Marion MacFarlane

MRC Toxicology Unit

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 5	2021

Other Publications

Article	Year
c-Myc protein synthesis is initiated from the internal ribosome entry segment during apoptosis. Molecular and cellular biology\| PubMed ID: 10648601	2000
Mechanisms of resistance to TRAIL-induced apoptosis in primary B cell chronic lymphocytic leukaemia. Oncogene\| PubMed ID: 12360407	2002
TRAIL-induced signalling and apoptosis. Toxicology letters\| PubMed ID: 12628743	2003
Caspase activation inhibits proteasome function during apoptosis. Molecular cell\| PubMed ID: 15068805	2004
Apoptosis and disease: a life or death decision. EMBO reports\| PubMed ID: 15218528	2004
TRAIL signals to apoptosis in chronic lymphocytic leukaemia cells primarily through TRAIL-R1 whereas cross-linked agonistic TRAIL-R2 antibodies facilitate signalling via TRAIL-R2. British journal of haematology\| PubMed ID: 17922877	2007
Recombinant TRAIL and TRAIL receptor analysis. Methods in enzymology\| PubMed ID: 18603130	2008
Cell death pathways--potential therapeutic targets. Xenobiotica; the fate of foreign compounds in biological systems\| PubMed ID: 19622004	2009
Mitochondrial fragmentation and neuronal cell death in response to the Bcl-2/Bcl-x(L)/Bcl-w antagonist ABT-737. Neuropharmacology\| PubMed ID: 20307556	2010
cIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms. Molecular cell\| PubMed ID: 21737330	2011
The 'complexities' of life and death: death receptor signalling platforms. Experimental cell research\| PubMed ID: 22542855	2012
A death effector domain chain DISC model reveals a crucial role for caspase-8 chain assembly in mediating apoptotic cell death. Molecular cell\| PubMed ID: 22683266	2012
Glucose--a sweet way to die: metabolic switching modulates tumor cell death. Cell cycle (Georgetown, Tex.)\| PubMed ID: 22983094	2012
Isolation, characterisation and reconstitution of cell death signalling complexes. Methods (San Diego, Calif.)\| PubMed ID: 23485576	2013
Notch4 Signaling Confers Susceptibility to TRAIL-Induced Apoptosis in Breast Cancer Cells. Journal of cellular biochemistry\| PubMed ID: 25704336	2015
Autophagy limits proliferation and glycolytic metabolism in acute myeloid leukemia. Cell death discovery\| PubMed ID: 26568842	2015
In Vitro Assembly and Analysis of the Apoptosome Complex. Cold Spring Harbor protocols\| PubMed ID: 26631121	2015
Activation, Isolation, and Analysis of the Death-Inducing Signaling Complex. Cold Spring Harbor protocols\| PubMed ID: 26631122	2015
Biochemical Analysis of Initiator Caspase-Activating Complexes: The Apoptosome and the Death-Inducing Signaling Complex. Cold Spring Harbor protocols\| PubMed ID: 26631130	2015
Co-operative and Hierarchical Binding of c-FLIP and Caspase-8: A Unified Model Defines How c-FLIP Isoforms Differentially Control Cell Fate. Molecular cell\| PubMed ID: 26990987	2016
Targeting cell death signalling in cancer: minimising 'Collateral damage'. British journal of cancer\| PubMed ID: 27140313	2016
Explant Cultures of Non-Small Cell Lung Carcinoma Enable Evaluation of Primary Tumor Responses to Anticancer Therapy. Cancer research\| PubMed ID: 28202521	2017
Caspase-10 Negatively Regulates Caspase-8-Mediated Cell Death, Switching the Response to CD95L in Favor of NF-κB Activation and Cell Survival. Cell reports\| PubMed ID: 28445729	2017
Long-Fiber Carbon Nanotubes Replicate Asbestos-Induced Mesothelioma with Disruption of the Tumor Suppressor Gene Cdkn2a (Ink4a/Arf). Current biology : CB\| PubMed ID: 29112861	2017
Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018. Cell death and differentiation\| PubMed ID: 29362479	2018
N-glycosylation of mouse TRAIL-R restrains TRAIL-induced apoptosis. Cell death & disease\| PubMed ID: 29717117	2018
Asbestos: Modern Insights for Toxicology in the Era of Engineered Nanomaterials. Chemical research in toxicology\| PubMed ID: 30156102	2018
Evaluation of apoptosis imaging biomarkers in a genetic model of cell death. EJNMMI research\| PubMed ID: 30783791	2019
Patient-derived explants, xenografts and organoids: 3-dimensional patient-relevant pre-clinical models in endometrial cancer. Gynecologic oncology\| PubMed ID: 31767187	2020
Patient-derived explants (PDEs) as a powerful preclinical platform for anti-cancer drug and biomarker discovery. British journal of cancer\| PubMed ID: 31894140	2020
Identification of a novel toxicophore in anti-cancer chemotherapeutics that targets mitochondrial respiratory complex I. eLife\| PubMed ID: 32432547	2020
Exploration of Matrix Effects in Laser Ablation Inductively Coupled Plasma Mass Spectrometry Imaging of Cisplatin-Treated Tumors. Analytical chemistry\| PubMed ID: 32545955	2020
Development of a patient-derived explant model for prediction of drug responses in endometrial cancer. Gynecologic oncology\| PubMed ID: 33309417	2021
Evaluating and comparing immunostaining and computational methods for spatial profiling of drug response in patient-derived explants. Laboratory investigation; a journal of technical methods and pathology\| PubMed ID: 33318618	2020