muscle atrophy in heart failure. Circulation\| PubMed ID: 20065166	2010
Extracellular signal-regulated kinase 1/2 (ERK1/2) signaling in cardiac hypertrophy. Annals of the New York Academy of Sciences\| PubMed ID: 20201891	2010
TRPC channels are necessary mediators of pathologic cardiac hypertrophy. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20351294	2010
Apoptotic cell death "Nixed" by an ER-mitochondrial necrotic pathway. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20448198	2010
Functional divergence of platelet protein kinase C (PKC) isoforms in thrombus formation on collagen. The Journal of biological chemistry\| PubMed ID: 20479008	2010
Enhanced basal contractility but reduced excitation-contraction coupling efficiency and beta-adrenergic reserve of hearts with increased Cav1.2 activity. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 20543081	2010
Proteasome functional insufficiency activates the calcineurin-NFAT pathway in cardiomyocytes and promotes maladaptive remodelling of stressed mouse hearts. Cardiovascular research\| PubMed ID: 20601385	2010
The IP3 receptor regulates cardiac hypertrophy in response to select stimuli. Circulation research\| PubMed ID: 20616315	2010
Debio-025 is more effective than prednisone in reducing muscular pathology in mdx mice. Neuromuscular disorders : NMD\| PubMed ID: 20637615	2010
CIB1 is a regulator of pathological cardiac hypertrophy. Nature medicine\| PubMed ID: 20639889	2010
The transcription factor GATA-6 regulates pathological cardiac hypertrophy. Circulation research\| PubMed ID: 20705924	2010
The role of calcium/calmodulin-activated calcineurin in rapid and slow endocytosis at central synapses. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 20810903	2010
Research priorities in hypertrophic cardiomyopathy: report of a Working Group of the National Heart, Lung, and Blood Institute. Circulation\| PubMed ID: 20837938	2010
Cyclophilin D controls mitochondrial pore-dependent Ca(2+) exchange, metabolic flexibility, and propensity for heart failure in mice. The Journal of clinical investigation\| PubMed ID: 20890047	2010
Magnetic resonance imaging assessment of cardiac dysfunction in Î´-sarcoglycan null mice. Neuromuscular disorders : NMD\| PubMed ID: 20934875	2011
Protein kinase Cα as a heart failure therapeutic target. Journal of molecular and cellular cardiology\| PubMed ID: 20937286	2011
Monophosphothreonyl extracellular signal-regulated kinases 1 and 2 (ERK1/2) are formed endogenously in intact cardiac myocytes and are enzymically active. Cellular signalling\| PubMed ID: 21044683	2011
Calcium influx through Cav1.2 is a proximal signal for pathological cardiomyocyte hypertrophy. Journal of molecular and cellular cardiology\| PubMed ID: 21111744	2011
GATA6 promotes angiogenic function and survival in endothelial cells by suppression of autocrine transforming growth factor beta/activin receptor-like kinase 5 signaling. The Journal of biological chemistry\| PubMed ID: 21127043	2011
Extracellular signal-regulated kinases 1 and 2 regulate the balance between eccentric and concentric cardiac growth. Circulation research\| PubMed ID: 21127295	2011
Molecular pathways underlying cardiac remodeling during pathophysiological stimulation. Circulation\| PubMed ID: 21173361	2010
TRPC channels as effectors of cardiac hypertrophy. Circulation research\| PubMed ID: 21252153	2011
Mitigation of muscular dystrophy in mice by SERCA overexpression in skeletal muscle. The Journal of clinical investigation\| PubMed ID: 21285509	2011
The transcription factor C/EBPbeta serves as a master regulator of physiologic cardiac hypertrophy. Circulation research\| PubMed ID: 21293006	2011
Moderate calcium channel dysfunction in adult mice with inducible cardiomyocyte-specific excision of the cacnb2 gene. The Journal of biological chemistry\| PubMed ID: 21357697	2011
Mechanisms of necroptosis in T cells. The Journal of experimental medicine\| PubMed ID: 21402742	2011
Dysfunctional ryanodine receptor and cardiac hypertrophy: role of signaling molecules. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 21421818	2011
Myostatin from the heart: local and systemic actions in cardiac failure and muscle wasting. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 21421824	2011
Modulation of chromatin position and gene expression by HDAC4 interaction with nucleoporins. The Journal of cell biology\| PubMed ID: 21464227	2011
A critical function for Ser-282 in cardiac Myosin binding protein-C phosphorylation and cardiac function. Circulation research\| PubMed ID: 21597010	2011
Unraveling the secrets of a double life: contractile versus signaling Ca2+ in a cardiac myocyte. Journal of molecular and cellular cardiology\| PubMed ID: 21600216	2012
Regulation of angiogenesis by a non-canonical Wnt-Flt1 pathway in myeloid cells. Nature\| PubMed ID: 21623369	2011
Placental growth factor regulates cardiac adaptation and hypertrophy through a paracrine mechanism. Circulation research\| PubMed ID: 21636802	2011
Tinman/Nkx2-5 acts via miR-1 and upstream of Cdc42 to regulate heart function across species. The Journal of cell biology\| PubMed ID: 21690310	2011
Serine 105 phosphorylation of transcription factor GATA4 is necessary for stress-induced cardiac hypertrophy in vivo. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21746915	2011
RhoA protects the mouse heart against ischemia/reperfusion injury. The Journal of clinical investigation\| PubMed ID: 21747165	2011
The permeability transition pore controls cardiac mitochondrial maturation and myocyte differentiation. Developmental cell\| PubMed ID: 21920313	2011
Inhibition of PKCÎ±/Î² with ruboxistaurin antagonizes heart failure in pigs after myocardial infarction injury. Circulation research\| PubMed ID: 21998327	2011
Decreased cardiac L-type CaÂ²âº channel activity induces hypertrophy and heart failure in mice. The Journal of clinical investigation\| PubMed ID: 22133878	2012
Pharmacological and genetic inhibition of calcineurin protects against carbachol-induced pathological zymogen activation and acinar cell injury. American journal of physiology. Gastrointestinal and liver physiology\| PubMed ID: 22323127	2012
Interaction between NFκB and NFAT coordinates cardiac hypertrophy and pathological remodeling. Circulation research\| PubMed ID: 22403241	2012
A thrombospondin-dependent pathway for a protective ER stress response. Cell\| PubMed ID: 22682248	2012
Placental growth factor as a protective paracrine effector in the heart. Trends in cardiovascular medicine\| PubMed ID: 22902069	2011
Constitutively active MEK1 rescues cardiac dysfunction caused by overexpressed GSK-3α during aging and hemodynamic pressure overload. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 22904158	2012
Lost in transgenesis: a user's guide for genetically manipulating the mouse in cardiac research. Circulation research\| PubMed ID: 22935533	2012
Sarcolipin is a newly identified regulator of muscle-based thermogenesis in mammals. Nature medicine\| PubMed ID: 22961106	2012
Unrestrained p38 MAPK activation in Dusp1/4 double-null mice induces cardiomyopathy. Circulation research\| PubMed ID: 22993413	2013
A TRPC6-dependent pathway for myofibroblast transdifferentiation and wound healing in vivo. Developmental cell\| PubMed ID: 23022034	2012
Is p53 the long-sought molecular trigger for cyclophilin D-regulated mitochondrial permeability transition pore formation and necrosis? Circulation research\| PubMed ID: 23104876	2012
Bile acids induce pancreatic acinar cell injury and pancreatitis by activating calcineurin. The Journal of biological chemistry\| PubMed ID: 23148215	2013
Mutual antagonism between IP(3)RII and miRNA-133a regulates calcium signals and cardiac hypertrophy. The Journal of cell biology\| PubMed ID: 23166348	2012
Molecular basis of physiological heart growth: fundamental concepts and new players. Nature reviews. Molecular cell biology\| PubMed ID: 23258295	2013
Signaling effectors underlying pathologic growth and remodeling of the heart. The Journal of clinical investigation\| PubMed ID: 23281408	2013
Physiologic functions of cyclophilin D and the mitochondrial permeability transition pore. Circulation journal : official journal of the Japanese Circulation Society\| PubMed ID: 23538482	2013
CaMKII does it again: even the mitochondria cannot escape its influence. Circulation research\| PubMed ID: 23620234	2013
Parsing good versus bad signaling pathways in the heart: role of calcineurin-nuclear factor of activated T-cells. Circulation research\| PubMed ID: 23788503	2013
Bax and Bak function as the outer membrane component of the mitochondrial permeability pore in regulating necrotic cell death in mice. eLife\| PubMed ID: 23991283	2013
Differential expression of embryonic epicardial progenitor markers and localization of cardiac fibrosis in adult ischemic injury and hypertensive heart disease. Journal of molecular and cellular cardiology\| PubMed ID: 24140724	2013
Myofibroblasts: trust your heart and let fate decide. Journal of molecular and cellular cardiology\| PubMed ID: 24189039	2014
Overexpression of the Na+/K+ ATPase α2 but not α1 isoform attenuates pathological cardiac hypertrophy and remodeling. Circulation research\| PubMed ID: 24218169	2014
Apoptosis repressor with a CARD domain (ARC) restrains Bax-mediated pathogenesis in dystrophic skeletal muscle. PloS one\| PubMed ID: 24312627	2013
Parsing the roles of the transcription factors GATA-4 and GATA-6 in the adult cardiac hypertrophic response. PloS one\| PubMed ID: 24391969	2013
Response to Torella et al. Circulation research\| PubMed ID: 24526680	2014
Enhanced Ca²⁺ influx from STIM1-Orai1 induces muscle pathology in mouse models of muscular dystrophy. Human molecular genetics\| PubMed ID: 24556214	2014
Genetic manipulation of the cardiac mitochondrial phosphate carrier does not affect permeability transition. Journal of molecular and cellular cardiology\| PubMed ID: 24768964	2014
c-kit+ cells minimally contribute cardiomyocytes to the heart. Nature\| PubMed ID: 24805242	2014
Repression of cyclin D1 expression is necessary for the maintenance of cell cycle exit in adult mammalian cardiomyocytes. The Journal of biological chemistry\| PubMed ID: 24821722	2014
P38α MAPK underlies muscular dystrophy and myofiber death through a Bax-dependent mechanism. Human molecular genetics\| PubMed ID: 24876160	2014
Identifying the components of the elusive mitochondrial permeability transition pore. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 25002521	2014
Transient receptor potential channels contribute to pathological structural and functional remodeling after myocardial infarction. Circulation research\| PubMed ID: 25047165	2014
Excess SMAD signaling contributes to heart and muscle dysfunction in muscular dystrophy. Human molecular genetics\| PubMed ID: 25070948	2014
Sumo E2 enzyme UBC9 is required for efficient protein quality control in cardiomyocytes. Circulation research\| PubMed ID: 25097219	2014
Myofiber-specific inhibition of TGFβ signaling protects skeletal muscle from injury and dystrophic disease in mice. Human molecular genetics\| PubMed ID: 25106553	2014
Letter by Molkentin regarding article, "The absence of evidence is not evidence of absence: the pitfalls of Cre Knock-Ins in the c-Kit Locus". Circulation research\| PubMed ID: 25258403	2014
Transforming growth factor β-activated kinase 1 signaling pathway critically regulates myocardial survival and remodeling. Circulation\| PubMed ID: 25278099	2014
The β isoform of the catalytic subunit of protein phosphatase 2B restrains platelet function by suppressing outside-in αII b β3 integrin signaling. Journal of thrombosis and haemostasis : JTH\| PubMed ID: 25330904	2014
RhoA signaling in cardiomyocytes protects against stress-induced heart failure but facilitates cardiac fibrosis. Science signaling\| PubMed ID: 25336613	2014
Targeting latent TGFβ release in muscular dystrophy. Science translational medicine\| PubMed ID: 25338755	2014
An emerging consensus on cardiac regeneration. Nature medicine\| PubMed ID: 25473919	2014
Physiological and pathological roles of the mitochondrial permeability transition pore in the heart. Cell metabolism\| PubMed ID: 25651175	2015
SERCA1 overexpression minimizes skeletal muscle damage in dystrophic mouse models. American journal of physiology. Cell physiology\| PubMed ID: 25652448	2015
Sarcolipin overexpression improves muscle energetics and reduces fatigue. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 25701006	2015
Genetic Analysis of Connective Tissue Growth Factor as an Effector of Transforming Growth Factor β Signaling and Cardiac Remodeling. Molecular and cellular biology\| PubMed ID: 25870108	2015
Exposure to Radiocontrast Agents Induces Pancreatic Inflammation by Activation of Nuclear Factor-κB, Calcium Signaling, and Calcineurin. Gastroenterology\| PubMed ID: 25980752	2015
Regulated necrotic cell death: the passive aggressive side of Bax and Bak. Circulation research\| PubMed ID: 25999420	2015
Necroptosis Interfaces with MOMP and the MPTP in Mediating Cell Death. PloS one\| PubMed ID: 26061004	2015
The Mitochondrial Calcium Uniporter Selectively Matches Metabolic Output to Acute Contractile Stress in the Heart. Cell reports\| PubMed ID: 26119742	2015
STIM1 elevation in the heart results in aberrant Ca²⁺ handling and cardiomyopathy. Journal of molecular and cellular cardiology\| PubMed ID: 26241845	2015
Cardiac-specific deletion of protein phosphatase 1β promotes increased myofilament protein phosphorylation and contractile alterations. Journal of molecular and cellular cardiology\| PubMed ID: 26334248	2015
Calcineurin Links Mitochondrial Elongation with Energy Metabolism. Cell metabolism\| PubMed ID: 26411342	2015
Dissection of Thrombospondin-4 Domains Involved in Intracellular Adaptive Endoplasmic Reticulum Stress-Responsive Signaling. Molecular and cellular biology\| PubMed ID: 26459760	2016
TAK1 Regulates Myocardial Response to Pathological Stress via NFAT, NFκB, and Bnip3 Pathways. Scientific reports\| PubMed ID: 26564789	2015
Deletion of Periostin Protects Against Atherosclerosis in Mice by Altering Inflammation and Extracellular Matrix Remodeling. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 26564821	2016
Persistent increases in Ca(2+) influx through Cav1.2 shortens action potential and causes Ca(2+) overload-induced afterdepolarizations and arrhythmias. Basic research in cardiology\| PubMed ID: 26611208	2016
MBNL1-mediated regulation of differentiation RNAs promotes myofibroblast transformation and the fibrotic response. Nature communications\| PubMed ID: 26670661	2015
Individual Cardiac Mitochondria Undergo Rare Transient Permeability Transition Pore Openings. Circulation research\| PubMed ID: 26712344	2016
Genetic overexpression of Serpina3n attenuates muscular dystrophy in mice. Human molecular genetics\| PubMed ID: 26744329	2016
Most of the Dust Has Settled: cKit+ Progenitor Cells Are an Irrelevant Source of Cardiac Myocytes In Vivo. Circulation research\| PubMed ID: 26837741	2016
Cyclophilin D regulates necrosis, but not apoptosis, of murine eosinophils. American journal of physiology. Gastrointestinal and liver physiology\| PubMed ID: 26893161	2016
Cathepsin S Contributes to the Pathogenesis of Muscular Dystrophy in Mice. The Journal of biological chemistry\| PubMed ID: 26966179	2016
A Tension-Based Model Distinguishes Hypertrophic versus Dilated Cardiomyopathy. Cell\| PubMed ID: 27114035	2016
DUSP8 Regulates Cardiac Ventricular Remodeling by Altering ERK1/2 Signaling. Circulation research\| PubMed ID: 27225478	2016
Genetic lineage tracing defines myofibroblast origin and function in the injured heart. Nature communications\| PubMed ID: 27447449	2016
Inositol 1,4,5-trisphosphate-mediated sarcoplasmic reticulum-mitochondrial crosstalk influences adenosine triphosphate production via mitochondrial Ca2+ uptake through the mitochondrial ryan... Cardiovascular research\| PubMed ID: 27496868	2016
Regulation of cardiac hypertrophy and remodeling through the dual-specificity MAPK phosphatases (DUSPs). Journal of molecular and cellular cardiology\| PubMed ID: 27575022	2016
Thrombospondin 1 protects pancreatic β-cells from lipotoxicity via the PERK-NRF2 pathway. Cell death and differentiation\| PubMed ID: 27588705	2016
Thrombospondin expression in myofibers stabilizes muscle membranes. eLife\| PubMed ID: 27669143	2016
Nemo-Like Kinase (NLK) Is a Pathological Signaling Effector in the Mouse Heart. PloS one\| PubMed ID: 27764156	2016
RCANs regulate the convergent roles of NFATc1 in bone homeostasis. Scientific reports\| PubMed ID: 27917924	2016
The Elusive Progenitor Cell in Cardiac Regeneration: Slip Slidin' Away. Circulation research\| PubMed ID: 28104772	2017
Fibroblast-Specific Genetic Manipulation of p38 Mitogen-Activated Protein Kinase In Vivo Reveals Its Central Regulatory Role in Fibrosis. Circulation\| PubMed ID: 28356446	2017
Caveolae-localized L-type Ca2+ channels do not contribute to function or hypertrophic signalling in the mouse heart. Cardiovascular research\| PubMed ID: 28402392	2017
Redefining the identity of cardiac fibroblasts. Nature reviews. Cardiology\| PubMed ID: 28436487	2017
The mitochondrial Na/Ca exchanger is essential for Ca homeostasis and viability. Nature\| PubMed ID: 28445457	2017
Preexisting endothelial cells mediate cardiac neovascularization after injury. The Journal of clinical investigation\| PubMed ID: 28650345	2017
An Unbiased High-Throughput Screen to Identify Novel Effectors That Impact on Cardiomyocyte Aggregate Levels. Circulation research\| PubMed ID: 28655832	2017
Cardiomyocyte Regeneration: A Consensus Statement. Circulation\| PubMed ID: 28684531	2017
Mitsugumin 29 regulates t-tubule architecture in the failing heart. Scientific reports\| PubMed ID: 28706255	2017
TGFBI functions similar to periostin but is uniquely dispensable during cardiac injury. PloS one\| PubMed ID: 28750100	2017
Pharmacological and Activated Fibroblast Targeting of Gβγ-GRK2 After Myocardial Ischemia Attenuates Heart Failure Progression. Journal of the American College of Cardiology\| PubMed ID: 28818206	2017
Fibroblast-specific TGF-β-Smad2/3 signaling underlies cardiac fibrosis. The Journal of clinical investigation\| PubMed ID: 28891814	2017
Spatial Gene Profiling in the Ischemic Heart: Fibroblasts Put on Their SOX. Circulation\| PubMed ID: 28993372	2017
Identity Crisis for Regenerative Cardiac cKit Cells. Circulation research\| PubMed ID: 29074532	2017
Autophagic cell death is dependent on lysosomal membrane permeability through Bax and Bak. eLife\| PubMed ID: 29148970	2017
BEX1 is an RNA-dependent mediator of cardiomyopathy. Nature communications\| PubMed ID: 29192139	2017
Increasing T-type calcium channel activity by β-adrenergic stimulation contributes to β-adrenergic regulation of heart rates. The Journal of physiology\| PubMed ID: 29274077	2018
Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018. Cell death and differentiation\| PubMed ID: 29362479	2018
Genetic Reduction in Left Ventricular Protein Kinase C-α and Adverse Ventricular Remodeling in Human Subjects. Circulation. Genomic and precision medicine\| PubMed ID: 29540468	2018
van Berlo et al. reply. Nature\| PubMed ID: 29565361	2018
Inhibiting Fibronectin Attenuates Fibrosis and Improves Cardiac Function in a Model of Heart Failure. Circulation\| PubMed ID: 29653926	2018
Specialized fibroblast differentiated states underlie scar formation in the infarcted mouse heart. The Journal of clinical investigation\| PubMed ID: 29664017	2018
Gata4-Dependent Differentiation of c-Kit Derived Endothelial Cells Underlies Artefactual Cardiomyocyte Regeneration in the Heart. Circulation\| PubMed ID: 29666070	2018
Defective Flux of Thrombospondin-4 through the Secretory Pathway Impairs Cardiomyocyte Membrane Stability and Causes Cardiomyopathy. Molecular and cellular biology\| PubMed ID: 29712757	2018
Developmental vascular regression is regulated by a Wnt/β-catenin, MYC and CDKN1A pathway that controls cell proliferation and cell death. Development (Cambridge, England)\| PubMed ID: 29777010	2018
New Myocyte Formation in the Adult Heart: Endogenous Sources and Therapeutic Implications. Circulation research\| PubMed ID: 29976685	2018
Genetic Lineage Tracing of Sca-1 Cells Reveals Endothelial but Not Myogenic Contribution to the Murine Heart. Circulation\| PubMed ID: 29991486	2018
Protein Kinase C Inhibition With Ruboxistaurin Increases Contractility and Reduces Heart Size in a Swine Model of Heart Failure With Reduced Ejection Fraction. JACC. Basic to translational science\| PubMed ID: 30062182	2017
Applying Modern Transcriptomics to Interrogate the Human Cardiac Fibroblast. JACC. Basic to translational science\| PubMed ID: 30167545	2016
Nuclear calcineurin is a sensor for detecting Ca release from the nuclear envelope via IPR. Journal of molecular medicine (Berlin, Germany)\| PubMed ID: 30293136	2018
Undeniable Evidence That the Adult Mammalian Heart Lacks an Endogenous Regenerative Stem Cell. Circulation\| PubMed ID: 30359129	2018
The mitochondrial calcium uniporter underlies metabolic fuel preference in skeletal muscle. JCI insight\| PubMed ID: 30429366	2018
Evidence for Minimal Cardiogenic Potential of Stem Cell Antigen 1-Positive Cells in the Adult Mouse Heart. Circulation\| PubMed ID: 30566022	2018
Cardiac-specific deficiency of the mitochondrial calcium uniporter augments fatty acid oxidation and functional reserve. Journal of molecular and cellular cardiology\| PubMed ID: 30615880	2019
Thrombospondin-3 augments injury-induced cardiomyopathy by intracellular integrin inhibition and sarcolemmal instability. Nature communications\| PubMed ID: 30622267	2019
Overlapping and differential functions of ATF6α versus ATF6β in the mouse heart. Scientific reports\| PubMed ID: 30765833	2019
ERK1/2 signaling induces skeletal muscle slow fiber-type switching and reduces muscular dystrophy disease severity. JCI insight\| PubMed ID: 30964448	2019
Disruption of valosin-containing protein activity causes cardiomyopathy and reveals pleiotropic functions in cardiac homeostasis. The Journal of biological chemistry\| PubMed ID: 31006653	2019
Cell-specific ablation of Hsp47 defines the collagen-producing cells in the injured heart JCI insight\| PubMed ID: 31393098	2019
The EYA3 tyrosine phosphatase activity promotes pulmonary vascular remodeling in pulmonary arterial hypertension. Nature communications\| PubMed ID: 31515519	2019
CARdiac Immunotherapy: T Cells Engineered to Treat the Fibrotic Heart. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 31585799	2019
Hippo signaling does it again: arbitrating cardiac fibroblast identity and activation. Genes & development\| PubMed ID: 31676733	2019
A novel class of cardioprotective small-molecule PTP inhibitors. Pharmacological research\| PubMed ID: 31759087	2020
An acute immune response underlies the benefit of cardiac stem cell therapy. Nature\| PubMed ID: 31775156	2020
MEF2C repressor variant deregulation leads to cell cycle re-entry and development of heart failure. EBioMedicine\| PubMed ID: 31911274	2020
Cysteine 202 of cyclophilin D is a site of multiple post-translational modifications and plays a role in cardioprotection. Cardiovascular research\| PubMed ID: 32129829	2021
Hyperglycemia Acutely Increases Cytosolic Reactive Oxygen Species via -linked GlcNAcylation and CaMKII Activation in Mouse Ventricular Myocytes. Circulation research\| PubMed ID: 32134364	2020
Cardiac Cell Therapy Rejuvenates the Infarcted Rodent Heart via Direct Injection but Not by Vascular Infusion. Circulation\| PubMed ID: 32202933	2020
MCUb Induction Protects the Heart From Postischemic Remodeling. Circulation research\| PubMed ID: 32299299	2020
A 20/20 view of ANT function in mitochondrial biology and necrotic cell death. Journal of molecular and cellular cardiology\| PubMed ID: 32454061	2020
Type 2 diabetes risk gene Dusp8 regulates hypothalamic Jnk signaling and insulin sensitivity. The Journal of clinical investigation\| PubMed ID: 32780722	2020
A specialized population of Periostin-expressing cardiac fibroblasts contributes to postnatal cardiomyocyte maturation and innervation. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 32817558	2020
Ontogeny of arterial macrophages defines their functions in homeostasis and inflammation. Nature communications\| PubMed ID: 32917889	2020
Interleukin-1α dependent survival of cardiac fibroblasts is associated with StAR/STARD1 expression and improved cardiac remodeling and function after myocardial infarction. Journal of molecular and cellular cardiology\| PubMed ID: 33130150	2020
Resident macrophages keep mitochondria running in the heart. Cell research\| PubMed ID: 33139923	2020