Deepak Shukla

Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago

Affiliated withUniversity of Illinois at Chicago

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 5	2021

Other Publications

Article	Year
Expanding the role of 3-O sulfated heparan sulfate in herpes simplex virus type-1 entry. Virology\| PubMed ID: 20004926	2010
Cellular expression of gH confers resistance to herpes simplex virus type-1 entry. Virology\| PubMed ID: 12890617	2003
A role for 3-O-sulfated heparan sulfate in cell fusion induced by herpes simplex virus type 1. The Journal of general virology\| PubMed ID: 15039523	2004
Characterization of heparan sulphate 3-O-sulphotransferase isoform 6 and its role in assisting the entry of herpes simplex virus type 1. The Biochemical journal\| PubMed ID: 15303968	2005
Herpes simplex virus entry receptor nectin-1 is widely expressed in the murine eye. Current eye research\| PubMed ID: 15590476	2004
Spinoculation of heparan sulfate deficient cells enhances HSV-1 entry, but does not abolish the need for essential glycoproteins in viral fusion. Journal of virological methods\| PubMed ID: 15908019	2005
A role for herpesvirus entry mediator as the receptor for herpes simplex virus 1 entry into primary human trabecular meshwork cells. Journal of virology\| PubMed ID: 16189018	2005
A role for 3-O-sulfotransferase isoform-4 in assisting HSV-1 entry and spread. Biochemical and biophysical research communications\| PubMed ID: 16259945	2005
A role for heparan sulfate 3-O-sulfotransferase isoform 2 in herpes simplex virus type 1 entry and spread. Virology\| PubMed ID: 16336986	2006
Expression of nectin-1 in normal and herpes simplex virus type 1-infected murine brain. Applied immunohistochemistry & molecular morphology : AIMM / official publication of the Society for Applied Immunohistochemistry\| PubMed ID: 16932027	2006
Role for 3-O-sulfated heparan sulfate as the receptor for herpes simplex virus type 1 entry into primary human corneal fibroblasts. Journal of virology\| PubMed ID: 16940509	2006
A novel role for phagocytosis-like uptake in herpes simplex virus entry. The Journal of cell biology\| PubMed ID: 17000878	2006
Soluble 3-O-sulfated heparan sulfate can trigger herpes simplex virus type 1 entry into resistant Chinese hamster ovary (CHO-K1) cells. The Journal of general virology\| PubMed ID: 17374750	2007
Viral inhibition studies on sulfated lignin, a chemically modified biopolymer and a potential mimic of heparan sulfate. Biomacromolecules\| PubMed ID: 17439173	2007
Herpes simplex virus type 2 entry into cultured human corneal fibroblasts is mediated by herpesvirus entry mediator. The Journal of general virology\| PubMed ID: 17622611	2007
Role of 3-O-sulfated heparan sulfate in virus-induced polykaryocyte formation. FEBS letters\| PubMed ID: 17765228	2007
Herpes simplex virus type 1 infection induces oxidative stress and the release of bioactive lipid peroxidation by-products in mouse P19N neural cell cultures. Journal of neurovirology\| PubMed ID: 17994426	2007
Using a 3-O-sulfated heparin octasaccharide to inhibit the entry of herpes simplex virus type 1. Biochemistry\| PubMed ID: 18457417	2008
HVEM and nectin-1 are the major mediators of herpes simplex virus 1 (HSV-1) entry into human conjunctival epithelium. Investigative ophthalmology & visual science\| PubMed ID: 18502984	2008
Herpes simplex virus type 1 induces filopodia in differentiated P19 neural cells to facilitate viral spread. Neuroscience letters\| PubMed ID: 18554796	2008
Antiviral activity of phytochemicals: a comprehensive review. Mini reviews in medicinal chemistry\| PubMed ID: 18855727	2008
Role of nectin-1, HVEM, and PILR-alpha in HSV-2 entry into human retinal pigment epithelial cells. Investigative ophthalmology & visual science\| PubMed ID: 19234349	2009
A sugar binding protein cyanovirin-N blocks herpes simplex virus type-1 entry and cell fusion. Antiviral research\| PubMed ID: 19665490	2009
An unusual dependence of human herpesvirus-8 glycoproteins-induced cell-to-cell fusion on heparan sulfate. Biochemical and biophysical research communications\| PubMed ID: 19747451	2009
Viral entry mechanisms: cellular and viral mediators of herpes simplex virus entry. The FEBS journal\| PubMed ID: 19878306	2009
Viral entry mechanisms: simplicity drives complexity. The FEBS journal\| PubMed ID: 19878309	2009
Expression of herpes virus entry mediator (HVEM) in the cornea and trigeminal ganglia of normal and HSV-1 infected mice. Current eye research\| PubMed ID: 19895317	2009
A role for heparan sulfate in viral surfing. Biochemical and biophysical research communications\| PubMed ID: 19909728	2010
The Importance of Heparan Sulfate in Herpesvirus Infection. Virologica Sinica\| PubMed ID: 19956628	2008
In vitro antiviral activity of neem (Azardirachta indica L.) bark extract against herpes simplex virus type-1 infection. Phytotherapy research : PTR\| PubMed ID: 20041417	2010
Mediators and mechanisms of herpes simplex virus entry into ocular cells. Current eye research\| PubMed ID: 20465436	2010
Phosphoinositide 3 kinase signalling may affect multiple steps during herpes simplex virus type-1 entry. The Journal of general virology\| PubMed ID: 20810749	2010
HSV-1 infection of human corneal epithelial cells: receptor-mediated entry and trends of re-infection. Molecular vision\| PubMed ID: 21139972	2010
Syndecan-1 and syndecan-2 play key roles in herpes simplex virus type-1 infection. The Journal of general virology\| PubMed ID: 21148276	2011
Chronic progressive deficits in neuron size, density and number in the trigeminal ganglia of mice latently infected with herpes simplex virus. Brain pathology (Zurich, Switzerland)\| PubMed ID: 21371157	2011
Corneal latency and transmission of herpes simplex virus-1. Future virology\| PubMed ID: 21436960	2011
Virostatic potential of micro-nano filopodia-like ZnO structures against herpes simplex virus-1. Antiviral research\| PubMed ID: 21893101	2011
An important role for syndecan-1 in herpes simplex virus type-1 induced cell-to-cell fusion and virus spread. PloS one\| PubMed ID: 21957484	2011
Herpes simplex virus infects most cell types in vitro: clues to its success. Virology journal\| PubMed ID: 22029482	2011
Early events in herpes simplex virus lifecycle with implications for an infection of lifetime. The open virology journal\| PubMed ID: 22291864	2012
Stem cell marker CD271 is expressed by vasculogenic mimicry-forming uveal melanoma cells in three-dimensional cultures. Molecular vision\| PubMed ID: 22419851	2012
Increased axonal expression of nectin-1 in multiple sclerosis plaques. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology\| PubMed ID: 22460696	2013
Nonprofessional phagocytosis can facilitate herpesvirus entry into ocular cells. Clinical & developmental immunology\| PubMed ID: 22481969	2012
A 3-O-sulfated heparan sulfate binding peptide preferentially targets herpes simplex virus 2-infected cells. Journal of virology\| PubMed ID: 22491462	2012
Herpes simplex epithelial and stromal keratitis: an epidemiologic update. Survey of ophthalmology\| PubMed ID: 22542912	2012
Role of heparan sulfate in sexually transmitted infections. Glycobiology\| PubMed ID: 22773448	2012
Prophylactic, therapeutic and neutralizing effects of zinc oxide tetrapod structures against herpes simplex virus type-2 infection. Antiviral research\| PubMed ID: 23047013	2012
Tin oxide nanowires suppress herpes simplex virus-1 entry and cell-to-cell membrane fusion. PloS one\| PubMed ID: 23110193	2012
Susceptibility of human iris stromal cells to herpes simplex virus 1 entry. Journal of virology\| PubMed ID: 23345512	2013
Members of 3-O-Sulfotransferases (3-OST) Family: A Valuable Tool from Zebrafish to Humans for Understanding Herpes Simplex Virus Entry. The open virology journal\| PubMed ID: 23358893	2013
Role of heparan sulfate in ocular diseases. Experimental eye research\| PubMed ID: 23410824	2013
Glycoprotein targeted therapeutics: a new era of anti-herpes simplex virus-1 therapeutics. Reviews in medical virology\| PubMed ID: 23440920	2013
Recent advances in vaccine development for herpes simplex virus types I and II. Human vaccines & immunotherapeutics\| PubMed ID: 23442925	2013
Role of Filopodia in HSV-1 Entry into Zebrafish 3-O-Sulfotransferase-3-Expressing Cells. The open virology journal\| PubMed ID: 23667409	2013
Exploiting herpes simplex virus entry for novel therapeutics. Viruses\| PubMed ID: 23752649	2013
Inhibition of myosin light chain kinase can be targeted for the development of new therapies against herpes simplex virus type-1 infection. Antiviral therapy\| PubMed ID: 23813409	2014
An investigative peptide-acyclovir combination to control herpes simplex virus type 1 ocular infection. Investigative ophthalmology & visual science\| PubMed ID: 23989188	2013
Zebrafish: modeling for herpes simplex virus infections. Zebrafish\| PubMed ID: 24266790	2014
Zebrafish 3-O-sulfotransferase-4 generated heparan sulfate mediates HSV-1 entry and spread. PloS one\| PubMed ID: 24498308	2014
Comprehensive analysis of herpes simplex virus 1 (HSV-1) entry mediated by zebrafish 3-O-Sulfotransferase isoforms: implications for the development of a zebrafish model of HSV-1 infection. Journal of virology\| PubMed ID: 25142596	2014
Characterization of a proteolytically stable D-peptide that suppresses herpes simplex virus 1 infection: implications for the development of entry-based antiviral therapy. Journal of virology\| PubMed ID: 25428865	2015
Corneal lymphangiogenesis in herpetic stromal keratitis. Survey of ophthalmology\| PubMed ID: 25444520	2015
Diversity of heparan sulfate and HSV entry: basic understanding and treatment strategies. Molecules (Basel, Switzerland)\| PubMed ID: 25665065	2015
A role for 3-O-sulfated heparan sulfate in promoting human cytomegalovirus infection in human iris cells. Journal of virology\| PubMed ID: 25717110	2015
Heparanase is a host enzyme required for herpes simplex virus-1 release from cells. Nature communications\| PubMed ID: 25912399	2015
Extended Release of an Anti-Heparan Sulfate Peptide From a Contact Lens Suppresses Corneal Herpes Simplex Virus-1 Infection. Investigative ophthalmology & visual science\| PubMed ID: 26780322	2016
Filopodia and Viruses: An Analysis of Membrane Processes in Entry Mechanisms. Frontiers in microbiology\| PubMed ID: 27014223	2016
Cell entry mechanisms of HSV: what we have learned in recent years. Future virology\| PubMed ID: 27066105	2015
Could zinc oxide tetrapod nanoparticles be used as an effective immunotherapy against HSV-2? Nanomedicine (London, England)\| PubMed ID: 27527812	2016
Role of metal and metal oxide nanoparticles as diagnostic and therapeutic tools for highly prevalent viral infections. Nanomedicine : nanotechnology, biology, and medicine\| PubMed ID: 27575283	2017
Cultured corneas show dendritic spread and restrict herpes simplex virus infection that is not observed with cultured corneal cells. Scientific reports\| PubMed ID: 28198435	2017
Zinc oxide tetrapods inhibit herpes simplex virus infection of cultured corneas. Molecular vision\| PubMed ID: 28275313	2017
Genital Herpes: Insights into Sexually Transmitted Infectious Disease. Microbial cell (Graz, Austria)\| PubMed ID: 28357380	2016
Effects of histatin-1 peptide on human corneal epithelial cells. PloS one\| PubMed ID: 28542418	2017
Viral Activation of Heparanase Drives Pathogenesis of Herpes Simplex Virus-1. Cell reports\| PubMed ID: 28700944	2017
Emerging Roles of Heparanase in Viral Pathogenesis. Pathogens (Basel, Switzerland)\| PubMed ID: 28927006	2017
Targeting Herpes Simplex Virus-1 gD by a DNA Aptamer Can Be an Effective New Strategy to Curb Viral Infection. Molecular therapy. Nucleic acids\| PubMed ID: 29246315	2017
Herpesvirus-encoded microRNAs detected in human gingiva alter host cell transcriptome and regulate viral infection. Biochimica et biophysica acta. Gene regulatory mechanisms\| PubMed ID: 29550353	2018
Viral miRNAs Alter Host Cell miRNA Profiles and Modulate Innate Immune Responses. Frontiers in immunology\| PubMed ID: 29559974	2018
prediction of cellular gene targets of herpesvirus encoded microRNAs. Data in brief\| PubMed ID: 29892642	2018
Herpes Simplex Virus 1 Infection Promotes the Growth of a Subpopulation of Tumor Cells in Three-Dimensional Uveal Melanoma Cultures. Journal of virology\| PubMed ID: 30045986	2018
Host Enzymes Heparanase and Cathepsin L Promote Herpes Simplex Virus 2 Release from Cells. Journal of virology\| PubMed ID: 30232188	2018
Pathogenesis of herpes simplex keratitis: The host cell response and ocular surface sequelae to infection and inflammation. The ocular surface\| PubMed ID: 30317007	2019
Herpesviruses and MicroRNAs: New Pathogenesis Factors in Oral Infection and Disease? Frontiers in immunology\| PubMed ID: 30319604	2018
Pathological processes activated by herpes simplex virus-1 (HSV-1) infection in the cornea. Cellular and molecular life sciences : CMLS\| PubMed ID: 30327839	2019
CRISPR-Cas based targeting of host and viral genes as an antiviral strategy. Seminars in cell & developmental biology\| PubMed ID: 30953741	2019
Drug-encapsulated carbon (DECON): A novel platform for enhanced drug delivery. Science advances\| PubMed ID: 31453334	2019
Current and Emerging Therapies for Ocular Herpes Simplex Virus Type-1 Infections. Microorganisms\| PubMed ID: 31658632	2019
Prior inhibition of AKT phosphorylation by BX795 can define a safer strategy to prevent herpes simplex virus-1 infection of the eye. The ocular surface\| PubMed ID: 31770600	2020
Heparanase-Regulated Syndecan-1 Shedding Facilitates Herpes Simplex Virus 1 Egress. Journal of virology\| PubMed ID: 31827001	2020
Heparanase, Heparan Sulfate and Viral Infection. Advances in experimental medicine and biology\| PubMed ID: 32274736	2020
Bacterial Pigment Prodigiosin Demonstrates a Unique Antiherpesvirus Activity That Is Mediated through Inhibition of Prosurvival Signal Transducers. Journal of virology\| PubMed ID: 32295926	2020
Wound Healing Properties of Histatin-5 and Identification of a Functional Domain Required for Histatin-5-Induced Cell Migration. Molecular therapy. Methods & clinical development\| PubMed ID: 32346548	2020
BX795 demonstrates potent antiviral benefits against herpes simplex Virus-1 infection of human cell lines. Antiviral research\| PubMed ID: 32380150	2020
Heparanase, cell signaling, and viral infections. Cellular and molecular life sciences : CMLS\| PubMed ID: 32462405	2020
Vaccines and Therapies in Development for SARS-CoV-2 Infections. Journal of clinical medicine\| PubMed ID: 32560227	2020
and Activity, Tolerability, and Mechanism of Action of BX795 as an Antiviral against Herpes Simplex Virus 2 Genital Infection. Antimicrobial agents and chemotherapy\| PubMed ID: 32601167	2020
Infection-Induced Porcine Ex Vivo Corneal Wound Model to Study the Efficacy of Herpes Simplex Virus-1 Entry and Replication Inhibitors. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 32808270	2021
Pharmaceutically Acceptable Carboxylic Acid-Terminated Polymers Show Activity and Selectivity against HSV-1 and HSV-2 and Synergy with Antiviral Drugs. ACS infectious diseases\| PubMed ID: 33078609	2020
Standalone or combinatorial phenylbutyrate therapy shows excellent antiviral activity and mimics CREB3 silencing. Science advances\| PubMed ID: 33277262	2020
The 3--sulfation of heparan sulfate modulates protein binding and lyase degradation. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 33441484	2021
Dysregulation of Cell Signaling by SARS-CoV-2. Trends in microbiology\| PubMed ID: 33451855	2021
Herpes Simplex Virus Cell Entry Mechanisms: An Update. Frontiers in cellular and infection microbiology\| PubMed ID: 33537244	2020
Pathobiology and treatment of viral keratitis. Experimental eye research\| PubMed ID: 33556334	2021
Disruption of innate defense responses by endoglycosidase HPSE promotes cell survival. JCI insight\| PubMed ID: 33621216	2021
Dissociation of DNA damage sensing by endoglycosidase HPSE. iScience\| PubMed ID: 33748723	2021
Entry receptor bias in evolutionarily distant HSV-1 clinical strains drives divergent ocular and nervous system pathologies. The ocular surface\| PubMed ID: 33766740	2021
Emerging Roles of Heparan Sulfate Proteoglycans in Viral Pathogenesis. Seminars in thrombosis and hemostasis\| PubMed ID: 33851373	2021
Role of Tunneling Nanotubes in Viral Infection, Neurodegenerative Disease, and Cancer. Frontiers in immunology\| PubMed ID: 34194434	2021
Heparan Sulfate Binding Cationic Peptides Restrict SARS-CoV-2 Entry. Pathogens (Basel, Switzerland)\| PubMed ID: 34202835	2021
Histatin-1 is an endogenous ligand of the sigma-2 receptor. The FEBS journal\| PubMed ID: 34233061	2021
Prophylactic treatment with BX795 blocks activation of AKT and its downstream targets to protect vaginal keratinocytes and vaginal epithelium from HSV-2 infection. Antiviral research\| PubMed ID: 34303747	2021
Histatin-1 Attenuates LPS-Induced Inflammatory Signaling in RAW264.7 Macrophages. International journal of molecular sciences\| PubMed ID: 34360629	2021
OPTN is a host intrinsic restriction factor against neuroinvasive HSV-1 infection. Nature communications\| PubMed ID: 34518549	2021
COVID-19 and oral diseases: Assessing manifestations of a new pathogen in oral infections. International reviews of immunology\| PubMed ID: 34525891	2021