Journal
/
Medicine
/
Implantation of Combined Telemetric ECG and Blood Pressure Transmitters to Determine Spontaneous Baroreflex Sensitivity in Conscious Mice
JoVE Journal
Medicine
This content is Free Access.
JoVE Journal Medicine
Implantation of Combined Telemetric ECG and Blood Pressure Transmitters to Determine Spontaneous Baroreflex Sensitivity in Conscious Mice

Implantation of Combined Telemetric ECG and Blood Pressure Transmitters to Determine Spontaneous Baroreflex Sensitivity in Conscious Mice

DOI:
10.3791/62101-v

•

09:56 min

•

February 14, 2021

•

, , , , , ,
1Center for Integrated Protein Science (CIPS-M) and Center for Drug Research, Department of Pharmacy,Ludwig-Maximilians-Universität München, 2German Center for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, 3Hannover Medical School,Institute for Neurophysiology

Chapters

  • 00:05Introduction
  • 01:34Dissection of the Left Common Carotid
  • 04:09Cannulation of the Left Common Carotid Artery
  • 05:11Placement of the Telemetry Device Body and ECG Leads
  • 07:29Results: Analysis of BRS Using the Sequence Method on Simultaneous Telemetric ECG and BP Recordings
  • 08:58Conclusion

Summary

Automatic Translation

Automatic Translation

The baroreflex is a heart-rate regulation mechanism by the autonomic nervous system in response to blood-pressure changes. We describe a surgical technique to implant telemetry transmitters for continuous and simultaneous measurement of electrocardiogram and blood pressure in mice. This can determine spontaneous baroreflex sensitivity, an important prognostic marker for cardiovascular disease.

Tags

Keywords: TelemetryECGBlood PressureBaroreflex SensitivityConscious MiceCardiovascular DiseaseMicrosurgeryCarotid ArteryAnesthesiaDepilatory CreamSkin IncisionBlunt DissectionParotid GlandSubmandibular GlandTrachea

Article

Embed

ADD TO PLAYLIST

Usage Statistics

Related Videos

check_url/62101?article_type=v

Pressure Controlled Ventilation to Induce Acute Lung Injury in Mice
check_url/62101?article_type=v

Hyperinsulinemic-euglycemic Clamps in Conscious, Unrestrained Mice
check_url/62101?article_type=v

Implantation of Radiotelemetry Transmitters Yielding Data on ECG, Heart Rate, Core Body Temperature and Activity in Free-moving Laboratory Mice
check_url/62101?article_type=v

Femoral Arterial and Venous Catheterization for Blood Sampling, Drug Administration and Conscious Blood Pressure and Heart Rate Measurements
check_url/62101?article_type=v

Generation and Quantitative Analysis of Pulsed Low Frequency Ultrasound to Determine the Sonic Sensitivity of Untreated and Treated Neoplastic Cells
check_url/62101?article_type=v

Long-term Blood Pressure Measurement in Freely Moving Mice Using Telemetry
check_url/62101?article_type=v

Novel Approach for Simultaneous Recording of Renal Sympathetic Nerve Activity and Blood Pressure with Intravenous Infusion in Conscious, Unrestrained Mice.
check_url/62101?article_type=v

Assessment of Respiratory Function in Conscious Mice by Double-chamber Plethysmography
check_url/62101?article_type=v

Ultrasound Imaging of the Thoracic and Abdominal Aorta in Mice to Determine Aneurysm Dimensions
check_url/62101?article_type=v

Implantation of an Isoproterenol Mini-Pump to Induce Heart Failure in Mice

Read Article