Sally A. Cowley

James Martin Stem Cell Facility, University of Oxford

Research Area

Biography

http://www.wsjlab.com/meet-the-lab/sally-cowley/

JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 6	2021

Other Publications

Article	Year
Derivation and characterisation of the human embryonic stem cell line, OxF1. In vitro cellular & developmental biology. Animal\| PubMed ID: 20333479	2010
Protein kinase C and NF-κB-dependent CD4 downregulation in macrophages induced by T cell-derived soluble factors: consequences for HIV-1 infection. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 21666058	2011
Episomal transgene expression in pluripotent stem cells. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 21822889	2011
Transportin 3 promotes a nuclear maturation step required for efficient HIV-1 integration. PLoS pathogens\| PubMed ID: 21901095	2011
Cellular reprogramming: a new approach to modelling Parkinson's disease. Biochemical Society transactions\| PubMed ID: 22988881	2012
Differentially expressed, variant U1 snRNAs regulate gene expression in human cells. Genome research\| PubMed ID: 23070852	2013
Efficient, long term production of monocyte-derived macrophages from human pluripotent stem cells under partly-defined and fully-defined conditions. PloS one\| PubMed ID: 23951090	2013
The productive entry pathway of HIV-1 in macrophages is dependent on endocytosis through lipid rafts containing CD4. PloS one\| PubMed ID: 24465876	2014
Physiological characterisation of human iPS-derived dopaminergic neurons. PloS one\| PubMed ID: 24586273	2014
CRISPR-mediated genotypic and phenotypic correction of a chronic granulomatous disease mutation in human iPS cells. Experimental hematology\| PubMed ID: 26101162	2015
The Current State of Naïve Human Pluripotency. Stem cells (Dayton, Ohio)\| PubMed ID: 26119873	2015
ER Stress and Autophagic Perturbations Lead to Elevated Extracellular α-Synuclein in GBA-N370S Parkinson's iPSC-Derived Dopamine Neurons. Stem cell reports\| PubMed ID: 26905200	2016
C9orf72 Hexanucleotide Expansions Are Associated with Altered Endoplasmic Reticulum Calcium Homeostasis and Stress Granule Formation in Induced Pluripotent Stem Cell-Derived Neurons from Pat... Stem cells (Dayton, Ohio)\| PubMed ID: 27097283	2016
Variant U1 snRNAs are implicated in human pluripotent stem cell maintenance and neuromuscular disease. Nucleic acids research\| PubMed ID: 27536002	2016
Transcriptomic profiling of purified patient-derived dopamine neurons identifies convergent perturbations and therapeutics for Parkinson's disease. Human molecular genetics\| PubMed ID: 28096185	2017
Multiplex High-Throughput Targeted Proteomic Assay To Identify Induced Pluripotent Stem Cells. Analytical chemistry\| PubMed ID: 28192931	2017
LRRK2 in peripheral and central nervous system innate immunity: its link to Parkinson's disease. Biochemical Society transactions\| PubMed ID: 28202666	2017
A Highly Efficient Human Pluripotent Stem Cell Microglia Model Displays a Neuronal-Co-culture-Specific Expression Profile and Inflammatory Response. Stem cell reports\| PubMed ID: 28591653	2017
MAPT Genetic Variation and Neuronal Maturity Alter Isoform Expression Affecting Axonal Transport in iPSC-Derived Dopamine Neurons. Stem cell reports\| PubMed ID: 28689993	2017
Excess α-synuclein compromises phagocytosis in iPSC-derived macrophages. Scientific reports\| PubMed ID: 28827786	2017
Alpha-synuclein induces the unfolded protein response in Parkinson's disease SNCA triplication iPSC-derived neurons. Human molecular genetics\| PubMed ID: 28973645	2017
A Simplified Method for Generating Purkinje Cells from Human-Induced Pluripotent Stem Cells. Cerebellum (London, England)\| PubMed ID: 29397531	2018
Stem cell modeling of mitochondrial parkinsonism reveals key functions of OPA1. Annals of neurology\| PubMed ID: 29604226	2018
LRRK2 is a negative regulator of phagosome maturation in macrophages. The EMBO journal\| PubMed ID: 29789389	2018
FRMD8 promotes inflammatory and growth factor signalling by stabilising the iRhom/ADAM17 sheddase complex. eLife\| PubMed ID: 29897336	2018
Genome editing in induced pluripotent stem cells rescues TAF1 levels in X-linked dystonia-parkinsonism. Movement disorders : official journal of the Movement Disorder Society\| PubMed ID: 30153385	2018
Neurodegeneration in SCA14 is associated with increased PKCγ kinase activity, mislocalization and aggregation. Acta neuropathologica communications\| PubMed ID: 30249303	2018
RIPK1 is a critical modulator of both tonic and TLR-responsive inflammatory and cell death pathways in human macrophage differentiation. Cell death & disease\| PubMed ID: 30250197	2018
Single-Cell Sequencing of iPSC-Dopamine Neurons Reconstructs Disease Progression and Identifies HDAC4 as a Regulator of Parkinson Cell Phenotypes. Cell stem cell\| PubMed ID: 30503143	2019
Microglial inflammation and phagocytosis in Alzheimer's disease: Potential therapeutic targets. British journal of pharmacology\| PubMed ID: 30740661	2019
Cellular α-synuclein pathology is associated with bioenergetic dysfunction in Parkinson's iPSC-derived dopamine neurons. Human molecular genetics\| PubMed ID: 30753527	2019
Proteolytic shedding of the prion protein via activation of metallopeptidase ADAM10 reduces cellular binding and toxicity of amyloid-β oligomers. The Journal of biological chemistry\| PubMed ID: 30872401	2019
An integrated transcriptomics and proteomics analysis reveals functional endocytic dysregulation caused by mutations in LRRK2. Neurobiology of disease\| PubMed ID: 30954703	2019
Lentiviral gene therapy vector with UCOE stably restores function in iPSC-derived neutrophils of a CDG patient. Matters\| PubMed ID: 31008103	2018
RNA sequencing reveals MMP2 and TGFB1 downregulation in LRRK2 G2019S Parkinson's iPSC-derived astrocytes. Neurobiology of disease\| PubMed ID: 31085228	2019
Application of CRISPR/Cas9 editing and digital droplet PCR in human iPSCs to generate novel knock-in reporter lines to visualize dopaminergic neurons. Stem cell research\| PubMed ID: 31733438	2019
A causal role for TRESK loss of function in migraine mechanisms. Brain : a journal of neurology\| PubMed ID: 31742594	2019
Impairment of Mitochondrial Calcium Buffering Links Mutations in C9ORF72 and TARDBP in iPS-Derived Motor Neurons from Patients with ALS/FTD. Stem cell reports\| PubMed ID: 32330447	2020
LRRK2 Is Recruited to Phagosomes and Co-recruits RAB8 and RAB10 in Human Pluripotent Stem Cell-Derived Macrophages. Stem cell reports\| PubMed ID: 32359446	2020
Patient fibroblast circadian rhythms predict lithium sensitivity in bipolar disorder. Molecular psychiatry\| PubMed ID: 32404948	2020
Generation of twenty four induced pluripotent stem cell lines from twenty four members of the Lothian Birth Cohort 1936. Stem cell research\| PubMed ID: 32450543	2020
Correction of amyotrophic lateral sclerosis related phenotypes in induced pluripotent stem cell-derived motor neurons carrying a hexanucleotide expansion mutation in C9orf72 by CRISPR/Cas9 g... Human molecular genetics\| PubMed ID: 32504093	2020
Rates of homology directed repair of CRISPR-Cas9 induced double strand breaks are lower in naïve compared to primed human pluripotent stem cells. Stem cell research\| PubMed ID: 32521498	2020
Profiling of naïve and primed human pluripotent stem cells reveals state-associated miRNAs. Scientific reports\| PubMed ID: 32601281	2020
Large-Scale Production of Human iPSC-Derived Macrophages for Drug Screening. International journal of molecular sciences\| PubMed ID: 32645954	2020
ADAM17-triggered TNF signalling protects the ageing Drosophila retina from lipid droplet-mediated degeneration. The EMBO journal\| PubMed ID: 32715522	2020
TREM2 Alzheimer's variant R47H causes similar transcriptional dysregulation to knockout, yet only subtle functional phenotypes in human iPSC-derived macrophages. Alzheimer's research & therapy\| PubMed ID: 33198789	2020
Honing the Double-Edged Sword: Improving Human iPSC-Microglia Models. Frontiers in immunology\| PubMed ID: 33363548	2020
Tissue-resident macrophages regulate lymphatic vessel growth and patterning in the developing heart. Development (Cambridge, England)\| PubMed ID: 33462113	2021