Lynne Howells

Leicester Cancer Research Center, University of Leicester

Research Area

Biography

Lynne Howells has not added Biography.
If you are Lynne Howells and would like to personalize this page please email our Author Liaison for assistance.

JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 5	2021

Other Publications

Article	Year
Indole-3-carbinol inhibits protein kinase B/Akt and induces apoptosis in the human breast tumor cell line MDA MB468 but not in the nontumorigenic HBL100 line. Molecular cancer therapeutics\| PubMed ID: 12479697	2002
Growth-inhibitory effects of the chemopreventive agent indole-3-carbinol are increased in combination with the polyamine putrescine in the SW480 colon tumour cell line. BMC cancer\| PubMed ID: 12525265	2003
Relevance of mitogen activated protein kinase (MAPK) and phosphotidylinositol-3-kinase/protein kinase B (PI3K/PKB) pathways to induction of apoptosis by curcumin in breast cells. Biochemical pharmacology\| PubMed ID: 12527329	2003
Prospects for plant-derived chemopreventive agents exhibiting multiple mechanisms of action. Current medicinal chemistry. Anti-cancer agents\| PubMed ID: 15992350	2005
Inhibition of phosphatidylinositol 3-kinase/protein kinase B signaling is not sufficient to account for indole-3-carbinol-induced apoptosis in some breast and prostate tumor cells. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 16322316	2005
Involvement of Nrf2, p38, B-Raf, and nuclear factor-kappaB, but not phosphatidylinositol 3-kinase, in induction of hemeoxygenase-1 by dietary polyphenols. Molecular pharmacology\| PubMed ID: 16354769	2006
Comparison of oxaliplatin- and curcumin-mediated antiproliferative effects in colorectal cell lines. International journal of cancer\| PubMed ID: 17330230	2007
Predicting the physiological relevance of in vitro cancer preventive activities of phytochemicals. Acta pharmacologica Sinica\| PubMed ID: 17723163	2007
Indole-3-carbinol enhances anti-proliferative, but not anti-invasive effects of oxaliplatin in colorectal cancer cell lines. Biochemical pharmacology\| PubMed ID: 18358454	2008
Preclinical colorectal cancer chemopreventive efficacy and p53-modulating activity of 3',4',5'-trimethoxyflavonol, a quercetin analogue. Cancer prevention research (Philadelphia, Pa.)\| PubMed ID: 20628003	2010
Curcumin ameliorates oxaliplatin-induced chemoresistance in HCT116 colorectal cancer cells in vitro and in vivo. International journal of cancer\| PubMed ID: 20839263	2011
Phase I randomized, double-blind pilot study of micronized resveratrol (SRT501) in patients with hepatic metastases--safety, pharmacokinetics, and pharmacodynamics. Cancer prevention research (Philadelphia, Pa.)\| PubMed ID: 21680702	2011
Prolonged biologically active colonic tissue levels of curcumin achieved after oral administration--a clinical pilot study including assessment of patient acceptability. Cancer prevention research (Philadelphia, Pa.)\| PubMed ID: 23233733	2013
The role of cancer stem cells in the anti-carcinogenicity of curcumin. Molecular nutrition & food research\| PubMed ID: 23900994	2013
Translating curcumin to the clinic for lung cancer prevention: evaluation of the preclinical evidence for its utility in primary, secondary, and tertiary prevention strategies. The Journal of pharmacology and experimental therapeutics\| PubMed ID: 24939419	2014
Cancer chemoprevention: factors influencing attitudes towards chemopreventive agents in high-risk populations. European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP)\| PubMed ID: 25259886	2014
The role of stromal fibroblasts in lung carcinogenesis: A target for chemoprevention? International journal of cancer\| PubMed ID: 25611701	2016
Potential for proteomic approaches in determining efficacy biomarkers following administration of fish oils rich in omega-3 fatty acids: application in pancreatic cancers. Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition\| PubMed ID: 25616520	2015
Characterization and propagation of tumor initiating cells derived from colorectal liver metastases: trials, tribulations and a cautionary note. PloS one\| PubMed ID: 25658706	2015
Combining curcumin (C3-complex, Sabinsa) with standard care FOLFOX chemotherapy in patients with inoperable colorectal cancer (CUFOX): study protocol for a randomised control trial. Trials\| PubMed ID: 25872567	2015
Curcumin inhibits cancer stem cell phenotypes in ex vivo models of colorectal liver metastases, and is clinically safe and tolerable in combination with FOLFOX chemotherapy. Cancer letters\| PubMed ID: 25979230	2015
Inhibition of prostate cancer cell growth by 3',4',5'-trimethoxyflavonol (TMFol). Cancer chemotherapy and pharmacology\| PubMed ID: 26017621	2015
Cancer chemoprevention: Evidence of a nonlinear dose response for the protective effects of resveratrol in humans and mice. Science translational medicine\| PubMed ID: 26223300	2015
Targeting pancreatic cancer using a combination of gemcitabine with the omega-3 polyunsaturated fatty acid emulsion, Lipidem™. Molecular nutrition & food research\| PubMed ID: 26603273	2016
Targeting cancer stem-like cells using dietary-derived agents - Where are we now? Molecular nutrition & food research\| PubMed ID: 27060283	2016
Curcumin mediates oxaliplatin-acquired resistance reversion in colorectal cancer cell lines through modulation of CXC-Chemokine/NF-κB signalling pathway. Scientific reports\| PubMed ID: 27091625	2016
Assessing barriers to a rational chemoprevention trial design in young patients with familial adenomatous polyposis. European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP)\| PubMed ID: 27128580	2017
Effects of Omegaven®, EPA, DHA and oxaliplatin on oesophageal adenocarcinoma cell lines growth, cytokine and cell signal biomarkers expression. Lipids in health and disease\| PubMed ID: 29378575	2018
An HPLC-UV method for the simultaneous quantification of curcumin and its metabolites in plasma and lung tissue: Potential for preclinical applications. Biomedical chromatography : BMC\| PubMed ID: 29744910	2018
Detection of Plasma Curcuminoids from Dietary Intake of Turmeric-Containing Food in Human Volunteers. Molecular nutrition & food research\| PubMed ID: 29943914	2018
Sensitivity of Colorectal Cancer to Arginine Deprivation Therapy is Shaped by Differential Expression of Urea Cycle Enzymes. Scientific reports\| PubMed ID: 30108309	2018
Circulating tumor DNA in patients with colorectal adenomas: assessment of detectability and genetic heterogeneity. Cell death & disease\| PubMed ID: 30166531	2018
Curcumin Combined with FOLFOX Chemotherapy Is Safe and Tolerable in Patients with Metastatic Colorectal Cancer in a Randomized Phase IIa Trial. The Journal of nutrition\| PubMed ID: 31132111	2019
Patient-derived explants (PDEs) as a powerful preclinical platform for anti-cancer drug and biomarker discovery. British journal of cancer\| PubMed ID: 31894140	2020
New Paradigms to Assess Consequences of Long-Term, Low-Dose Curcumin Exposure in Lung Cancer Cells. Molecules (Basel, Switzerland)\| PubMed ID: 31963196	2020
Myeloid derived suppressor cells are reduced and T regulatory cells stabilised in patients with advanced pancreatic cancer treated with gemcitabine and intravenous omega 3. Annals of translational medicine\| PubMed ID: 32309319	2020
Association of Type 2 Diabetes With Cancer: A Meta-analysis With Bias Analysis for Unmeasured Confounding in 151 Cohorts Comprising 32 Million People. Diabetes care\| PubMed ID: 32910779	2020
Risk of cancer incidence and mortality associated with diabetes: A systematic review with trend analysis of 203 cohorts. Nutrition, metabolism, and cardiovascular diseases : NMCD\| PubMed ID: 33223399	2021
Evaluating and comparing immunostaining and computational methods for spatial profiling of drug response in patient-derived explants. Laboratory investigation; a journal of technical methods and pathology\| PubMed ID: 33318618	2020