Catrin Pritchard

Leicester Cancer Research Center, University of Leicester

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 5	2021

Other Publications

Article	Year
MEK kinase activity is not necessary for Raf-1 function. The EMBO journal\| PubMed ID: 11296227	2001
ERK signalling and oncogene transformation are not impaired in cells lacking A-Raf. Oncogene\| PubMed ID: 11821947	2002
MEKK1 plays a critical role in activating the transcription factor C/EBP-beta-dependent gene expression in response to IFN-gamma. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12048245	2002
Expression of kinase suppressor of Ras in the normal adult and embryonic mouse. Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research\| PubMed ID: 12133899	2002
cAMP-dependent protein kinase and Ca2+ influx through L-type voltage-gated calcium channels mediate Raf-independent activation of extracellular regulated kinase in response to glucagon-like ... The Journal of biological chemistry\| PubMed ID: 12364324	2002
Analysis of the role of the SA gene in blood pressure regulation by gene targeting. Hypertension (Dallas, Tex. : 1979)\| PubMed ID: 12707288	2003
Raf proteins and cancer: B-Raf is identified as a mutational target. Biochimica et biophysica acta\| PubMed ID: 12781369	2003
B-Raf acts via the ROCKII/LIMK/cofilin pathway to maintain actin stress fibers in fibroblasts. Molecular and cellular biology\| PubMed ID: 15199148	2004
A critical function for B-Raf at multiple stages of myelopoiesis. Blood\| PubMed ID: 15784729	2005
A-Raf and Raf-1 work together to influence transient ERK phosphorylation and Gl/S cell cycle progression. Oncogene\| PubMed ID: 15856007	2005
Expression of endogenous oncogenic V600EB-raf induces proliferation and developmental defects in mice and transformation of primary fibroblasts. Cancer research\| PubMed ID: 16357158	2005
Mouse models for BRAF-induced cancers. Biochemical Society transactions\| PubMed ID: 17956344	2007
Lineage tracing of cardiac explant derived cells. PloS one\| PubMed ID: 18414652	2008
Cdx2 initiates histodifferentiation of the midgut endoderm. FEBS letters\| PubMed ID: 18577384	2008
CRAF autophosphorylation of serine 621 is required to prevent its proteasome-mediated degradation. Molecular cell\| PubMed ID: 18922468	2008
Talin 2 is a large and complex gene encoding multiple transcripts and protein isoforms. The FEBS journal\| PubMed ID: 19220457	2009
Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF. Cell\| PubMed ID: 20141835	2010
Studies on the morphology and spreading of human endothelial cells define key inter- and intramolecular interactions for talin1. European journal of cell biology\| PubMed ID: 20605055	2010
V600EBraf induces gastrointestinal crypt senescence and promotes tumour progression through enhanced CpG methylation of p16INK4a. EMBO molecular medicine\| PubMed ID: 20941790	2010
BRAF inactivation drives aneuploidy by deregulating CRAF. Cancer research\| PubMed ID: 20978199	2010
Endothelial cell talin1 is essential for embryonic angiogenesis. Developmental biology\| PubMed ID: 21081121	2011
Thyrotrophin receptor signaling dependence of Braf-induced thyroid tumor initiation in mice. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21220306	2011
Mechanisms of aneuploidy induction by RAS and RAF oncogenes. American journal of cancer research\| PubMed ID: 22016838	2011
Cdx2 determines the fate of postnatal intestinal endoderm. Development (Cambridge, England)\| PubMed ID: 22190642	2012
Regulation of MEK/ERK pathway output by subcellular localization of B-Raf. Biochemical Society transactions\| PubMed ID: 22260667	2012
The intermediate-activity (L597V)BRAF mutant acts as an epistatic modifier of oncogenic RAS by enhancing signaling through the RAF/MEK/ERK pathway. Genes & development\| PubMed ID: 22892241	2012
Mice carrying a complete deletion of the talin2 coding sequence are viable and fertile. Biochemical and biophysical research communications\| PubMed ID: 22925892	2012
A new mode of RAF autoregulation: a further complication in the inhibitor paradox. Cancer cell\| PubMed ID: 23680140	2013
A complex secretory program orchestrated by the inflammasome controls paracrine senescence. Nature cell biology\| PubMed ID: 23770676	2013
Hematopoietic expression of oncogenic BRAF promotes aberrant growth of monocyte-lineage cells resistant to PLX4720. Molecular cancer research : MCR\| PubMed ID: 24152792	2013
Long-term channel block is required to inhibit cellular transformation by human ether-à-go-go-related gene (hERG1) potassium channels. Molecular pharmacology\| PubMed ID: 24830940	2014
Tracking genomic cancer evolution for precision medicine: the lung TRACERx study. PLoS biology\| PubMed ID: 25003521	2014
KRAS(G12D)-mediated oncogenic transformation of thyroid follicular cells requires long-term TSH stimulation and is regulated by SPRY1. Laboratory investigation; a journal of technical methods and pathology\| PubMed ID: 26146959	2015
MGL ligand expression is correlated to BRAF mutation and associated with poor survival of stage III colon cancer patients. Oncotarget\| PubMed ID: 26172302	2015
The cholesterol-binding protein NPC2 restrains recruitment of stromal macrophage-lineage cells to early-stage lung tumours. EMBO molecular medicine\| PubMed ID: 26183450	2015
Regulation of BRAF protein stability by a negative feedback loop involving the MEK-ERK pathway but not the FBXW7 tumour suppressor. Cellular signalling\| PubMed ID: 26898828	2016
Phosphorylations of Serines 21/9 in Glycogen Synthase Kinase 3α/β Are Not Required for Cell Lineage Commitment or WNT Signaling in the Normal Mouse Intestine. PloS one\| PubMed ID: 27284979	2016
Inactivation of TGFβ receptors in stem cells drives cutaneous squamous cell carcinoma. Nature communications\| PubMed ID: 27558455	2016
Raf Kinases Are Essential for Phosphate Induction of ERK1/2 Phosphorylation in Hypertrophic Chondrocytes and Normal Endochondral Bone Development. The Journal of biological chemistry\| PubMed ID: 28073913	2017
Explant Cultures of Non-Small Cell Lung Carcinoma Enable Evaluation of Primary Tumor Responses to Anticancer Therapy. Cancer research\| PubMed ID: 28202521	2017
Attenuation Limits Progression of -Induced Papillary Thyroid Cancer Cells and Sensitizes Them to BRAF Inhibitor PLX4720. Cancer research\| PubMed ID: 28242615	2017
KRAS expression in lung-resident myeloid cells promotes pulmonary LCH-like neoplasm sensitive to statin treatment. Blood\| PubMed ID: 28550040	2017
Profiling tumour heterogeneity through circulating tumour DNA in patients with pancreatic cancer. Oncotarget\| PubMed ID: 29152076	2017
Over-expressed, N-terminally truncated BRAF is detected in the nucleus of cells with nuclear phosphorylated MEK and ERK. Heliyon\| PubMed ID: 30603699	2018
Early detection of pre-malignant lesions in a KRAS-driven mouse lung cancer model by monitoring circulating free DNA. Disease models & mechanisms\| PubMed ID: 30760495	2019
Patient-derived explants, xenografts and organoids: 3-dimensional patient-relevant pre-clinical models in endometrial cancer. Gynecologic oncology\| PubMed ID: 31767187	2020
Patient-derived explants (PDEs) as a powerful preclinical platform for anti-cancer drug and biomarker discovery. British journal of cancer\| PubMed ID: 31894140	2020
DNMT3B Oncogenic Activity in Human Intestinal Cancer Is Not Linked to CIMP or BRAFV600E Mutation. iScience\| PubMed ID: 32058953	2020
Reduced Protumorigenic Tumor-Associated Macrophages With Statin Use in Premalignant Human Lung Adenocarcinoma. JNCI cancer spectrum\| PubMed ID: 32190817	2020
Exploration of Matrix Effects in Laser Ablation Inductively Coupled Plasma Mass Spectrometry Imaging of Cisplatin-Treated Tumors. Analytical chemistry\| PubMed ID: 32545955	2020
Fibroblast-Derived STC-1 Modulates Tumor-Associated Macrophages and Lung Adenocarcinoma Development. Cell reports\| PubMed ID: 32579928	2020
Development of a patient-derived explant model for prediction of drug responses in endometrial cancer. Gynecologic oncology\| PubMed ID: 33309417	2021
Evaluating and comparing immunostaining and computational methods for spatial profiling of drug response in patient-derived explants. Laboratory investigation; a journal of technical methods and pathology\| PubMed ID: 33318618	2020
Ras/MAPK Dysregulation in Development Causes a Skeletal Myopathy in an Activating Braf Mouse Model for Cardio-facio-cutaneous Syndrome. Developmental dynamics : an official publication of the American Association of Anatomists\| PubMed ID: 33522658	2021
Digoxin treatment reactivates in vivo radioactive iodide uptake and correlates with favorable clinical outcome in non-medullary thyroid cancer. Cellular oncology (Dordrecht)\| PubMed ID: 33534128	2021