Andre F. Palmer

William G. Lowrie Department of Chemical and Biomolecular Engineering, The Ohio State University

Affiliated withThe Ohio State University

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 8	2021
Publication title Cited by 3	2024

Other Publications

Article	Year
Self-assembled poly(butadiene)-b-poly(ethylene oxide) polymersomes as paclitaxel carriers. Biotechnology progress\| PubMed ID: 17269699	2007
Hemoglobin-based O2 carrier O2 affinity and capillary inlet pO2 are important factors that influence O2 transport in a capillary. Biotechnology progress\| PubMed ID: 17555329	2007
Purification of bovine hemoglobin via fast performance liquid chromatography. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences\| PubMed ID: 17581802	2007
Preparation of ultrapure bovine and human hemoglobin by anion exchange chromatography. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences\| PubMed ID: 18359279	2008
Biocompatible and biodegradable polymersome encapsulated hemoglobin: a potential oxygen carrier. Bioconjugate chemistry\| PubMed ID: 18442283	2008
Site-selective glycosylation of hemoglobin on Cys beta93. Bioconjugate chemistry\| PubMed ID: 18925771	2008
Hemoglobin-based oxygen carrier and convection enhanced oxygen transport in a hollow fiber bioreactor. Biotechnology and bioengineering\| PubMed ID: 19072844	2009
Tangential flow filtration of hemoglobin. Biotechnology progress\| PubMed ID: 19224583	2009
Perfluorocarbon facilitated O(2) transport in a hepatic hollow fiber bioreactor. Biotechnology progress\| PubMed ID: 19565662	2009
Purification of hemoglobin by tangential flow filtration with diafiltration. Biotechnology progress\| PubMed ID: 19621471	2009
The quaternary structure of tetrameric hemoglobin regulates the oxygen affinity of polymerized hemoglobin. Biotechnology progress\| PubMed ID: 19725116	2009
Effects of the molecular mass of tense-state polymerized bovine hemoglobin on blood pressure and vasoconstriction. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 19745190	2009
Mixtures of hemoglobin-based oxygen carriers and perfluorocarbons exhibit a synergistic effect in oxygenating hepatic hollow fiber bioreactors. Biotechnology and bioengineering\| PubMed ID: 19816963	2010
Large scale production of vesicles by hollow fiber extrusion: a novel method for generating polymersome encapsulated hemoglobin dispersions. Langmuir : the ACS journal of surfaces and colloids\| PubMed ID: 20000689	2010
Tissue oxygenation after exchange transfusion with ultrahigh-molecular-weight tense- and relaxed-state polymerized bovine hemoglobins. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 20061539	2010
Functional comparison of hemoglobin purified by different methods and their biophysical implications. Biotechnology and bioengineering\| PubMed ID: 20073089	2010
Synthesis, biophysical properties and pharmacokinetics of ultrahigh molecular weight tense and relaxed state polymerized bovine hemoglobins. Biomaterials\| PubMed ID: 20149433	2010
High throughput assembly of spatially controlled 3D cell clusters on a micro/nanoplatform. Lab on a chip\| PubMed ID: 20221567	2010
Hemoglobin regulates the metabolic, synthetic, detoxification, and biotransformation functions of hepatoma cells cultured in a hollow fiber bioreactor. Tissue engineering. Part A\| PubMed ID: 20528678	2010
Hemoglobin regulates the metabolic and synthetic function of rat insulinoma cells cultured in a hollow fiber bioreactor. Biotechnology and bioengineering\| PubMed ID: 20552668	2010
Polymerization of human hemoglobin using the crosslinker 1,11-bis(maleimido)triethylene glycol for use as an oxygen carrier. Biotechnology progress\| PubMed ID: 20564360	2010
Biophysical properties and oxygenation potential of high-molecular-weight glutaraldehyde-polymerized human hemoglobins maintained in the tense and relaxed quaternary states. Tissue engineering. Part A\| PubMed ID: 20979534	2011
Purification of hemoglobin from red blood cells using tangential flow filtration and immobilized metal ion affinity chromatography. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences\| PubMed ID: 21195679	2011
Effects of T- and R-state stabilization on deoxyhemoglobin-nitrite reactions and stimulation of nitric oxide signaling. Nitric oxide : biology and chemistry\| PubMed ID: 21277987	2011
Synthesis and biophysical properties of polymerized human serum albumin. Biotechnology progress\| PubMed ID: 21312376	2011
Development of a dichloroacetic acid-hemoglobin conjugate as a potential targeted anti-cancer therapeutic. Biotechnology and bioengineering\| PubMed ID: 21328317	2011
Small-volume resuscitation from hemorrhagic shock using high-molecular-weight tense-state polymerized hemoglobins. The Journal of trauma\| PubMed ID: 21336190	2011
Structure of Greyhound hemoglobin: origin of high oxygen affinity. Acta crystallographica. Section D, Biological crystallography\| PubMed ID: 21543841	2011
Synthesis, biophysical properties, and oxygenation potential of variable molecular weight glutaraldehyde-polymerized bovine hemoglobins with low and high oxygen affinity. Biotechnology progress\| PubMed ID: 21584950	2011
Simple method for preparing poly(ethylene glycol)-surface-conjugated liposome-encapsulated hemoglobins: physicochemical properties, long-term storage stability, and their reactions with O2, ... Langmuir : the ACS journal of surfaces and colloids\| PubMed ID: 21678920	2011
Liposomes surface conjugated with human hemoglobin target delivery to macrophages. Biotechnology and bioengineering\| PubMed ID: 22012493	2012
Small-volume resuscitation from hemorrhagic shock with polymerized human serum albumin. The American journal of emergency medicine\| PubMed ID: 22100469	2011
Simulation of NO and O(2) transport facilitated by polymerized hemoglobin solutions in an arteriole that takes into account wall shear stress-induced NO production. Biophysical chemistry\| PubMed ID: 22285312	2012
Hypervolemic infusion of Lumbricus terrestris erythrocruorin purified by tangential-flow filtration. Transfusion\| PubMed ID: 22304397	2012
Down selection of polymerized bovine hemoglobins for use as oxygen releasing therapeutics in a guinea pig model. Toxicological sciences : an official journal of the Society of Toxicology\| PubMed ID: 22416071	2012
Encapsulation of hemoglobin inside liposomes surface conjugated with poly(ethylene glycol) attenuates their reactions with gaseous ligands and regulates nitric oxide dependent vasodilation. Biotechnology progress\| PubMed ID: 22467599	2012
Site-selective glycosylation of hemoglobin with variable molecular weight oligosaccharides: potential alternative to PEGylation. Journal of the American Chemical Society\| PubMed ID: 22489605	2012
Hemoglobin encapsulated poly(ethylene glycol) surface conjugated vesicles attenuate vasoactivity of cell-free hemoglobin. Current drug discovery technologies\| PubMed ID: 22564169	2012
High-efficiency matrix modulus-induced cardiac differentiation of human mesenchymal stem cells inside a thermosensitive hydrogel. Acta biomaterialia\| PubMed ID: 22729021	2012
The Reactivity of Polymersome Encapsulated Hemoglobin with Physiologically Important Gaseous Ligands: Oxygen, Carbon Monoxide and Nitric Oxide. Macromolecules\| PubMed ID: 22865934	2012
Oxygen delivery during extreme anemia with ultra-pure earthworm hemoglobin. Life sciences\| PubMed ID: 22982347	2012
Addition of ascorbic acid solution to stored murine red blood cells increases posttransfusion recovery and decreases microparticles and alloimmunization. Transfusion\| PubMed ID: 23384196	2013
Scaffold architecture controls insulinoma clustering, viability, and insulin production. Tissue engineering. Part A\| PubMed ID: 24410263	2014
Blood substitutes. Annual review of biomedical engineering\| PubMed ID: 24819476	2014
Biophysical Properties of Lumbricus terrestris Erythrocruorin and Its Potential Use as a Red Blood Cell Substitute. Journal of functional biomaterials\| PubMed ID: 24956515	2012
Hemoglobin regulates the migration of glioma cells along poly(ε-caprolactone)-aligned nanofibers. Biotechnology progress\| PubMed ID: 25044995	2014
Modeling hemoglobin and hemoglobin:haptoglobin complex clearance in a non-rodent species-pharmacokinetic and therapeutic implications. Frontiers in physiology\| PubMed ID: 25346694	2014
Evaluating the capacity to generate and preserve nitric oxide bioactivity in highly purified earthworm erythrocruorin: a giant polymeric hemoglobin with potential blood substitute properties... The Journal of biological chemistry\| PubMed ID: 25371199	2015
Methemoglobin is an endogenous toll-like receptor 4 ligand-relevance to subarachnoid hemorrhage. International journal of molecular sciences\| PubMed ID: 25751721	2015
Cotransplantation of Polymerized Hemoglobin Reduces β-Cell Hypoxia and Improves β-Cell Function in Intramuscular Islet Grafts. Transplantation\| PubMed ID: 26426924	2015
Haptoglobin Preserves Vascular Nitric Oxide Signaling during Hemolysis. American journal of respiratory and critical care medicine\| PubMed ID: 26694989	2016
Transfusion with packed red blood cells while awaiting lung transplantation is associated with reduced survival after lung transplantation. Clinical transplantation\| PubMed ID: 27653312	2016
Quantification of Active Apohemoglobin Heme-Binding Sites via Dicyanohemin Incorporation. Biochemistry\| PubMed ID: 28846391	2017
The quaternary state of polymerized human hemoglobin regulates oxygenation of breast cancer solid tumors: A theoretical and experimental study. PloS one\| PubMed ID: 29414985	2018
Single cell analysis of aged RBCs: quantitative analysis of the aged cells and byproducts. The Analyst\| PubMed ID: 30617361	2019
A Subpopulation of Monocytes in Normal Human Blood Has Significant Magnetic Susceptibility: Quantification and Potential Implications. Cytometry. Part A : the journal of the International Society for Analytical Cytology\| PubMed ID: 30958642	2019
An Hb-mediated circulating macrophage contributing to pulmonary vascular remodeling in sickle cell disease. JCI insight\| PubMed ID: 31391342	2019
Haptoglobin administration into the subarachnoid space prevents hemoglobin-induced cerebral vasospasm. The Journal of clinical investigation\| PubMed ID: 31454333	2019
Novel manufacturing method for producing apohemoglobin and its biophysical properties. Biotechnology and bioengineering\| PubMed ID: 31612988	2020
Controlled Polymerization and Ultrafiltration Increase the Consistency of Polymerized Hemoglobin for Use as an Oxygen Carrier. Bioconjugate chemistry\| PubMed ID: 31868349	2020
Quantification of the Mean and Distribution of Hemoglobin Content in Normal Human Blood Using Cell Tracking Velocimetry. Analytical chemistry\| PubMed ID: 31874030	2020
Injectable biodegradable bi-layered capsule for sustained delivery of bevacizumab in treating wet age-related macular degeneration. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 31981659	2020
Resuscitation From Hemorrhagic Shock With Fresh and Stored Blood and Polymerized Hemoglobin. Shock (Augusta, Ga.)\| PubMed ID: 32097242	2020
Poly(ethylene glycol) Surface-Conjugated Apohemoglobin as a Synthetic Heme Scavenger. Biomacromolecules\| PubMed ID: 32186855	2020
Apohemoglobin-haptoglobin complex attenuates the pathobiology of circulating acellular hemoglobin and heme. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 32302494	2020
Tangential flow filtration of haptoglobin. Biotechnology progress\| PubMed ID: 32348635	2020
Anti-inflammatory effects of haptoglobin on LPS-stimulated macrophages: Role of HMGB1 signaling and implications in chronic wound healing. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society\| PubMed ID: 32428978	2020
Targeted Myoglobin Delivery as a Strategy for Enhancing the Sensitivity of Hypoxic Cancer Cells to Radiation. iScience\| PubMed ID: 32464594	2020
Comprehensive characterization of tense and relaxed quaternary state glutaraldehyde polymerized bovine hemoglobin as a function of cross-link density. Biotechnology and bioengineering\| PubMed ID: 32472694	2020
Balance between oxygen transport and blood rheology during resuscitation from hemorrhagic shock with polymerized bovine hemoglobin. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 32552431	2020
Apohemoglobin-haptoglobin complexes attenuate the hypertensive response to low-molecular-weight polymerized hemoglobin. Blood advances\| PubMed ID: 32559292	2020
Hyperferritinemia in critically ill COVID-19 patients - Is ferritin the product of inflammation or a pathogenic mediator? Clinica chimica acta; international journal of clinical chemistry\| PubMed ID: 32579952	2020
Polymerized human hemoglobin facilitated modulation of tumor oxygenation is dependent on tumor oxygenation status and oxygen affinity of the hemoglobin-based oxygen carrier. Scientific reports\| PubMed ID: 32647211	2020
Tumor vascular status controls oxygen delivery facilitated by infused polymerized hemoglobins with varying oxygen affinity. PLoS computational biology\| PubMed ID: 32817659	2020
Safety profile of high molecular weight polymerized hemoglobins. Transfusion\| PubMed ID: 33104250	2021
Polymerized human hemoglobin increases the effectiveness of cisplatin-based chemotherapy in non-small cell lung cancer. Oncotarget\| PubMed ID: 33144918	2020
Vessel-on-a-chip models for studying microvascular physiology, transport, and function in vitro. American journal of physiology. Cell physiology\| PubMed ID: 33176110	2021
Early Intervention in Ischemic Tissue with Oxygen Nanocarriers Enables Successful Implementation of Restorative Cell Therapies. Cellular and molecular bioengineering\| PubMed ID: 33184576	2020
Synthesis of Hemoglobin-Based Oxygen Carrier Nanoparticles By Desolvation Precipitation. Langmuir : the ACS journal of surfaces and colloids\| PubMed ID: 33205655	2020
Purification of Mega-Hemoglobin for Diverse Oxygen Therapeutic Applications. ACS biomaterials science & engineering\| PubMed ID: 33313397	2020
Resuscitation from hemorrhagic shock after traumatic brain injury with polymerized hemoglobin. Scientific reports\| PubMed ID: 33510204	2021
High fat high sucrose diet-induced dyslipidemia in guinea pigs. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 33703947	2021
Purification and analysis of a protein cocktail capable of scavenging cell-free hemoglobin, heme, and iron. Transfusion\| PubMed ID: 33817808	2021
Structural Stability and Biophysical Properties of the Mega-Protein Erythrocruorin Are Regulated by Polyethylene Glycol Surface Coverage. Biomacromolecules\| PubMed ID: 33821616	2021
Immunomagnetic sequential ultrafiltration (iSUF) platform for enrichment and purification of extracellular vesicles from biofluids. Scientific reports\| PubMed ID: 33850163	2021
Polymerized albumin restores impaired hemodynamics in endotoxemia and polymicrobial sepsis. Scientific reports\| PubMed ID: 34035380	2021
Magnetophoretic and spectral characterization of oxyhemoglobin and deoxyhemoglobin: Chemical versus enzymatic processes. PloS one\| PubMed ID: 34478473	2021
Biophysical properties of tense quaternary state polymerized human hemoglobins bracketed between 500 kDa and 0.2 μm in size. Biotechnology progress\| PubMed ID: 34626100	2021
Tangential flow filtration facilitated fractionation and PEGylation of low and high-molecular weight polymerized hemoglobins and their biophysical properties. Biotechnology and bioengineering\| PubMed ID: 34672363	2021
Modern cross-linking strategies for synthesizing acellular hemoglobin-based oxygen carriers. Biotechnology progress\| PubMed ID: 19194934	2008
Mathematical model of NO and O2 transport in an arteriole facilitated by hemoglobin based O2 carriers. Biophysical chemistry\| PubMed ID: 19318228	2009
Erythrocytes Are Oxygen-Sensing Regulators of the Cerebral Microcirculation. Neuron\| PubMed ID: 27499087	2016
Mixtures of tense and relaxed state polymerized human hemoglobin regulate oxygen affinity and tissue construct oxygenation. PloS one\| PubMed ID: 29020036	2017
Intrinsically magnetic susceptibility in human blood and its potential impact on cell separation: Non-classical and intermediate monocytes have the strongest magnetic behavior in fresh human... Experimental hematology\| PubMed ID: 34015390	2021
Attenuating ischemia-reperfusion injury with polymerized albumin. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 34913740	2022
Polymerized Hemoglobin With Increased Molecular Size Reduces Toxicity in Healthy Guinea Pigs. ACS applied bio materials\| PubMed ID: 35025344	2020
Enhanced Photodynamic Therapy Using the Apohemoglobin-Haptoglobin Complex as a Carrier of Aluminum Phthalocyanine. ACS applied bio materials\| PubMed ID: 35025448	2020
Potential of cell tracking velocimetry as an economical and portable hematology analyzer. Scientific reports\| PubMed ID: 35105914	2022
Scalable manufacturing platform for the production of methemoglobin as a non-oxygen carrying control material in studies of cell-free hemoglobin solutions. PloS one\| PubMed ID: 35171971	2022
Lyophilized annelid mega-hemoglobin retains its' quaternary structure and oxygen equilibrium properties after room temperature storage for over 6 months. PloS one\| PubMed ID: 35176086	2022
Tangential flow filtration facilitated washing of human red blood cells: A proof-of-concept study. Vox sanguinis\| PubMed ID: 35262216	2022
Scalable production and complete biophysical characterization of poly(ethylene glycol) surface conjugated liposome encapsulated hemoglobin (PEG-LEH). PloS one\| PubMed ID: 35802716	2022
An immunogold single extracellular vesicular RNA and protein ( SERP) biochip to predict responses to immunotherapy in non-small cell lung cancer patients. Journal of extracellular vesicles\| PubMed ID: 36093740	2022
Scalable manufacturing platform for the production of PEGylated heme albumin. Biotechnology and bioengineering\| PubMed ID: 36111455	2022
Pilot scale production and characterization of next generation high molecular weight and tense quaternary state polymerized human hemoglobin. Biotechnology and bioengineering\| PubMed ID: 36120842	2022
Apohemoglobin-haptoglobin complex alleviates iron toxicity in mice with β-thalassemia via scavenging of cell-free hemoglobin and heme. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie\| PubMed ID: 36308920	2022
Sustained release of heme-albumin as a potential novel therapeutic approach for age-related macular degeneration. Biomaterials science\| PubMed ID: 36342429	2022
Safety and efficacy of human polymerized hemoglobin on guinea pig resuscitation from hemorrhagic shock. Scientific reports\| PubMed ID: 36443351	2022
Biophysical Analysis and Preclinical Pharmacokinetics-Pharmacodynamics of Tangential Flow Filtration Fractionated Polymerized Human Hemoglobin as a Red Blood Cell Substitute. Biomacromolecules\| PubMed ID: 36877888	2023
Photocatalytic Synthesis of a Polydopamine-Coated Acellular Mega-Hemoglobin as a Potential Oxygen Therapeutic with Antioxidant Properties. Biomacromolecules\| PubMed ID: 37027799	2023
ZIF-8 metal organic framework nanoparticle loaded with tense quaternary state polymerized bovine hemoglobin: potential red blood cell substitute with antioxidant properties. Nanoscale\| PubMed ID: 37114464	2023
Biocompatibility of the oxygen carrier polymerized human hemoglobin towards HepG2/C3A cells. Heliyon\| PubMed ID: 37215914	2023
Polymerized human hemoglobin with low and high oxygen affinity in trauma models. Translational research : the journal of laboratory and clinical medicine\| PubMed ID: 37268039	2023
Engineering Therapeutics to Detoxify Hemoglobin, Heme, and Iron. Annual review of biomedical engineering\| PubMed ID: 37289555	2023
ICAM-1-decorated extracellular vesicles loaded with miR-146a and drive immunomodulation and hinder tumor progression in a murine model of breast cancer. Biomaterials science\| PubMed ID: 37646133	2023
The Molecular Size of Bioengineered Oxygen Carriers Determines Tissue Oxygenation in a Hypercholesterolemia Guinea Pig Model of Hemorrhagic Shock and Resuscitation. Molecular pharmaceutics\| PubMed ID: 37843033	2023
Engineering a tunable micropattern-array assay to sort single extracellular vesicles and particles to detect RNA and protein in situ. Journal of extracellular vesicles\| PubMed ID: 37908159	2023
Polymerized Human Hemoglobin-Based Oxygen Carrier Preserves Lung Allograft Function During Normothermic Ex Vivo Lung Perfusion. ASAIO journal (American Society for Artificial Internal Organs : 1992)\| PubMed ID: 38266069	2024
Macrophage modulation by polymerized hemoglobins: Potential as a wound-healing therapy. Technology\| PubMed ID: 38486857	2019
Toxic side-effects of diaspirin cross-linked human hemoglobin are attenuated by the apohemoglobin-haptoglobin complex. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie\| PubMed ID: 38603886	2024
Novel high molecular weight polymerized hemoglobin in a non-obese model of cardiovascular and metabolic dysfunction. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie\| PubMed ID: 38815289	2024
Integrated Antigenic and Nucleic Acid Detection in Single Virions and Extracellular Vesicles with Viral Content. Advanced healthcare materials\| PubMed ID: 38820600	2024