Christopher Aiken

Department of Pathology, Vanderbilt University School of Medicine

Affiliated withVanderbilt University School of Medicine

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 47	2011

Other Publications

Article	Year
Nef-mediated downregulation of CD4 enhances human immunodeficiency virus type 1 replication in primary T lymphocytes. Journal of virology\| PubMed ID: 11932428	2002
Formation of a human immunodeficiency virus type 1 core of optimal stability is crucial for viral replication. Journal of virology\| PubMed ID: 11991995	2002
Disassembly of human immunodeficiency virus type 1 cores in vitro reveals association of Nef with the subviral ribonucleoprotein complex. Journal of virology\| PubMed ID: 12634398	2003
Nef does not affect the efficiency of human immunodeficiency virus type 1 fusion with target cells. Journal of virology\| PubMed ID: 12970449	2003
Small-molecule inhibition of human immunodeficiency virus type 1 replication by specific targeting of the final step of virion maturation. Journal of virology\| PubMed ID: 14694123	2004
Bifunctional anti-human immunodeficiency virus type 1 small molecules with two novel mechanisms of action. Antimicrobial agents and chemotherapy\| PubMed ID: 14742233	2004
Assembly properties of the human immunodeficiency virus type 1 CA protein. Journal of virology\| PubMed ID: 14963157	2004
Coupling of human immunodeficiency virus type 1 fusion to virion maturation: a novel role of the gp41 cytoplasmic tail. Journal of virology\| PubMed ID: 15016865	2004
Nef stimulates human immunodeficiency virus type 1 replication in primary T cells by enhancing virion-associated gp120 levels: coreceptor-dependent requirement for Nef in viral replication. Journal of virology\| PubMed ID: 15163722	2004
The sequence of the CA-SP1 junction accounts for the differential sensitivity of HIV-1 and SIV to the small molecule maturation inhibitor 3-O-{3',3'-dimethylsuccinyl}-betulinic acid. Retrovirology\| PubMed ID: 15225375	2004
Structural requirements for recognition of the human immunodeficiency virus type 1 core during host restriction in owl monkey cells. Journal of virology\| PubMed ID: 15613315	2005
Betulinic acid derivatives as HIV-1 antivirals. Trends in molecular medicine\| PubMed ID: 15649820	2005
Antimicrobial peptides from amphibian skin potently inhibit human immunodeficiency virus infection and transfer of virus from dendritic cells to T cells. Journal of virology\| PubMed ID: 16140737	2005
Inhibition of HIV-1 maturation via drug association with the viral Gag protein in immature HIV-1 particles. The Journal of biological chemistry\| PubMed ID: 16251182	2005
Maturation of the viral core enhances the fusion of HIV-1 particles with primary human T cells and monocyte-derived macrophages. Virology\| PubMed ID: 16375941	2006
A mutation in the human immunodeficiency virus type 1 Gag protein destabilizes the interaction of the envelope protein subunits gp120 and gp41. Journal of virology\| PubMed ID: 16474147	2006
Evidence for a functional link between uncoating of the human immunodeficiency virus type 1 core and nuclear import of the viral preintegration complex. Journal of virology\| PubMed ID: 16571788	2006
Saturation of TRIM5 alpha-mediated restriction of HIV-1 infection depends on the stability of the incoming viral capsid. Virology\| PubMed ID: 16624363	2006
Analysis of HIV-1-X4 fusion with immature dendritic cells identifies a specific restriction that is independent of CXCR4 levels. The Journal of investigative dermatology\| PubMed ID: 16917492	2007
Human immunodeficiency virus type 1 resistance to the small molecule maturation inhibitor 3-O-(3',3'-dimethylsuccinyl)-betulinic acid is conferred by a variety of single amino acid substitut... Journal of virology\| PubMed ID: 17035324	2006
Selective restriction of Nef-defective human immunodeficiency virus type 1 by a proteasome-dependent mechanism. Journal of virology\| PubMed ID: 17108041	2007
A mutation in alpha helix 3 of CA renders human immunodeficiency virus type 1 cyclosporin A resistant and dependent: rescue by a second-site substitution in a distal region of CA. Journal of virology\| PubMed ID: 17267487	2007
Maturation-dependent human immunodeficiency virus type 1 particle fusion requires a carboxyl-terminal region of the gp41 cytoplasmic tail. Journal of virology\| PubMed ID: 17609279	2007
Analysis of human cell heterokaryons demonstrates that target cell restriction of cyclosporine-resistant human immunodeficiency virus type 1 mutants is genetically dominant. Journal of virology\| PubMed ID: 17715216	2007
Escape from the dominant HLA-B27-restricted cytotoxic T-lymphocyte response in Gag is associated with a dramatic reduction in human immunodeficiency virus type 1 replication. Journal of virology\| PubMed ID: 17804494	2007
Nef enhances HIV-1 infectivity via association with the virus assembly complex. Virology\| PubMed ID: 18191978	2008
Proteasomal degradation of TRIM5alpha during retrovirus restriction. PLoS pathogens\| PubMed ID: 18497858	2008
Biochemical characterization of a recombinant TRIM5alpha protein that restricts human immunodeficiency virus type 1 replication. Journal of virology\| PubMed ID: 18799573	2008
Cyclophilin A-dependent restriction of human immunodeficiency virus type 1 capsid mutants for infection of nondividing cells. Journal of virology\| PubMed ID: 18829762	2008
Cell-free assays for HIV-1 uncoating. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 19020817	2009
Viral and cellular factors that regulate HIV-1 uncoating. Current opinion in HIV and AIDS\| PubMed ID: 19372808	2006
Structural convergence between Cryo-EM and NMR reveals intersubunit interactions critical for HIV-1 capsid function. Cell\| PubMed ID: 19914170	2009
Anti-HIV activity of defective cyanovirin-N mutants is restored by dimerization. The Journal of biological chemistry\| PubMed ID: 20147291	2010
TRIM5alpha disrupts the structure of assembled HIV-1 capsid complexes in vitro. Journal of virology\| PubMed ID: 20410272	2010
Small-molecule inhibition of human immunodeficiency virus type 1 infection by virus capsid destabilization. Journal of virology\| PubMed ID: 20962083	2011
Structure of the HIV-1 full-length capsid protein in a conformationally trapped unassembled state induced by small-molecule binding. Journal of molecular biology\| PubMed ID: 21146540	2011
Rhesus TRIM5Î± disrupts the HIV-1 capsid at the inter-hexamer interfaces. PLoS pathogens\| PubMed ID: 21455494	2011
免疫学： TRIM5 没有双重职责。 Nature\| PubMed ID: 21512569	2011
Maturation-induced cloaking of neutralization epitopes on HIV-1 particles. PLoS pathogens\| PubMed ID: 21931551	2011
HIV Nuclear Entry: Clearing the Fog. Viruses\| PubMed ID: 21994675	2010
RING domain mutations uncouple TRIM5Î± restriction of HIV-1 from inhibition of reverse transcription and acceleration of uncoating. Journal of virology\| PubMed ID: 22114335	2012