Martin Biel

Center for Integrated Protein Science (CIPS-M) and Center for Drug Research, Ludwig-Maximilians-Universität München

Affiliated withLudwig-Maximilians-Universität München German Center for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance

Research Area

Medicine

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 4	2021

Other Publications

Article	Year
Molecular cloning and functional characterization of a new modulatory cyclic nucleotide-gated channel subunit from mouse retina. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 10662822	2000
Role of subunit heteromerization and N-linked glycosylation in the formation of functional hyperpolarization-activated cyclic nucleotide-gated channels. The Journal of biological chemistry\| PubMed ID: 12928435	2003
Impaired channel targeting and retinal degeneration in mice lacking the cyclic nucleotide-gated channel subunit CNGB1. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 15634774	2005
An arginine residue in the pore region is a key determinant of chloride dependence in cardiac pacemaker channels. The Journal of biological chemistry\| PubMed ID: 15644313	2005
Impaired opsin targeting and cone photoreceptor migration in the retina of mice lacking the cyclic nucleotide-gated channel CNGA3. Investigative ophthalmology & visual science\| PubMed ID: 15790924	2005
The murine HCN3 gene encodes a hyperpolarization-activated cation channel with slow kinetics and unique response to cyclic nucleotides. The Journal of biological chemistry\| PubMed ID: 15923185	2005
A novel mechanism of modulation of hyperpolarization-activated cyclic nucleotide-gated channels by Src kinase. The Journal of biological chemistry\| PubMed ID: 16079136	2005
The enhancement of HCN channel instantaneous current facilitated by slow deactivation is regulated by intracellular chloride concentration. Pflugers Archiv : European journal of physiology\| PubMed ID: 16715293	2006
Loss of CNGB1 protein leads to olfactory dysfunction and subciliary cyclic nucleotide-gated channel trapping. The Journal of biological chemistry\| PubMed ID: 16980309	2006
Switching off calcium-dependent inactivation in L-type calcium channels by an autoinhibitory domain. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17028172	2006
Contribution of the receptor guanylyl cyclase GC-D to chemosensory function in the olfactory epithelium. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17724338	2007
Function and dysfunction of CNG channels: insights from channelopathies and mouse models. Molecular neurobiology\| PubMed ID: 17917115	2007
Cyclic nucleotide-regulated cation channels. The Journal of biological chemistry\| PubMed ID: 19054768	2009
Cyclic nucleotide-gated channels. Handbook of experimental pharmacology\| PubMed ID: 19089328	2009
The two-pore channel TPCN2 mediates NAADP-dependent Ca(2+)-release from lysosomal stores. Pflugers Archiv : European journal of physiology\| PubMed ID: 19557428	2009
Hyperpolarization-activated cation channels: from genes to function. Physiological reviews\| PubMed ID: 19584315	2009
Calmodulin is a functional regulator of Cav1.4 L-type Ca2+ channels. The Journal of biological chemistry\| PubMed ID: 19717559	2009
Characterization of two-pore channel 2 (TPCN2)-mediated Ca2+ currents in isolated lysosomes. The Journal of biological chemistry\| PubMed ID: 20495006	2010
Grueneberg ganglion neurons are finely tuned cold sensors. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 20519530	2010
Restoration of cone vision in the CNGA3-/- mouse model of congenital complete lack of cone photoreceptor function. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 20628362	2010
An olfactory subsystem that detects carbon disulfide and mediates food-related social learning. Current biology : CB\| PubMed ID: 20637621	2010
Planar patch clamp approach to characterize ionic currents from intact lysosomes. Science signaling\| PubMed ID: 21139138	2010
The glutamic acid-rich protein is a gating inhibitor of cyclic nucleotide-gated channels. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 21209198	2011
The cGMP-dependent protein kinase II Is an inhibitory modulator of the hyperpolarization-activated HCN2 channel. PloS one\| PubMed ID: 21347269	2011
HCN3 contributes to the ventricular action potential waveform in the murine heart. Circulation research\| PubMed ID: 21903939	2011
Exploring HCN channels as novel drug targets. Nature reviews. Drug discovery\| PubMed ID: 22094868	2011
Gene therapy restores missing cone-mediated vision in the CNGA3-/- mouse model of achromatopsia. Advances in experimental medicine and biology\| PubMed ID: 22183332	2012
CNGA3 deficiency affects cone synaptic terminal structure and function and leads to secondary rod dysfunction and degeneration. Investigative ophthalmology & visual science\| PubMed ID: 22247469	2012
Role of TRPML and two-pore channels in endolysosomal cation homeostasis. The Journal of pharmacology and experimental therapeutics\| PubMed ID: 22518024	2012
Regulation of hyperpolarization-activated cyclic nucleotide-gated (HCN) channel activity by cCMP. The Journal of biological chemistry\| PubMed ID: 22715094	2012
Gene therapy restores vision and delays degeneration in the CNGB1(-/-) mouse model of retinitis pigmentosa. Human molecular genetics\| PubMed ID: 22802073	2012
The role of HCN channels in ventricular repolarization. Trends in cardiovascular medicine\| PubMed ID: 22902068	2011
Complex regulation of voltage-dependent activation and inactivation properties of retinal voltage-gated Cav1.4 L-type Ca2+ channels by Ca2+-binding protein 4 (CaBP4). The Journal of biological chemistry\| PubMed ID: 22936811	2012
Isotope-based analysis of modified tRNA nucleosides correlates modification density with translational efficiency. Angewandte Chemie (International ed. in English)\| PubMed ID: 23037940	2012
Characterization of neurite outgrowth and ectopic synaptogenesis in response to photoreceptor dysfunction. Cellular and molecular life sciences : CMLS\| PubMed ID: 23269435	2013
Up-regulation of hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3) by specific interaction with K+ channel tetramerization domain-containing protein 3 (KCTD3). The Journal of biological chemistry\| PubMed ID: 23382386	2013
Loss of cone cyclic nucleotide-gated channel leads to alterations in light response modulating system and cellular stress response pathways: a gene expression profiling study. Human molecular genetics\| PubMed ID: 23740940	2013
Gene replacement therapy for retinal CNG channelopathies. Molecular genetics and genomics : MGG\| PubMed ID: 23861024	2013
cGMP accumulation causes photoreceptor degeneration in CNG channel deficiency: evidence of cGMP cytotoxicity independently of enhanced CNG channel function. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 24027293	2013
Mosaic synaptopathy and functional defects in Cav1.4 heterozygous mice and human carriers of CSNB2. Human molecular genetics\| PubMed ID: 24163243	2014
Gene therapy restores vision and delays degeneration in the CNGB1(-/-) mouse model of retinitis pigmentosa. Advances in experimental medicine and biology\| PubMed ID: 24664765	2014
Peripherin-2 couples rhodopsin to the CNG channel in outer segments of rod photoreceptors. Human molecular genetics\| PubMed ID: 24963162	2014
A small molecule restores function to TRPML1 mutant isoforms responsible for mucolipidosis type IV. Nature communications\| PubMed ID: 25119295	2014
High susceptibility to fatty liver disease in two-pore channel 2-deficient mice. Nature communications\| PubMed ID: 25144390	2014
Retinal gene delivery by adeno-associated virus (AAV) vectors: Strategies and applications. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V\| PubMed ID: 25615882	2015
Ebola virus. Two-pore channels control Ebola virus host cell entry and are drug targets for disease treatment. Science (New York, N.Y.)\| PubMed ID: 25722412	2015
Impact of Hyperpolarization-activated, Cyclic Nucleotide-gated Cation Channel Type 2 for the Xenon-mediated Anesthetic Effect: Evidence from In Vitro and In Vivo Experiments. Anesthesiology\| PubMed ID: 25782754	2015
TET3 is recruited by REST for context-specific hydroxymethylation and induction of gene expression. Cell reports\| PubMed ID: 25843715	2015
Vitreal delivery of AAV vectored Cnga3 restores cone function in CNGA3-/-/Nrl-/- mice, an all-cone model of CNGA3 achromatopsia. Human molecular genetics\| PubMed ID: 25855802	2015
Expression of Ca²⁺-permeable two-pore channels rescues NAADP signalling in TPC-deficient cells. The EMBO journal\| PubMed ID: 25872774	2015
Electroretinographic assessment of rod- and cone-mediated bipolar cell pathways using flicker stimuli in mice. Scientific reports\| PubMed ID: 26029863	2015
cGMP/Protein Kinase G Signaling Suppresses Inositol 1,4,5-Trisphosphate Receptor Phosphorylation and Promotes Endoplasmic Reticulum Stress in Photoreceptors of Cyclic Nucleotide-gated Channe... The Journal of biological chemistry\| PubMed ID: 26124274	2015
Retinitis pigmentosa: impact of different Pde6a point mutations on the disease phenotype. Human molecular genetics\| PubMed ID: 26188004	2015
Corticotropin-Releasing Hormone Receptor Type 1 (CRHR1) Clustering with MAGUKs Is Mediated via Its C-Terminal PDZ Binding Motif. PloS one\| PubMed ID: 26352593	2015
Comprehensive multilevel in vivo and in vitro analysis of heart rate fluctuations in mice by ECG telemetry and electrophysiology. Nature protocols\| PubMed ID: 26658468	2016
Loss of HCN1 enhances disease progression in mouse models of CNG channel-linked retinitis pigmentosa and achromatopsia. Human molecular genetics\| PubMed ID: 26740549	2016
In Vivo Analysis of Disease-Associated Point Mutations Unveils Profound Differences in mRNA Splicing of Peripherin-2 in Rod and Cone Photoreceptors. PLoS genetics\| PubMed ID: 26796962	2016
HCN1 Channels Enhance Rod System Responsivity in the Retina under Conditions of Light Exposure. PloS one\| PubMed ID: 26807953	2016
Peripherin-2 differentially interacts with cone opsins in outer segments of cone photoreceptors. Human molecular genetics\| PubMed ID: 27033727	2016
Determination of Rod and Cone Influence to the Early and Late Dynamic of the Pupillary Light Response. Investigative ophthalmology & visual science\| PubMed ID: 27152964	2016
Gene therapy for achromatopsia. The journal of gene medicine\| PubMed ID: 28095637	2017
Two-Pore Channel Function Is Crucial for the Migration of Invasive Cancer Cells. Cancer research\| PubMed ID: 28108508	2017
Cone Genesis Tracing by the Chrnb4-EGFP Mouse Line: Evidences of Cellular Material Fusion after Cone Precursor Transplantation. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 28143742	2017
Mosaic synaptopathy and functional defects in Cav1.4 heterozygous mice and human carriers of CSNB2. Human molecular genetics\| PubMed ID: 28365780	2017
Recombinant tandem of pore-domains in a Weakly Inward rectifying K channel 2 (TWIK2) forms active lysosomal channels. Scientific reports\| PubMed ID: 28381826	2017
From mucolipidosis type IV to Ebola: TRPML and two-pore channels at the crossroads of endo-lysosomal trafficking and disease. Cell calcium\| PubMed ID: 28457591	2017
Endoplasmic reticulum (ER) Ca-channel activity contributes to ER stress and cone death in cyclic nucleotide-gated channel deficiency. The Journal of biological chemistry\| PubMed ID: 28495882	2017
Peripherin-2 and Rom-1 have opposing effects on rod outer segment targeting of retinitis pigmentosa-linked peripherin-2 mutants. Scientific reports\| PubMed ID: 28539581	2017
Photopharmacological control of bipolar cells restores visual function in blind mice. The Journal of clinical investigation\| PubMed ID: 28581442	2017
Patch-clamp technique to characterize ion channels in enlarged individual endolysosomes. Nature protocols\| PubMed ID: 28726848	2017
Small Molecules for Early Endosome-Specific Patch Clamping. Cell chemical biology\| PubMed ID: 28732201	2017
Protein kinase A regulates inflammatory pain sensitization by modulating HCN2 channel activity in nociceptive sensory neurons. Pain\| PubMed ID: 28767511	2017
TPC2 polymorphisms associated with a hair pigmentation phenotype in humans result in gain of channel function by independent mechanisms. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 28923947	2017
AAV8 Can Induce Innate and Adaptive Immune Response in the Primate Eye. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 28970046	2017
Abstracts from the 8th International Conference on cGMP Generators, Effectors and Therapeutic Implications : Bamberg, Germany. 23-25 June, 2017. BMC pharmacology & toxicology\| PubMed ID: 29035170	2017
Superior Retinal Gene Transfer and Biodistribution Profile of Subretinal Versus Intravitreal Delivery of AAV8 in Nonhuman Primates. Investigative ophthalmology & visual science\| PubMed ID: 29117317	2017
Gene Supplementation Rescues Rod Function and Preserves Photoreceptor and Retinal Morphology in Dogs, Leading the Way Toward Treating Human -Retinitis Pigmentosa. Human gene therapy\| PubMed ID: 29212382	2017
Gene Therapy Successfully Delays Degeneration in a Mouse Model of -Linked Retinitis Pigmentosa (RP43). Human gene therapy\| PubMed ID: 29212391	2017
Endolysosomal Cation Channels and Cancer-A Link with Great Potential. Pharmaceuticals (Basel, Switzerland)\| PubMed ID: 29303993	2018
Early Microglia Activation Precedes Photoreceptor Degeneration in a Mouse Model of CNGB1-Linked Retinitis Pigmentosa. Frontiers in immunology\| PubMed ID: 29354133	2017
Retinal Cyclic Nucleotide-Gated Channels: From Pathophysiology to Therapy. International journal of molecular sciences\| PubMed ID: 29518895	2018
Hif1a inactivation rescues photoreceptor degeneration induced by a chronic hypoxia-like stress. Cell death and differentiation\| PubMed ID: 29666476	2018
Humoral Immune Response After Intravitreal But Not After Subretinal AAV8 in Primates and Patients. Investigative ophthalmology & visual science\| PubMed ID: 29677353	2018
Development of Methodology and Study Protocol: Safety and Efficacy of a Single Subretinal Injection of rAAV.hCNGA3 in Patients with CNGA3-Linked Achromatopsia Investigated in an Exploratory ... Human gene therapy. Clinical development\| PubMed ID: 30187779	2018
In Vitro Evaluation of AAV Vectors for Retinal Gene Therapy. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 30324456	2019
Optimized Subretinal Injection Technique for Gene Therapy Approaches. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 30324458	2019
The protein interaction networks of mucolipins and two-pore channels. Biochimica et biophysica acta. Molecular cell research\| PubMed ID: 30395881	2019
Accessory heterozygous mutations in cone photoreceptor CNGA3 exacerbate CNG channel-associated retinopathy. The Journal of clinical investigation\| PubMed ID: 30418171	2018
Abolishing cAMP sensitivity in HCN2 pacemaker channels induces generalized seizures. JCI insight\| PubMed ID: 31045576	2019
HCN3 ion channels: roles in sensory neuronal excitability and pain. The Journal of physiology\| PubMed ID: 31290157	2019
Intrinsic Differential Scanning Fluorimetry for Fast and Easy Identification of Adeno-Associated Virus Serotypes. Journal of pharmaceutical sciences\| PubMed ID: 31639391	2020
Enigmatic rhodopsin mutation creates an exceptionally strong splice acceptor site. Human molecular genetics\| PubMed ID: 31816042	2020
Advancing Gene Therapy for PDE6A Retinitis Pigmentosa. Advances in experimental medicine and biology\| PubMed ID: 31884596	2019
Neuropathic and cAMP-induced pain behavior is ameliorated in mice lacking CNGB1. Neuropharmacology\| PubMed ID: 32272140	2020
Safety and Vision Outcomes of Subretinal Gene Therapy Targeting Cone Photoreceptors in Achromatopsia: A Nonrandomized Controlled Trial. JAMA ophthalmology\| PubMed ID: 32352493	2020
TPC1 deficiency or blockade augments systemic anaphylaxis and mast cell activity. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 32661165	2020
Antisense Oligonucleotide- and CRISPR-Cas9-Mediated Rescue of mRNA Splicing for a Deep Intronic CLRN1 Mutation. Molecular therapy. Nucleic acids\| PubMed ID: 32841912	2020
A gene therapy for inherited blindness using dCas9-VPR-mediated transcriptional activation. Science advances\| PubMed ID: 32875106	2020
cAMP-dependent regulation of HCN4 controls the tonic entrainment process in sinoatrial node pacemaker cells. Nature communications\| PubMed ID: 33144559	2020