Hisaysohi Hayashi

Laboratory of Physiology, University of Shizuoka

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 12	2021

Other Publications

Article	Year
[Effects of green tea extract on galactosamine-induced hepatic injury in rats]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica\| PubMed ID: 1464398	1992
Properties of active magnesium flux across the small intestine of the guinea pig. The Japanese journal of physiology\| PubMed ID: 1474677	1992
Studies on absorption, distribution, excretion and metabolism of ginseng saponins. V. The decomposition products of ginsenoside Rb2 in the large intestine of rats. Chemical & pharmaceutical bulletin\| PubMed ID: 2076572	1990
[Effect of shakuyaku-extract on electrical stimulation induced contraction of guinea pig ileum]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan\| PubMed ID: 2352132	1990
Decreased density of alpha 2-adrenoceptors in medulla oblongata of spontaneously hypertensive rats. Journal of cardiovascular pharmacology\| PubMed ID: 2471890	1989
Basolateral Cl-/HCO3- exchange in epithelial cells from guinea pig distal colon. The Japanese journal of physiology\| PubMed ID: 7752547	1994
Transmural potential changes associated with the in vitro absorption of theanine in the guinea pig intestine. Bioscience, biotechnology, and biochemistry\| PubMed ID: 8987851	1996
Abnormality in plasma catecholamines and myocardial adrenoceptors in cardiomyopathic BIO 53.58 Syrian hamsters and improvement by metoprolol treatment. The Journal of pharmacology and experimental therapeutics\| PubMed ID: 9400015	1997
Low-dose irradiation induces expression of heat shock protein 70 mRNA and thermo- and radio-resistance in myeloid leukemia cell line. Biological & pharmaceutical bulletin\| PubMed ID: 9635495	1998
Regulation of intracellular pH during H+-coupled oligopeptide absorption in enterocytes from guinea-pig ileum. The Journal of physiology\| PubMed ID: 9706032	1998
Brain distribution of 6-mercaptopurine is regulated by the efflux transport system in the blood-brain barrier. Life sciences\| PubMed ID: 10794520	2000
Na+-dependent recovery of intracellular pH from acid loading in mouse colonic crypt cells. The Tohoku journal of experimental medicine\| PubMed ID: 11321046	2001
Improved brain delivery of a nonsteroidal anti-inflammatory drug with a synthetic glyceride ester: a preliminary attempt at a CNS drug delivery system for the therapy of Alzheimer's disease. Journal of drug targeting\| PubMed ID: 11328663	2000
Studies of the constituents of Uruguayan propolis. Journal of agricultural and food chemistry\| PubMed ID: 12166959	2002
Cholinergic inhibition of electrogenic sodium absorption in the guinea pig distal colon. American journal of physiology. Gastrointestinal and liver physiology\| PubMed ID: 12444010	2003
Rhythmical contractions in pulmonary arteries of monocrotaline-induced pulmonary hypertensive rats. Pflugers Archiv : European journal of physiology\| PubMed ID: 14517679	2003
Biphasic response of cutaneous blood flow induced by passive cutaneous anaphylaxis in rats. European journal of pharmacology\| PubMed ID: 14660036	2003
Identification of metabolites in plasma and urine of Uruguayan propolis-treated rats. Journal of agricultural and food chemistry\| PubMed ID: 15137857	2004
Association of paracellin-1 with ZO-1 augments the reabsorption of divalent cations in renal epithelial cells. The Journal of biological chemistry\| PubMed ID: 15496416	2004
Formulation study and drug release mechanism of a new theophylline sustained-release preparation. International journal of pharmaceutics\| PubMed ID: 16154302	2005
Design and synthesis of artificial phospholipid for selective cleavage of integral membrane protein. Chemical communications (Cambridge, England)\| PubMed ID: 16158119	2005
Short-chain fatty acid receptor, GPR43, is expressed by enteroendocrine cells and mucosal mast cells in rat intestine. Cell and tissue research\| PubMed ID: 16453106	2006
Phosphorylation of paracellin-1 at Ser217 by protein kinase A is essential for localization in tight junctions. Journal of cell science\| PubMed ID: 16608877	2006
Functional characterization of Cl-/HCO3- exchange in villous cells of the mouse ileum. Biomedical research (Tokyo, Japan)\| PubMed ID: 17213682	2006
Propionate absorption associated with bicarbonate secretion in vitro in the mouse cecum. Pflugers Archiv : European journal of physiology\| PubMed ID: 17242958	2007
Genetic polymorphism of C452T (T127I) in human gamma-glutamyl hydrolase in a Japanese population. Biological & pharmaceutical bulletin\| PubMed ID: 17409534	2007
Identification of cell proliferation-associated epitope on CD98 oncoprotein using phage display random peptide library. Cancer science\| PubMed ID: 17711505	2007
Expression of the short-chain fatty acid receptor, GPR43, in the human colon. Journal of molecular histology\| PubMed ID: 17899402	2008
pH stat studies on bicarbonate secretion in the isolated mouse ileum. Biomedical research (Tokyo, Japan)\| PubMed ID: 18000336	2007
Exclusion of actin-binding protein p57/coronin-1 from bacteria-containing phagosomes in macrophages infected with Legionella. Biological & pharmaceutical bulletin\| PubMed ID: 18451508	2008
Application of fluorescence polarization immunoassay for determination of methotrexate-polyglutamates in rheumatoid arthritis patients. The Tohoku journal of experimental medicine\| PubMed ID: 18509240	2008
Elevated production of Legionella-specific immunoglobulin A in A/J mice is accompanied by T-helper 1-type polarization. Immunology letters\| PubMed ID: 18973775	2008
Antibody epitope peptides as potential inducers of IgG antibodies against CD98 oncoprotein. Cancer science\| PubMed ID: 19018757	2009
Effect of VKORC1-1639 G>A polymorphism, body weight, age, and serum albumin alterations on warfarin response in Japanese patients. Thrombosis research\| PubMed ID: 19135231	2009
Plasma total homocysteine level and methylenetetrahydrofolate reductase 677C>T genetic polymorphism in Japanese patients with rheumatoid arthritis. Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals\| PubMed ID: 19283524	2009
Regulation of intestinal Cl-/HCO3- exchanger SLC26A3 by intracellular pH. American journal of physiology. Cell physiology\| PubMed ID: 19321737	2009
Generation of a recombinant single-chain variable fragment (scFv) targeting 5-methyl-2'-deoxycytidine. Journal of biochemistry\| PubMed ID: 19815683	2010
Genetic polymorphisms in folate pathway enzymes as a possible marker for predicting the outcome of methotrexate therapy in Japanese patients with rheumatoid arthritis. Journal of clinical pharmacy and therapeutics\| PubMed ID: 19827168	2009
Proteinase-activated receptors-1 and 2 induce electrogenic Cl- secretion in the mouse cecum by distinct mechanisms. American journal of physiology. Gastrointestinal and liver physiology\| PubMed ID: 20413722	2010
Proteomic analysis of growth phase-dependent expression of Legionella pneumophila proteins which involves regulation of bacterial virulence traits. PloS one\| PubMed ID: 20661449	2010
Dihydrofolate reductase gene intronic 19-bp deletion polymorphisms in a Japanese population. Drug metabolism and pharmacokinetics\| PubMed ID: 20834190	2010
Generation of AcGFP fusion with single-chain Fv selected from a phage display library constructed from mice hyperimmunized against 5-methyl 2'-deoxycytidine. Protein engineering, design & selection : PEDS\| PubMed ID: 20876190	2010
[Recurrent education for pharmacists to support regional medicine]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan\| PubMed ID: 21212612	2011
Enhancement of cell-cell contact by claudin-4 in renal epithelial Madin-Darby canine kidney cells. Journal of cellular biochemistry\| PubMed ID: 21938738	2012
An artifact derived from a pseudogene led to the discovery of microRNA binding site polymorphism in the 3'-untranslated region of the human dihydrofolate reductase gene. Drug metabolism and pharmacokinetics\| PubMed ID: 22201119	2012
Genotype distributions and allele frequencies of possible major depressive disorder-associated single nucleotide polymorphisms, cyclic adenosine monophosphate response element binding protei... Biological & pharmaceutical bulletin\| PubMed ID: 22293360	2012
Expression of β-adrenergic-like octopamine receptors during Drosophila development. Zoological science\| PubMed ID: 22303848	2012
Subepithelial trypsin induces enteric nerve-mediated anion secretion by activating proteinase-activated receptor 1 in the mouse cecum. The journal of physiological sciences : JPS\| PubMed ID: 22389134	2012
Effect of menstrual cycle phase on the ventilatory response to rising body temperature during exercise. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 22604882	2012
Influence of CYP4F2 polymorphisms and plasma vitamin K levels on warfarin sensitivity in Japanese pediatric patients. Drug metabolism and pharmacokinetics\| PubMed ID: 22892446	2013
A single nucleotide polymorphism of reduced folate carrier 1 predicts methotrexate efficacy in Japanese patients with rheumatoid arthritis. Drug metabolism and pharmacokinetics\| PubMed ID: 22971639	2013
Polymorphisms of the UDP-glucuronosyl transferase 1A genes are associated with adverse events in cancer patients receiving irinotecan-based chemotherapy. The Tohoku journal of experimental medicine\| PubMed ID: 23303296	2013
Association of ABCB1 polymorphisms with the antiemetic efficacy of granisetron plus dexamethasone in breast cancer patients. Drug metabolism and pharmacokinetics\| PubMed ID: 23358260	2013
Ezrin is required for the functional regulation of the epithelial sodium proton exchanger, NHE3. PloS one\| PubMed ID: 23405179	2013
A case study on the association of variation of bitter-taste receptor gene TAS2R38 with the height, weight and energy intake in Japanese female college students. Journal of nutritional science and vitaminology\| PubMed ID: 23535535	2013
Hyperosmolarity-induced up-regulation of claudin-4 mediated by NADPH oxidase-dependent H2O2 production and Sp1/c-Jun cooperation. Biochimica et biophysica acta\| PubMed ID: 23816505	2013
[Personalized drug therapy-directed clinical pharmacology research based on genetic polymorphisms and pharmacokinetics analysis]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan\| PubMed ID: 24088351	2013
The JFFMA assessment of flavoring substances structurally related to menthol and uniquely used in Japan. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association\| PubMed ID: 24309148	2014
Simultaneous microdetermination of bosentan, ambrisentan, sildenafil, and tadalafil in plasma using liquid chromatography/tandem mass spectrometry for pediatric patients with pulmonary arter... Journal of pharmaceutical and biomedical analysis\| PubMed ID: 24309556	2014
Masked function of amino acid sensors on pancreatic hormone secretion in ventromedial hypothalamic (VMH) lesioned rats with marked hyperinsulinemia. Obesity research & clinical practice\| PubMed ID: 24331525	2012
Cell proliferation in ventromedial hypothalamic lesioned rats inhibits acute gastric mucosal lesions. Obesity research & clinical practice\| PubMed ID: 24331526	2012
Ventromedial hypothalamic lesions enhance small intestinal cell proliferation in mice. Obesity research & clinical practice\| PubMed ID: 24331527	2012
Activation of focal adhesion kinase via M1 muscarinic acetylcholine receptor is required in restitution of intestinal barrier function after epithelial injury. Biochimica et biophysica acta\| PubMed ID: 24365239	2014
Influence of uridine diphosphate glucuronosyltransferase 2B7 -161C>T polymorphism on the concentration of valproic acid in pediatric epilepsy patients. Therapeutic drug monitoring\| PubMed ID: 24365988	2014
Bladder endothelin-1 receptor binding of bosentan and ambrisentan. Journal of pharmacological sciences\| PubMed ID: 24389822	2014
Luminal trypsin induces enteric nerve-mediated anion secretion in the mouse cecum. The journal of physiological sciences : JPS\| PubMed ID: 24421180	2014
Identification of anti-CD98 antibody mimotopes for inducing antibodies with antitumor activity by mimotope immunization. Cancer science\| PubMed ID: 24484217	2014
Endothelin-1 receptors in rat tissues: characterization by bosentan, ambrisentan and CI-1020. Biological & pharmaceutical bulletin\| PubMed ID: 24583865	2014
Effect of the STAT3 inhibitor STX-0119 on the proliferation of a temozolomide-resistant glioblastoma cell line. International journal of oncology\| PubMed ID: 24820265	2014
Effect of postprandial thermogenesis on the cutaneous vasodilatory response during exercise. Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme\| PubMed ID: 24844468	2014
4217C>A polymorphism in carbamoyl-phosphate synthase 1 gene may not associate with hyperammonemia development during valproic acid-based therapy. Epilepsy research\| PubMed ID: 24888247	2014
Retrospective analysis of severe neutropenia in patients receiving concomitant administration of docetaxel and clarithromycin. Chemotherapy\| PubMed ID: 25011542	2013
A novel immunochromatographic system for easy-to-use detection of group 1 avian influenza viruses with acquired human-type receptor binding specificity. Biosensors & bioelectronics\| PubMed ID: 25461160	2015
Autocrine regulation of ecdysone synthesis by β3-octopamine receptor in the prothoracic gland is essential for Drosophila metamorphosis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 25605909	2015
Muscarinic cholinoceptor-mediated activation of JNK negatively regulates intestinal secretion in mice. Journal of pharmacological sciences\| PubMed ID: 25704031	2015
Plasma vitamin K concentrations depend on CYP4F2 polymorphism and influence on anticoagulation in Japanese patients with warfarin therapy. Thrombosis research\| PubMed ID: 25747538	2015
Hyperosmolarity-Induced Down-Regulation of Claudin-2 Mediated by Decrease in PKCβ-Dependent GATA-2 in MDCK Cells. Journal of cellular physiology\| PubMed ID: 25825272	2015
Relationship between ABCB1 gene polymorphisms and severe neutropenia in patients with breast cancer treated with doxorubicin/cyclophosphamide chemotherapy. Drug metabolism and pharmacokinetics\| PubMed ID: 25989890	2015
Reduced folate carrier 1 gene expression levels are correlated with methotrexate efficacy in Japanese patients with rheumatoid arthritis. Drug metabolism and pharmacokinetics\| PubMed ID: 26003891	2015
JaCVAM-organized international validation study of the in vivo rodent alkaline comet assay for the detection of genotoxic carcinogens: I. Summary of pre-validation study results. Mutation research. Genetic toxicology and environmental mutagenesis\| PubMed ID: 26212293	2015
JaCVAM-organized international validation study of the in vivo rodent alkaline comet assay for detection of genotoxic carcinogens: II. Summary of definitive validation study results. Mutation research. Genetic toxicology and environmental mutagenesis\| PubMed ID: 26212295	2015
Production and Purification of Secretory Simian Cytidine Monophosphate-N-acetylneuraminic Acid Hydroxylase Using Baculovirus-Protein Expression System. Biological & pharmaceutical bulletin\| PubMed ID: 26235586	2015
Simultaneous and rapid determination of gefitinib, erlotinib and afatinib plasma levels using liquid chromatography/tandem mass spectrometry in patients with non-small-cell lung cancer. Biomedical chromatography : BMC\| PubMed ID: 26525154	2016
Fluvoxamine, an anti-depressant, inhibits human glioblastoma invasion by disrupting actin polymerization. Scientific reports\| PubMed ID: 26988603	2016
Bioanalysis of bevacizumab and infliximab by high-temperature reversed-phase liquid chromatography with fluorescence detection after immunoaffinity magnetic purification. Analytica chimica acta\| PubMed ID: 27016445	2016
Characteristics of hyperthermia-induced hyperventilation in humans. Temperature (Austin, Tex.)\| PubMed ID: 27227102	2016
Influence of ABCB1 and ABCG2 polymorphisms on the antiemetic efficacy in patients with cancer receiving cisplatin-based chemotherapy: a TRIPLE pharmacogenomics study. The pharmacogenomics journal\| PubMed ID: 27241063	2017
Combination of a STAT3 Inhibitor and an mTOR Inhibitor Against a Temozolomide-resistant Glioblastoma Cell Line. Cancer genomics & proteomics\| PubMed ID: 28031240	2017
Signal-transducing adaptor protein-2 promotes generation of functional long-term memory CD8+ T cells by preventing terminal effector differentiation. Oncotarget\| PubMed ID: 28430604	2017
Japan Flavour and Fragrance Materials Association's (JFFMA) safety assessment of food-flavouring substances uniquely used in Japan that belong to the class of aliphatic primary alcohols, ald... Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment\| PubMed ID: 28540764	2017
Overexpression of KCNJ2 in induced pluripotent stem cell-derived cardiomyocytes for the assessment of QT-prolonging drugs. Journal of pharmacological sciences\| PubMed ID: 28615142	2017
A clustering approach to identify and characterize the asthma and chronic obstructive pulmonary disease overlap phenotype. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology\| PubMed ID: 28658564	2017
The anti-tumor activity of the STAT3 inhibitor STX-0119 occurs via promotion of tumor-infiltrating lymphocyte accumulation in temozolomide-resistant glioblastoma cell line. Immunology letters\| PubMed ID: 28716484	2017
Up-regulation of claudin-2 expression by aldosterone in colonic epithelial cells of mice fed with NaCl-depleted diets. Scientific reports\| PubMed ID: 28939904	2017
Genetic risk factors for chemotherapy-induced nausea and vomiting in patients with cancer receiving cisplatin-based chemotherapy. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer\| PubMed ID: 29177570	2018
Concomitant alteration in number and affinity of PX and muscarinic receptors are associated with bladder dysfunction in early stage of diabetic rats. International urology and nephrology\| PubMed ID: 29368246	2018
Time-Dependent Decline in Serum Phenytoin Concentration With Heightened Convulsive Seizure Risk by Prolonged Administration of Fosphenytoin in Japanese: A Retrospective Study. Therapeutic drug monitoring\| PubMed ID: 29683874	2018
Effect of food intake on the ventilatory response to increasing core temperature during exercise. Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme\| PubMed ID: 29944847	2019
Luminal Na homeostasis has an important role in intestinal peptide absorption in vivo. American journal of physiology. Gastrointestinal and liver physiology\| PubMed ID: 30138575	2018
Antigen delivery targeted to tumor-associated macrophages overcomes tumor immune resistance. The Journal of clinical investigation\| PubMed ID: 30628894	2019
High-Throughput Bioanalysis of Bevacizumab in Human Plasma Based on Enzyme-Linked Aptamer Assay Using Anti-Idiotype DNA Aptamer. Analytical chemistry\| PubMed ID: 30667211	2019
Anti-Idiotype DNA Aptamer Affinity Purification⁻High-Temperature Reversed-Phase Liquid Chromatography: A Simple, Accurate, and Selective Bioanalysis of Bevacizumab. Molecules (Basel, Switzerland)\| PubMed ID: 30823418	2019
Effect of food intake on respiratory chemosensitivity to CO in young adults. Journal of physiological anthropology\| PubMed ID: 31287028	2019
Probabilistic exposure assessment of aggregate rates of dermal exposure of Japanese women and children to parabens in personal care products. Chemosphere\| PubMed ID: 31520983	2020
Kinetics-Based Structural Requirements of Human Immunoglobulin G Binding Peptides. ACS omega\| PubMed ID: 31528791	2019
Impact of combination therapy with anti-PD-1 blockade and a STAT3 inhibitor on the tumor-infiltrating lymphocyte status. Immunology letters\| PubMed ID: 31586551	2019
Na-Coupled Nutrient Cotransport Induced Luminal Negative Potential and Claudin-15 Play an Important Role in Paracellular Na Recycling in Mouse Small Intestine. International journal of molecular sciences\| PubMed ID: 31936130	2020
Theanine, the Main Amino Acid in Tea, Prevents Stress-Induced Brain Atrophy by Modifying Early Stress Responses. Nutrients\| PubMed ID: 31936294	2020
Upregulation of Claudin-7 Expression by Angiotensin II in Colonic Epithelial Cells of Mice Fed with NaCl-Depleted Diets. International journal of molecular sciences\| PubMed ID: 32093310	2020
Discovery of a Potent Anticancer Agent PVHD303 with Activity. ACS medicinal chemistry letters\| PubMed ID: 32551013	2020
Genome-wide association meta-analysis identifies GP2 gene risk variants for pancreatic cancer. Nature communications\| PubMed ID: 32581250	2020
Angulin-2/ILDR1, a tricellular tight junction protein, does not affect water transport in the mouse large intestine. Scientific reports\| PubMed ID: 32587380	2020
Proteolytic cleavage of Podocin by Matriptase exacerbates podocyte injury. The Journal of biological chemistry\| PubMed ID: 32907879	2020
Effect of therapeutic plasma exchange on phenytoin plasma concentration in patients receiving intravenous fosphenytoin therapy. Die Pharmazie\| PubMed ID: 33305722	2020
Inverse regulation of claudin-2 and -7 expression by p53 and hepatocyte nuclear factor 4α in colonic MCE301 cells. Tissue barriers\| PubMed ID: 33356822	2021
Segmental differences in Slc26a3-dependent Cl absorption and HCO secretion in the mouse large intestine in vitro in Ussing chambers. The journal of physiological sciences : JPS\| PubMed ID: 33514305	2021
Acute effect of green tea catechins on uric acid metabolism after alcohol ingestion in Japanese men. Clinical rheumatology\| PubMed ID: 33569708	2021
A novel cooling method using carbon dioxide-rich water after passive heating. Journal of thermal biology\| PubMed ID: 33627279	2021
Design of synthetic polymer nanoparticles that inhibit glucose absorption from the intestine. Biochemical and biophysical research communications\| PubMed ID: 34004514	2021