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JoVE Journal Cancer Research
Patient-Derived Tumor Explants As a "Live" Preclinical Platform for Predicting Drug Resistance in Patients
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Patient-Derived Tumor Explants As a "Live" Preclinical Platform for Predicting Drug Resistance in Patients

Article DOI: 10.3791/62130-v • 07:42 min • February 7th, 2021
February 7th, 2021 •
1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 2, 1
1Leicester Cancer Research Center, University of Leicester, 2MRC Toxicology Unit

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Summary
Automatic Translation

This paper describes methods for the generation, drug treatment, and analysis of patient-derived explants for assessing tumor drug responses in a live, patient-relevant, preclinical model system.

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Patient-derived Tumor Explants Preclinical Platform Drug Resistance Immediate Drug Response Data Patient Outcomes 3D Context Pathological Features Architectural Features Metabolism Mechanism Of Action Pharmacodynamic Biomarkers Surgical Equipment Culture Dish Fresh Medium Dental Wax Surface Tissue Fragments Formalin Solution Incubation Wells Of A Six-well Plate Organotypic Culture Insert Dish Carbon Dioxide Incubator
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